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  1. Article: Venovenous Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome Due to Severe Fever With Thrombocytopenia Syndrome.

    Fukumoto, Nobu / Miyamoto, Kyohei / Nakashima, Tsuyoshi / Kato, Seiya

    Cureus

    2023  Volume 15, Issue 5, Page(s) e39138

    Abstract: Few cases of acute respiratory distress syndrome (ARDS) in severe fever with thrombocytopenia syndrome (SFTS) have been treated with venovenous extracorporeal membrane oxygenation (VV-ECMO), and its role remains unclear. A 73-year-old Japanese woman ... ...

    Abstract Few cases of acute respiratory distress syndrome (ARDS) in severe fever with thrombocytopenia syndrome (SFTS) have been treated with venovenous extracorporeal membrane oxygenation (VV-ECMO), and its role remains unclear. A 73-year-old Japanese woman presented with multiple organ failure (MOF) due to SFTS, including liver, neural, hematologic, renal, and ARDS. VV-ECMO for refractory hypoxemia under lung-protective ventilation with prone positioning led to gradual respiratory improvement, and she was successfully weaned on the 19th day of hospitalization. However, she died from persistent MOF on the 60th day of hospitalization. VV-ECMO contributed to recovery from ARDS but not from the ultimate cause of death, i.e., MOF. SFTS could have variable MOFs with different disease trajectories, which influence the decision for VV-ECMO.
    Language English
    Publishing date 2023-05-17
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.39138
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: A Case Report of Deep Cerebral Venous Thrombosis Presenting Unilateral Lesion: The Association of Asymmetric Venous Outflow and Unilateral Lesion.

    Oshima, Seiya / Ikenouchi, Hajime / Miyamoto, Tatsuo / Yamamoto, Naoki / Endo, Kaoru

    Cureus

    2023  Volume 15, Issue 4, Page(s) e36988

    Abstract: A 60-year-old man was admitted to our hospital due to progressive aphasia and right hemiparesis. Brain magnetic resonance imaging showed the left thalamus and basal ganglia lesion. Digital subtraction angiography showed the vein of Galen and straight ... ...

    Abstract A 60-year-old man was admitted to our hospital due to progressive aphasia and right hemiparesis. Brain magnetic resonance imaging showed the left thalamus and basal ganglia lesion. Digital subtraction angiography showed the vein of Galen and straight sinus occlusion, suggesting cerebral venous thrombosis. Since his left transverse sinus was hypoplastic, his left deep cerebral lesion was due to the left deep cerebral vein congestion by the asymmetrical venous outflow. After anticoagulant therapy, his symptom and unilateral lesion improved. Clinicians should consider the vein of Galen and straight sinus thrombosis even in unilateral deep cerebral lesions.
    Language English
    Publishing date 2023-04-01
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.36988
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Plant Mitochondrial-Targeted Gene Delivery by Peptide/DNA Micelles Quantitatively Surface-Modified with Mitochondrial Targeting and Membrane-Penetrating Peptides.

    Abe, Naoya / Fujita, Seiya / Miyamoto, Takaaki / Tsuchiya, Kousuke / Numata, Keiji

    Biomacromolecules

    2023  Volume 24, Issue 8, Page(s) 3657–3665

    Abstract: Plant mitochondria play essential roles in metabolism and respiration. Recently, there has been growing interest in mitochondrial transformation for developing crops with commercially valuable traits, such as resistance to environmental stress and ... ...

    Abstract Plant mitochondria play essential roles in metabolism and respiration. Recently, there has been growing interest in mitochondrial transformation for developing crops with commercially valuable traits, such as resistance to environmental stress and shorter fallow periods. Mitochondrial targeting and cell membrane penetration functions are crucial for improving the gene delivery efficiency of mitochondrial transformation. Here, we developed a peptide-based carrier, referred to as Cytcox/KAibA-Mic, that contains multifunctional peptides for efficient transfection into plant mitochondria. We quantified the mitochondrial targeting and cell membrane-penetrating peptide modification rates to control their functions. The modification rates were easily determined from high-performance liquid chromatography chromatograms. Additionally, the gene carrier size remained constant even when the mitochondrial targeting peptide modification rate was altered. Using this gene carrier, we can quantitatively investigate the relationships between various peptide modifications and transfection efficiency and optimize the gene carrier conditions for mitochondrial transfection.
    MeSH term(s) Micelles ; Gene Transfer Techniques ; Mitochondria/metabolism ; Transfection ; DNA/chemistry ; Cell-Penetrating Peptides/chemistry
    Chemical Substances Micelles ; DNA (9007-49-2) ; Cell-Penetrating Peptides
    Language English
    Publishing date 2023-06-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1526-4602
    ISSN (online) 1526-4602
    DOI 10.1021/acs.biomac.3c00391
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Letter to the Editor concerning "Alterations of 3D acetabular and lower limb parameters in adolescent idiopathic scoliosis" by Karam M, et al. (Eur Spine J [2020]; 29(8):2010-2017): Does windswept deformity of the knee exist in 274 participants with adolescent idiopathic scoliosis?

