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Article: [A patient with rheumatoid arthritis who developed liver cirrhosis after increased soft drinks intake].

Yamashita, Nobuyuki / Miyagi, Yugo / Maekawa, Makiko / Tsukamoto, Hiroshi

Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics

2022 Volume 59, Issue 2, Page(s) 244–248

Abstract: A Japanese woman in her 80s with rheumatoid arthritis (RA) was admitted for weakness, edema, and ascites. She was obese (148 cm in height, 60 kg in weight) and had a high gamma-glutamyltransferase level according to her laboratory findings before ... ...

Abstract	A Japanese woman in her 80s with rheumatoid arthritis (RA) was admitted for weakness, edema, and ascites. She was obese (148 cm in height, 60 kg in weight) and had a high gamma-glutamyltransferase level according to her laboratory findings before treatment. She had received methotrexate (MTX) at a dose of 6 mg/week for 1 year and 9 months. She had consumed large amounts of soft drinks (about 110 g of sugar/day) for a long time, but during the course of treatment for RA, she began drinking even more (170 g/day). Her condition improved with the discontinuation of MTX, adequate nutrition, and administration of diuretics. We diagnosed her with liver cirrhosis caused by both drug-induced hepatic injury due to MTX and by exacerbation of non-alcoholic steatohepatitis due to excessive sugar intake.
MeSH term(s)	Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/drug therapy ; Carbonated Beverages ; Female ; Humans ; Liver Cirrhosis/chemically induced ; Liver Cirrhosis/drug therapy ; Methotrexate/adverse effects ; Sugars/adverse effects
Chemical Substances	Sugars ; Methotrexate (YL5FZ2Y5U1)
Language	Japanese
Publishing date	2022-06-01
Publishing country	Japan
Document type	Journal Article
ZDB-ID	604107-3
ISSN	0300-9173
ISSN	0300-9173
DOI	10.3143/geriatrics.59.244
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Article ; Online: Interleukin-4 induced 1-mediated resistance to an immune checkpoint inhibitor through suppression of CD8

Hirose, Shiho / Mashima, Tetsuo / Yuan, Xunmei / Yamashita, Makiko / Kitano, Shigehisa / Torii, Shinichi / Migita, Toshiro / Seimiya, Hiroyuki

Cancer science

2024 Volume 115, Issue 3, Page(s) 791–803

Abstract: Cancer cells adopt multiple strategies to escape tumor surveillance by the host immune system and aberrant amino acid metabolism in the tumor microenvironment suppresses the immune system. Among the amino acid-metabolizing enzymes is an L-amino-acid ... ...

Abstract	Cancer cells adopt multiple strategies to escape tumor surveillance by the host immune system and aberrant amino acid metabolism in the tumor microenvironment suppresses the immune system. Among the amino acid-metabolizing enzymes is an L-amino-acid oxidase called interleukin-4 induced 1 (IL4I1), which depletes essential amino acids in immune cells and is associated with a poor prognosis in various cancer types. Although IL4I1 is involved in immune metabolism abnormalities, its effect on the therapeutic efficacy of immune checkpoint inhibitors is unknown. In this study, we established murine melanoma cells overexpressing IL4I1 and investigated their effects on the intratumor immune microenvironment and the antitumor efficacy of anti-programmed death-ligand 1 (PD-L1) antibodies (Abs) in a syngeneic mouse model. As a result, we found that IL4I1-overexpressing B16-F10-derived tumors showed resistance to anti-PD-L1 Ab therapy. Transcriptome analysis revealed that immunosuppressive genes were globally upregulated in the IL4I1-overexpressing tumors. Consistently, we showed that IL4I1-overexpressing tumors exhibited an altered subset of lymphoid cells and particularly significant suppression of cytotoxic T cell infiltration compared to mock-infected B16-F10-derived tumors. After treatment with anti-PD-L1 Abs, we also found a more prominent elevation of tumor-associated macrophage (TAM) marker, CD68, in the IL4I1-overexpressing tumors than in the mock tumors. Consistently, we confirmed an enhanced TAM infiltration in the IL4I1-overexpressing tumors and a functional involvement of TAMs in the tumor growth. These observations indicate that IL4I1 reprograms the tumor microenvironment into an immunosuppressive state and thereby confers resistance to anti-PD-L1 Abs.
MeSH term(s)	Mice ; Animals ; Melanoma/drug therapy ; Melanoma/genetics ; Melanoma/metabolism ; Immune Checkpoint Inhibitors/pharmacology ; Immune Checkpoint Inhibitors/therapeutic use ; Interleukin-4/metabolism ; CD8-Positive T-Lymphocytes ; Amino Acids/metabolism ; Tumor Microenvironment ; B7-H1 Antigen
Chemical Substances	Immune Checkpoint Inhibitors ; Interleukin-4 (207137-56-2) ; Amino Acids ; B7-H1 Antigen
Language	English
Publishing date	2024-01-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2115647-5
ISSN	1349-7006 ; 1349-7006
ISSN (online)	1349-7006
ISSN	1349-7006
DOI	10.1111/cas.16073
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Article ; Online: Experiences of crisis communication during radiation emergency and risk communication for recovery of the community in Fukushima.

Takamura, Noboru / Orita, Makiko / Taira, Yasuyuki / Matsunaga, Hitomi / Yamashita, Shunichi

Journal of radiation research

2021 Volume 62, Issue Supplement_1, Page(s) i95–i100

Abstract: Since 2011, Nagasaki University (Nagasaki, Japan) has been assisting the reconstruction efforts of Kawauchi Village (Fukushima Prefecture), which was the first village to decide to return to their home town after the evacuation due to the accident at the ...

Abstract	Since 2011, Nagasaki University (Nagasaki, Japan) has been assisting the reconstruction efforts of Kawauchi Village (Fukushima Prefecture), which was the first village to decide to return to their home town after the evacuation due to the accident at the Fukushima Daiichi Nuclear Power Station. In April 2013, Nagasaki University and the Kawauchi Government Office concluded an agreement concerning comprehensive cooperation toward the reconstruction of the village. Furthermore, we began comprehensive support for the residents of Tomioka who returned to their hometown in 2017, and of Ohkuma town in 2020. On the basis of the experiences in Kawauchi, Tomioka and Ohkuma, it is clear that the cooperation of residents, local authorities and specialists is essential for the recovery of areas affected by the accident at the Fukushima Daiichi Nuclear Power Station. Accumulated experiences and practices should be carefully evaluated and recorded to prepare for unexpected nuclear disasters in the future.
MeSH term(s)	Communication ; Disasters ; Emergencies ; Fukushima Nuclear Accident ; Humans ; Radiation Exposure ; Residence Characteristics
Language	English
Publishing date	2021-05-12
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	603983-2
ISSN	1349-9157 ; 0449-3060
ISSN (online)	1349-9157
ISSN	0449-3060
DOI	10.1093/jrr/rraa113
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Article ; Online: RNA interference in late-stage hereditary transthyretin amyloidosis: a clinicopathological study.

Beck, Goichi / Yonenobu, Yuki / Kawai, Makiko / Ikenaka, Kensuke / Sera, Fusako / Ozono, Tatsuhiko / Shimada, Yuki / Yamashita, Rika / Sakata, Yasushi / Morii, Eiichi / Yoshinaga, Tsuneaki / Ando, Yukio / Murayama, Shigeo / Mochizuki, Hideki

Journal of neurology

2023 Volume 270, Issue 9, Page(s) 4544–4548

MeSH term(s)	Humans ; RNA Interference ; Amyloid Neuropathies, Familial/genetics ; Mutation/genetics ; Prealbumin/genetics
Chemical Substances	Prealbumin
Language	English
Publishing date	2023-05-08
Publishing country	Germany
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	187050-6
ISSN	1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
ISSN (online)	1432-1459
ISSN	0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
DOI	10.1007/s00415-023-11754-7
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Article ; Online: Correction: Expression of hormone receptors is associated with specific immunological profiles of the breast cancer microenvironment.

