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  1. Article ; Online: Interview with Future Medicinal Chemistry's US Senior Editor, Iwao Ojima. Interview by Issac Bruce.

    Ojima, Iwao

    Future medicinal chemistry

    2012  Volume 4, Issue 16, Page(s) 2019–2022

    Abstract: Professor Iwao Ojima studied at the University of Tokyo (Japan) before being appointed as a Senior ... a visiting professor in European, North American and Asian academic institutions. Professor Ojima agreed ... to provide his expertise to the journal. Professor Ojima spoke to Future Medicinal Chemistry about why ...

    Abstract Professor Iwao Ojima studied at the University of Tokyo (Japan) before being appointed as a Senior Research Fellow and Group Leader at the Sagami Institute of Chemical Research. He is now Director of the Institute of Chemical Biology and Drug Discovery at State University of New York (USA) and has been a visiting professor in European, North American and Asian academic institutions. Professor Ojima agreed to serve as the US Senior Editor of Future Medicinal Chemistry when it launched in 2009 and continues to provide his expertise to the journal. Professor Ojima spoke to Future Medicinal Chemistry about why medicinal chemistry is such an exciting field to work in, the state of the pharmaceutical industry, and what features and issues make this journal unique.
    MeSH term(s) Chemistry, Pharmaceutical/economics ; Chemistry, Pharmaceutical/education ; Chemistry, Pharmaceutical/methods ; Computational Biology/economics ; Computational Biology/education ; Computational Biology/methods ; Drug Discovery/economics ; Drug Discovery/education ; Drug Discovery/methods ; Humans ; Periodicals as Topic
    Language English
    Publishing date 2012-10
    Publishing country England
    Document type Interview
    ISSN 1756-8927
    ISSN (online) 1756-8927
    DOI 10.4155/fmc.12.151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Fluorine in medicinal chemistry and chemical biology

    Ojima, Iwao

    2009  

    Author's details ed. by Iwao Ojima
    Keywords Pharmaceutical chemistry ; Fluorine compounds
    Subject code 615.27312
    Language English
    Size XVI, 624, [16] S. : Ill., graph. Darst., 26cm
    Publisher Wiley-Blackwell
    Publishing place Chichester
    Publishing country Great Britain
    Document type Book
    Note Formerly CIP
    HBZ-ID HT015944310
    ISBN 1-4051-6720-3 ; 978-1-4051-6720-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 A 2774 order for loan Magazin

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  3. Article ; Online: Recent advances in tumor-targeting chemotherapy drugs.

    Ojima, Iwao

    Cancer drug resistance (Alhambra, Calif.)

    2021  Volume 4, Issue 4, Page(s) 885–887

    Language English
    Publishing date 2021-09-08
    Publishing country United States
    Document type Journal Article
    ISSN 2578-532X
    ISSN (online) 2578-532X
    DOI 10.20517/cdr.2021.86
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Anticancer agents

    Ojima, Iwao

    frontiers in cancer chemotherapy ; [meeting (219th, 2000, San Francisco, Calif.)]

    (ACS symposium series ; 796)

    2001  

    Institution American Chemical Society
    Author's details Iwao Ojima ... ed. [American Chemical Society]
    Series title ACS symposium series ; 796
    Collection
    Keywords Antineoplastic Agents / therapeutic use ; Neoplasms / drug therapy ; Antineoplastic agents ; Cytostatikum ; Pharmakotherapie
    Subject Arzneimitteltherapie ; Arzneitherapie ; Medikamentöse Therapie ; Zytostatikum ; Cancerotoxischer Stoff ; Carcinostatikum ; Krebsmittel ; Antineoplastikum ; Anticarcinogen ; Antikarzinogen ; Anticancerogen ; Antineoplastisches Mittel
    Subject code 616.994061
    Language English
    Size XII, 364 S. : Ill., graph. Darst.
    Publisher American Chemical Soc
    Publishing place Washington, DC
    Publishing country United States
    Document type Book
    HBZ-ID HT013551810
    ISBN 0-8412-3745-X ; 978-0-8412-3745-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2003 A 843 order for loan Magazin

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  5. Article: Great Challenges in Organic Chemistry.

    Ojima, Iwao

    Frontiers in chemistry

    2017  Volume 5, Page(s) 52

    Language English
    Publishing date 2017-07-12
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2711776-5
    ISSN 2296-2646
    ISSN 2296-2646
    DOI 10.3389/fchem.2017.00052
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book: Biomedical frontiers of fluorine chemistry

    Ojima, Iwao

    developed from symposia

    (ACS symposium series ; 639)

    1996  

    Author's details Iwao Ojima, ed
    Series title ACS symposium series ; 639
    Collection
    Keywords Hydrocarbons, Fluorinated / chemical synthesis / congresses ; Hydrocarbons, Fluorinated / metabolism / congresses ; Hydrocarbons, Fluorinated / therapeutic use / congresses ; Fluororganische Verbindungen ; Biochemie ; Pharmakologie
    Subject Arzneimittellehre ; Arzneimittelwirkung ; Arzneiwirkung ; Experimentelle Pharmakologie ; Organofluorverbindungen ; Organische Fluorverbindungen ; Fluorierte Verbindungen ; Biologische Chemie
    Language English
    Size XI, 356 S. : graph. Darst.
    Publisher American Chemical Soc
    Publishing place Washington, DC
    Publishing country United States
    Document type Book
    HBZ-ID HT007710221
    ISBN 0-8412-3442-6 ; 978-0-8412-3442-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1997 A 6875 order for loan Magazin