    Sugita, Takehiko / Aizawa, Toshimi / Sasaki, Akira / Miyamoto, Seiya / Miyatake, Naohisa / Kamimura, Masayuki / Yahata, Kenichirou

    European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

    2023  Volume 32, Issue 11, Page(s) 4073

    MeSH term(s) Humans ; Adolescent ; Scoliosis/surgery ; Kyphosis ; Lower Extremity ; Knee Joint ; Acetabulum
    Language English
    Publishing date 2023-09-13
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 1115375-1
    ISSN 1432-0932 ; 0940-6719
    ISSN (online) 1432-0932
    ISSN 0940-6719
    DOI 10.1007/s00586-023-07862-7
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3437: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Comparison of clinical severity, genotype and toxin gene expression of binary toxin-producing

    Matsumoto, Asami / Yamagishi, Yuka / Miyamoto, Kentaro / Higashi, Seiya / Oka, Kentaro / Takahashi, Motomichi / Mikamo, Hiroshige

    Access microbiology

    2022  Volume 4, Issue 10, Page(s) acmi000362

    Abstract: ... The ... ...

    Abstract The emerging
    Language English
    Publishing date 2022-10-20
    Publishing country England
    Document type Journal Article
    ISSN 2516-8290
    ISSN (online) 2516-8290
    DOI 10.1099/acmi.0.000362
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: High-risk Patients With Colorectal Liver Metastases Assessed by the Beppu Score Can Have Excellent Survival Through Multidisciplinary Treatment Including Local Ablation.

    Beppu, Toru / Yamamura, Kensuke / Masuda, Toshiro / Miyamoto, Hideaki / Nasu, Jiro / Saito, Seiya / Doi, Koichi / Katsumori, Takashi / Oda, Tsutomu / Isiko, Takatoshi

    Anticancer research

    2024  Volume 44, Issue 4, Page(s) 1533–1539

    Abstract: Background/aim: The Beppu score assessed by the Japanese Society of Hepato-Biliary-Pancreatic Surgery nomogram helps predict postoperative disease-free survival for patients with resectable colorectal liver metastases (CRLM). Using the Beppu score, ... ...

    Abstract Background/aim: The Beppu score assessed by the Japanese Society of Hepato-Biliary-Pancreatic Surgery nomogram helps predict postoperative disease-free survival for patients with resectable colorectal liver metastases (CRLM). Using the Beppu score, patients with resectable CRLM were divided into three groups according to recurrence risk: low (≤6 points), moderate (7-10 points), and high-risk (≥11 points). Hepatectomy following preoperative chemotherapy is recommended for high-risk patients. The surgical outcome, local recurrence rates, and long-term survival were assessed, focusing on local ablation.
    Patients and methods: Twenty high-risk and unresectable CRLM patients were enrolled between April 2016 and April 2022. Hepatectomy with or without local ablation was performed after induction chemotherapy. Local ablation was permissive for patients with effective chemotherapy (partial response and stable disease) with CRLM ≤2 cm and ≥5 mm distant from major vessels.
    Results: The median diameters and numbers of CRLM were 26 (10-150) mm and 9 (1-46). All 18 patients who received preoperative chemotherapy were disease controls. Local ablation was performed simultaneously on hepatectomy in 14 patients. The median diameters and numbers of the ablated nodules were 12 (5-17) mm and 3 (1-21). Local recurrence was 8.5% per 82 ablative nodules. Three-year disease-free and five-year overall survival was 57.4% and 56.2%, respectively. There was no significant difference in patients with or without local ablation.
    Conclusion: Our treatment strategy for high-risk CRLM patients is feasible and can provide an excellent long-term prognosis regardless of adding local ablation to hepatectomy.
    MeSH term(s) Humans ; Colorectal Neoplasms/pathology ; Prognosis ; Hepatectomy ; Combined Modality Therapy ; Liver Neoplasms/surgery ; Liver Neoplasms/pathology ; Neoplasm Recurrence, Local/pathology ; Retrospective Studies
    Language English
    Publishing date 2024-03-27
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    DOI 10.21873/anticanres.16950
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1642: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article ; Online: Diverse pro-inflammatory ability of mutated spike protein derived from variant strains of SARS-CoV-2.

    Kawata, Daisuke / Iwai, Hideyuki / Oba, Seiya / Komiya, Yoji / Koike, Ryuji / Miyamoto, Sho / Kanno, Takayuki / Ainai, Akira / Suzuki, Tadaki / Hosoya, Tadashi / Yasuda, Shinsuke

    Cytokine

    2024  Volume 178, Page(s) 156592

    Abstract: The severity of COVID-19 has been reported to differ among SARS-CoV-2 mutant variants. The overactivation of macrophages is involved in severe COVID-19, yet the effects of SARS-CoV-2 mutations on macrophages remain poorly understood. To clarify the ... ...