Hanamura, Toru / Kitano, Shigehisa / Kagamu, Hiroshi / Yamashita, Makiko / Terao, Mayako / Okamura, Takuho / Kumaki, Nobue / Hozumi, Katsuto / Iwamoto, Takayuki / Honda, Chikako / Kurozumi, Sasagu / Niikura, Naoki

Breast cancer research : BCR

2023 Volume 25, Issue 1, Page(s) 28

Language	English
Publishing date	2023-03-20
Publishing country	England
Document type	Published Erratum
ZDB-ID	2015059-3
ISSN	1465-542X ; 1465-5411
ISSN (online)	1465-542X
ISSN	1465-5411
DOI	10.1186/s13058-023-01637-0
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Zs.A 5494: Show issues

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Article ; Online: Pathological complete response to neoadjuvant chemotherapy may improve antitumor immune response via reduction of regulatory T cells in muscle-invasive bladder cancer.

Ikarashi, Daiki / Kitano, Shigehisa / Tsuyukubo, Takashi / Yamashita, Makiko / Matsuura, Tomohiko / Maekawa, Shigekatsu / Kato, Renpei / Kato, Yoichiro / Kanehira, Mitsugu / Takata, Ryo / Sugai, Tamotsu / Obara, Wataru

Scientific reports

2024 Volume 14, Issue 1, Page(s) 1442

Abstract: The prognosis for patients who achieve a pathologic complete response in bladder cancer is excellent, but the association between their prognosis and the tumor microenvironment is unclear. We investigated the tumor immune microenvironment of those with ... ...

Abstract	The prognosis for patients who achieve a pathologic complete response in bladder cancer is excellent, but the association between their prognosis and the tumor microenvironment is unclear. We investigated the tumor immune microenvironment of those with pathological complete response after platinum-based neoadjuvant chemotherapy for cT2-4aN0M0 bladder cancer using multiplex fluorescence immunohistochemistry. Our retrospective study included 12 patients with pathological complete response who underwent radical cystectomy following neoadjuvant chemotherapy for cT2-4aN0M0 muscle-invasive bladder cancer. We assessed the density of several immune cell types in pretreatment and posttreatment tissues via multiplex fluorescence immunohistochemical analysis. The median age was 67 years; 10 patients were male. Nine (75%) and 3 (25%) patients were cT2 and cT3, respectively. The 5-year progression-free and overall survivals were 90% and 100%, respectively. The densities of regulatory T cells (Treg; CD3
MeSH term(s)	Humans ; Male ; Aged ; Female ; T-Lymphocytes, Regulatory/pathology ; Retrospective Studies ; Neoadjuvant Therapy ; Neoplasm Staging ; Urinary Bladder Neoplasms/pathology ; Cystectomy ; Pathologic Complete Response ; Immunity ; Muscles/pathology ; Neoplasm Invasiveness/pathology ; Tumor Microenvironment
Language	English
Publishing date	2024-01-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-51273-7
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Article ; Online: Investigating the immunological function of alpha-2-glycoprotein 1, zinc-binding in regulating tumor response in the breast cancer microenvironment.

Hanamura, Toru / Yokoyama, Kozue / Kitano, Shigehisa / Kagamu, Hiroshi / Yamashita, Makiko / Terao, Mayako / Okamura, Takuho / Kumaki, Nobue / Hozumi, Katsuto / Iwamoto, Takayuki / Honda, Chikako / Kurozumi, Sasagu / Richer, Jennifer K / Niikura, Naoki

Cancer immunology, immunotherapy : CII

2024 Volume 73, Issue 3, Page(s) 42

Abstract: Background: Alpha-2-glycoprotein 1, zinc-binding (ZAG), a secreted protein encoded by the AZGP1 gene, is structurally similar to HLA class I. Despite its presumed immunological function, little is known about its role in tumor immunity. In this study, ... ...