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  7. Article ; Online: Great Challenges in Organic Chemistry

    Iwao Ojima

    Frontiers in Chemistry, Vol

    2017  Volume 5

    Keywords grand challenges ; interface of organic chemistry ; new frontiers ; interdisciplinary ; multidisciplinary ; Chemistry ; QD1-999
    Language English
    Publishing date 2017-07-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  8. Article: Strategic Incorporation of Fluorine into Taxoid Anticancer Agents for Medicinal Chemistry and Chemical Biology Studies.

    Ojima, Iwao

    Journal of fluorine chemistry

    2017  Volume 198, Page(s) 10–23

    Abstract: This account exemplifies our recent progress on the strategic incorporation of fluorine and organofluorine groups to taxoid anticancer agents and their tumor-targeted drug delivery systems (TTDDSs) for medicinal chemistry and chemical biology studies. ... ...

    Abstract This account exemplifies our recent progress on the strategic incorporation of fluorine and organofluorine groups to taxoid anticancer agents and their tumor-targeted drug delivery systems (TTDDSs) for medicinal chemistry and chemical biology studies. Novel 3'-difluorovinyltaxoids were strategically designed to block the metabolism by cytochrome P-450, synthesized, and evaluated for their cytotoxicity against drug-sensitive and multidrug-resistant (MDR) human cancer cell lines. 3'-Difluorovinyltaxoids exhibited impressive activities against these cancer cell lines. More significantly, a representative 3'-difluorovinyltaxoid exhibited 230-33,000 times higher potency than conventional anticancer drugs against cancer stem cell-enriched HCT-116 cell line. Studies on the mechanism of action (MOA) of these fluorotaxoids were performed by tubulin polymerization assay, morphology analysis by electron microscopy (EM) and protein binding assays. Novel
    Language English
    Publishing date 2017-01-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1491286-7
    ISSN 0022-1139
    ISSN 0022-1139
    DOI 10.1016/j.jfluchem.2016.12.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Strategies for the drug discovery and development of taxane anticancer therapeutics.

    Wang, Changwei / Aguilar, Angelo / Ojima, Iwao

    Expert opinion on drug discovery

    2022  Volume 17, Issue 11, Page(s) 1193–1207

    Abstract: Introduction: Paclitaxel and docetaxel have been extensively used in the clinic over the past three decades. Although the patents of these first-generation taxanes have expired, their clinical applications, particularly new formulations and combination ... ...

    Abstract Introduction: Paclitaxel and docetaxel have been extensively used in the clinic over the past three decades. Although the patents of these first-generation taxanes have expired, their clinical applications, particularly new formulations and combination therapies, are under active investigations. Inspired by the notable success of Abraxane and Lipusu, new formulations have been extensively developed. In parallel, to overcome multidrug resistance (MDR) and to eradicate cancer stem cells, immense efforts have been made on the discovery and development of new-generation taxanes with improved potency and superior pharmacological properties.
    Areas covered: This review covers (a) natural sources of advanced intermediates used for semi-synthesis of taxane API, (b) new formulations, (c) the major issues of FDA approved taxanes, (d) the design and development of next-generation taxanes, (e) new mechanisms of action, and (f) a variety of taxane-based drug delivery systems.
    Expert opinion: As the highly potent next-generation taxanes can eradicate cancer stem cells and overcome MDR, the priority is to develop these compounds as an integral part of cancer therapy, especially for pancreatic, colon and prostate cancers which hardly respond to checkpoint inhibitors. In order to mitigate undesirable side effects, the exploration of effective nanoformulations and tumor-targeted drug delivery systems are essential.
    Language English
    Publishing date 2022-10-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2259618-5
    ISSN 1746-045X ; 1746-0441
    ISSN (online) 1746-045X
    ISSN 1746-0441
    DOI 10.1080/17460441.2022.2131766
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6388: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Book ; Online: Frontiers in Chemistry: Rising Stars

    Suib, Steve / Ju, Huangxian / Cosnier, Serge / Ohtani, Bunsho / Wade, John D. / Garnier, Gil / Vincent Myung, Nosang / Carlos, Luís D. / Kassiou, Michael / Zhang, Fan / Ojima, Iwao / Musto, Pellegrino / James, Tony D. / Hofer, Thomas S. / De Visser, Sam P.

    2020  

    Keywords Science: general issues ; Green and Sustainable Chemistry ; Analytical Chemistry ; Theoretical and Computational Chemistry ; Polymer Chemistry ; Medicinal and Pharmaceutical Chemistry ; Organic Chemistry ; Nanoscience ; Catalysis and Photocatalysis ; Supramolecular Chemistry ; Electrochemistry ; Inorganic Chemistry ; Chemical Biology
    Size 1 electronic resource (910 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230771
    ISBN 9782889635801 ; 2889635805
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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