LIVIVO - Search results -

Search results

Result 1 - 10 of total 1671

Search options

Article ; Online: Effect of enhanced p CO 2 levels on the production of DOC and TEP in short-term bioassay experiments

G. A. MacGilchrist / T. Shi / T. Tyrrell / S. Richier / C. M. Moore / C. Dumousseaud / E. P. Achterberg

Biogeosciences Discussions, Vol 11, Iss 3, Pp 3701-

2014 Volume 3730

Abstract: It has been proposed that increasing levels of p CO 2 in the surface ocean will lead to more ... experiments that considered the effect of four different p CO 2 scenarios (ambient, 550, 750 and 1000 μatm ... conditions, varied considerably between locations. We did not observe any strong or consistent effect of p CO 2 ...

Abstract	It has been proposed that increasing levels of p CO 2 in the surface ocean will lead to more partitioning of the organic carbon fixed by marine primary production into the dissolved rather than the particulate fraction. This process may result in enhanced accumulation of dissolved organic carbon (DOC) in the surface ocean and/or concurrent accumulation of transparent exopolymer particles (TEP), with important implications for the functioning of the marine carbon cycle. We investigated this in shipboard bioassay experiments that considered the effect of four different p CO 2 scenarios (ambient, 550, 750 and 1000 μatm) on unamended natural phytoplankton communities from a range of locations in the northwest European shelf seas. The environmental settings, in terms of nutrient availability, phytoplankton community structure and growth conditions, varied considerably between locations. We did not observe any strong or consistent effect of p CO 2 on DOC production. There was a significant but highly variable effect of p CO 2 on the production of TEP. In three of the five experiments, variation of TEP production between p CO 2 treatments was caused by the effect of p CO 2 on phytoplankton growth rather than a direct effect on TEP production. In one of the five experiments, there was evidence of enhanced TEP production at high p CO 2 (twice as much production over the 96 h incubation period in the 750 μatm treatment compared with the ambient treatment) independent of indirect effects, as hypothesised by previous studies. Our results suggest that the environmental setting of experiments (community structure, nutrient availability and occurrence of phytoplankton growth) is a key factor determining the TEP response to p CO 2 perturbations.
Keywords	Geology ; QE1-996.5 ; Science ; Q ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2014-03-01T00:00:00Z
Publisher	Copernicus GmbH
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Effect of enhanced p CO 2 levels on the production of dissolved organic carbon and transparent exopolymer particles in short-term bioassay experiments

G. A. MacGilchrist / T. Shi / T. Tyrrell / S. Richier / C. M. Moore / C. Dumousseaud / E. P. Achterberg

Biogeosciences, Vol 11, Iss 13, Pp 3695-

2014 Volume 3706

Abstract	It has been proposed that increasing levels of p CO 2 in the surface ocean will lead to more partitioning of the organic carbon fixed by marine primary production into the dissolved rather than the particulate fraction. This process may result in enhanced accumulation of dissolved organic carbon (DOC) in the surface ocean and/or concurrent accumulation of transparent exopolymer particles (TEPs), with important implications for the functioning of the marine carbon cycle. We investigated this in shipboard bioassay experiments that considered the effect of four different p CO 2 scenarios (ambient, 550, 750 and 1000 μatm) on unamended natural phytoplankton communities from a range of locations in the northwest European shelf seas. The environmental settings, in terms of nutrient availability, phytoplankton community structure and growth conditions, varied considerably between locations. We did not observe any strong or consistent effect of p CO 2 on DOC production. There was a significant but highly variable effect of p CO 2 on the production of TEPs. In three of the five experiments, variation of TEP production between p CO 2 treatments was caused by the effect of p CO 2 on phytoplankton growth rather than a direct effect on TEP production. In one of the five experiments, there was evidence of enhanced TEP production at high p CO 2 (twice as much production over the 96 h incubation period in the 750 μatm treatment compared with the ambient treatment) independent of indirect effects, as hypothesised by previous studies. Our results suggest that the environmental setting of experiments (community structure, nutrient availability and occurrence of phytoplankton growth) is a key factor determining the TEP response to p CO 2 perturbations.
Keywords	Ecology ; QH540-549.5 ; Life ; QH501-531 ; Geology ; QE1-996.5
Language	English
Publishing date	2014-07-01T00:00:00Z
Publisher	Copernicus Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Relation of pulse pressure to long-distance gait speed in community-dwelling older adults: findings from the LIFE-P study.

