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Article: The effect of fixation plate use on bone healing during the reconstruction of mandibular defects.

Hong, Khang Do Gia / Kim, Seong-Gon / Park, Young-Wook

Journal of the Korean Association of Oral and Maxillofacial Surgeons

2019 Volume 45, Issue 5, Page(s) 276–284

Abstract: Objectives: This study sought to compare efficiency results between the use of a customized implant (CI) and a reconstruction plate (RP) in mandibular defect reconstruction in an animal model.: Materials and methods: Fifteen rabbits underwent surgery ...

Abstract	Objectives: This study sought to compare efficiency results between the use of a customized implant (CI) and a reconstruction plate (RP) in mandibular defect reconstruction in an animal model. Materials and methods: Fifteen rabbits underwent surgery to create a defect in the right side of the mandible and were randomly divided into two groups. For reconstruction of the mandibular defect, the RP group (n=5) received five-hole mini-plates without bone grafting and the CI group (n=10) received fabricated CIs based on the cone-beam computed tomography (CBCT) data taken preoperatively. The CI group was further divided into two subgroups depending on the time of CBCT performance preoperatively, as follows: a six-week CI (6WCI) group (n=5) and a one-week CI (1WCI) group (n=5). Daily food intake amount (DFIA) was measured to assess the recovery rate. Radiographic images were acquired to evaluate screw quantity. CBCT and histological examination were performed in the CI subgroup after sacrifice. Results: The 1WCI group showed the highest value in peak average recovery rate and the fastest average recovery rate. In terms of reaching a 50% recovery rate, the 1WCI group required the least number of days as compared with the other groups (2.6±1.3 days), while the RP group required the least number of days to reach an 80% recovery rate (7.8±2.2 days). The 1WCI group showed the highest percentage of intact screws (94.3%). New bone formation was observed in the CI group during histological examination. Conclusion: Rabbits with mandibular defects treated with CI showed higher and faster recovery rates and more favorable screw status as compared with those treated with a five-hole mini-plate without bone graft.
Language	English
Publishing date	2019-10-30
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2763851-0
ISSN	2234-5930 ; 2234-7550
ISSN (online)	2234-5930
ISSN	2234-7550
DOI	10.5125/jkaoms.2019.45.5.276
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Recent advances in dental implants.

Hong, Do Gia Khang / Oh, Ji-Hyeon

Maxillofacial plastic and reconstructive surgery

2017 Volume 39, Issue 1, Page(s) 33

Abstract: Dental implants are a common treatment for the loss of teeth. This paper summarizes current knowledge on implant surfaces, immediate loading versus conventional loading, short implants, sinus lifting, and custom implants using three-dimensional printing. ...

Abstract	Dental implants are a common treatment for the loss of teeth. This paper summarizes current knowledge on implant surfaces, immediate loading versus conventional loading, short implants, sinus lifting, and custom implants using three-dimensional printing. Most of the implant surface modifications showed good osseointegration results. Regarding biomolecular coatings, which have been recently developed and studied, good results were observed in animal experiments. Immediate loading had similar clinical outcomes compared to conventional loading and can be used as a successful treatment because it has the advantage of reducing treatment times and providing early function and aesthetics. Short implants showed similar clinical outcomes compared to standard implants. A variety of sinus augmentation techniques, grafting materials, and alternative techniques, such as tilted implants, zygomatic implants, and short implants, can be used. With the development of new technologies in three-dimension and computer-aided design/computer-aided manufacturing (CAD/CAM) customized implants can be used as an alternative to conventional implant designs. However, there are limitations due to the lack of long-term studies or clinical studies. A long-term clinical trial and a more predictive study are needed.
Language	English
Publishing date	2017-11-05
Publishing country	England
Document type	Journal Article ; Review
ISSN	2288-8101
ISSN	2288-8101
DOI	10.1186/s40902-017-0132-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Effect of Sericin on Bone Regeneration in a Streptozotocin-Induced Type I Diabetes Animal Model

Khang Do Gia Hong / Yei-Jin Kang / Ji-Hyeon Oh / Seong-Gon Kim / Young-Wook Park / You-Young Jo / HaeYong Kweon / Horatiu Rotaru

Applied Sciences, Vol 11, Iss 4, p

2021 Volume 1369

Abstract: There is an association between diabetes and impaired bone healing. The purpose of this study was to determine whether sericin had a positive effect on bone regeneration with streptozotocin-induced diabetes in a rat model. Sprague Dawley rats ( n = 21) ... ...

