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  1. Article ; Online: S

    Bandyopadhyay, Parijat / Pramanick, Ishika / Biswas, Rupam / Ps, Sabarinath / Sreedharan, Sreesa / Singh, Shalini / Rajmani, Raju S / Laxman, Sunil / Dutta, Somnath / Singh, Amit

    Science advances

    2022  Volume 8, Issue 25, Page(s) eabo0097

    Abstract: Methionine and cysteine metabolisms are important for the survival and pathogenesis ... ...

    Abstract Methionine and cysteine metabolisms are important for the survival and pathogenesis of
    MeSH term(s) Animals ; Cryoelectron Microscopy ; Cystathionine beta-Synthase/chemistry ; Cystathionine beta-Synthase/genetics ; Cystathionine beta-Synthase/metabolism ; Cysteine/metabolism ; Methionine/metabolism ; Mice ; Mycobacterium tuberculosis/metabolism ; Oxidation-Reduction ; Pyridoxal Phosphate/metabolism ; S-Adenosylmethionine/metabolism ; Sulfur/metabolism
    Chemical Substances Pyridoxal Phosphate (5V5IOJ8338) ; Sulfur (70FD1KFU70) ; S-Adenosylmethionine (7LP2MPO46S) ; Methionine (AE28F7PNPL) ; Cystathionine beta-Synthase (EC 4.2.1.22) ; Cysteine (K848JZ4886)
    Language English
    Publishing date 2022-06-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.abo0097
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: S

    Chandra, Girish / Patel, Samridhi / Panchal, Manoj / Singh, Durg Vijay

    Mini reviews in medicinal chemistry

    2020  Volume 21, Issue 7, Page(s) 833–846

    Abstract: ... mechanisms. One of the potential mechanisms is to hamper protein synthesis by blocking the gene expression. S ... the intracellular accumulation of S-Adenosyl-L-homocysteine, elevating the ratio of SAH to S-adenosylmethionine (SAM ... In other words, S-Adenosyl-Lhomocysteine hydrolase regulates methyltransferase reactions. In this way, SAH ...

    Abstract Parasite Plasmodium falciparum is continuously giving a challenge to human beings by changing itself against most of the antimalarial drugs and its consequences can be seen in the form of a huge number of deaths each year especially in the poor and developing country. Due to its drug resistance ability, new drugs are regularly needed to kill the organism. Many new drugs have been developed based on different mechanisms. One of the potential mechanisms is to hamper protein synthesis by blocking the gene expression. S-Adenosyl-L-homocysteine (SAH) hydrolase is a NAD+ dependent tetrameric enzyme, which is responsible for the reversible hydrolysis of AdoHcy to adenosine and L-homocysteine, has been recognized as a new target for antimalarial agents since the parasite has a specific SAH hydrolase. The inhibition of SAH hydrolase causes the intracellular accumulation of S-Adenosyl-L-homocysteine, elevating the ratio of SAH to S-adenosylmethionine (SAM) and inhibiting SAM-dependent methyltransferase that catalyzes methylation of the capped structure at the 5'-terminus of mRNA, and other methylation reaction which is essential for parasite proliferation. In other words, S-Adenosyl-Lhomocysteine hydrolase regulates methyltransferase reactions. In this way, SAH hydrolase inhibitors can be used for the treatment of different diseases like malaria, cancer, viral infection, etc. by ultimately stopping the synthesis of protein. Many antiviral drugs have been synthesized and marketed which are based on the inhibition of SAH hydrolase. This review summarises the development of SAH inhibitors developed over the last 20 years and their potentiality for the treatment of malaria.
    MeSH term(s) Adenosylhomocysteinase/antagonists & inhibitors ; Adenosylhomocysteinase/metabolism ; Antimalarials/chemical synthesis ; Antimalarials/chemistry ; Antimalarials/pharmacology ; Drug Development ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Molecular Structure ; Parasitic Sensitivity Tests ; Plasmodium falciparum/drug effects ; Plasmodium falciparum/enzymology
    Chemical Substances Antimalarials ; Enzyme Inhibitors ; Adenosylhomocysteinase (EC 3.3.1.1)
    Language English
    Publishing date 2020-12-21
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2104081-3
    ISSN 1875-5607 ; 1389-5575
    ISSN (online) 1875-5607
    ISSN 1389-5575
    DOI 10.2174/1389557521666201218155321
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5891: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Book ; Online: Making Home(s) in Displacement : Critical Reflections on a Spatial Practice

