Result 1 - 10 of total 11
A review"
2020
| Keywords | covid19 |
|---|---|
| Publisher | Wiley |
| Publishing country | us |
| Document type | Book ; Online |
| DOI | 10.1002/btpr.3078/v2/response1 |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
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2020 Volume 37, Issue 1, Page(s) e3078
Abstract: Recently, a corona virus disease (COVID-19) caused by a novel corona virus (sevier acute respiratory syndrome corona virus 2; SARS-CoV-2), rapidly spread throughout the world. It has been resulted an unprecedented public health crisis and has become a ... ...
| Abstract | Recently, a corona virus disease (COVID-19) caused by a novel corona virus (sevier acute respiratory syndrome corona virus 2; SARS-CoV-2), rapidly spread throughout the world. It has been resulted an unprecedented public health crisis and has become a global threat. WHO declared it as a pandemic due to rapid transmission and severity of the disease. According to WHO, as of 22nd of August 2020, the disease spread over 213 countries of the world having 22,812,491 confirmed cases and 795,132 deaths recorded worldwide. In the absence of suitable antiviral drugs and vaccines, the current pandemic has created an urgent need for accurate diagnostic tools that would be helpful for early detection of the patients. Many tests including classical and high-throughput techniques have developed and obtained U.S. Food and drug administration (FDA) approval. However, efforts are being made to develop new diagnostic tools for detection of the disease. Several molecular diagnostic tests such as real-time-polymerase chain reaction, real-time isothermal loop-mediated amplification (RT-LAMP), full genome analysis by next-generation sequencing, clustered regularly interspaced short palindromic repeats technique and microarray-based assays along with other techniques such as computed tomography scan, biomarkers, biosensor, nanotechnology, serological test, enzyme-linked immunosorbent assay (ELISA), isolation of viral strain in cell culture are currently available for diagnosis of COVID-19 infection. This review provides a brief overview of promising high-throughput techniques currently used for detection of SARS-CoV-2, along with their scope and limitations that may be used for effective control of the disease. |
|---|---|
| MeSH term(s) | COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/virology ; COVID-19 Testing/methods ; Enzyme-Linked Immunosorbent Assay/methods ; Humans ; Molecular Diagnostic Techniques/methods ; Pandemics ; SARS-CoV-2/isolation & purification ; Sensitivity and Specificity |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-09-21 |
| Publishing country | United States |
| Document type | Journal Article ; Review |
| ZDB-ID | 165657-0 |
| ISSN | 1520-6033 ; 8756-7938 |
| ISSN (online) | 1520-6033 |
| ISSN | 8756-7938 |
| DOI | 10.1002/btpr.3078 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 4253: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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Biotechnol Prog
Abstract: Recently, a corona virus disease (COVID-19) caused by a novel corona virus (sevier acute respiratory syndrome corona virus 2; SARS-CoV-2), rapidly spread throughout the world. It has been resulted an unprecedented public health crisis and has become a ... ...
| Abstract | Recently, a corona virus disease (COVID-19) caused by a novel corona virus (sevier acute respiratory syndrome corona virus 2; SARS-CoV-2), rapidly spread throughout the world. It has been resulted an unprecedented public health crisis and has become a global threat. WHO declared it as a pandemic due to rapid transmission and severity of the disease. According to WHO, as of 22nd of August 2020, the disease spread over 213 countries of the world having 22,812,491 confirmed cases and 795,132 deaths recorded worldwide. In the absence of suitable antiviral drugs and vaccines, the current pandemic has created an urgent need for accurate diagnostic tools that would be helpful for early detection of the patients. Many tests including classical and high-throughput techniques have developed and obtained U.S. Food and drug administration (FDA) approval. However, efforts are being made to develop new diagnostic tools for detection of the disease. Several molecular diagnostic tests such as real-time-polymerase chain reaction, real-time isothermal loop-mediated amplification (RT-LAMP), full genome analysis by next-generation sequencing, clustered regularly interspaced short palindromic repeats technique and microarray-based assays along with other techniques such as computed tomography scan, biomarkers, biosensor, nanotechnology, serological test, enzyme-linked immunosorbent assay (ELISA), isolation of viral strain in cell culture are currently available for diagnosis of COVID-19 infection. This review provides a brief overview of promising high-throughput techniques currently used for detection of SARS-CoV-2, along with their scope and limitations that may be used for effective control of the disease. |
|---|---|
| Keywords | covid19 |
| Publisher | WHO |
| Document type | Article |
| Note | WHO #Covidence: #754886 |
| Database | COVID19 |
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2018 Volume 22, Issue 2, Page(s) 145.e1–145.e6
Abstract: Purpose: To estimate the prevalence and causes of visual impairment and other ocular comorbidities among tribal children in an urban school population in eastern India.: Method: In this cross-sectional study, vision screening tests were administered ... ...