Heffernan, Kevin S / Manini, Todd M / Hsu, Fang-Chi / Blair, Steven N / Nicklas, Barbara J / Kritchevsky, Stephen B / Newman, Anne B / Sutton-Tyrrell, Kim / Church, Timothy S / Haskell, William L / Fielding, Roger A

PloS one

2012 Volume 7, Issue 11, Page(s) e49544

Abstract: ... in the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) study.: Methods: Brachial ... speed than those within the lowest PP tertile (p<0.05). Following stepwise multiple regression, PP was ... significantly and inversely associated with 400-meter gait speed (p<0.05). Other significant predictors of gait ...

Abstract	Background: Reduced gait speed is associated with falls, late-life disability, hospitalization/institutionalization and cardiovascular morbidity and mortality. Aging is also accompanied by a widening of pulse pressure (PP) that contributes to ventricular-vascular uncoupling. The purpose of this study was to test the hypothesis that PP is associated with long-distance gait speed in community-dwelling older adults in the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) study. Methods: Brachial blood pressure and 400-meter gait speed (average speed maintained over a 400-meter walk at "usual" pace) were assessed in 424 older adults between the ages of 70-89 yrs at risk for mobility disability (mean age=77 yrs; 31% male). PP was calculated as systolic blood pressure (BP) - diastolic BP. Results: Patients with a history of heart failure and stroke (n=42) were excluded leaving 382 participants for final analysis. When categorized into tertiles of PP, participants within the highest PP tertile had significantly slower gait speed than those within the lowest PP tertile (p<0.05). Following stepwise multiple regression, PP was significantly and inversely associated with 400-meter gait speed (p<0.05). Other significant predictors of gait speed included: handgrip strength, body weight, age and history of diabetes mellitus (p<0.05). Mean arterial pressure, systolic BP and diastolic BP were not predictors of gait speed. Conclusions: Pulse pressure is associated long-distance gait speed in community-dwelling older adults. Vascular senescence and altered ventricular-vascular coupling may be associated with the deterioration of mobility and physical function in older adults.
MeSH term(s)	Accidental Falls/prevention & control ; Aged ; Aged, 80 and over ; Blood Pressure/physiology ; Exercise ; Female ; Gait/physiology ; Heart Rate ; Humans ; Life Style ; Male ; ROC Curve ; Regression Analysis ; Walking
Language	English
Publishing date	2012-11-21
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0049544
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: A.P.C. viruses and respiratory disease in Northern England.

ZAIMAN, E / BALDUCCI, D / TYRRELL, D A

Lancet (London, England)

2003 Volume 269, Issue 6890, Page(s) 595–596

MeSH term(s)	England ; Humans ; Respiration Disorders ; Respiratory System ; Respiratory Tract Diseases ; Virus Diseases ; Viruses
Language	English
Publishing date	2003-03-17
Publishing country	England
Document type	Journal Article
ZDB-ID	3306-6
ISSN	1474-547X ; 0140-6736 ; 0023-7507
ISSN (online)	1474-547X
ISSN	0140-6736 ; 0023-7507
DOI	10.1016/s0140-6736(55)92590-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ua VI Zs.5: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 94: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Relation of Pulse Pressure to Long-Distance Gait Speed in Community-Dwelling Older Adults: Findings from the LIFE-P Study

Heffernan, Kevin S / Blair, Steven N / Church, Timothy S / Fielding, Roger A / Haskell, William L / Hsu, Fang-Chi / Kritchevsky, Stephen B / Manini, Todd M / Newman, Anne B / Nicklas, Barbara J / Scuteri, Angelo / Sutton-Tyrrell, Kim

PloS one. , v. 7, no. 11

2012

Abstract: ... in the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) study. Brachial blood pressure and 400 ... than those within the lowest PP tertile (p<0.05). Following stepwise multiple regression, PP was significantly and inversely ... associated with 400-meter gait speed (p<0.05). Other significant predictors of gait speed included: handgrip ...