    Beeckmans, Luce / Gola, Alessandra / Singh, Ashika / Heynen, Hilde

    2022  

    Keywords Architecture ; Migration, immigration & emigration ; Refugees & political asylum ; Home-making;migration;spatial practices;displacement;refugee shelter;urban citizenship
    Size 1 electronic resource (420 pages)
    Publisher Leuven University Press
    Publishing place Leuven
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021233343
    ISBN 9789461664099 ; 9461664095
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Book ; Online: S-REINFORCE

    Dutta, Rajdeep / Wang, Qincheng / Singh, Ankur / Kumarjiguda, Dhruv / Xiaoli, Li / Jayavelu, Senthilnath

    A Neuro-Symbolic Policy Gradient Approach for Interpretable Reinforcement Learning

    2023  

    Abstract: This paper presents a novel RL algorithm, S-REINFORCE, which is designed to generate interpretable ... S-REINFORCE algorithm on various dynamic decision-making problems with low and high dimensional ... solutions. By leveraging the strengths of both NN and SR, S-REINFORCE produces policies that are not only ...

    Abstract This paper presents a novel RL algorithm, S-REINFORCE, which is designed to generate interpretable policies for dynamic decision-making tasks. The proposed algorithm leverages two types of function approximators, namely Neural Network (NN) and Symbolic Regressor (SR), to produce numerical and symbolic policies, respectively. The NN component learns to generate a numerical probability distribution over the possible actions using a policy gradient, while the SR component captures the functional form that relates the associated states with the action probabilities. The SR-generated policy expressions are then utilized through importance sampling to improve the rewards received during the learning process. We have tested the proposed S-REINFORCE algorithm on various dynamic decision-making problems with low and high dimensional action spaces, and the results demonstrate its effectiveness and impact in achieving interpretable solutions. By leveraging the strengths of both NN and SR, S-REINFORCE produces policies that are not only well-performing but also easy to interpret, making it an ideal choice for real-world applications where transparency and causality are crucial.

    Comment: 10 pages, 7 figures
    Keywords Computer Science - Machine Learning ; Computer Science - Artificial Intelligence
    Subject code 006
    Publishing date 2023-05-12
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: S. boulardii

    Lenka, Satyajit / Singh, Deepak / Paul, Sandip / Gayen, Anindita / Chandra, Manabendra

    ACS infectious diseases

    2021  Volume 7, Issue 4, Page(s) 733–745

    Abstract: Probiotic ... ...

    Abstract Probiotic yeast
    MeSH term(s) Bacterial Adhesion ; Cell Wall ; Erythrocytes/microbiology ; Escherichia coli ; Humans ; Probiotics ; Saccharomyces
    Language English
    Publishing date 2021-03-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2373-8227
    ISSN (online) 2373-8227
    DOI 10.1021/acsinfecdis.0c00413
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Article ; Online: Feeding India’s babies

    Ray, Soumyajit / Ashok, Sattvika / Avula, Rasmi / Nguyen, Phuong Hong / Hemalatha, R. / Singh, S. K. / Chamois, Sylvie / Menon, Purnima / Avula, R.

    Insights on trends and patterns from the National Family Health Surveys, 2015-16 to 2019-21

    2023  

    Abstract: ... World Health Organization and UNICEF’s 2021 guidelines. ... Non-PR ... IFPRI1; POSHAN; 2 Promoting Healthy Diets and Nutrition ...

    Abstract Early life nutrition sets the stage for the health, nutrition, and development of young children. Optimal infant and young child feeding (IYCF) practices begin with timely initiation of breastfeeding, followed by exclusive breastfeeding and complementary feeding. This Data Note provides an overview of trends and patterns in IYCF practices in India at the national-, state-, and district levels based on the 2015-16 and 2019-21 National Family Health Surveys (NFHS) data. IYCF indicators were created following World Health Organization and UNICEF’s 2021 guidelines.

