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  1. Article ; Online: Toward a better risk stratification for late antibody-mediated rejection in ABO incompatible kidney recipients.

    Grimbert, Philippe

    Transplant international : official journal of the European Society for Organ Transplantation

    2017  Volume 30, Issue 9, Page(s) 863–864

    MeSH term(s) ABO Blood-Group System ; Antibodies ; Blood Group Incompatibility ; Graft Rejection ; Graft Survival ; Humans ; Kidney Transplantation
    Chemical Substances ABO Blood-Group System ; Antibodies
    Language English
    Publishing date 2017
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.1111/tri.12976
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  2. Article ; Online: Anti-CD38 therapy for PLA2R-positive membranous nephropathy resistant to conventional immunosuppression.

    Stehlé, Thomas / Grimbert, Philippe / Remy, Philippe / Moktefi, Anissa / Audard, Vincent / El Karoui, Khalil

    Kidney international

    2022  Volume 101, Issue 2, Page(s) 416–418

    MeSH term(s) Glomerulonephritis, Membranous/drug therapy ; Humans ; Immunosuppression Therapy ; Receptors, Phospholipase A2
    Chemical Substances Receptors, Phospholipase A2
    Language English
    Publishing date 2022-01-22
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2021.11.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Évaluation de la présence d’une infirmière en pratique avancée dans la prise en charge des transplantés rénaux.

    Boncourt, Cécile / Londero, Tiphanie / Grimbert, Philippe / Matignon, Marie

    Nephrologie & therapeutique

    2021  Volume 17, Issue 6, Page(s) 451–457

    Abstract: The establishment of a new profession requires anticipating its added value and defining its field of intervention. This article explores the needs of a model of care in kidney transplantation through the study of epidemiological data and an exploratory ... ...

    Title translation Evaluation of the presence of an advanced practice nurse in the care of kidney transplant patients.
    Abstract The establishment of a new profession requires anticipating its added value and defining its field of intervention. This article explores the needs of a model of care in kidney transplantation through the study of epidemiological data and an exploratory survey within a university hospital center in Île-de-France. The results define the limits of current care and assert the place of the advanced practice nurse in the renal transplantation sector. Her role is established with the patient and his entourage, the transplant center and the professionals of the city.
    MeSH term(s) Advanced Practice Nursing ; Female ; France ; Hospitals, University ; Humans ; Kidney Transplantation
    Language French
    Publishing date 2021-06-09
    Publishing country France
    Document type Journal Article
    ZDB-ID 2229575-6
    ISSN 1872-9177 ; 1769-7255
    ISSN (online) 1872-9177
    ISSN 1769-7255
    DOI 10.1016/j.nephro.2021.03.005
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  4. Article ; Online: Belatacept inhibit human B cell germinal center development in immunodeficient mice.

    Samson, Chloé / Thiolat, Allan / Moktefi, Anissa / Cohen, José L / Pilon, Caroline / Grimbert, Philippe

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 13816

    Abstract: The humoral response mediated by alloantibodies directed against donor HLA molecules (DSAs) is one of the main causes of graft loss in kidney transplantation. Understanding the pathophysiology leading to humoral kidney rejection as the development of ... ...

    Abstract The humoral response mediated by alloantibodies directed against donor HLA molecules (DSAs) is one of the main causes of graft loss in kidney transplantation. Understanding the pathophysiology leading to humoral kidney rejection as the development of therapeutic tools is therefore a main objective in the field of solid organ transplantation and necessitate adapted experimental models. Among the immunosuppressive agents used in renal transplantation, belatacept, a fusion protein targeting T costimulatory molecules has shown its ability to prevent more efficiently the secretion of DSA by different mechanisms including a direct action on plasma cells but also on B lymphocytes and follicular helper T lymphocytes (Tfh) cooperation. This cellular cooperation occurs within germinal centers (GC), the seat of B lymphocytes differentiation. Here, we aimed to develop a dedicated mouse model in which human GC would be functional to study the effect of belatacept on GC formation and the ability of B lymphocytes to secrete immunoglobulin. We next demonstrate that belatacept inhibits the formation of these GCs, by inhibiting the frequency of Tfh and B lymphocytes. This alters the B maturation and therefore the generation of plasma cells and consequently, immunoglobulin secretion.
    MeSH term(s) Humans ; Animals ; Mice ; Abatacept/pharmacology ; Germinal Center ; B-Lymphocytes ; Immunosuppressive Agents/pharmacology ; Plasma Cells
    Chemical Substances Abatacept (7D0YB67S97) ; Immunosuppressive Agents
    Language English
    Publishing date 2023-08-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-40700-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: HLA Desensitization in Solid Organ Transplantation: Anti-CD38 to Across the Immunological Barriers.

