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  1. Article ; Online: SPLUNC1 α6 Peptidomimetic: A Novel Therapeutic for Asthma.

    Vlahos, Ross

    American journal of respiratory cell and molecular biology

    2022  Volume 66, Issue 3, Page(s) 241–242

    MeSH term(s) Animals ; Asthma/drug therapy ; Inflammation ; Mice ; ORAI1 Protein ; Peptidomimetics/pharmacology ; Peptidomimetics/therapeutic use ; Phosphoproteins/metabolism
    Chemical Substances ORAI1 Protein ; Orai1 protein, mouse ; Peptidomimetics ; Phosphoproteins
    Language English
    Publishing date 2022-01-11
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2021-0451ED
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    Zs.A 2851: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  2. Article ; Online: E-vaping and high-fat diet consumption: It's all a hazy memory.

    Vlahos, Ross

    Brain, behavior, and immunity

    2021  Volume 95, Page(s) 23–24

    MeSH term(s) Brain ; Diet, High-Fat/adverse effects ; Nicotine ; Smoking Cessation ; Vaping
    Chemical Substances Nicotine (6M3C89ZY6R)
    Language English
    Publishing date 2021-04-16
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ZDB-ID 639219-2
    ISSN 1090-2139 ; 0889-1591
    ISSN (online) 1090-2139
    ISSN 0889-1591
    DOI 10.1016/j.bbi.2021.04.009
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    Zs.A 2276: Show issues Location:
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    Zs.MO 327: Show issues

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  3. Article ; Online: The vape has gone to your head.

    Vlahos, Ross

    Brain, behavior, and immunity

    2020  Volume 89, Page(s) 5–6

    MeSH term(s) Blood-Brain Barrier ; Electronic Nicotine Delivery Systems ; Vaping
    Language English
    Publishing date 2020-08-03
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ZDB-ID 639219-2
    ISSN 1090-2139 ; 0889-1591
    ISSN (online) 1090-2139
    ISSN 0889-1591
    DOI 10.1016/j.bbi.2020.07.047
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    Zs.A 2276: Show issues Location:
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    Zs.MO 327: Show issues

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  4. Article ; Online: FSTL-1: A New Player in the Prevention of Emphysema.

    Vlahos, Ross

    American journal of respiratory and critical care medicine

    2020  Volume 201, Issue 8, Page(s) 886–888

    MeSH term(s) Emphysema ; Humans ; Pulmonary Emphysema ; Smoke
    Chemical Substances Smoke
    Language English
    Publishing date 2020-01-13
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.201912-2402ED
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  5. Article ; Online: Lipids in Chronic Obstructive Pulmonary Disease: A Target for Future Therapy?

    Vlahos, Ross

    American journal of respiratory cell and molecular biology

    2019  Volume 62, Issue 3, Page(s) 273–274

    MeSH term(s) Airway Resistance ; Humans ; Lipids ; Pulmonary Disease, Chronic Obstructive ; Smoking ; Transferases (Other Substituted Phosphate Groups)
    Chemical Substances Lipids ; Transferases (Other Substituted Phosphate Groups) (EC 2.7.8.-) ; phosphatidylcholine-ceramide phosphocholine transferase (EC 2.7.8.-)
    Language English
    Publishing date 2019-10-02
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2019-0338ED
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    Zs.A 2851: Show issues Location:
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  6. Article ; Online: Musculoskeletal crosstalk in chronic obstructive pulmonary disease and comorbidities: Emerging roles and therapeutic potentials.

    Mou, Kevin / Chan, Stanley M H / Vlahos, Ross

    Pharmacology & therapeutics

    2024  Volume 257, Page(s) 108635

    Abstract: Chronic Obstructive Pulmonary Disease (COPD) is a multifaceted respiratory disorder characterized by progressive airflow limitation and systemic implications. It has become increasingly apparent that COPD exerts its influence far beyond the respiratory ... ...

    Abstract Chronic Obstructive Pulmonary Disease (COPD) is a multifaceted respiratory disorder characterized by progressive airflow limitation and systemic implications. It has become increasingly apparent that COPD exerts its influence far beyond the respiratory system, extending its impact to various organ systems. Among these, the musculoskeletal system emerges as a central player in both the pathogenesis and management of COPD and its associated comorbidities. Muscle dysfunction and osteoporosis are prevalent musculoskeletal disorders in COPD patients, leading to a substantial decline in exercise capacity and overall health. These manifestations are influenced by systemic inflammation, oxidative stress, and hormonal imbalances, all hallmarks of COPD. Recent research has uncovered an intricate interplay between COPD and musculoskeletal comorbidities, suggesting that muscle and bone tissues may cross-communicate through the release of signalling molecules, known as "myokines" and "osteokines". We explored this dynamic relationship, with a particular focus on the role of the immune system in mediating the cross-communication between muscle and bone in COPD. Moreover, we delved into existing and emerging therapeutic strategies for managing musculoskeletal disorders in COPD. It underscores the development of personalized treatment approaches that target both the respiratory and musculoskeletal aspects of COPD, offering the promise of improved well-being and quality of life for individuals grappling with this complex condition. This comprehensive review underscores the significance of recognizing the profound impact of COPD on the musculoskeletal system and its comorbidities. By unravelling the intricate connections between these systems and exploring innovative treatment avenues, we can aspire to enhance the overall care and outcomes for COPD patients, ultimately offering hope for improved health and well-being.
    MeSH term(s) Humans ; Quality of Life ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Comorbidity ; Lung ; Musculoskeletal Diseases/epidemiology ; Musculoskeletal Diseases/therapy
    Language English
    Publishing date 2024-03-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 194735-7
    ISSN 1879-016X ; 0163-7258
    ISSN (online) 1879-016X
    ISSN 0163-7258
    DOI 10.1016/j.pharmthera.2024.108635
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    Zs.A 1183: Show issues Location:
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  7. Article ; Online: Clinical utility of pulmonary function and blood biomarker measurements.