| Abstract | Purpose: To estimate the prevalence and causes of visual impairment and other ocular comorbidities among tribal children in an urban school population in eastern India. Method: In this cross-sectional study, vision screening tests were administered to tribal school children. Demographic data, including name, age, sex, home district, height, and weight of each child, and examination data, including unaided and pinhole visual acuity, external eye examination with a flashlight, slit-lamp examination, intraocular pressure (IOP) measurement, and undilated fundus photography, were collected. Children with visual acuity of less than 20/20, abnormal anterior or posterior segment findings, and IOP of >21 mm Hg were referred for further evaluation. Results: Of 10,038 children (5,840 males [58.2%]) screened, 335 (median age, 9 years; range, 6-17 years) were referred. Refractive error was the most common cause of visual impairment (59.52%; 95% CI, 51.97-66.65) followed by amblyopia (17.2%; 95% CI, 12.3-23.6) and posterior segment anomaly (14.88%; 95% CI, 10.2-21.0). The prevalence of best-corrected visual acuity of 20/40 was 0.13%. The prevalence of blindness was 0.03%. Conclusions: Visual impairment among tribal children in this residential school is an uncommon but important disability. |
|---|---|
| MeSH term(s) | Adolescent ; Amblyopia/diagnosis ; Amblyopia/epidemiology ; Child ; Cross-Sectional Studies ; Ethnic Groups/statistics & numerical data ; Female ; Humans ; India/epidemiology ; Intraocular Pressure/physiology ; Male ; Prevalence ; Refractive Errors/diagnosis ; Refractive Errors/epidemiology ; Slit Lamp Microscopy ; Urban Population/statistics & numerical data ; Vision Screening ; Vision, Low/epidemiology ; Visual Acuity/physiology ; Visually Impaired Persons/statistics & numerical data |
| Language | English |
| Publishing date | 2018-03-16 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 1412476-2 |
| ISSN | 1528-3933 ; 1091-8531 |
| ISSN (online) | 1528-3933 |
| ISSN | 1091-8531 |
| DOI | 10.1016/j.jaapos.2017.10.020 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 5188: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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Surgical neurology international
2016 Volume 7, Issue Suppl 28, Page(s) S767–S774
Abstract: Background: Subacute subdural hematoma (SASDH) is an entity which is yet to capture the popular imagination among the neurosurgeons. Its management is often equated clinically to that of the chronic subdural hematoma (CSDH). However, their neurological ... ...
| Abstract | Background: Subacute subdural hematoma (SASDH) is an entity which is yet to capture the popular imagination among the neurosurgeons. Its management is often equated clinically to that of the chronic subdural hematoma (CSDH). However, their neurological deterioration is usually rapid, which seems to align them with acute subdural hematoma (ASDH). We proceed for their epidemiological evaluation. The advantages of a novel "double barrel technique (DbT)" over the conventional burrhole drainage are also presented. Methods: This retrospective study was conducted on all the patients having clinical and radiological evidence of SASDH, admitted to a tertiary care referral institute, during the period August 2013 to December 2015. Postoperatively, patients were followed-up for 3-24 months. Results: 46.87% of the patients belonged to the 35-54 year age group with a male predominance (3.6:1); 68.7% had a history of alcohol abuse, whereas aspirin users were 25%. 87.5% cases were unilateral, 18.75% were hemispheric, and 46.87% were present on the left side. Altered consciousness (100%) followed by headache (37.5%) were the most common presenting clinical features. Conclusion: SASDH is an uncommon neurosurgical entity (0.89% of traumatic brain injury cases in our study) and mimics both CSDH as well as ASDH. The true incidence of SASDH may have been underestimated due to its clinical imitation with CSDH. This study in a South Asian nation also provides the epidemiological data of this rare neurosurgical entity. Outcome of surgery is good; our retrospective study confirms that "DbT" is an adequate and safe treatment. However, a better designed, randomized control trial will be needed to reinforce our findings. |
|---|---|
| Language | English |
| Publishing date | 2016-11-09 |
| Publishing country | United States |
| Document type | Journal Article |
| ISSN | 2229-5097 |
| ISSN | 2229-5097 |
| DOI | 10.4103/2152-7806.193730 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2014 Volume 10, Issue 5, Page(s) 1104–1116
Abstract: Scrutinizing various nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) genes in higher eukaryotes is very important for understanding the intriguing mechanism of the host defense against pathogens. The nucleotide-binding domain (NACHT), ...