Title variant	Aging, Pulse Pressure and Gait Speed
Abstract	Reduced gait speed is associated with falls, late-life disability, hospitalization/institutionalization and cardiovascular morbidity and mortality. Aging is also accompanied by a widening of pulse pressure (PP) that contributes to ventricular-vascular uncoupling. The purpose of this study was to test the hypothesis that PP is associated with long-distance gait speed in community-dwelling older adults in the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) study. Brachial blood pressure and 400-meter gait speed (average speed maintained over a 400-meter walk at “usual” pace) were assessed in 424 older adults between the ages of 70–89 yrs at risk for mobility disability (mean age = 77 yrs; 31% male). PP was calculated as systolic blood pressure (BP) – diastolic BP. Patients with a history of heart failure and stroke (n = 42) were excluded leaving 382 participants for final analysis. When categorized into tertiles of PP, participants within the highest PP tertile had significantly slower gait speed than those within the lowest PP tertile (p<0.05). Following stepwise multiple regression, PP was significantly and inversely associated with 400-meter gait speed (p<0.05). Other significant predictors of gait speed included: handgrip strength, body weight, age and history of diabetes mellitus (p<0.05). Mean arterial pressure, systolic BP and diastolic BP were not predictors of gait speed. Pulse pressure is associated long-distance gait speed in community-dwelling older adults. Vascular senescence and altered ventricular-vascular coupling may be associated with the deterioration of mobility and physical function in older adults.
Keywords	body weight ; diabetes mellitus ; elderly ; gait ; heart failure ; lifestyle ; males ; morbidity ; mortality ; patients ; risk ; stroke ; systolic blood pressure
Language	English
Dates of publication	2012-1121
Publishing place	Public Library of Science
Document type	Article
ISSN	1932-6203
DOI	10.1371/journal.pone.0049544
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: P.014 VASCULAR MARKERS OF PREMATURE ATHEROSCLEROSIS IN PAEDIATRIC SYSTEMIC LUPUS ERYTHEMATOSUS AND DISEASE, THERAPY, METABOLIC AND INFLAMMATORY CORRELATES

T. Bradley* / L. Nukumizu / C. Boros / C. Slorach / P. Tyrrell / M. Cheung / B. McCrindle / E. Silverman

Artery Research, Vol 1, Iss

2007 Volume 1

Keywords	Specialties of internal medicine ; RC581-951 ; Diseases of the circulatory (Cardiovascular) system ; RC666-701
Language	English
Publishing date	2007-06-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Comparative in vitro activities of retapamulin (SB-275833) against 141 clinical isolates of Propionibacterium spp., including 117 P. acnes isolates.

Goldstein, Ellie J C / Citron, Diane M / Merriam, C Vreni / Warren, Yumi A / Tyrrell, Kerin L / Fernandez, Helen T

Antimicrobial agents and chemotherapy

2005 Volume 50, Issue 1, Page(s) 379–381

Abstract: Using the NCCLS agar dilution method, we studied the in vitro activity of retapamulin (SB-275833) against 141 clinical isolates of Propionibacterium species, including seven multiresistant strains, and found retapamulin to be the most active agent among ... ...

Abstract	Using the NCCLS agar dilution method, we studied the in vitro activity of retapamulin (SB-275833) against 141 clinical isolates of Propionibacterium species, including seven multiresistant strains, and found retapamulin to be the most active agent among those tested with MICs of < or = 1 microg/ml against all isolates.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Bridged Bicyclo Compounds, Heterocyclic/pharmacology ; Diterpenes/pharmacology ; Gram-Positive Bacterial Infections/microbiology ; Humans ; Microbial Sensitivity Tests ; Polycyclic Compounds ; Propionibacterium/drug effects ; Propionibacterium/isolation & purification ; Propionibacterium acnes/drug effects ; Propionibacterium acnes/isolation & purification ; Pleuromutilins
Chemical Substances	Anti-Bacterial Agents ; Bridged Bicyclo Compounds, Heterocyclic ; Diterpenes ; Polycyclic Compounds ; retapamulin (4MG6O8991R)
Language	English
Publishing date	2005-12-23
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	217602-6
ISSN	1098-6596 ; 0066-4804
ISSN (online)	1098-6596
ISSN	0066-4804
DOI	10.1128/AAC.50.1.379-381.2006
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 809: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Einzelsignatur: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Analysis of NIH K99/R00 awards and the career progression of awardees.

Woitowich, Nicole C / Hengel, Sarah R / Solis, Christopher / Vilgalys, Tauras P / Babdor, Joel / Tyrrell, Daniel J

eLife

2024 Volume 12

Abstract: Many postdoctoral fellows and scholars who hope to secure tenure-track faculty positions in the United States apply to the National Institutes of Health (NIH) for a Pathway to Independence Award. This award has two phases (K99 and R00) and provides ... ...

