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Article ; Online: Prevención de la enfermedad vascular. Cómo optimizar las medidas para mantener la salud vascular óptima.

García Donaire, José Antonio

Hipertension y riesgo vascular

2020 Volume 38, Issue 1, Page(s) 1–3

Title translation	Prevention of vascular disease. How to optimise measures to maintain optimal vascular Health.
MeSH term(s)	Humans ; Risk Factors ; Vascular Diseases/prevention & control
Language	Spanish
Publishing date	2020-12-30
Publishing country	Spain
Document type	Editorial
ISSN	1989-4805
ISSN (online)	1989-4805
DOI	10.1016/j.hipert.2021.01.001
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Article ; Online: Laparoscopic adrenalectomy vs. radiofrequency ablation for the treatment of primary aldosteronism. A single center retrospective cohort analysis adjusted with propensity score.

Cano-Valderrama, Oscar / González-Nieto, Jimena / Abad-Cardiel, María / Ochagavía, Santiago / Rünkle, Isabelle / Méndez, José V / García-Donaire, José A / Cuesta-Hernández, Martín / Armijo, Javier E / Miguel-Novoa, Paz / Torres, Antonio J / Martell-Claros, Nieves

Surgical endoscopy

2021 Volume 36, Issue 3, Page(s) 1970–1978

Abstract: Background: Laparoscopic adrenalectomy (LA) is the gold standard treatment for unilateral primary aldosteronism. However, satisfactory results have also been published with radiofrequency ablation (RFA). The aim of this study was to compare LA and RFA ... ...

Abstract	Background: Laparoscopic adrenalectomy (LA) is the gold standard treatment for unilateral primary aldosteronism. However, satisfactory results have also been published with radiofrequency ablation (RFA). The aim of this study was to compare LA and RFA for the treatment of primary aldosteronism. Methods: A retrospective cohort study of the patients who underwent LA or RFA in a single center was performed. Morbidity and long-term effectiveness (cure rate and blood pressure control) were analyzed. A multivariate analysis with a propensity score was also performed. Results: Thirty-four patients were included in the study, 24 in the LA group and 10 in the RFA group. Hypertension had been diagnosed a median of 12 years before the intervention. Hypertension was properly controlled before the intervention in 55.9% of the patients. Hypertensive crisis was more common during RFA (4.2% vs. 70.0%, p < 0.001), although no patient suffered any complication because of these crises. LA was longer (174.6 vs. 105.5 min, p = 0.001) and had a longer length of stay (median 2 vs 1 days, p < 0.001). No severe complications were observed in any of the patients. After a median follow-up of 46.2 months, more patients had hypertension cured and blood pressure controlled in the LA group (29.2% vs. 0%, p = 0.078 and 95.5% vs. 50.0%, p = 0.006, respectively). Also, patients in the LA group were taking less antihypertensive drugs (1.8 vs. 3.0, p = 0.054) or mineralocorticoid receptor antagonists (41.7% vs. 90.0%, p = 0.020). Multivariate analysis adjusted by propensity score showed that LA had an OR = 11.3 (p = 0.138) for hypertension cure and an OR = 55.1 (p = 0.040) for blood pressure control. Conclusions: Although RFA was a less invasive procedure than LA, hypertension was cured and blood pressure was properly controlled in more patients from the LA group. Patients who underwent LA were taking less antihypertensive drugs than patients who had undergone RFA.
MeSH term(s)	Adrenalectomy/methods ; Cohort Studies ; Humans ; Hyperaldosteronism/surgery ; Laparoscopy/methods ; Propensity Score ; Radiofrequency Ablation ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2021-04-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	639039-0
ISSN	1432-2218 ; 0930-2794
ISSN (online)	1432-2218
ISSN	0930-2794
DOI	10.1007/s00464-021-08481-3
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Article ; Online: Denervación renal en el tratamiento de la hipertensión arterial. Posicionamiento conjunto de la SEH-LELHA y la ACI-SEC

Oriol Rodríguez-Leor / Fernando Jaén-Águila / Julián Segura / Iván J. Núñez-Gil / Arturo García-Touchard / Esther Rubio / Maribel Troya / Juan Diego-Mediavilla / Ángel Cequier / Raúl Moreno / Nieves Martell / Paola Beltrán / Eduardo Molina / José Antonio García-Donaire

REC: Interventional Cardiology, Vol 4, Iss 1, Pp 39-

2022 Volume 46

Abstract: RESUMEN La hipertensión arterial es el factor de riesgo cardiovascular más prevalente. A pesar del tratamiento farmacológico, un alto porcentaje de pacientes no consiguen un adecuado control. La denervación renal es una intervención mínimamente invasiva ... ...