Abstract	There is an association between diabetes and impaired bone healing. The purpose of this study was to determine whether sericin had a positive effect on bone regeneration with streptozotocin-induced diabetes in a rat model. Sprague Dawley rats ( n = 21) were assigned to one of three groups. A critical-sized bone defect was created on the calvaria. In the sericin group (S group, n = 7), the bone defect was filled with a sericin–gelatin combination, whereas in the gelatin group (G group, n = 7), only gelatin sponge was used. The control group (N group, n = 7) did not receive any graft. New bone formation was evaluated by micro-computerized tomogram and histological analysis. The regenerated bone volume in group S was the highest among the three groups (3.87 ± 2.51 mm 3 ), followed by group N (1.71 ± 1.65 mm 3 ) and group G (1.24 ± 1.05 mm 3 ). The application of sericin in combination with a gelatin sponge enhanced the process of bone regeneration in streptozotocin-induced type I diabetes animal model.
Keywords	sericin ; type 1 diabetes ; healing ; bone graft ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	616
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Custom Implant for Reconstruction of Mandibular Continuity Defect.

Lee, Sang-Woon / Kim, Hyung Giun / Ham, Min Ji / Hong, Do Gia Khang / Kim, Seong-Gon / Rotaru, Horatiu

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

2017 Volume 76, Issue 6, Page(s) 1370–1376

Abstract: Purpose: The purpose of this study was to compare the daily food intake rate and the rate of screw loosening between 2 groups of rabbits with mandibular continuity defects: custom implant (CI) group and 5-hole mini-plate group.: Materials and methods!# ...

Abstract	Purpose: The purpose of this study was to compare the daily food intake rate and the rate of screw loosening between 2 groups of rabbits with mandibular continuity defects: custom implant (CI) group and 5-hole mini-plate group. Materials and methods: Two types of cylindrical implants were printed, and their physical strength was compared. In this study using rabbits, 1 group (n = 5) received a CI for the reconstruction of a mandibular continuity defect (CI group) and the other group (n = 5) received a 5-hole mini-plate without a bone graft (reconstruction plate [RP] group). After reconstruction, the daily food intake rate and the rate of screw loosening were examined postoperatively. Histologic examination in the CI group was performed 3 months after the operation. Results: The design that mimicked the mandible showed greater physical strength. The amount of time required to achieve 50% recovery was shorter in the CI group than in the RP group (P = .011). The total number of loosened screws in the CI group was lower than that in the RP group at 3 months postoperatively (P = .008). New bone formation in the porous CI was evident in the CI group. Conclusions: Rabbits with mandibular continuity defects treated with CIs for reconstruction showed faster recovery of the daily food intake rate and fewer loosened screws than those treated with a 5-hole mini-plate without bone graft.
MeSH term(s)	Animals ; Rabbits ; Bone Plates ; Cone-Beam Computed Tomography ; Eating ; Mandibular Reconstruction/instrumentation ; Printing, Three-Dimensional ; Prosthesis Design ; Prosthesis Failure ; Random Allocation ; Surgical Mesh
Language	English
Publishing date	2017-12-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	392404-x
ISSN	1531-5053 ; 0278-2391
ISSN (online)	1531-5053
ISSN	0278-2391
DOI	10.1016/j.joms.2017.12.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Liquid biopsy uncovers distinct patterns of DNA methylation and copy number changes in NSCLC patients with different EGFR-TKI resistant mutations.

Nguyen, Hoai-Nghia / Cao, Ngoc-Phuong Thi / Van Nguyen, Thien-Chi / Le, Khang Nguyen Duy / Nguyen, Dat Thanh / Nguyen, Quynh-Tho Thi / Nguyen, Thai-Hoa Thi / Van Nguyen, Chu / Le, Ha Thu / Nguyen, Mai-Lan Thi / Nguyen, Trieu Vu / Tran, Vu Uyen / Luong, Bac An / Le, Linh Gia Hoang / Ho, Quoc Chuong / Pham, Hong-Anh Thi / Vo, Binh Thanh / Nguyen, Luan Thanh / Dang, Anh-Thu Huynh /

Nguyen, Sinh Duy / Do, Duc Minh / Do, Thanh-Thuy Thi / Hoang, Anh Vu / Dinh, Kiet Truong / Phan, Minh-Duy / Giang, Hoa / Tran, Le Son

Scientific reports

2021 Volume 11, Issue 1, Page(s) 16436

Abstract: Targeted therapy with tyrosine kinase inhibitors (TKI) provides survival benefits to a majority of patients with non-small cell lung cancer (NSCLC). However, resistance to TKI almost always develops after treatment. Although genetic and epigenetic ... ...