Abstract	Background: Alpha-2-glycoprotein 1, zinc-binding (ZAG), a secreted protein encoded by the AZGP1 gene, is structurally similar to HLA class I. Despite its presumed immunological function, little is known about its role in tumor immunity. In this study, we thus aimed to determine the relationship between the expression of AZGP1/ZAG and the immunological profiles of breast cancer tissues at both the gene and protein level. Methods: Using a publicly available gene expression dataset from a large-scale breast cancer cohort, we conducted gene set enrichment analysis (GSEA) to screen the biological processes associated with AZGP1. We analyzed the correlation between AZGP1 expression and immune cell composition in breast cancer tissues, estimated using CIBERSORTx. Previously, we evaluated the infiltration of 11 types of immune cells for 45 breast cancer tissues using flow cytometry (FCM). ZAG expression was evaluated by immunohistochemistry on these specimens and analyzed for its relationship with immune cell infiltration. The action of ZAG in M1/M2 polarization models using primary cultures of human peripheral blood mononuclear cells (PBMC)-derived macrophage (Mφ) was analyzed based on the expression of M1/M2 markers (CD86, CD80/CD163, MRC1) and HLA class I/II by FCM. Results: AZGP1 expression was negatively correlated with multiple immunological processes and specific immune cell infiltration including Mφ M1 using GSEA and CIBERSORTx. ZAG expression was associated with decreased infiltration of monocytes/macrophages, non-classical monocytes, and myeloid-derived suppressor cells in tumor tissues assessed using FCM. In in vitro analyses, ZAG decreased the expression of CD80, CD163, MRC1, and HLA classes I/II in the M1 polarization model and the expression of CD163 and MRC1 in the M2 polarization model. Conclusion: ZAG is suggested to be a novel immunoregulatory factor affecting the Mφ phenotype in breast cancer tissues.
MeSH term(s)	Female ; Humans ; B7-1 Antigen ; Breast Neoplasms ; Glycoproteins ; Leukocytes, Mononuclear ; Tumor Microenvironment ; Zinc
Chemical Substances	B7-1 Antigen ; Glycoproteins ; Zinc (J41CSQ7QDS) ; AZGP1 protein, human
Language	English
Publishing date	2024-02-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	195342-4
ISSN	1432-0851 ; 0340-7004
ISSN (online)	1432-0851
ISSN	0340-7004
DOI	10.1007/s00262-024-03629-1
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Article ; Online: Potential treatment option of rivaroxaban for breastfeeding women: A case series.

Yamashita, Yugo / Hira, Daiki / Morita, Makiko / Katsube, Yurie / Takakura, Masahito / Tomotaki, Hiroko / Tomotaki, Seiichi / Xiong, Wei / Shiomi, Hiroki / Horie, Takahiro / Ueshima, Satoshi / Mizuno, Tomoyuki / Terada, Tomohiro / Ono, Koh

Thrombosis research

2024 Volume 237, Page(s) 141–144

Abstract: The use of direct oral anticoagulants (DOACs) in breastfeeding women is currently challenging due to limited safety data for breastfeeding infants, and there have been no previous studies on the drug concentration in breastfeeding infants. We treated 2 ... ...

Abstract	The use of direct oral anticoagulants (DOACs) in breastfeeding women is currently challenging due to limited safety data for breastfeeding infants, and there have been no previous studies on the drug concentration in breastfeeding infants. We treated 2 patients (one case was twin pregnancy) with venous thromboembolisms in breastfeeding women administered rivaroxaban at our institution. Blood samples from the mothers and breastmilk samples were collected at time 0 and 2 h after the rivaroxaban administration, breastfeeding was conducted 2 h after the rivaroxaban administration, and blood samples from the infants were collected 2 h after breastfeeding (4 h after maternal rivaroxaban administration). The milk-to-plasma (M:P) ratios were 0.27 in Case 1 and 0.32 in Case 2. The estimated relative infant dose (RID) was 0.82 % in Case 1 Children 1 and 2, and 1.27 % in Case 2. The rivaroxaban concentration in the infant plasma was below the lower limit of quantification in all infants. In addition, even in the high-exposure case simulation based on 5 days of breastfeeding in Case 2, the infant plasma concentration level was below the lower limit of quantification. At 3 months of follow-up, breastfeeding was continued, and all infants grew and developed without any health problems including bleeding events. The current case series showed that there were no pharmacokinetic or clinical concerns for breastfeeding women or breastfed infants, and provides support for rivaroxaban as a safe treatment option for these patients.
MeSH term(s)	Humans ; Rivaroxaban/therapeutic use ; Rivaroxaban/pharmacokinetics ; Female ; Breast Feeding ; Adult ; Factor Xa Inhibitors/therapeutic use ; Factor Xa Inhibitors/pharmacokinetics ; Milk, Human/chemistry ; Milk, Human/metabolism ; Infant ; Venous Thromboembolism/drug therapy ; Infant, Newborn ; Pregnancy
Chemical Substances	Rivaroxaban (9NDF7JZ4M3) ; Factor Xa Inhibitors
Language	English
Publishing date	2024-04-05
Publishing country	United States
Document type	Case Reports ; Journal Article ; Letter
ZDB-ID	121852-9
ISSN	1879-2472 ; 0049-3848
ISSN (online)	1879-2472
ISSN	0049-3848
DOI	10.1016/j.thromres.2024.04.003
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Zs.A 863: Show issues

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Article ; Online: Insufficiency of hepatocyte growth factor activator inhibitor-1 confers lymphatic invasion of tongue carcinoma cells.

Izumi, Aya / Yamamoto, Koji / Kawaguchi, Makiko / Yamashita, Fumiki / Fukushima, Tsuyoshi / Kiwaki, Takumi / Tanaka, Hiroyuki / Yamashita, Yoshihiro / Kataoka, Hiroaki

Cancer science

2022 Volume 113, Issue 6, Page(s) 2179–2193

Abstract: Hepatocyte growth factor (HGF) activator inhibitor type-1 (HAI-1), encoded by the SPINT1 gene, is a transmembrane protease inhibitor that regulates membrane-anchored serine proteases, particularly matriptase. Here, we explored the role of HAI-1 in tongue ...