Abstract	Many postdoctoral fellows and scholars who hope to secure tenure-track faculty positions in the United States apply to the National Institutes of Health (NIH) for a Pathway to Independence Award. This award has two phases (K99 and R00) and provides funding for up to 5 years. Using NIH data for the period 2006-2022, we report that ~230 K99 awards were made every year, representing up to ~$250 million annual investment. About 40% of K99 awardees were women and ~89% of K99 awardees went on to receive an R00 award annually. Institutions with the most NIH funding produced the most recipients of K99 awards and recruited the most recipients of R00 awards. The time between a researcher starting an R00 award and receiving a major NIH award (such as an R01) ranged between 4.6 and 7.4 years, and was significantly longer for women, for those who remained at their home institution, and for those hired by an institution that was not one of the 25 institutions with the most NIH funding. Shockingly, there has yet to be a K99 awardee at a historically Black college or university. We go on to show how K99 awardees flow to faculty positions, and to identify various factors that influence the future success of individual researchers and, therefore, also influence the composition of biomedical faculty at universities in the United States.
MeSH term(s)	Humans ; Female ; United States ; Male ; Biomedical Research ; National Institutes of Health (U.S.) ; Awards and Prizes ; Health Personnel ; Research Personnel
Language	English
Publishing date	2024-01-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.88984
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Measuring brain docosahexaenoic acid turnover as a marker of metabolic consumption.

Klievik, Brinley J / Tyrrell, Aidan D / Chen, Chuck T / Bazinet, Richard P

Pharmacology & therapeutics

2023 Volume 248, Page(s) 108437

Abstract: Docosahexaenoic acid (DHA, 22:6n-3) accretion in brain phospholipids is critical for maintaining the structural fluidity that permits proper assembly of protein complexes for signaling. Furthermore, membrane DHA can be released by phospholipase ... ...

Abstract	Docosahexaenoic acid (DHA, 22:6n-3) accretion in brain phospholipids is critical for maintaining the structural fluidity that permits proper assembly of protein complexes for signaling. Furthermore, membrane DHA can be released by phospholipase A
MeSH term(s)	Mice ; Animals ; Docosahexaenoic Acids/chemistry ; Docosahexaenoic Acids/metabolism ; Brain/metabolism ; Inflammation/metabolism ; Signal Transduction ; Oxidative Stress
Chemical Substances	Docosahexaenoic Acids (25167-62-8)
Language	English
Publishing date	2023-05-17
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	194735-7
ISSN	1879-016X ; 0163-7258
ISSN (online)	1879-016X
ISSN	0163-7258
DOI	10.1016/j.pharmthera.2023.108437
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1183: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Living in uncertainty while a spouse is undergoing a cognitive assessment: Voices of women care partners.

Hedman, Ragnhild / Hillerås, Pernilla / Tyrrell, Marie

Dementia (London, England)

2022 Volume 21, Issue 8, Page(s) 2631–2646

Abstract: Introduction: Women often support partners with cognitive symptoms during the assessment process and when they are receiving a cognitive diagnosis. Living with a partner with cognitive symptoms can be stressful; however, there is limited insights into ... ...

Abstract	Introduction: Women often support partners with cognitive symptoms during the assessment process and when they are receiving a cognitive diagnosis. Living with a partner with cognitive symptoms can be stressful; however, there is limited insights into the specific experiences of older women during the assessment process. Previous research indicates that there are gender differences in the experiences of spousal caregiving; however, further research is needed in regard to the experiences of men and women as care partners. Therefore, the aim of the present study was to describe women's experiences of living with a partner undergoing a cognitive assessment. Methods: Semi-structured interviews were conducted with seven women when their male partners commenced a cognitive assessment and after the assessment had been completed. The interviews were analysed with abductive content analysis. Findings: Uncertainty permeated the women's experiences. Antecedents, attributes and strategies to manage the uncertainty were described. Conclusion: The participants expressed informational and existential uncertainty when their partner underwent a cognitive assessment. A lack of knowledge regarding the assessment process and cognitive diagnoses, especially mild cognitive impairment, was identified. Further, there was a need to process existential uncertainty evoked by the situation.
MeSH term(s)	Male ; Female ; Humans ; Aged ; Spouses/psychology ; Caregivers/psychology ; Uncertainty ; Dementia ; Cognition
Language	English
Publishing date	2022-09-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2084045-7
ISSN	1741-2684 ; 1471-3012
ISSN (online)	1741-2684
ISSN	1471-3012
DOI	10.1177/14713012221128448
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito