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  1. Article: Effect of an unsupervised walking program on tolerance to exercise in patients with chronic obstructive pulmonary disease.

    Martin-Deleon, Roberto / Jurado-Garcia, Antonio / Arenas-De Larriva, Maria Del Sol / Feu-Collado, Nuria / Santos-Luna, Francisco / Jurado-Gamez, Bernabe

    Journal of thoracic disease

    2020  Volume 12, Issue 12, Page(s) 7494–7497

    Language English
    Publishing date 2020-12-28
    Publishing country China
    Document type Journal Article
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd-20-2272
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Can neurosphere production help restore inner ear transduction?

    Collado, Maria Sol / Holt, Jeffrey R

    Proceedings of the National Academy of Sciences of the United States of America

    2008  Volume 106, Issue 1, Page(s) 8–9

    MeSH term(s) Animals ; Ear, Inner/physiopathology ; Hair Cells, Auditory, Inner/cytology ; Hearing Loss/therapy ; Humans ; Neurons/cytology ; Neurons/transplantation ; Stem Cell Transplantation
    Language English
    Publishing date 2008-12-31
    Publishing country United States
    Document type Comment ; Journal Article ; Review
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.0811804106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article ; Online: The Maternal Diet Index and Offspring Microbiota at 1 Month of Life: Insights from the Mediterranean Birth Cohort MAMI.

    Cabrera-Rubio, Raúl / Pickett-Nairne, Kaci / González-Solares, Sonia / Collado, Maria Carmen / Venter, Carina

    Nutrients

    2024  Volume 16, Issue 2

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Infant ; Pregnancy ; Female ; Humans ; Birth Cohort ; Cross-Sectional Studies ; Microbiota ; Diet ; Mothers ; Vegetables ; Bifidobacterium
    Language English
    Publishing date 2024-01-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu16020314
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  4. Article ; Online: Identification of 2,2-Dimethylbutanoic Acid (HST5040), a Clinical Development Candidate for the Treatment of Propionic Acidemia and Methylmalonic Acidemia.

    Armstrong, Allison J / Henke, Brad R / Collado, Maria Sol / Taylor, Justin M / Pourtaheri, Taylor D / Dillberger, John E / Roper, Thomas D / Wamhoff, Brian R / Olson, Matthew W / Figler, Robert A / Hoang, Stephen A / Reardon, John E / Johns, Brian A

    Journal of medicinal chemistry

    2021  Volume 64, Issue 8, Page(s) 5037–5048

    Abstract: Propionic acidemia (PA) and methylmalonic acidemia (MMA) are rare autosomal recessive disorders of propionyl-CoA (P-CoA) catabolism, caused by a deficiency in the enzymes P-CoA carboxylase and methylmalonyl-CoA (M-CoA) mutase, respectively. PA and MMA ... ...

    Abstract Propionic acidemia (PA) and methylmalonic acidemia (MMA) are rare autosomal recessive disorders of propionyl-CoA (P-CoA) catabolism, caused by a deficiency in the enzymes P-CoA carboxylase and methylmalonyl-CoA (M-CoA) mutase, respectively. PA and MMA are classified as intoxication-type inborn errors of metabolism because the intramitochondrial accumulation of P-CoA, M-CoA, and other metabolites results in secondary inhibition of multiple pathways of intermediary metabolism, leading to organ dysfunction and failure. Herein, we describe the structure-activity relationships of a series of short-chain carboxylic acids which reduce disease-related metabolites in PA and MMA primary hepatocyte disease models. These studies culminated in the identification of 2,2-dimethylbutanoic acid (
    MeSH term(s) Acyl Coenzyme A/metabolism ; Amino Acid Metabolism, Inborn Errors/drug therapy ; Amino Acid Metabolism, Inborn Errors/pathology ; Animals ; Area Under Curve ; Butyrates/chemistry ; Butyrates/metabolism ; Butyrates/therapeutic use ; Cells, Cultured ; Dogs ; Drug Evaluation, Preclinical ; Half-Life ; Hepatocytes/cytology ; Hepatocytes/metabolism ; Humans ; Mice ; Models, Biological ; Propionic Acidemia/drug therapy ; Propionic Acidemia/pathology ; ROC Curve ; Rats ; Structure-Activity Relationship
    Chemical Substances Acyl Coenzyme A ; Butyrates ; methylmalonyl-coenzyme A (1264-45-5) ; propionyl-coenzyme A (317-66-8) ; 2,2-dimethylbutyric acid (AY606CN05O)
    Language English
    Publishing date 2021-04-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.1c00124
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 151: Show issues Location:
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    Zs.MB 1: Show issues

