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  1. Book ; Online ; E-Book: Woher Kommt Gewalt?

    Bogerts, Bernhard

    Erklärungen Aus Neurowissenschaften, Psychologie, Soziologie and Co

    2021  

    Language German
    Size 1 online resource (283 pages)
    Publisher Springer Berlin / Heidelberg
    Publishing place Berlin, Heidelberg
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-662-63338-8 ; 3-662-63337-X ; 978-3-662-63338-0 ; 978-3-662-63337-3
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Increased densities of T and B lymphocytes indicate neuroinflammation in subgroups of schizophrenia and mood disorder patients.

    Schlaaff, Konstantin / Dobrowolny, Henrik / Frodl, Thomas / Mawrin, Christian / Gos, Tomasz / Steiner, Johann / Bogerts, Bernhard

    Brain, behavior, and immunity

    2020  Volume 88, Page(s) 497–506

    Abstract: ... BBB) impairment has not yet been investigated in this context. Densities of T and B lymphocytes were ... for T cells, anti-CD20 for B cells), followed by automated microscopic image acquisition and analysis ...

    Abstract An increasing number of clinical, epidemiological and genetic studies as well as investigations of CSF and blood suggests that neuroinflammation plays an essential role in the etiology of schizophrenia and mood disorders. However, direct neuropathological evidence of inflammation within the brain tissue remains sparse and the regional distribution of lymphocytes as surrogate markers of blood-brain barrier (BBB) impairment has not yet been investigated in this context. Densities of T and B lymphocytes were assessed in coronal whole brain sections of 22 patients with schizophrenia and 20 patients suffering from major depression or bipolar disorder, compared to 20 individuals without neuropsychiatric disorders from the Magdeburg Brain Collection. Cell densities were determined by immunohistochemical staining (anti-CD3 for T cells, anti-CD20 for B cells), followed by automated microscopic image acquisition and analysis. Hierarchical clustering and detailed cluster analysis were performed to detect possible subgroups of patients. Regional distribution was assessed by analysis of color coded mappings based on microsopic scans. Elevated lymphocyte density was found in 7 out of 20 mood disorder patients (adj. p = 0.022; Fisher's exact test, FET), 9 out of 22 schizophrenic patients (adj. p = 0.014; FET) and in 1 of 20 controls (p < 0.005; FET). Several cases showed different patterns of infiltration affecting cortical regions or subcortical white matter, while some presented diffuse infiltration. In two thirds of patients, no increased lymphocyte density could be found. The current findings indicate that lymphocyte infiltration occurs in a greater proportion of schizophrenia and mood disorder patients as compared to healthy controls. Under healthy conditions lymphocytes rarely cross the BBB. Thus, higher densities are considered indicators of neuroinflammation associated with an impairment of the BBB.
    MeSH term(s) B-Lymphocytes ; Bipolar Disorder ; Brain ; Humans ; Mood Disorders ; Schizophrenia ; T-Lymphocytes
    Language English
    Publishing date 2020-04-10
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639219-2
    ISSN 1090-2139 ; 0889-1591
    ISSN (online) 1090-2139
    ISSN 0889-1591
    DOI 10.1016/j.bbi.2020.04.021
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  3. Article: Liebe und Eifersucht bis zum Wahn gesteigert. Übersicht von B. Bogerts, Magdeburg

    Bogerts, B.

    MMW-Fortschritte der Medizin

    2005  Volume 147, Issue 6, Page(s) 26

    Language German
    Document type Article
    ZDB-ID 1478211-x
    ISSN 1438-3276
    Database Current Contents Medicine

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  4. Book: Woher kommt Gewalt? Von Neurowissenschaft bis Soziologie - Eine mehrdimensionale Betrachtung

    Bogerts, Bernhard

    2021  

    Abstract: Warum tun Menschen so etwas!? Dies ist oft die erste Frage, die sich aufdrängt, wenn wir in den Medien oder im echten Leben Zeugen von Gewalt werden. Dieses Buch gibt umfassende Antworten: Es erklärt die Ursachen von Gewalt nicht aus der eingeschränkten ... ...