Abstract	RESUMEN La hipertensión arterial es el factor de riesgo cardiovascular más prevalente. A pesar del tratamiento farmacológico, un alto porcentaje de pacientes no consiguen un adecuado control. La denervación renal es una intervención mínimamente invasiva para el tratamiento de la hipertensión que implica la interrupción de los nervios simpáticos renales mediante un abordaje con catéter. Los estudios iniciales mostraron resultados prometedores, pero los controvertidos resultados del ensayo SYMPLICITY HTN-3 llevaron al abandono de la técnica. En los últimos 3 años han aparecido los resultados de nuevos ensayos clínicos, con nuevos dispositivos y en diferentes poblaciones, que demuestran definitivamente la eficacia de la denervación renal. En este documento de posicionamiento conjunto de la Sociedad Española de Hipertensión-Liga Española para la Lucha contra la Hipertensión Arterial (SEH-LELHA) y la Asociación de Cardiología Intervencionista de la Sociedad Española de Cardiología (ACI-SEC) se revisa la evidencia disponible sobre la eficacia y la seguridad de la denervación renal en el tratamiento de la hipertensión. A partir de los resultados de los ensayos clínicos, se generan recomendaciones sobre qué pacientes y en qué condiciones podrían ser candidatos a una denervación renal.
Keywords	Hipertensión arterial ; Denervación renal ; Presión arterial ; Internal medicine ; RC31-1245
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	Permanyer
Document type	Article ; Online
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Article ; Online: Renal denervation for the management of hypertension. Joint position statement from the SEH-LELHA and the ACI-SEC

REC: Interventional Cardiology (English Ed.), Vol 4, Iss 1, Pp 39-

2022 Volume 46

Abstract: ABSTRACT Hypertension is the most prevalent cardiovascular risk factor. Despite pharmacological treatment, a high percentage of patients do not achieve an adequate blood pressure control. Renal sympathetic denervation is a minimally invasive intervention ...

Abstract	ABSTRACT Hypertension is the most prevalent cardiovascular risk factor. Despite pharmacological treatment, a high percentage of patients do not achieve an adequate blood pressure control. Renal sympathetic denervation is a minimally invasive intervention for the management of hypertension involving the interruption of the renal artery sympathetic nervous system using a catheter-based approach. The early studies showed promising results, but the controversial results coming from the SYMPLICITY HTN-3 trial sent this technique into oblivion. Over the last 3 years, new clinical trials have appeared including new devices used in different populations, which definitively proves the effectiveness of renal sympathetic denervation. This joint position statement from the Spanish Society of Hypertension-Spanish League for Combating High Blood Pressure (SEH-LELHA), and the Interventional Cardiology Association of the Spanish Society of Cardiology (ACI-SEC) reviews the evidence available on the efficacy and safety profile of renal sympathetic denervation for the management of hypertension. Based on the results of clinical trials, recommendations have been established on what patients may be eligible for renal sympathetic denervation and under what circumstances.
Keywords	Hypertension ; Renal sympathetic denervation ; Blood pressure ; Medicine ; R
Subject code	616
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	Permanyer
Document type	Article ; Online
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Article ; Online: Recent advances in the management of hypertension.

García-Donaire, José Antonio / Ruilope, Luis M

F1000 medicine reports

2010 Volume 2

Abstract: Recently, there have been several reports related to the adequacy of blood pressure (BP) control in high-risk hypertensive patients. These aspects have been reviewed in the recently published reappraisal of the European Society of Hypertension guidelines, ...