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  5. Article ; Online: A novel small molecule approach for the treatment of propionic and methylmalonic acidemias.

    Armstrong, Allison J / Collado, Maria Sol / Henke, Brad R / Olson, Matthew W / Hoang, Stephen A / Hamilton, Christin A / Pourtaheri, Taylor D / Chapman, Kimberly A / Summar, Marshall M / Johns, Brian A / Wamhoff, Brian R / Reardon, John E / Figler, Robert A

    Molecular genetics and metabolism

    2021  Volume 133, Issue 1, Page(s) 71–82

    Abstract: Propionic Acidemia (PA) and Methylmalonic Acidemia (MMA) are inborn errors of metabolism affecting the catabolism of valine, isoleucine, methionine, threonine and odd-chain fatty acids. These are multi-organ disorders caused by the enzymatic deficiency ... ...

    Abstract Propionic Acidemia (PA) and Methylmalonic Acidemia (MMA) are inborn errors of metabolism affecting the catabolism of valine, isoleucine, methionine, threonine and odd-chain fatty acids. These are multi-organ disorders caused by the enzymatic deficiency of propionyl-CoA carboxylase (PCC) or methylmalonyl-CoA mutase (MUT), resulting in the accumulation of propionyl-coenzyme A (P-CoA) and methylmalonyl-CoA (M-CoA in MMA only). Primary metabolites of these CoA esters include 2-methylcitric acid (MCA), propionyl-carnitine (C3), and 3-hydroxypropionic acid, which are detectable in both PA and MMA, and methylmalonic acid, which is detectable in MMA patients only (Chapman et al., 2012). We deployed liver cell-based models that utilized PA and MMA patient-derived primary hepatocytes to validate a small molecule therapy for PA and MMA patients. The small molecule, HST5040, resulted in a dose-dependent reduction in the levels of P-CoA, M-CoA (in MMA) and the disease-relevant biomarkers C3, MCA, and methylmalonic acid (in MMA). A putative working model of how HST5040 reduces the P-CoA and its derived metabolites involves the conversion of HST5040 to HST5040-CoA driving the redistribution of free and conjugated CoA pools, resulting in the differential reduction of the aberrantly high P-CoA and M-CoA. The reduction of P-CoA and M-CoA, either by slowing production (due to increased demands on the free CoA (CoASH) pool) or enhancing clearance (to replenish the CoASH pool), results in a net decrease in the CoA-derived metabolites (C3, MCA and MMA (MMA only)). A Phase 2 study in PA and MMA patients will be initiated in the United States.
    MeSH term(s) Acyl Coenzyme A/metabolism ; Amino Acid Metabolism, Inborn Errors/drug therapy ; Amino Acid Metabolism, Inborn Errors/genetics ; Amino Acid Metabolism, Inborn Errors/pathology ; Carnitine/metabolism ; Cell Line ; Citrates/metabolism ; Hepatocytes/drug effects ; Humans ; Methylmalonyl-CoA Decarboxylase/genetics ; Methylmalonyl-CoA Mutase/deficiency ; Methylmalonyl-CoA Mutase/genetics ; Propionic Acidemia/drug therapy ; Propionic Acidemia/genetics ; Propionic Acidemia/pathology ; Small Molecule Libraries/pharmacology
    Chemical Substances Acyl Coenzyme A ; Citrates ; Small Molecule Libraries ; methylmalonyl-coenzyme A (1264-45-5) ; propionyl-coenzyme A (317-66-8) ; 2-methylcitric acid (6061-96-7) ; Methylmalonyl-CoA Mutase (EC 5.4.99.2) ; Methylmalonyl-CoA Decarboxylase (EC 7.2.4.3) ; Carnitine (S7UI8SM58A)
    Language English
    Publishing date 2021-03-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1418518-0
    ISSN 1096-7206 ; 1096-7192
    ISSN (online) 1096-7206
    ISSN 1096-7192
    DOI 10.1016/j.ymgme.2021.03.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 617: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Specializations of intercellular junctions are associated with the presence and absence of hair cell regeneration in ears from six vertebrate classes.