    Title translation Where does violence come from?. From neuroscience to sociology - A multidimensional view (DeepL)
    Abstract Warum tun Menschen so etwas!? Dies ist oft die erste Frage, die sich aufdrängt, wenn wir in den Medien oder im echten Leben Zeugen von Gewalt werden. Dieses Buch gibt umfassende Antworten: Es erklärt die Ursachen von Gewalt nicht aus der eingeschränkten Sicht einer einzelnen Fachdisziplin, sondern verbindet die Erklärungsansätze aus Hirnforschung, Kriminologie, Soziologie, Psychologie, Psychiatrie, Genetik, Pädagogik, Geschichtswissenschaften und Justiz zu einem großen, spannenden und verständlichen Bild - auf unterhaltsame Weise und auf dem aktuellen Stand der Wissenschaft(en). Und immer nah an Fallbeispielen, die uns die erschreckende Vielfalt menschlicher Gewalt vor Augen führen: Gewalthandlungen einzelner Täter, Gewalt zwischen Gruppen, Randale und Krawalle durch Gangs und Hooligans, gewaltsame ethnische und religiöse Konflikte, Extremgewalt in Form von Amok und Terror bis hin zu kriegerischen Auseinandersetzungen und Völkermord. Nicht zuletzt kann das Wissen aus diesem Buch dazu beitragen, eine andere große Frage zu beantworten: Wie kann Gewalt eingedämmt oder gar verhindert werden? (c) Der/die Herausgeber bzw. der/die Autor(en), exklusiv lizenziert durch Springer-Verlag GmbH - Inhalt: (1) Formen von Gewalt. (2) Vorkommen, Häufigkeit und Folgen von Gewalt. (3) Warum gehört Gewaltneigung zu den menschlichen Eigenschaften? (4) Erblichkeit aggressiven Verhaltens. (5) Neurobiologie der Gewalt. (6) Hirnstruktur und Hirnfunktion von Gewalttätern. (7) Bedeutung von Hormonen und Botenstoffen des Gehirns. (8) Geschlechterdifferenz der Gewaltneigung. (9) Psychische Störungen und Gewaltneigung. (10) Alkohol, Drogen und Gewalt. (11) Psychologie der Gewalt. (12) Gewalt als Selbstzweck und Lustgewinn. (13) Soziale Ursachen von Gewalt. (14) Gewalt bei Kindern und Jugendlichen - frühe Risikofaktoren. (15) Amok und School Shooting. (16) Terror. (17) Kollektive Gewalt, Fremdenfeindlichkeit, Pogrome, Völkermord. (18) Sexuelle Gewalt. (19) Religion und Gewalt. (20) Schlussfolgerungen für die Vorhersage und Prävention von Gewalt. (c) ZPID
    Keywords Epidemiologie ; Epidemiology ; Etiology ; Genetics ; Genetik ; Gewalt ; Gewaltprävention ; Neuro-Wissenschaften ; Neurosciences ; Psychologie ; Psychology ; Sociology ; Soziologie ; Theorien ; Theories ; Violence ; Violence Prevention ; Ätiologie
    Language German
    Size 293 S.
    Publisher Springer
    Publishing place Berlin, Heidelberg
    Document type Book
    ISBN 978-3-662-63338-0 ; 3-662-63338-8
    DOI 10.1007/978-3-662-63338-0
    Database PSYNDEX

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  5. Book: Where does violence come from? A multidimensional approach to its causes and manifestations

    Bogerts, Bernhard

    2021  

    Abstract: Where does violence come from? How can people do such things? These are often the first questions that arise when we witness violence in the in the media or in real life. This book provides comprehensive answers by combining the explanatory approaches ... ...