Abstract	Recently, there have been several reports related to the adequacy of blood pressure (BP) control in high-risk hypertensive patients. These aspects have been reviewed in the recently published reappraisal of the European Society of Hypertension guidelines, and this short review comments on and briefly extends the discussion of this situation. In summary, a low BP goal when cardiorenal disease is advanced can be risky. However, attaining normal BP levels at earlier stages in the cardiorenal continuum is probably totally adequate.
Language	English
Publishing date	2010-03-15
Publishing country	England
Document type	Journal Article
ISSN	1757-5931
ISSN (online)	1757-5931
DOI	10.3410/M2-19
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Article ; Online: 'Multiple action fixed combination. Present or future?'.

García-Donaire, José Antonio / Ruilope, Luis Miguel

Fundamental & clinical pharmacology

2010 Volume 24, Issue 1, Page(s) 37–42

Abstract: Cardiovascular disease (CVD) is the most common cause of death in Western countries and will continue to be so in upcoming years. A close correlation has been demonstrated among CVD, stroke, ischemic heart disease, renal failure and a number of ... ...

Abstract	Cardiovascular disease (CVD) is the most common cause of death in Western countries and will continue to be so in upcoming years. A close correlation has been demonstrated among CVD, stroke, ischemic heart disease, renal failure and a number of modifiable risk factors. As cardiovascular (CV) risk factors commonly co-exist, high-risk patients with hypertension, obesity and diabetes may well benefit from a multiple action combination of CV agents with synergistic efficacy. Control of blood pressure (BP) and the other CV risk factors is still far from the optimal rates and achievement of internationally accepted goals must be imperative. The benefits of achieving these goals, including significant reductions in CV morbidity and mortality, are well documented. Thus, a rigorous effort to improve BP goal attainment is required. Most of the patients will need two or more antihypertensives to achieve BP goal. Administering of two drugs in a single-dose formulation substantially improves patient compliance compared with separate agent administration. Fixed-dose combination therapy can offer potential advantages over individual agents, including increased efficacy, reduced incidence of adverse effects, lower healthcare costs and improved patient compliance through the use of a single medication administered once daily. Currently available fixed-dose agents include several combinations with complementary pharmacodynamic activity. Last, the polypill includes several CV acting agents that affects various CV risk factors and offers encouraging results, although more data are needed to strengthen the polypill concept, its efficacy and safety.
MeSH term(s)	Animals ; Blood Pressure/drug effects ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/prevention & control ; Drug Combinations ; Drug Synergism ; Humans ; Hypertension/complications ; Hypertension/drug therapy ; Medication Adherence ; Risk Factors
Chemical Substances	Drug Combinations
Language	English
Publishing date	2010-02
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	639134-5
ISSN	1472-8206 ; 0767-3981
ISSN (online)	1472-8206
ISSN	0767-3981
DOI	10.1111/j.1472-8206.2009.00799.x
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Article ; Online: Are lead, cadmium and mercury risk factors for resistant hypertension?

Corbatón Anchuelo, Arturo / Martell Claros, Nieves / Abad Cardiel, María / García Donaire, José Antonio / Fuentes Ferrer, Manuel / Bravo Gómez, Andrés / Llorente Martín, Elena / Zamora Trillo, Angielys / Bonmatí Torres, Gonzalo / González-Estecha, Montserrat

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)

2024 Volume 84, Page(s) 127417

Abstract: Background: Lead (Pb), cadmium (Cd) and mercury (Hg) are toxic trace elements that represent a public health problem as risk factors for cardiovascular disease and hypertension (HT) and could also contribute to the development of resistant hypertension ( ...