    Abstract The severity of COVID-19 has been reported to differ among SARS-CoV-2 mutant variants. The overactivation of macrophages is involved in severe COVID-19, yet the effects of SARS-CoV-2 mutations on macrophages remain poorly understood. To clarify the effects, we examined whether mutations of spike proteins (S-proteins) affect macrophage activation. CD14
    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19 ; Spike Glycoprotein, Coronavirus/genetics ; Ataxia Telangiectasia Mutated Proteins
    Chemical Substances spike protein, SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; Ataxia Telangiectasia Mutated Proteins (EC 2.7.11.1)
    Language English
    Publishing date 2024-04-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 1018055-2
    ISSN 1096-0023 ; 1043-4666
    ISSN (online) 1096-0023
    ISSN 1043-4666
    DOI 10.1016/j.cyto.2024.156592
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2840: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: A case of infective endocarditis in which vegetation was detected by contrast-enhanced CT.

    Nemoto, Shigeki / Miyamoto, Kyohei / Nakashima, Tsuyoshi / Shibata, Mami / Nakamura, Ryo / Honda, Kentaro / Nishimura, Yoshiharu / Kato, Seiya

    Acute medicine & surgery

    2022  Volume 9, Issue 1, Page(s) e762

    Language English
    Publishing date 2022-06-06
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2751184-4
    ISSN 2052-8817 ; 2052-8817
    ISSN (online) 2052-8817
    ISSN 2052-8817
    DOI 10.1002/ams2.762
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  9. Article ; Online: Heart rate recovery is useful for evaluating the recovery of exercise tolerance in patients with heart failure and atrial fibrillation.

    Tanaka, Seiya / Miyamoto, Taro / Mori, Yusuke / Harada, Takashi / Tasaki, Hiromi

    Heart and vessels

    2021  Volume 36, Issue 10, Page(s) 1551–1557

    Abstract: This study aimed to examine the factors that contribute to improvement of exercise tolerance in patients with heart failure (HF) and atrial fibrillation (AF) following cardiac rehabilitation. Our hypothesis is that parasympathetic values are important ... ...

    Abstract This study aimed to examine the factors that contribute to improvement of exercise tolerance in patients with heart failure (HF) and atrial fibrillation (AF) following cardiac rehabilitation. Our hypothesis is that parasympathetic values are important for recovering exercise tolerance in those patients. We included 84 consecutive patients with HF and AF (mean age: 69 ± 15 years, 80% men). All of the patients underwent a cardiopulmonary exercise test and had pre and post 5 month cardiac rehabilitation assessed. After 155 ± 11 days and 44 ± 8 sessions, 73 patients (86%) showed an increase in peak oxygen uptake (VO
    MeSH term(s) Aged ; Aged, 80 and over ; Atrial Fibrillation/diagnosis ; Exercise Test ; Exercise Tolerance ; Female ; Heart Failure ; Heart Rate ; Humans ; Male ; Middle Aged ; Oxygen Consumption
    Language English
    Publishing date 2021-03-30
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 89678-0
    ISSN 1615-2573 ; 0910-8327 ; 0935-736X
    ISSN (online) 1615-2573
    ISSN 0910-8327 ; 0935-736X
    DOI 10.1007/s00380-021-01839-6
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    Zs.A 2049: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Combination of the Modified Loop Technique and De Vega Annuloplasty in Dogs with Mitral Regurgitation.

    Aoki, Takuma / Miyamoto, Takashi / Fukamachi, Naoyuki / Niimi, Seiya / Jingya, Yao / Wakao, Yoshito

    Animals : an open access journal from MDPI

    2022  Volume 12, Issue 13

    Abstract: Background: Detailed surgical techniques for treating canine mitral regurgitation have not been previously reported. Method: This case series included six consecutive client-owned dogs with mitral regurgitation. All dogs underwent a combined protocol, ... ...

    Abstract Background: Detailed surgical techniques for treating canine mitral regurgitation have not been previously reported. Method: This case series included six consecutive client-owned dogs with mitral regurgitation. All dogs underwent a combined protocol, including the modified loop technique and De Vega annuloplasty (MODEL surgery), in 2021. Artificial loops covering 80% of the length of the strut chordae tendineae were used for chordal replacement. Mitral annuloplasty was subjectively performed, targeting the circumference of the septal leaflet. Results: The breeds were Chihuahua-mixed breed, Spitz, Pomeranian, Cavalier King Charles Spaniel, and Chihuahua, with average ages and weights of 11.4 ± 2.3 years and 5.49 ± 2.98 kg, respectively. The aortic cross-clamp, pumping, and surgery times were 64.0 ± 7.5 min, 168.5 ± 39.1 min, and 321.0 ± 53.1 min, respectively. After MODEL surgery, left atrial-to-aortic ratios significantly decreased from 2.20 ± 0.18 to 1.26 ± 0.22 (p < 0.01), and left ventricular end-diastolic internal diameter normalized to body weight significantly decreased from 2.03 ± 0.26 to 1.48 ± 0.20 (p < 0.01). In all cases, the clinical signs disappeared or improved significantly. Conclusions: MODEL surgery increased mitral valve coaptation, normalized heart sizes, and significantly improved clinical signs in dogs with mitral regurgitation.
    Language English
    Publishing date 2022-06-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani12131653
    Database MEDical Literature Analysis and Retrieval System OnLINE

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