Abstract	Targeted therapy with tyrosine kinase inhibitors (TKI) provides survival benefits to a majority of patients with non-small cell lung cancer (NSCLC). However, resistance to TKI almost always develops after treatment. Although genetic and epigenetic alterations have each been shown to drive resistance to TKI in cell line models, clinical evidence for their contribution in the acquisition of resistance remains limited. Here, we employed liquid biopsy for simultaneous analysis of genetic and epigenetic changes in 122 Vietnamese NSCLC patients undergoing TKI therapy and displaying acquired resistance. We detected multiple profiles of resistance mutations in 51 patients (41.8%). Of those, genetic alterations in EGFR, particularly EGFR amplification (n = 6), showed pronounced genome instability and genome-wide hypomethylation. Interestingly, the level of hypomethylation was associated with the duration of response to TKI treatment. We also detected hypermethylation in regulatory regions of Homeobox genes which are known to be involved in tumor differentiation. In contrast, such changes were not observed in cases with MET (n = 4) and HER2 (n = 4) amplification. Thus, our study showed that liquid biopsy could provide important insights into the heterogeneity of TKI resistance mechanisms in NSCLC patients, providing essential information for prediction of resistance and selection of subsequent treatment.
MeSH term(s)	Adult ; Aged ; Antineoplastic Agents/therapeutic use ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; Cohort Studies ; DNA Copy Number Variations ; DNA Methylation ; Drug Resistance, Neoplasm/genetics ; ErbB Receptors/genetics ; Female ; Humans ; Liquid Biopsy/methods ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Male ; Middle Aged ; Mutation ; Protein Kinase Inhibitors/therapeutic use
Chemical Substances	Antineoplastic Agents ; Protein Kinase Inhibitors ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1)
Language	English
Publishing date	2021-08-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-95985-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Liquid biopsy uncovers distinct patterns of DNA methylation and copy number changes in NSCLC patients with different EGFR-TKI resistant mutations

Hoai-Nghia Nguyen / Ngoc-Phuong Thi Cao / Thien-Chi Van Nguyen / Khang Nguyen Duy Le / Dat Thanh Nguyen / Quynh-Tho Thi Nguyen / Thai-Hoa Thi Nguyen / Chu Van Nguyen / Ha Thu Le / Mai-Lan Thi Nguyen / Trieu Vu Nguyen / Vu Uyen Tran / Bac An Luong / Linh Gia Hoang Le / Quoc Chuong Ho / Hong-Anh Thi Pham / Binh Thanh Vo / Luan Thanh Nguyen / Anh-Thu Huynh Dang /

Sinh Duy Nguyen / Duc Minh Do / Thanh-Thuy Thi Do / Anh Vu Hoang / Kiet Truong Dinh / Minh-Duy Phan / Hoa Giang / Le Son Tran

Scientific Reports, Vol 11, Iss 1, Pp 1-

2021 Volume 12

Abstract: Abstract Targeted therapy with tyrosine kinase inhibitors (TKI) provides survival benefits to a majority of patients with non-small cell lung cancer (NSCLC). However, resistance to TKI almost always develops after treatment. Although genetic and ... ...

Abstract	Abstract Targeted therapy with tyrosine kinase inhibitors (TKI) provides survival benefits to a majority of patients with non-small cell lung cancer (NSCLC). However, resistance to TKI almost always develops after treatment. Although genetic and epigenetic alterations have each been shown to drive resistance to TKI in cell line models, clinical evidence for their contribution in the acquisition of resistance remains limited. Here, we employed liquid biopsy for simultaneous analysis of genetic and epigenetic changes in 122 Vietnamese NSCLC patients undergoing TKI therapy and displaying acquired resistance. We detected multiple profiles of resistance mutations in 51 patients (41.8%). Of those, genetic alterations in EGFR, particularly EGFR amplification (n = 6), showed pronounced genome instability and genome-wide hypomethylation. Interestingly, the level of hypomethylation was associated with the duration of response to TKI treatment. We also detected hypermethylation in regulatory regions of Homeobox genes which are known to be involved in tumor differentiation. In contrast, such changes were not observed in cases with MET (n = 4) and HER2 (n = 4) amplification. Thus, our study showed that liquid biopsy could provide important insights into the heterogeneity of TKI resistance mechanisms in NSCLC patients, providing essential information for prediction of resistance and selection of subsequent treatment.
Keywords	Medicine ; R ; Science ; Q
Subject code	616 ; 610
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Boeica konchurangensis sp. nov. (Gesneriaceae) from Gia Lai plateau, Vietnam

