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  1. Book ; Online ; E-Book: Herb-Drug Combinations

    Hemaiswarya, Shanmugam / Kumar Prabhakar, Pranav / Doble, Mukesh

    A New Complementary Therapeutic Strategy

    2022  

    Abstract: Plant extracts or their pure natural constituents have been used traditionally for thousands of years for treating diseases with considerable success in India and other Asian countries. In addition, they have also been used as complements or supplements ... ...

    Author's details by Shanmugam Hemaiswarya, Pranav Kumar Prabhakar, Mukesh Doble
    Abstract Plant extracts or their pure natural constituents have been used traditionally for thousands of years for treating diseases with considerable success in India and other Asian countries. In addition, they have also been used as complements or supplements with conventional medicine. This book discusses the latest research in the application of combination therapy, namely herbs and drugs, in the treatment of a range of communicable and non-communicable diseases to achieve a synergistic effect. This synergy may help in reducing the amount of drug, its toxicity, side effects, and development of resistance as well as improve its efficacy. The book also discusses the pharmacodynamic and pharmacokinetic parameters, experimental tools to determine the impact of combination, computational approaches to identify synergy, statistical analysis of data, and clinical and regulatory issues. The book is useful for researchers in the fields of pharmacology, pharmacy and medicinal chemistry and those working in pharmaceutical and nutraceutical industries. This book could open up new strategies to focus on multiple targets to combat complex diseases unlike the single targeted drugs that are being currently marketed by the pharmaceuticals industries.
    Keywords Pharmacology ; Pharmacy ; Alternative medicine ; Pharmacovigilance ; Medicinal chemistry ; Complementary and Alternative Medicine ; Drug Safety and Pharmacovigilance ; Medicinal Chemistry
    Subject code 016.61378
    Language English
    Size 1 online resource (285 pages)
    Edition 1st ed. 2022.
    Publisher Springer Nature Singapore ; Imprint: Springer
    Publishing place Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 981-19-5125-X ; 9789811951244 ; 978-981-19-5125-1 ; 9811951241
    DOI 10.1007/978-981-19-5125-1
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Comment on Kalra S, Arora S, Kapoor N. (J Pak Med Assoc. 2023;73:1544-5) Use of Dairy Products in People Living with Diabetes.

    Kumar, Prabhakar Pranav

    JPMA. The Journal of the Pakistan Medical Association

    2024  Volume 74, Issue 1, Page(s) 193

    MeSH term(s) Humans ; Diabetes Mellitus ; Dairy Products
    Language English
    Publishing date 2024-01-13
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 603873-6
    ISSN 0030-9982
    ISSN 0030-9982
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 845: Show issues Location:
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  3. Article ; Online: Preface

    Prabhakar Pranav Kumar

    BIO Web of Conferences, Vol 86, p

    2024  Volume 00001

    Keywords Microbiology ; QR1-502 ; Physiology ; QP1-981 ; Zoology ; QL1-991
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Combination therapy: A New Tool for the Management of Obesity.

    Prabhakar, Pranav Kumar

    Endocrine, metabolic & immune disorders drug targets

    2023  

    Abstract: Obesity is a long-term lifestyle problem that can lead to disastrous consequences. Lifestyle interventions are one of the initial lines of management strategies for obesity but in long term, it is not very effective in the management of obesity. Some ... ...