    Vlahos, Ross

    Respirology (Carlton, Vic.)

    2018  Volume 24, Issue 1, Page(s) 13–14

    MeSH term(s) Biomarkers ; Cross-Sectional Studies ; Humans ; Lipoprotein(a) ; Lung ; Respiratory Physiological Phenomena
    Chemical Substances Biomarkers ; Lipoprotein(a)
    Language English
    Publishing date 2018-10-19
    Publishing country Australia
    Document type Editorial ; Comment
    ZDB-ID 1435849-9
    ISSN 1440-1843 ; 1323-7799
    ISSN (online) 1440-1843
    ISSN 1323-7799
    DOI 10.1111/resp.13430
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    Zs.A 4957: Show issues Location:
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  8. Article ; Online: E-Cigarettes: Inducing Inflammation that Spans Generations.

    Vlahos, Ross

    American journal of respiratory cell and molecular biology

    2018  Volume 58, Issue 3, Page(s) 286–287

    MeSH term(s) Animals ; Cytokines/biosynthesis ; Electronic Nicotine Delivery Systems ; Female ; Humans ; Inflammation/chemically induced ; Mice ; Models, Animal ; Nicotine/adverse effects ; Pregnancy ; Smoking/adverse effects ; Smoking/mortality
    Chemical Substances Cytokines ; Nicotine (6M3C89ZY6R)
    Language English
    Publishing date 2018
    Publishing country United States
    Document type Editorial
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2017-0306ED
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2851: Show issues Location:
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  9. Article ; Online: Assessing Lung Inflammation and Pathology in Preclinical Models of Chronic Obstructive Pulmonary Disease.

    Vlahos, Ross / Wang, Hao / Bozinovski, Steven

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2691, Page(s) 97–109

    Abstract: Chronic obstructive pulmonary disease (COPD) is an incurable disease that is a major cause of mortality and morbidity worldwide. Cigarette smoking is a major cause of COPD and triggers progressive airflow limitation, chronic lung inflammation, and ... ...

    Abstract Chronic obstructive pulmonary disease (COPD) is an incurable disease that is a major cause of mortality and morbidity worldwide. Cigarette smoking is a major cause of COPD and triggers progressive airflow limitation, chronic lung inflammation, and irreversible lung damage and decline in lung function. COPD patients often experience various extrapulmonary comorbid diseases, including cardiovascular disease, skeletal muscle wasting, lung cancer, and cognitive decline which markedly impact on disease morbidity, progression, and mortality. People with COPD are also susceptible to respiratory infections which cause exacerbations of the underlying disease (AECOPD). The mechanisms and mediators underlying COPD and its comorbidities are poorly understood and current COPD therapy is relatively ineffective. We and others have used animal modelling systems to explore the mechanisms underlying COPD, AECOPD, and comorbidities of COPD with the goal of identifying novel therapeutic targets. Here we provide a preclinical model and protocols to assess the cellular, molecular, and pathological consequences of cigarette smoke exposure and the development of comorbidities of COPD.
    MeSH term(s) Animals ; Pulmonary Disease, Chronic Obstructive/etiology ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Pneumonia/complications ; Lung/pathology ; Comorbidity ; Disease Models, Animal ; Inflammation/pathology
    Language English
    Publishing date 2023-06-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3331-1_8
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  10. Article ; Online: Targeting accelerated pulmonary ageing to treat chronic obstructive pulmonary disease-induced neuropathological comorbidities.

    De Luca, Simone N / Vlahos, Ross

    British journal of pharmacology

    2023  Volume 181, Issue 1, Page(s) 3–20

    Abstract: Chronic obstructive pulmonary disease (COPD) is a major incurable health burden, ranking as the third leading cause of death worldwide, mainly driven by cigarette smoking. COPD is characterised by persistent airway inflammation, lung function decline and ...

    Abstract Chronic obstructive pulmonary disease (COPD) is a major incurable health burden, ranking as the third leading cause of death worldwide, mainly driven by cigarette smoking. COPD is characterised by persistent airway inflammation, lung function decline and premature ageing with the presence of pulmonary senescent cells. This review proposes that cellular senescence, a state of stable cell cycle arrest linked to ageing, induced by inflammation and oxidative stress in COPD, extends beyond the lungs and affects the systemic circulation. This pulmonary senescent profile will reach other organs via extracellular vesicles contributing to brain inflammation and damage, and increasing the risk of neurological comorbidities, such as stroke, cerebral small vessel disease and Alzheimer's disease. The review explores the role of cellular senescence in COPD-associated brain conditions and investigates the relationship between cellular senescence and circadian rhythm in COPD. Additionally, it discusses potential therapies, including senomorphic and senolytic treatments, as novel strategies to halt or improve the progression of COPD.
    MeSH term(s) Humans ; Lung/metabolism ; Pulmonary Disease, Chronic Obstructive/complications ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Pulmonary Disease, Chronic Obstructive/metabolism ; Aging ; Cellular Senescence ; Oxidative Stress
    Language English
    Publishing date 2023-11-15
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 80081-8
    ISSN 1476-5381 ; 0007-1188
    ISSN (online) 1476-5381
    ISSN 0007-1188
    DOI 10.1111/bph.16263
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