Abstract	Background: Lead (Pb), cadmium (Cd) and mercury (Hg) are toxic trace elements that represent a public health problem as risk factors for cardiovascular disease and hypertension (HT) and could also contribute to the development of resistant hypertension (rHT) AIMS: To compare the blood concentrations of Pb, Cd and Hg in subjects with resistant and non-resistant HT and to define whether there is a relationship between its levels and rHT. Methods: Cross-sectional study. Subjects aged ≥ 21 to ≤ 80 years with a body mass index < 40 kg/m2 were recruited on a discretionary basis from October 2001 to October 2004 in a hypertension unit of a tertiary hospital amongst those sent to the hypertension unit by their family physician. Resistant hypertension was defined according to the American Heart Association (AHA) criteria. Whole blood concentrations of Cd, Pb and Hg were measured by electrothermal atomic absorption spectrometry. Results: 46 out of 73 included subjects (63%) suffered from rHT. Blood Pb median: HT 3.9 (IQR 2.7-5.2) vs. rHT 3.6 (IQR 2.8-6.0) µg/dL (p=0.941). Blood Cd median: HT 0.07 (IQR 0.07-0.80) vs. rHT 0.30 (IQR 0.07-0.65) µg/L (p=0.681). Blood Hg median: HT 7.9 (IQR 5.8-12.9) vs. rHT 7.3 (IQR 4.6-13.3) µg/L (p=0.611). Considering the 75th percentile of each element (Pb: 5.55 µg/dL, Cd: 0.75 µg/L, Hg: 13.15 µg/L), a multiple logistic regression analysis (adjusted for age, BMI, diabetes mellitus, clearance of creatinine and only for Cd the smoking habit) showed an OR = 3.44 (0.84-14.10, p=0.086) for Pb, OR = 1.80 (0.39-8.24, p=0.451), for Cd and OR = 2.31 (0.59-9.14, p=0.232) for Hg. Moreover, the stratified analyses showed that men with Pb ≥5.55 µg/dL have a 14 times higher risk of suffering from rHT (p=0.026). Interestingly, a 9-fold increased risk was found for non-obese subjects with elevated Pb levels, above 5.55 µg/dL (p=0.029). Also in men, the probability of suffering from rHT was more than 7 times higher if Cd levels were ≥ 0.75 µg/L (p=0.076). Most smokers had higher Cd levels, with a high risk of suffering from rHT (ORa 12.6 (0.8-200.2), p=0.072). Conclusion: A higher blood Pb levels, defined by the 75th percentile (Pb ≥ 5.55 µg/dL), is associated with a greater risk of suffering from rHT and to a lesser extent in the case of Cd and Hg.
Language	English
Publishing date	2024-02-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1236267-0
ISSN	1878-3252 ; 1611-602X ; 0946-672X
ISSN (online)	1878-3252 ; 1611-602X
ISSN	0946-672X
DOI	10.1016/j.jtemb.2024.127417
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Article ; Online: Consensus document for lipid profile testing and reporting in Spanish clinical laboratories: what parameters should a basic lipid profile include?

Arrobas Velilla, Teresa / Guijarro, Carlos / Ruiz, Raquel Campuzano / Piñero, Manuel Rodríguez / Valderrama Marcos, José Francisco / Pérez Pérez, Antonio / Botana López, Antonio M / López, Ana Morais / García Donaire, José Antonio / Obaya, Juan Carlos / Castilla-Guerra, Luis / Carratalá, Vicente Pallares / Cabello, Isabel Egocheaga / Lazo, Mercedes Salgueira / Castellanos Rodrigo, María Mar / Mostaza Prieto, José María / Gómez Doblas, Juan José / Buño Soto, Antonio

Advances in laboratory medicine

2023 Volume 4, Issue 2, Page(s) 138–156

Abstract: Cardiovascular diseases (CVD) continue to be the main cause of death in our country. Adequate control of lipid metabolism disorders is a key challenge in cardiovascular prevention that is far from being achieved in real clinical practice. There is a ... ...

Abstract	Cardiovascular diseases (CVD) continue to be the main cause of death in our country. Adequate control of lipid metabolism disorders is a key challenge in cardiovascular prevention that is far from being achieved in real clinical practice. There is a great heterogeneity in the reports of lipid metabolism from Spanish clinical laboratories, which may contribute to its poor control. For this reason, a working group of the main scientific societies involved in the care of patients at vascular risk, has prepared this document with a consensus proposal on the determination of the basic lipid profile in cardiovascular prevention, recommendations for its realization and unification of criteria to incorporate the lipid control goals appropriate to the vascular risk of the patients in the laboratory reports.
Language	Spanish
Publishing date	2023-06-05
Publishing country	Germany
Document type	Journal Article
ISSN	2628-491X
ISSN (online)	2628-491X
DOI	10.1515/almed-2023-0047
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Article ; Online: Consensus document for lipid profile determination and reporting in Spanish clinical laboratories. What parameters should be included in a basic lipid profile?