| Abstract | Scrutinizing various nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) genes in higher eukaryotes is very important for understanding the intriguing mechanism of the host defense against pathogens. The nucleotide-binding domain (NACHT), leucine-rich repeat (LRR), and pyrin domains (PYD)-containing protein 3 (Nalp3), is an intracellular innate immune receptor and is associated with several immune system related disorders. Despite Nalp3's protective role during a pathogenic invasion, the molecular features and structural organization of this crucial protein is poorly understood. Using comparative modeling and molecular dynamics simulations, we have studied the structural architecture of Nalp3 domains, and characterized the dynamic and energetic parameters of adenosine triphosphate (ATP) binding in NACHT, and pathogen-derived ligands muramyl dipeptide (MDP) and imidazoquinoline with LRR domains. The results suggested that walker A, B and extended walker B motifs were the key ATP binding regions in NACHT that mediate self-oligomerization. The analysis of the binding sites of MDP and imidazoquinoline revealed LRR 7-9 to be the most energetically favored site for imidazoquinoline interaction. However, the binding free energy calculations using the Molecular Mechanics/Poisson-Boltzmann Surface Area (MM/PBSA) method indicated that MDP is incompatible for activating the Nalp3 molecule in its monomeric form, and suggest its complex interaction with NOD2 or other NLRs accounts for MDP recognition. The high binding affinity of ATP with NACHT was correlated to the experimental data for human NLRs. Our binding site prediction for imidazoquinoline in LRR warrants further investigation via in vivo models. This is the first study that provides ligand recognition in mouse Nalp3 and its spatial structural arrangements. |
|---|---|
| MeSH term(s) | Amino Acid Sequence ; Animals ; Binding Sites ; Carrier Proteins/chemistry ; Humans ; Ligands ; Mice ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Molecular Sequence Data ; Mutagenesis, Site-Directed ; NLR Family, Pyrin Domain-Containing 3 Protein ; Principal Component Analysis ; Protein Structure, Tertiary ; Reproducibility of Results ; Sequence Alignment ; Sequence Analysis, DNA ; Thermodynamics |
| Chemical Substances | Carrier Proteins ; Ligands ; NLR Family, Pyrin Domain-Containing 3 Protein ; Nlrp3 protein, mouse |
| Language | English |
| Publishing date | 2014-05 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 2188635-0 |
| ISSN | 1742-2051 ; 1742-206X |
| ISSN (online) | 1742-2051 |
| ISSN | 1742-206X |
| DOI | 10.1039/c3mb70600a |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Surgical Neurology International, Vol 7, Iss 29, Pp 767-
A novel technique
2016 Volume 774
Abstract: Background: Subacute subdural hematoma (SASDH) is an entity which is yet to capture the popular imagination among the neurosurgeons. Its management is often equated clinically to that of the chronic subdural hematoma (CSDH). However, their neurological ... ...
| Abstract | Background: Subacute subdural hematoma (SASDH) is an entity which is yet to capture the popular imagination among the neurosurgeons. Its management is often equated clinically to that of the chronic subdural hematoma (CSDH). However, their neurological deterioration is usually rapid, which seems to align them with acute subdural hematoma (ASDH). We proceed for their epidemiological evaluation. The advantages of a novel "double barrel technique (DbT)" over the conventional burrhole drainage are also presented. Methods: This retrospective study was conducted on all the patients having clinical and radiological evidence of SASDH, admitted to a tertiary care referral institute, during the period August 2013 to December 2015. Postoperatively, patients were followed-up for 3-24 months. Results: 46.87% of the patients belonged to the 35-54 year age group with a male predominance (3.6:1); 68.7% had a history of alcohol abuse, whereas aspirin users were 25%. 87.5% cases were unilateral, 18.75% were hemispheric, and 46.87% were present on the left side. Altered consciousness (100%) followed by headache (37.5%) were the most common presenting clinical features. Conclusion: SASDH is an uncommon neurosurgical entity (0.89% of traumatic brain injury cases in our study) and mimics both CSDH as well as ASDH. The true incidence of SASDH may have been underestimated due to its clinical imitation with CSDH. This study in a South Asian nation also provides the epidemiological data of this rare neurosurgical entity. Outcome of surgery is good; our retrospective study confirms that "DbT" is an adequate and safe treatment. However, a better designed, randomized control trial will be needed to reinforce our findings. |
|---|---|
| Keywords | Alcohol ; double barrel technique ; neomembrane ; subacute subdural hematoma ; trivial trauma ; Medicine ; R ; Surgery ; RD1-811 ; Internal medicine ; RC31-1245 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Neurology. Diseases of the nervous system ; RC346-429 |
| Subject code | 610 ; 616 |
| Language | English |
| Publishing date | 2016-01-01T00:00:00Z |
| Publisher | Medknow Publications |
| Document type | Article ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
Indian Journal of Medical Research
A preliminary analysis
2020 Volume 152, Issue 1, Page(s) 100
| Keywords | General Biochemistry, Genetics and Molecular Biology ; General Medicine ; covid19 |
|---|---|
| Language | English |
| Publisher | Medknow |
| Publishing country | in |
| Document type | Article ; Online |
| ZDB-ID | 390883-5 |
| ISSN | 0019-5340 ; 0971-5916 |
| ISSN | 0019-5340 ; 0971-5916 |
| DOI | 10.4103/ijmr.ijmr_2890_20 |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
| Ua VI Zs.143: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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Indian J Microbiol. 2022 Dec., v. 62, no. 4 p.627-633
2022
Abstract: ... revealed 97% homology with C. violeceum. The bacterial genome composed of 64.87% of G + C content ... spectinomycin. Our findings corroborated the lethal effect of C. violeceum in a new host (elephant ...