    Title translation Woher kommt die Gewalt? Ein multidimensionaler Ansatz für ihre Ursachen und Erscheinungsformen (DeepL)
    Abstract Where does violence come from? How can people do such things? These are often the first questions that arise when we witness violence in the in the media or in real life. This book provides comprehensive answers by combining the explanatory approaches from criminology, sociology, psychology, psychiatry, brain research, genetics, pedagogy, historical sciences, and justice into a big, exciting, and comprehensible picture - in an entertaining way with current, state-of-the art science(s). Multiple case studies are presented that show us the frightening diversity of human violence: acts of violence by individual perpetrators; violence between groups; riots and tumults by gangs and hooligans; violent ethnic and religious conflicts; extreme violence in the form of amok and terror; and up to armed conflicts, pogroms, and genocide. Last but not least, the knowledge gained from this book can help answer another big question: how can violence be contained or even prevented? (c) The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG - Contents: (1) Manifestations of violence. (2) Incidence, frequency and consequences of violence. (3) Why ist he tendency to violence a human trait? (4) Heritability of aggressive behavior. (5) Neurobiology of violence. (6) Brain pathology in violent offenders. (7) The role of hormones and messenger substances in the brain. (8) Gender differences in the propensity for violence. (9) Mental disorders and violence. (10) Alcohol, drugs and violence. (11) Psychology of violence. (12) Violence as an end in itself and lust gain. (13) Social causes of violence. (14) Violence in children and adolescents: Early risk factors. (15) Rampage and school shooting. (16) Terror. (17) Collective violence, xenophobia, pogroms, genocide. (18) Sexual violence. (19) Religion and violence. (20) Conclusions for the prediction and prevention of violence. (c) ZPID
    Keywords Aggressionsverhalten ; Aggressive Behavior ; Cognitive Neuroscience ; Criminal Behavior ; Gewalt ; Gewaltverbrechen ; Kognitive Neurowissenschaft ; Kriminelles Verhalten ; Neurobiologie ; Neurobiology ; Neuropsychologie ; Neuropsychology ; Personality ; Persönlichkeit ; Social Influences ; Soziale Einflüsse ; Theorien ; Theories ; Violence ; Violent Crime
    Language English
    Size 222 pp.
    Publisher Springer International Publishing
    Publishing place Cham
    Document type Book
    ISBN 978-3-030-81792-3 ; 3-030-81792-X
    DOI 10.1007/978-3-030-81792-3
    Database PSYNDEX

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  6. Article ; Online: Acute schizophrenia is accompanied by reduced T cell and increased B cell immunity.

    Steiner, Johann / Jacobs, Roland / Panteli, Benjamin / Brauner, Mareike / Schiltz, Kolja / Bahn, Sabine / Herberth, Marlis / Westphal, Sabine / Gos, Tomasz / Walter, Martin / Bernstein, Hans-Gert / Myint, Aye Mu / Bogerts, Bernhard

    European archives of psychiatry and clinical neuroscience

    2010  Volume 260, Issue 7, Page(s) 509–518

    Abstract: ... while the FCI was related to B cell numbers (CD19(+): r = 0.390, P = 0.003). Considering these covariates ... a lower level of T helper cells (P = 0.010), a reduced CD4/CD8 ratio (P = 0.029), and elevated B cells (P ... cytotoxic cells (P = 0.005) increased, while B cell counts declined (P = 0.049). In conclusion, acute ...