Velilla, Teresa Arrobas / Guijarro, Carlos / Ruiz, Raquel Campuzano / Piñero, Manuel Rodríguez / Francisco Valderrama Marcos, José / López, Antonio M Botana / López, Ana Morais / Antonio García Donaire, José / Obaya, Juan Carlos / Castilla Guerra, Luis / Carratalá, Vicente Pallares / Cabello, Isabel Egocheaga / Lazo, Mercedes Salgueira / Rodrigo, María Mar Castellanos / María Mostaza Prieto, José / Doblas, Juan José Gómez / Soto, Antonio Buño

Nefrologia

2023 Volume 43, Issue 4, Page(s) 474–483

Abstract	Cardiovascular diseases (CVD) continue to be the main cause of death in our country. Adequate control of lipid metabolism disorders is a key challenge in cardiovascular prevention that is far from being achieved in real clinical practice. There is a great heterogeneity in the reports of lipid metabolism from Spanish clinical laboratories, which may contribute to its poor control. For this reason, a working group of the main scientific societies involved in the care of patients at vascular risk, has prepared this document with a consensus proposal on the determination of the basic lipid profile in cardiovascular prevention, recommendations for its realization and unification of criteria to incorporate the lipid control goals appropriate to the vascular risk of the patients in the laboratory reports.
MeSH term(s)	Humans ; Lipids ; Laboratories, Clinical ; Consensus ; Cardiovascular Diseases/prevention & control
Chemical Substances	Lipids
Language	English
Publishing date	2023-10-08
Publishing country	Spain
Document type	Practice Guideline ; Journal Article
ZDB-ID	2837917-2
ISSN	2013-2514 ; 2013-2514
ISSN (online)	2013-2514
ISSN	2013-2514
DOI	10.1016/j.nefroe.2023.08.002
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Article ; Online: Consensus document for lipid profile testing and reporting in Spanish clinical laboratories.

Arrobas Velilla, Teresa / Guijarro, Carlos / Campuzano Ruiz, Raquel / Rodríguez Piñero, Manuel / Valderrama Marcos, José Francisco / Botana López, Antonio M / Morais López, Ana / García Donaire, José Antonio / Obaya, Juan Carlos / Castilla Guerra, Luis / Pallares Carratalá, Vicente / Egocheaga Cabello, Isabel / Salgueira Lazo, Mercedes / Castellanos Rodrigo, María Mar / Mostaza Prieto, José María / Gómez Doblas, Juan José / Buño Soto, Antonio

Endocrinologia, diabetes y nutricion

2023 Volume 70, Issue 7, Page(s) 501–510

Abstract	Cardiovascular diseases (CVD) continue to be the main cause of death in our country. Adequate control of lipid metabolism disorders is a key challenge in cardiovascular prevention that is far from being achieved in real clinical practice. There is a great heterogeneity in the reports of lipid metabolism from Spanish clinical laboratories, which may contribute to its poor control. For this reason, a working group of the main scientific societies involved in the care of patients at vascular risk, has prepared this document with a consensus proposal on the determination of the basic lipid profile in cardiovascular prevention, recommendations for its realization and unification of criteria to incorporate the lipid control goals appropriate to the vascular risk of the patients in the laboratory reports.
MeSH term(s)	Humans ; Laboratories, Clinical ; Consensus ; Cardiovascular Diseases/prevention & control ; Cardiovascular Diseases/etiology ; Lipid Metabolism ; Lipids
Chemical Substances	Lipids
Language	English
Publishing date	2023-06-01
Publishing country	Spain
Document type	Practice Guideline ; Journal Article
ISSN	2530-0180
ISSN (online)	2530-0180
DOI	10.1016/j.endien.2023.05.012
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