    Abstract Obesity is a long-term lifestyle problem that can lead to disastrous consequences. Lifestyle interventions are one of the initial lines of management strategies for obesity but in long term, it is not very effective in the management of obesity. Some people also manage their weight with bariatric surgery, which is now the most effective obesity treatment. Synthetic pharmaceuticals make a bridge between lifestyle modification and bariatric surgery-based obesity management. The major problem associated with monotherapy without side effects is that these are moderately effective and also need in higher doses. The combination therapy is already used for many serious and complicated disease treatments and management and has shown efficacy as well. Generally, we use two or more medicines with different of actions for a better effect. The commonly used combination therapy for obesity management includes low-dose phentermine and prolonged and slow-releasing mechanism topiramate; naltrexone along with bupropion. Phentermine with inhibitors of Na-glucose cotransporter-2 or glucagon-like peptide-1 (GLP-1) agonist with gastric hormone or Na-glucose cotransporter-2 is two more viable combo therapy. This combination strategy aims to achieve success in the bariatric surgery and the scientific community is working in this direction.
    Language English
    Publishing date 2023-08-25
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2228325-0
    ISSN 2212-3873 ; 1871-5303
    ISSN (online) 2212-3873
    ISSN 1871-5303
    DOI 10.2174/1871530323666230825140808
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5824: Show issues Location:
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  5. Article ; Online: Pathophysiology of Diabetic Secondary Complication and their Management.

    Prabhakar, Pranav Kumar

    Current diabetes reviews

    2021  Volume 17, Issue 4, Page(s) 395–396

    MeSH term(s) Diabetes Complications ; Diabetes Mellitus/epidemiology ; Humans
    Language English
    Publishing date 2021-05-24
    Publishing country United Arab Emirates
    Document type Editorial
    ISSN 1875-6417
    ISSN (online) 1875-6417
    DOI 10.2174/157339981704210326092455
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Comment on Kalra S, Arora S, Kapoor N. (J Pak Med Assoc. 2023;73:1544-5) Use of Dairy Products in People Living with Diabetes

    Prabhakar Pranav Kumar

    Journal of the Pakistan Medical Association, Vol 74, Iss

    2023  Volume 1

    Abstract: Dear Editor, I am writing to express my thoughts on the recent paper titled "Use of Dairy Products in People Living with Diabetes." As someone who is deeply concerned about the well-being of individuals with diabetes and the evolving landscape of dietary ...

    Abstract Dear Editor, I am writing to express my thoughts on the recent paper titled "Use of Dairy Products in People Living with Diabetes." As someone who is deeply concerned about the well-being of individuals with diabetes and the evolving landscape of dietary recommendations for managing this condition, I found this research to be both informative and timely.1 Dairy product consumption could impact the susceptibility to type 2 diabetes mellitus (T2DM), but the results from different studies have been contradictory. Additionally, there has been limited exploration of the wide range of dairy product types. A slight elevation in daily consumption of dairy items like low-fat dairy, cheese, and yogurt might play a role in T2DM prevention. However, this hypothesis requires validation through randomized controlled trials.2 The paper provides a comprehensive overview of the role of dairy products in the diets of people living with diabetes. It is clear that dietary choices play a crucial role in managing blood glucose levels and overall health for those with diabetes. While the authors acknowledge the potential benefits of dairy consumption, such as the rich source of essential nutrients like calcium and vitamin D, they also highlight some of the challenges and concerns related to dairy consumption among this population. Continues.
    Keywords Medicine ; R
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Pakistan Medical Association
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Editorial: New mechanisms for anti-cancer drugs.

    Shahid, Ayaz / Prakash, Ajit / Mustafa, Saad / Prabhakar, Pranav Kumar

    Frontiers in pharmacology

    2024  Volume 15, Page(s) 1387942

    Language English
    Publishing date 2024-04-05
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1387942
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Editorial: Advanced approaches in the diagnosis and treatment of diabetes mellitus and secondary complications.

    Sivakumar, Ponnurengam Malliappan / Prasad, Ram / Prabhakar, Pranav Kumar

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1291637

    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 1/complications
    Language English
    Publishing date 2023-09-20
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1291637
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Bacterial Siderophores and Their Potential Applications: A Review.

    Prabhakar, Pranav Kumar

    Current molecular pharmacology

    2020  Volume 13, Issue 4, Page(s) 295–305

    Abstract: The bacterial infection is one of the major health issues throughout the world. To protect humans from the infection and infectious agents, it is important to understand the mechanism of interaction of pathogens along with their susceptible hosts. This ... ...