    Abstract Previous studies of lymphocyte distribution in schizophrenia have yielded inconsistent results, as summarized in the present study. Based on our own original data, potential confounds that might explain these variations are analyzed and discussed. Blood samples from 26 patients with acute paranoid schizophrenia were investigated in comparison with 32 matched healthy controls by flow cytometry (CD3, CD4, CD8, CD19, and CD56 phenotyping). A subgroup of drug-free patients was followed up after 6 weeks of treatment. Cotinine levels and the free cortisol index (FCI) were provided in order to control for medication, smoking, and stress. Cotinine levels correlated with natural killer (NK) cell counts (CD3⁻/CD56(+): r = -0.383, P = 0.003) while the FCI was related to B cell numbers (CD19(+): r = 0.390, P = 0.003). Considering these covariates, a lower level of T helper cells (P = 0.010), a reduced CD4/CD8 ratio (P = 0.029), and elevated B cells (P = 0.008) were found during acute psychosis. After 6 weeks of medication, an inverse pattern was observed in initially drug-free patients: total T cell (P = 0.005), T helper (P = 0.003), and T suppressor/cytotoxic cells (P = 0.005) increased, while B cell counts declined (P = 0.049). In conclusion, acute paranoid schizophrenia may be accompanied by a reduced T cell defense and a shift towards B cell immunity, which normalizes in response to treatment. In addition to disease stage or subtype and medication, cigarette smoking and stress are important co-factors.
    MeSH term(s) Acute Disease ; Adult ; Antigens, CD/metabolism ; Antipsychotic Agents/pharmacology ; Antipsychotic Agents/therapeutic use ; B-Lymphocytes/classification ; B-Lymphocytes/drug effects ; B-Lymphocytes/immunology ; Case-Control Studies ; Cotinine/metabolism ; Enzyme-Linked Immunosorbent Assay/methods ; Female ; Flow Cytometry/methods ; Follow-Up Studies ; Humans ; Hydrocortisone/metabolism ; Killer Cells, Natural/drug effects ; Killer Cells, Natural/physiology ; Male ; Middle Aged ; Psychiatric Status Rating Scales ; Schizophrenia, Paranoid/drug therapy ; Schizophrenia, Paranoid/immunology ; Schizophrenia, Paranoid/pathology ; Schizophrenia, Paranoid/physiopathology ; Smoking/physiopathology ; Statistics, Nonparametric ; Stress, Psychological/physiopathology ; T-Lymphocytes/classification ; T-Lymphocytes/drug effects ; T-Lymphocytes/physiology
    Chemical Substances Antigens, CD ; Antipsychotic Agents ; Cotinine (K5161X06LL) ; Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2010-01-27
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1045583-8
    ISSN 1433-8491 ; 0175-758X ; 0940-1334
    ISSN (online) 1433-8491
    ISSN 0175-758X ; 0940-1334
    DOI 10.1007/s00406-010-0098-x
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  7. Article ; Online: Neuroanatomical correlates of aggressiveness: a case-control voxel- and surface-based morphometric study.

    Seidenbecher, Stephanie / Schöne, Maria / Kaufmann, Jörn / Schiltz, Kolja / Bogerts, Bernhard / Frodl, Thomas

    Brain structure & function

    2023  Volume 229, Issue 1, Page(s) 31–46

    Abstract: Aggression occurs across the population ranging on a symptom continuum. Most previous studies have used magnetic resonance imaging in clinical/forensic samples, which is associated with several confounding factors. The present study examined structural ... ...

    Abstract Aggression occurs across the population ranging on a symptom continuum. Most previous studies have used magnetic resonance imaging in clinical/forensic samples, which is associated with several confounding factors. The present study examined structural brain characteristics in two healthy samples differing only in their propensity for aggressive behavior. Voxel- and surface-based morphometry (SBM) analyses were performed on 29 male martial artists and 32 age-matched male controls. Martial artists had significantly increased mean gray matter volume in two frontal (left superior frontal gyrus and bilateral anterior cingulate cortex) and one parietal (bilateral posterior cingulate gyrus and precuneus) brain clusters compared to controls (whole brain: p < 0.001, cluster level: family-wise error (FWE)-corrected). SBM analyses revealed a trend for greater gyrification indices in martial artists compared to controls in the left lateral orbital frontal cortex and the left pars orbitalis (whole brain: p < 0.001, cluster level: FWE-corrected). The results indicate brain structural differences between martial artists and controls in frontal and parietal brain areas critical for emotion processing/inhibition of emotions as well as empathic processes. The present study highlights the importance of studying healthy subjects with a propensity for aggressive behavior in future structural MRI research on aggression.
    MeSH term(s) Humans ; Male ; Aggression/psychology ; Brain/diagnostic imaging ; Brain/pathology ; Gray Matter/diagnostic imaging ; Gray Matter/pathology ; Cerebral Cortex/pathology ; Case-Control Studies ; Magnetic Resonance Imaging/methods
    Language English
    Publishing date 2023-10-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2273162-3
    ISSN 1863-2661 ; 1863-2653
    ISSN (online) 1863-2661
    ISSN 1863-2653
    DOI 10.1007/s00429-023-02715-x
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  8. Book: Die Hirnstruktur Schizophrener und ihre Bedeutung für die Pathophysiologie und Psychopathologie der Erkrankung

    Bogerts, Bernhard

    18 Tabellen

    (Sammlung psychiatrischer und neurologischer Einzeldarstellungen)