Abstract	Hepatocyte growth factor (HGF) activator inhibitor type-1 (HAI-1), encoded by the SPINT1 gene, is a transmembrane protease inhibitor that regulates membrane-anchored serine proteases, particularly matriptase. Here, we explored the role of HAI-1 in tongue squamous cell carcinoma (TSCC) cells. An immunohistochemical study of HAI-1 in surgically resected TSCC revealed the cell surface immunoreactivity of HAI-1 in the main portion of the tumor. The immunoreactivity decreased in the infiltrative front, and this decrease correlated with enhanced lymphatic invasion as judged by podoplanin immunostaining. In vitro homozygous deletion of SPINT1 (HAI-1KO) in TSCC cell lines (HSC3 and SAS) suppressed the cell growth rate but significantly enhanced invasion in vitro. The loss of HAI-1 resulted in enhanced pericellular activities of proteases, such as matriptase and urokinase-type plasminogen activator, which induced activation of HGF/MET signaling in the co-culture with pro-HGF-expressing fibroblasts and plasminogen-dependent plasmin generation, respectively. The enhanced plasminogen-dependent plasmin generation was abrogated partly by matriptase silencing. Culture supernatants of HAI-1KO cells had enhanced potency for converting the proform of vascular endothelial growth factor-C (VEGF-C), a lymphangiogenesis factor, into the mature form in a plasminogen-dependent manner. Furthermore, HGF significantly stimulated VEGF-C expression in TSCC cells. Orthotopic xenotransplantation into nude mouse tongue revealed enhanced lymphatic invasion of HAI-1KO TSCC cells compared to control cells. Our results suggest that HAI-1 insufficiency leads to dysregulated pericellular protease activity, which eventually orchestrates robust activation of protease-dependent growth factors, such as HGF and VEGF-C, in a tumor microenvironment to contribute to TSCC progression.
MeSH term(s)	Animals ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/pathology ; Fibrinolysin/genetics ; Homozygote ; Humans ; Mice ; Plasminogen/genetics ; Proteinase Inhibitory Proteins, Secretory/genetics ; Proteinase Inhibitory Proteins, Secretory/metabolism ; Sequence Deletion ; Serine Endopeptidases ; Tongue Neoplasms/genetics ; Tongue Neoplasms/pathology ; Tumor Microenvironment ; Vascular Endothelial Growth Factor C/genetics
Chemical Substances	Proteinase Inhibitory Proteins, Secretory ; SPINT1 protein, human ; Vascular Endothelial Growth Factor C ; Plasminogen (9001-91-6) ; Serine Endopeptidases (EC 3.4.21.-) ; Fibrinolysin (EC 3.4.21.7)
Language	English
Publishing date	2022-04-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2115647-5
ISSN	1349-7006 ; 1349-7006
ISSN (online)	1349-7006
ISSN	1349-7006
DOI	10.1111/cas.15346
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Article ; Online: Spontaneous resolution of focal eosinophilic myositis of the adductor pollicis complicated by lung lesions.

Yamashita, Sayuri / Kawasumi, Hidenaga / Kimura, Makiko / Tateishi, Mutsuto

Modern rheumatology case reports

2019 Volume 4, Issue 1, Page(s) 106–109

Abstract: Eosinophilic myositis is characterised by peripheral blood eosinophilia and eosinophilic infiltration in muscles, and is comprised three subtypes: focal eosinophilic myositis (FEM), eosinophilic polymyositis, and eosinophilic perimyositis. Muscle ... ...

Abstract	Eosinophilic myositis is characterised by peripheral blood eosinophilia and eosinophilic infiltration in muscles, and is comprised three subtypes: focal eosinophilic myositis (FEM), eosinophilic polymyositis, and eosinophilic perimyositis. Muscle involvement of FEM is usually limited to the lower legs, and pulmonary complications have not been reported. We report a rare case of FEM in the left adductor pollicis complicated by lung lesions. A 37-year-old woman developed swelling of the first web space in the left hand. Magnetic resonance imaging (MRI) of the left hand demonstrated increased signal on fat-suppressed T2-weighted imaging in the left adductor pollicis. A muscle biopsy specimen demonstrated perimysial and endomysial infiltration of mononuclear cells and eosinophils, and necrosis and regeneration of muscle fibres. Chest computed tomography (CT) revealed upper-lobe-dominant ground-glass opacities (GGO). Both focal myositis and pulmonary lesions improved without treatment. This case suggests that FEM could involve adductor pollicis and have pulmonary lesions. In this case, myositis and GGO resolved spontaneously. Some FEM cases treated with glucocorticoids were reported in the past. Further studies are required to determine whether patients with FEM require therapeutic intervention.
MeSH term(s)	Adult ; Eosinophilia/pathology ; Female ; Humans ; Lung/diagnostic imaging ; Lung/pathology ; Magnetic Resonance Imaging ; Muscle, Skeletal/diagnostic imaging ; Muscle, Skeletal/pathology ; Myositis/diagnosis ; Remission, Spontaneous ; Tomography, X-Ray Computed
Language	English
Publishing date	2019-09-23
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	2472-5625
ISSN (online)	2472-5625
DOI	10.1080/24725625.2019.1667605
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