    Burns, Joseph C / Collado, Maria Sol / Oliver, Eric R / Corwin, Jeffrey T

    The Journal of comparative neurology

    2013  Volume 521, Issue 6, Page(s) 1430–1448

    Abstract: Sensory hair cell losses lead to hearing and balance deficits that are permanent for mammals, but temporary for nonmammals because supporting cells in their ears give rise to replacement hair cells. In mice and humans, vestibular supporting cells grow ... ...

    Abstract Sensory hair cell losses lead to hearing and balance deficits that are permanent for mammals, but temporary for nonmammals because supporting cells in their ears give rise to replacement hair cells. In mice and humans, vestibular supporting cells grow exceptionally large circumferential F-actin belts and their junctions express E-cadherin in patterns that strongly correlate with postnatal declines in regeneration capacity. In contrast, chicken supporting cells retain thin F-actin belts throughout life and express little E-cadherin. To determine whether the junctions in chicken ears might be representative of other ears that also regenerate hair cells, we investigated inner ears from dogfish sharks, zebrafish, bullfrogs, Xenopus, turtles, and the lizard, Anolis. As in chickens, the supporting cells in adult zebrafish, Xenopus, and turtle ears retained thin circumferential F-actin belts and expressed little E-cadherin. Supporting cells in adult sharks and bullfrogs also retained thin belts, but were not tested for E-cadherin. Supporting cells in adult Anolis exhibited wide, but porous webs of F-actin and strong E-cadherin expression. Anolis supporting cells also showed some cell cycle reentry when cultured. The results reveal that the association between thin F-actin belts and low E-cadherin is shared by supporting cells in anamniotes, turtles, and birds, which all can regenerate hair cells. Divergent junctional specializations in supporting cells appear to have arisen independently in Anolis and mammals. The presence of webs of F-actin at the junctions in Anolis appears compatible with supporting cell proliferation, but the solid reinforcement of the F-actin belts in mammals is associated with its absence.
    MeSH term(s) Animals ; Chickens ; Dogfish ; Ear/physiology ; Female ; Hair Cells, Auditory/classification ; Hair Cells, Auditory/physiology ; Humans ; Intercellular Junctions/classification ; Intercellular Junctions/physiology ; Lizards ; Male ; Mice ; Rana catesbeiana ; Regeneration/physiology ; Species Specificity ; Turtles ; Vertebrates ; Xenopus laevis ; Zebrafish
    Language English
    Publishing date 2013-04-15
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 3086-7
    ISSN 1096-9861 ; 0021-9967 ; 0092-7317
    ISSN (online) 1096-9861
    ISSN 0021-9967 ; 0092-7317
    DOI 10.1002/cne.23250
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    In stock of ZB MED Cologne/Königswinter

    Ub I Zs.66: Show issues Location:
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  7. Article: Can neurosphere production help restore inner ear transduction?