    Joher, Nizar / Matignon, Marie / Grimbert, Philippe

    Frontiers in immunology

    2021  Volume 12, Page(s) 688301

    Abstract: The presence of anti-human leucocyte antigen (HLA) antibodies in the potential solid organ transplant recipient's blood is one of the main barriers to access to a transplantation. The HLA sensitization is associated with longer waitlist time, antibody ... ...

    Abstract The presence of anti-human leucocyte antigen (HLA) antibodies in the potential solid organ transplant recipient's blood is one of the main barriers to access to a transplantation. The HLA sensitization is associated with longer waitlist time, antibody mediated rejection and transplant lost leading to increased recipient's morbidity and mortality. However, solid organ transplantation across the HLA immunological barriers have been reported in recipients who were highly sensitized to HLA using desensitization protocols. These desensitization regimens are focused on the reduction of circulating HLA antibodies. Despite those strategies improve rates of transplantation, it remains several limitations including persistent high rejection rate and worse long-term outcomes when compare with non-sensitized recipient population. Currently, interest is growing in the development of new desensitization approaches which, beyond targeting antibodies, would be based on the modulation of alloimmune pathways. Plasma cells appears as an interesting target given their critical role in antibody production. In the last decade, CD38-targeting immunotherapies, such as daratumumab, have been recognized as a key component in the treatment of myeloma by inducing an important plasma cell depletion. This review focuses on an emerging concept based on targeting CD38 to desensitize in the field of transplantation.
    MeSH term(s) ADP-ribosyl Cyclase 1/antagonists & inhibitors ; ADP-ribosyl Cyclase 1/immunology ; ADP-ribosyl Cyclase 1/metabolism ; Animals ; Antibodies, Monoclonal/therapeutic use ; Desensitization, Immunologic ; Graft Rejection/immunology ; Graft Rejection/metabolism ; Graft Rejection/prevention & control ; Graft Survival/drug effects ; HLA Antigens/immunology ; Histocompatibility ; Humans ; Isoantibodies/blood ; Membrane Glycoproteins/antagonists & inhibitors ; Membrane Glycoproteins/immunology ; Membrane Glycoproteins/metabolism ; Molecular Targeted Therapy ; Organ Transplantation/adverse effects ; Plasma Cells/drug effects ; Plasma Cells/immunology ; Plasma Cells/metabolism ; Risk Factors ; Treatment Outcome
    Chemical Substances Antibodies, Monoclonal ; HLA Antigens ; Isoantibodies ; Membrane Glycoproteins ; daratumumab (4Z63YK6E0E) ; CD38 protein, human (EC 3.2.2.5) ; ADP-ribosyl Cyclase 1 (EC 3.2.2.6)
    Language English
    Publishing date 2021-05-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.688301
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  6. Article ; Online: Long-term after donation, who are the living kidney donors?*.

    Grimbert, Philippe

    Transplant international : official journal of the European Society for Organ Transplantation

    2012  Volume 25, Issue 4, Page(s) 383–384

    MeSH term(s) Female ; Humans ; Kidney Transplantation ; Living Donors ; Male
    Language English
    Publishing date 2012-04
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.1111/j.1432-2277.2012.01459.x
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  7. Book: Nom de Dieu!

    Grimbert, Philippe

    roman

    2014  

    Author's details Philippe Grimbert
    Language French
    Size 193 S, 21 cm
    Publisher Grasset
    Publishing place Paris
    Document type Book
    ISBN 2246853672 ; 9782246853671
    Database Former special subject collection: coastal and deep sea fishing

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  8. Article ; Online: Optical coherence tomography angiography analysis of changes in the retina and the choroid after hemodialysis for end stage kidney disease.

    Zegrari, Samira / Mouallem, Alexandra / Audard, Vincent / Jouan, Narindra / Grimbert, Philippe / Jung, Camille / Sakhi, Hichem / Souied, Eric H / Miere, Alexandra

    International ophthalmology

    2023  Volume 43, Issue 12, Page(s) 4473–4479

    Abstract: Purpose: To study effects of hemodialysis (HD) on retinal and choroidal vasculature in patients with end-stage kidney disease (ESKD) using optical coherence tomography angiography (OCTA).: Methods: In this prospective study, we investigated eyes of ... ...