    1990  

    Series title Sammlung psychiatrischer und neurologischer Einzeldarstellungen
    Keywords Brain / pathology ; Schizophrenia / physiopathology ; Schizophrenia / pathology ; Schizophrenie ; Gehirn ; Pathophysiologie ; Psychopathologie
    Subject Pathopsychologie ; Cerebrum ; Hirn ; Encephalon ; Enzephalon ; Hirngewebe ; Hirnmasse ; Gehirnmasse ; Spaltungsirresein ; Schizophrene Psychose ; Pathologische Physiologie ; Physiologische Pathologie ; Physiopathologie
    Size 66 S. : Ill., graph. Darst.
    Edition 1. Aufl.
    Publisher Thieme
    Publishing place Stuttgart u.a.
    Document type Book
    HBZ-ID HT003508920
    ISBN 3-13-735801-9 ; 978-3-13-735801-5
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1990 A 4751 order for loan Magazin

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  9. Article ; Online: Psychiatrische Diagnosesysteme zur Einordnung terroristischer Gewalttäter unzureichend.

    Seidenbecher, S / Steinmetz, C / Möller-Leimkühler, A-M / Bogerts, B

    Der Nervenarzt

    2020  Volume 92, Issue 3, Page(s) 275–276

    Title translation Psychiatric diagnosis system for classification of terroristic perpetrators of violence insufficient.
    MeSH term(s) Humans ; Mental Disorders/diagnosis ; Terrorism ; Violence
    Language German
    Publishing date 2020-09-22
    Publishing country Germany
    Document type Letter
    ZDB-ID 123291-5
    ISSN 1433-0407 ; 0028-2804
    ISSN (online) 1433-0407
    ISSN 0028-2804
    DOI 10.1007/s00115-020-00994-x
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  10. Article ; Online: Terrorismus aus psychiatrischer Sicht.

    Seidenbecher, S / Steinmetz, C / Möller-Leimkühler, A-M / Bogerts, B

    Der Nervenarzt

    2020  Volume 91, Issue 5, Page(s) 422–432

    Abstract: Background: Terrorism belongs to the extreme forms of violence that have so far received little attention in psychiatric research and are rarely mentioned in textbooks of psychiatry. After terror attacks, however, the question regularly arises whether ... ...

    Title translation Psychiatric aspects of terrorism.
    Abstract Background: Terrorism belongs to the extreme forms of violence that have so far received little attention in psychiatric research and are rarely mentioned in textbooks of psychiatry. After terror attacks, however, the question regularly arises whether terrorists suffer from mental disorders.
    Objective and methods: The aim of this review is to summarize the multidimensional causes of terrorism with special emphasis on psychopathological aspects of the perpetrators. In addition to a brief summary of the historical background and recent developments in terrorism, a literature search was performed using PubMed, SCOPUS, PsychInfo and PsychARTICLES.
    Results: From a psychiatric point of view, a differentiation between lone terrorists and group terrorists is essential. Lone terrorists have a much higher prevalence of psychiatric disorders, such as psychotic, paranoid and affective symptoms. The majority of terrorists acting in groups rarely suffer from such mental disorders. For these perpetrators biographic aspects and socialization, group dynamics and ideological personality profiles with narcissistic, histrionic, fanatic and antisocial components are more relevant. The phenomenon of terrorism predominantly being a male domain is discussed.
    Conclusion: The manifold manifestations of terrorism are caused by complex patterns of interacting biographic, sociological, ideological and psychopathological components that differ between lone acting and group terrorists. The real causes for acts of terrorism are not various ideologies permitting violence but consist more of a pre-existing violence-oriented mentality of the perpetrators looking for such ideologies to justify their acts. The possibilities of psychiatry in prevention and early recognition are limited. Some recently developed scales for risk assessment of extreme violence are mentioned.
    MeSH term(s) Humans ; Male ; Mental Disorders/complications ; Sex Factors ; Terrorism/psychology ; Terrorism/statistics & numerical data ; Violence/psychology
    Language German
    Publishing date 2020-07-30
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 123291-5
    ISSN 1433-0407 ; 0028-2804
    ISSN (online) 1433-0407
    ISSN 0028-2804
    DOI 10.1007/s00115-020-00894-0
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