    Collado, Maria Sol / Holt, Jeffrey R

    Proceedings of the National Academy of Sciences of the United States of America. 2009 Jan. 6, v. 106, no. 1

    2009  

    Language English
    Dates of publication 2009-0106
    Size p. 8-9.
    Publishing place National Academy of Sciences
    Document type Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

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  8. Article ; Online: Variations in shape-sensitive restriction points mirror differences in the regeneration capacities of avian and mammalian ears.

    Collado, Maria Sol / Burns, Joseph C / Meyers, Jason R / Corwin, Jeffrey T

    PloS one

    2011  Volume 6, Issue 8, Page(s) e23861

    Abstract: When inner ear hair cells die, humans and other mammals experience permanent hearing and balance deficits, but non-mammalian vertebrates quickly recover these senses after epithelial supporting cells give rise to replacement hair cells. A postnatal ... ...

    Abstract When inner ear hair cells die, humans and other mammals experience permanent hearing and balance deficits, but non-mammalian vertebrates quickly recover these senses after epithelial supporting cells give rise to replacement hair cells. A postnatal decline in cellular plasticity appears to limit regeneration in mammalian balance organs, where declining proliferation responses are correlated with decreased spreading of supporting cells on artificial and native substrates. By culturing balance epithelia on substrates that differed in flexibility, we assessed spreading effects independent of age, showing a strong correlation between shape change and supporting cell proliferation. Then we made excision wounds in utricles cultured from young and old chickens and mice and compared quantified levels of spreading and proliferation. In utricles from young mice, and both young and old chickens, wounds re-epithelialized in <24 hours, while those in utricles from mature mice took three times longer. More cells changed shape in the fastest healing wounds, which accounted for some differences in the levels of proliferation, but inter-species and age-related differences in shape-sensitive restriction points, i.e., the cellular thresholds for shape changes that promote S-phase, were evident and may be particularly influential in the responses to hair cell losses in vivo.
    MeSH term(s) Acoustic Maculae/drug effects ; Acoustic Maculae/pathology ; Acoustic Maculae/physiology ; Animals ; Bromodeoxyuridine/metabolism ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Cell Shape/drug effects ; Chickens/anatomy & histology ; Collagen/pharmacology ; Drug Combinations ; Ear/pathology ; Ear/physiology ; Labyrinth Supporting Cells/drug effects ; Labyrinth Supporting Cells/pathology ; Laminin/pharmacology ; Mice ; Proteoglycans/pharmacology ; Regeneration/drug effects ; Regeneration/physiology ; S Phase/drug effects ; Wound Healing/drug effects
    Chemical Substances Drug Combinations ; Laminin ; Proteoglycans ; matrigel (119978-18-6) ; Collagen (9007-34-5) ; Bromodeoxyuridine (G34N38R2N1)
    Language English
    Publishing date 2011-08-31
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0023861
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  9. Article: Risk Factors for

    Samper-Cativiela, Clara / Prieto, Maria Esther / Collado, Soledad / De Frutos, Cristina / Branscum, Adam J / Saez, Jose Luis / Alvarez, Julio

    Animals : an open access journal from MDPI

    2023  Volume 13, Issue 20

    Abstract: ... Trends ... ...

    Abstract Trends in
    Language English
    Publishing date 2023-10-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani13203181
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  10. Article: Influence of Diet, Sex, and Viral Infections on the Gut Microbiota Composition of

    Martínez-Solís, María / Collado, María Carmen / Herrero, Salvador

    Frontiers in microbiology

    2020  Volume 11, Page(s) 753

    Abstract: The gut microbiota plays essential roles in processes related with metabolism, physiology, and immunity in all organisms, including insects. In the present work, we performed a broad analysis of ... ...

    Abstract The gut microbiota plays essential roles in processes related with metabolism, physiology, and immunity in all organisms, including insects. In the present work, we performed a broad analysis of the
    Language English
    Publishing date 2020-05-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2020.00753
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