| Abstract | This study reports a rare fatal case of Chromobacterium violeceum OUAT_2017 strain infection in an Asiatic elephant calf in India. Necropsy revealed pus-filled nodules in liver, spleen, and lungs. Nutrient broth cultures of nodule content showed sediment of violet pigment whereas smooth, non-diffusible, violet-pigmented, homogeneous colonies appeared on nutrient agar. The organism was found to be non-haemolytic and resistant to 8 of the 24 antibiotics tested in vitro. Partial 16S rRNA gene sequence measuring 1410 bp revealed 97% homology with C. violeceum. The bacterial genome composed of 64.87% of G + C content with total size of 4,681,202 bp. The genome annotation has 42 genes responsible for multidrug antibiotic resistance with the presence of Aminoglycoside-modifying enzymes (AAC (6’)) that targets streptomycin and spectinomycin. Our findings corroborated the lethal effect of C. violeceum in a new host (elephant) that enriched scientific information on epidemiological picture and whole genome sequencing as well. |
|---|---|
| Keywords | Chromobacterium violaceum ; agar ; antibiotic resistance ; calves ; genome ; liver ; necropsy ; nucleotide sequences ; pathogens ; sediments ; spectinomycin ; spleen ; streptomycin ; India |
| Language | English |
| Dates of publication | 2022-12 |
| Size | p. 627-633. |
| Publishing place | Springer India |
| Document type | Article ; Online |
| ZDB-ID | 413422-9 |
| ISSN | 0973-7715 ; 0046-8991 |
| ISSN (online) | 0973-7715 |
| ISSN | 0046-8991 |
| DOI | 10.1007/s12088-022-01047-4 |
| Database | NAL-Catalogue (AGRICOLA) |
| Zs.A 2617: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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Chemosphere. 2021 Nov., v. 282
2021
Abstract: ... the strain (CWB-54) was identified as Exiguobacterium mexicanum. When this bacterium was grown at 35 °C, 100 ...
| Abstract | Hexavalent chromium is a highly toxic element generated due to indiscriminate chromite mining in Sukinda, Odisha. In the present research investigation a relatively higher Cr(VI) resistant (900 mg L⁻¹) bacterium CWB-54 was isolated from the chromite mine water. Based on the biochemical and molecular analysis the strain (CWB-54) was identified as Exiguobacterium mexicanum. When this bacterium was grown at 35 °C, 100 rpm, pH~8.0, and fructose as an electron donor, it could reduce the total hexavalent chromium (100 mg L⁻¹) supplemented in the medium within 33 h of incubation period. Though experiment was carried out to study the effect of Mn, Ni, Cd, Hg and Zn on Cr(VI) reduction by the strain E. mexicanum it has been observed that in the presence of Cd and Hg, Cr(VI) reduction drastically decreased. Characterization of Cr(VI) reduced product by SEM-EDX and TEM analysis revealed intracellular and extracellular Cr(III) deposition in the bacterium, which is assumed to be Cr(OH)3 precipitate in nanometric size. But the extracellular chromate reductase enzyme production is found to be negligible as compared to the intracellular enzyme production. The increased concentration of Cr(VI) above (1000 mg L⁻¹) also showed the genotoxic effect on the DNA. Several reports have been published on Exiguobacterium sp. on different scientific aspect but the current report on the reduction of toxic Cr(VI) by a new species E. mexicanum is a novel one which established the potentiality of this microorganism for a broad area of application. |
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| Keywords | DNA ; Exiguobacterium ; bacteria ; chromates ; chromium ; fructose ; genotoxicity ; intracellular enzymes ; new species ; oxidoreductases ; soil |
| Language | English |
| Dates of publication | 2021-11 |
| Publishing place | Elsevier Ltd |
| Document type | Article |
| Note | NAL-AP-2-clean |
| ZDB-ID | 120089-6 |
| ISSN | 1879-1298 ; 0045-6535 ; 0366-7111 |
| ISSN (online) | 1879-1298 |
| ISSN | 0045-6535 ; 0366-7111 |
| DOI | 10.1016/j.chemosphere.2021.131135 |
| Database | NAL-Catalogue (AGRICOLA) |
| Zs.A 2540: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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