    Abstract Purpose: To study effects of hemodialysis (HD) on retinal and choroidal vasculature in patients with end-stage kidney disease (ESKD) using optical coherence tomography angiography (OCTA).
    Methods: In this prospective study, we investigated eyes of patients undergoing hemodialysis for ESKD from Mondor University Hospital. Only one eye/patient was considered. Subfoveal choroidal thickness (SCT) was measured on enhanced-depth imaging optical coherence tomography (EDI-OCT) before and after the hemodialysis session. OCTA was used to extract retinal vascular density (superficial and deep capillary plexus, SCP, DCP) and choriocapillaris non-perfusion. Clinical, demographic and biological parameters (Blood B-Nitric Peptid rate prior to HD session) were reviewed.
    Results: Twenty patients (mean age 53.2 ± 13.6 years, 10 males and 10 females) were included in this prospective study. SCT significantly decreased after the HD session (234.3 ± 56.14 µm before HD to 211.9 ± 60.79 µm after hemodialysis (Wilcoxon signed-rank test, p = 0.003)). Non-perfusion in the choriocapillaris significantly increased after HD (41.65 ± 3.58 before HD, 42.95 ± 3.19 after HD, p = 0.036) while no significant modification of the vascular density was observed in the retinal vasculature (SCP, DCP) around the macular zone or the optic nerve. An increased plasma B-Nitric Peptide (BNP) level prior to the onset of the HD session was significantly correlated with the decrease of the SCT (r = 0.45, p = 0.043).
    Conclusion: Hemodialysis in patients with ESKD is associated with a significant decrease in SCT and an increase in non-perfusion in the choriocapillaris on OCTA. A High BNP level prior to the onset of the hemodialysis appears to be correlated with the decrease in SCT.
    MeSH term(s) Male ; Female ; Humans ; Adult ; Middle Aged ; Aged ; Fluorescein Angiography/methods ; Tomography, Optical Coherence/methods ; Prospective Studies ; Retina ; Retinal Vessels/diagnostic imaging ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/therapy ; Renal Dialysis/adverse effects ; Choroid/blood supply
    Language English
    Publishing date 2023-08-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 800087-6
    ISSN 1573-2630 ; 0165-5701
    ISSN (online) 1573-2630
    ISSN 0165-5701
    DOI 10.1007/s10792-023-02847-3
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    Zs.A 1479: Show issues Location:
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  9. Article ; Online: The authors reply.

    Joher, Nizar / Moktefi, Anissa / Grimbert, Philippe / Pagot, Eléonore / Jouan, Narindra / El Karoui, Khalil / Champy, Cécile Maud / Matignon, Marie / Stehlé, Thomas

    Kidney international

    2022  Volume 102, Issue 2, Page(s) 446–447

    Language English
    Publishing date 2022-07-20
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2022.04.044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 797: Show issues Location:
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  10. Article ; Online: mTOR inhibitors and risk of chronic antibody-mediated rejection after kidney transplantation: where are we now?

    Grimbert, Philippe / Thaunat, Olivier

    Transplant international : official journal of the European Society for Organ Transplantation

    2017  Volume 30, Issue 7, Page(s) 647–657

    Abstract: Antibody-mediated rejection (AMR) usually starts with generation of donor-specific anti-HLA antibodies (DSAs), arising from a B-cell response to antigen recognition. In vitro and preclinical data demonstrate that mammalian target of rapamycin (mTOR) ... ...

    Abstract Antibody-mediated rejection (AMR) usually starts with generation of donor-specific anti-HLA antibodies (DSAs), arising from a B-cell response to antigen recognition. In vitro and preclinical data demonstrate that mammalian target of rapamycin (mTOR) inhibition attenuates the mTOR-mediated intracellular signaling pathway involved in AMR-related kidney damage. The limited available data from immunological studies in kidney transplant patients, however, have not shown such effects in vivo. In terms of clinical immunosuppression, the overriding influence on rates of de novo DSA (dnDSA) or AMR-regardless of the type of regimen-is patient adherence. To date, limited data from patients given mTOR inhibitor therapy with adequate concurrent immunosuppression, such as reduced-exposure calcineurin inhibitor (CNI) therapy, have not shown an adverse effect on the risk of dnDSA or AMR. Early switch to an mTOR inhibitor (<6-12 months post-transplant) in a CNI-free regimen, in contrast, can increase the risk of dnDSA, especially if adjunctive therapy is inadequate. Late conversion to CNI-free therapy with mTOR inhibition does not appear to affect the risk of dnDSA. More data, from prospective studies, are required to fully understand that association between use of mTOR inhibitors with different types of concomitant therapy and risk of dnDSA and AMR.
    Language English
    Publishing date 2017-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.1111/tri.12975
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