Quang, Bui Hong / Hai, Do Van / Khang, Nguyen Sinh / Linh, Le Thi Mai / Binh, Tran Duc / Son, Doan Hoang / Anh, Tran Thi Phuong / Möller, Michael

Nordic journal of botany. 2019 May, v. 37, no. 5

2019

Abstract: Boeica konchurangensis B.H.Quang, D.V.Hai & Mich.Möller, a new species of Gesneriaceae from the Gia ...

Abstract	Boeica konchurangensis B.H.Quang, D.V.Hai & Mich.Möller, a new species of Gesneriaceae from the Gia Lai Province of Vietnam is described, illustrated, and colour photographs of the species are provided. This new species has an almost actinomorphic corolla and shows morphological similarities with B. porosa, but differs from it by a shorter peduncle, a near‐actinomorphic purple corolla with a distinctly broad campanulate tube and a shorter capsule.
Keywords	Gesneriaceae ; color ; corolla ; new species ; peduncle ; photographs ; scientific illustration ; taxon descriptions ; Vietnam
Language	English
Dates of publication	2019-05
Publishing place	Blackwell Publishing Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	2406507-9
ISSN	1756-1051 ; 0107-055X
ISSN (online)	1756-1051
ISSN	0107-055X
DOI	10.1111/njb.02333
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Premna vietnamensis (Lamiaceae, Premnoideae), a distinct new species from the Central Highlands of Vietnam.

Hai, Do Van / Min, Dao-Zhang / Khang, Nguyen Sinh / Tan, Yun-Hong / Thoa, Pham Thi Kim / Bramley, Gemma L C / de Kok, Rogier P J / Li, Bo

PloS one

2018 Volume 13, Issue 5, Page(s) e0195811

Abstract: Premna vietnamensis, a distinct new species which is endemic to Gia Lai Province in Central ...

Abstract	Premna vietnamensis, a distinct new species which is endemic to Gia Lai Province in Central Highlands of Vietnam, is described and illustrated. It is characterized by its calyx tube bearing a semi-globose fleshy appendage, which has not been reported before from all known congeneric taxa, as well as from the Lamiaceae. A phylogenetic analysis of the whole Lamiaceae based on a sampling including representatives from all 12 currently recognized subfamilies confirmed the placement of this new species within Premna of the Premnoideae. Morphologically and geographically, P. vietnamensis is most similar to P. stenobotrys, but differs significantly in many aspects.
MeSH term(s)	DNA, Plant/genetics ; Lamiaceae/classification ; Lamiaceae/genetics ; Phylogeny ; Sequence Analysis, DNA ; Vietnam
Chemical Substances	DNA, Plant
Language	English
Publishing date	2018
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0195811
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Premna vietnamensis (Lamiaceae, Premnoideae), a distinct new species from the Central Highlands of Vietnam.

Do Van Hai / Dao-Zhang Min / Nguyen Sinh Khang / Yun-Hong Tan / Pham Thi Kim Thoa / Gemma L C Bramley / Rogier P J de Kok / Bo Li

PLoS ONE, Vol 13, Iss 5, p e

2018 Volume 0195811

Abstract: Premna vietnamensis, a distinct new species which is endemic to Gia Lai Province in Central ...

Abstract	Premna vietnamensis, a distinct new species which is endemic to Gia Lai Province in Central Highlands of Vietnam, is described and illustrated. It is characterized by its calyx tube bearing a semi-globose fleshy appendage, which has not been reported before from all known congeneric taxa, as well as from the Lamiaceae. A phylogenetic analysis of the whole Lamiaceae based on a sampling including representatives from all 12 currently recognized subfamilies confirmed the placement of this new species within Premna of the Premnoideae. Morphologically and geographically, P. vietnamensis is most similar to P. stenobotrys, but differs significantly in many aspects.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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