    Abstract The bacterial infection is one of the major health issues throughout the world. To protect humans from the infection and infectious agents, it is important to understand the mechanism of interaction of pathogens along with their susceptible hosts. This will help us to develop a novel strategy for designing effective new drugs or vaccines. As iron is an essential metal ion required for all the living systems for their growth, as well, it is needed by pathogenic bacterial cells for their growth and development inside host tissues. To get iron from the host tissues, microbes developed an iron-chelating system called siderophore and also corresponding receptors. Siderophores are low molecular weight organic complex produced by different strains of bacteria for the procurement of iron from the environment or host body under the iron deficient-conditions. Mostly in the environment at physiological pH, the iron is present in the ferric ionic form (Fe3+), which is water- insoluble and thus inaccessible for them. Such a condition promotes the generation of siderophores. These siderophores have been used in different areas such as agriculture, treatment of diseases, culture the unculturable strains of bacteria, promotion of plant growth, controlling phytopathogens, detoxification of heavy metal contamination, etc. In the medical field, siderophores can be used as "Trojan Horse Strategy", which forms a complex with antibiotics and also delivers these antibiotics to the desired locations, especially in antibiotic-resistant bacteria. The promising application of siderophore-based use of antibiotics for the management of bacterial resistance can be strategies to be used.
    MeSH term(s) Animals ; Anti-Bacterial Agents/pharmacology ; Antineoplastic Agents/pharmacology ; Bacteria/metabolism ; Biological Transport/drug effects ; Biosensing Techniques ; Humans ; Siderophores/chemistry ; Siderophores/classification ; Siderophores/metabolism
    Chemical Substances Anti-Bacterial Agents ; Antineoplastic Agents ; Siderophores
    Language English
    Publishing date 2020-06-10
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ISSN 1874-4702
    ISSN (online) 1874-4702
    DOI 10.2174/1874467213666200518094445
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Potential Therapeutic Targets for the management of Diabetes Mellitus Type 2.

    Kumar Prabhakar, Pranav / Batiha, Gaber El-Saber

    Current medicinal chemistry

    2023  

    Abstract: Diabetes is one of the lifelong chronic metabolic diseases which is prevalent globally. There is a continuous rise in the number of people suffering from this disease with time. It is characterized by hyperglycemia, which leads to severe damage to the ... ...

    Abstract Diabetes is one of the lifelong chronic metabolic diseases which is prevalent globally. There is a continuous rise in the number of people suffering from this disease with time. It is characterized by hyperglycemia, which leads to severe damage to the body's system, such as blood vessels and nerves. Diabetes occurs due to the dysfunction of pancreatic β-cell which leads to the reduction in the production of insulin or body cells unable to use insulin produce efficiently. As per the data shared International diabetes federation (IDF), there are around 415 million affected by this disease worldwide. There are a number of hit targets available that can be focused on treating diabetes. There are many drugs available and still under development for the treatment of type 2 diabetes. Inhibition of gluconeogenesis, lipolysis, fatty acid oxidation, and glucokinase activator is emerging targets for type 2 diabetes treatment. Diabetes management can be supplemented with drug intervention for obesity. The antidiabetic drug sale is the second-largest in the world, trailing only that of cancer. The future of managing diabetes will be guided by research on various novel targets and the development of various therapeutic leads, such as GLP-1 agonists, DPP-IV inhibitors, and SGLT2 inhibitors that have recently completed their different phases of clinical trials. Among these therapeutic targets associated with type 2 diabetes, this review focused on some common therapeutic targets for developing novel drug candidates of the newer generation with better safety and efficacy.
    Language English
    Publishing date 2023-05-01
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 1319315-6
    ISSN 1875-533X ; 0929-8673
    ISSN (online) 1875-533X
    ISSN 0929-8673
    DOI 10.2174/0929867330666230501172557
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4432: Show issues Location:
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