    Non-PR

    IFPRI1; POSHAN; 2 Promoting Healthy Diets and Nutrition for all; CRP4

    Nutrition, Diets, and Health (NDH); Food and Nutrition Policy; SAR; A4NH

    CGIAR Research Program on Agriculture for Nutrition and Health (A4NH)
    Keywords INDIA ; SOUTH ASIA ; ASIA ; nutrition ; health ; child development ; infant feeding ; breastfeeding ; surveys
    Subject code 360
    Language English
    Publisher International Food Policy Research Institute (IFPRI)
    Publishing country us
    Document type Book ; Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Catalytic Aminium Radical-Cation Salt (Magic Blue)-Initiated S

    Singh, Bharat / Kashyap, Suraj / Singh, Shishir / Gupta, Sikha / Ghorai, Manas K

    The Journal of organic chemistry

    2024  Volume 89, Issue 4, Page(s) 2247–2263

    Abstract: ... radical-cation salt (Magic Blue)-initiated S ...

    Abstract A simple and atom economic protocol for the construction of C-X/C-C bonds via catalytic aminium radical-cation salt (Magic Blue)-initiated S
    Language English
    Publishing date 2024-02-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.3c02194
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4473: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Article: Complete genome sequence of S-type

    Singh, Vinod Kumar / Das, Chayanika / Kumar, Amit / Prajapati, Malyaj R / Yadav, Sharad Kumar

    3 Biotech

    2024  Volume 14, Issue 2, Page(s) 38

    Abstract: The present report communicates the first complete genome sequence of S-type ...

    Abstract The present report communicates the first complete genome sequence of S-type
    Language English
    Publishing date 2024-01-17
    Publishing country Germany
    Document type Case Reports
    ZDB-ID 2600522-0
    ISSN 2190-5738 ; 2190-572X
    ISSN (online) 2190-5738
    ISSN 2190-572X
    DOI 10.1007/s13205-023-03896-2
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  9. Article ; Online: Stable excited dication: trapping on the S

    Singh, Vaibhav / Cheng, Chuan / Weinacht, Thomas / Matsika, Spiridoula

    Physical chemistry chemical physics : PCCP

    2022  Volume 24, Issue 35, Page(s) 20701–20708

    Abstract: Combined theoretical and experimental work examines the dynamics of dication formaldehyde produced by strong field ionization. Trajectory surface hopping dynamics on the first several singlet electronic states of the formaldehyde dication are used to ... ...

    Abstract Combined theoretical and experimental work examines the dynamics of dication formaldehyde produced by strong field ionization. Trajectory surface hopping dynamics on the first several singlet electronic states of the formaldehyde dication are used to examine the relaxation pathways and dissociation channels, while kinetic energy distributions after strong field ionization of formaldehyde and deuterated formaldehyde are used to confirm the theoretical predictions. We find that the first excited state of the formaldehyde dication is stable, neither decays to the ground state nor dissociates, even though the ground state and higher lying states are directly dissociative. The stability of the first excited state is explained by its symmetry which does not allow for radiative or nonradiative transitions to the ground state and by large barriers to dissociate on the excited state surface.
    Language English
    Publishing date 2022-09-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d2cp02604j
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  10. Article ; Online: Detection and localization of S

    Nath, Madhwendra / Srivastava, Subodh / Kulshrestha, Niharika / Singh, Dilbag

    Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine

    2021  Volume 235, Issue 6, Page(s) 615–624

    Abstract: ... made to detect and localize the major heart sounds, that is, S ...

    Abstract Adults born after 1970s are more prone to cardiovascular diseases. Death rate percentage is quite high due to heart related diseases. Therefore, there is necessity to enquire the problem or detection of heart diseases earlier for their proper treatment. As, Valvular heart disease, that is, stenosis and regurgitation of heart valve, are also a major cause of heart failure; which can be diagnosed at early-stage by detection and analysis of heart sound signal, that is, HS signal. In this proposed work, an attempt has been made to detect and localize the major heart sounds, that is, S
    MeSH term(s) Algorithms ; Heart ; Heart Auscultation ; Heart Sounds ; Humans ; Phonocardiography ; Signal Processing, Computer-Assisted
    Language English
    Publishing date 2021-03-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 1065942-0
    ISSN 2041-3033 ; 0046-2039 ; 0954-4119
    ISSN (online) 2041-3033
    ISSN 0046-2039 ; 0954-4119
    DOI 10.1177/0954411921998108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2652: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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