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Article ; Online: MRD at the End of Induction and EFS in T-cell Lymphoblastic Lymphoma: Children's Oncology Group Trial AALL1231.

Hayashi, Robert J / Hermiston, Michelle L / Wood, Brent L / Teachey, David Trent / Devidas, Meenakshi / Chen, Zhiguo / Annett, Robert D / Asselin, Barbara L / August, Keith / Cho, Steve / Dunsmore, Kimberly P / Freedman, Jason Lawrence / Galardy, Paul J / Harker-Murray, Paul / Horton, Terzah M / Jaju, Alok / Lam, Allison / Messinger, Yoav H / Miles, Rodney R /

Okada, Maki / Patel, Samir / Schafer, Eric Stephen / Schechter, Tal / Shimano, Kristin A / Singh, Neelam / Steele, Amii / Sulis, Maria Luisa / Vargas, Sarah / Winter, Stuart S / Wood, Charlotte / Zweider-McKay, Patrick A / Loh, Mignon L / Hunger, Stephen P / Raetz, Elizabeth A / Bollard, Catherine M / Allen, Carl E

Blood

2024

Abstract: Defining prognostic variables in T-lymphoblastic lymphoma (T-LL) remains a challenge. AALL1231 was ... a COG phase 3 clinical trial for newly diagnosed with T Acute Lymphoblastic leukemia or T-LL patients ... minimal residual disease (MRD) at the end of induction (EOI) were collected in T-LL analyzed to assess the correlation ...

Abstract	Defining prognostic variables in T-lymphoblastic lymphoma (T-LL) remains a challenge. AALL1231 was a COG phase 3 clinical trial for newly diagnosed with T Acute Lymphoblastic leukemia or T-LL patients randomizing children and young adults to a modified augmented BFM backbone to receive standard therapy (Arm A) or with addition of bortezomib (Arm B). Optional bone marrow (BM) samples to assess minimal residual disease (MRD) at the end of induction (EOI) were collected in T-LL analyzed to assess the correlation of MRD at the EOI to event-free survival (EFS). Eighty-six (41%) of the 209 T-LL patients accrued to this trial submitted samples for MRD assessment. Patients with MRD <0.1% (n= 75) at EOI had a superior 4-year EFS versus those with MRD >0.1% (n= 11), (89.0±4.4% versus 63.6±17.2%, p= 0.025). Overall survival did not significantly differ between the two groups. Cox regression for EFS using Arm A as a reference demonstrated that MRD EOI ≥0.1% was associated with a greater risk of inferior outcome (Hazard Ratio, HR= 3.73 (1.12-12.40, p= 0.032), which was independent of treatment arm assignment. Consideration to incorporate MRD at EOI into future trials will help establish its value in defining risk groups. CT# NCT02112916.
Language	English
Publishing date	2024-03-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood.2023021184
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Zs.MO 364: Show issues

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Article ; Online: Chitinase-3-like 1 regulates T

Curtiss, Miranda L / Rosenberg, Alexander F / Scharer, Christopher D / Mousseau, Betty / Benavides, Natalia A Ballesteros / Bradley, John E / León, Beatriz / Steele, Chad / Randall, Troy D / Lund, Frances E

Frontiers in immunology

2023 Volume 14, Page(s) 1158493

Abstract: ... To address whether Chi3l1 also contributes to T: Results: As anticipated, we observed impaired T ...

Abstract	Introduction: Data from patient cohorts and mouse models of atopic dermatitis, food allergy and asthma strongly support a role for chitinase-3-like-1 protein (CHI3L1) in allergic disease. Methods: To address whether Chi3l1 also contributes to T Results: As anticipated, we observed impaired T Discussion: These results suggest that
MeSH term(s)	Animals ; Mice ; Chitinases/metabolism ; Helminthiasis ; Helminths ; Immunoglobulin E ; Interleukin-4/metabolism ; T-Lymphocytes, Helper-Inducer
Chemical Substances	Chitinases (EC 3.2.1.14) ; Immunoglobulin E (37341-29-0) ; Interleukin-4 (207137-56-2) ; Chil1 protein, mouse
Language	English
Publishing date	2023-07-27
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1158493
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Article ; Online: Human intestinal myofibroblasts deposited collagen VI enhances adhesiveness for T cells - A novel mechanism for maintenance of intestinal inflammation.

Matrix biology : journal of the International Society for Matrix Biology

2022 Volume 113, Page(s) 1–21

Abstract: ... molecule-coated scaffolds were tested for their adhesiveness for T cells. Matrisome was analysed via ... decellularized colonic ECM from IBD bound more T cells compared to control. Control HIMFs exposed to the pro ... to transforming growth factor-β1 (TGF-β1) decreased ECM adhesiveness to T cells. Matrisome analysis of the HIMF-derived ECM ...

Abstract	Objective: Inflammatory bowel diseases (IBD) cause chronic intestinal damage and extracellular matrix (ECM) remodeling. The ECM may play an active role in inflammation by modulating immune cell functions, including cell adhesion, but this hypothesis has not been tested in IBD. Design: Primary human intestinal myofibroblast (HIMF)-derived ECM from IBD and controls, 3D decellularized colon or ECM molecule-coated scaffolds were tested for their adhesiveness for T cells. Matrisome was analysed via proteomics. Functional integrin blockade was used to investigate the underlying mechanism. Analysis of the pediatric Crohn's disease (CD) RISK inception cohort was used to explore an altered ECM gene expression as a potential predictor for a future complicated disease course. Results: HIMF-derived ECM and 3D decellularized colonic ECM from IBD bound more T cells compared to control. Control HIMFs exposed to the pro-inflammatory cytokines Iinterleukin-1β (IL-1β) and tumor necrosis factor (TNF) increased, and to transforming growth factor-β1 (TGF-β1) decreased ECM adhesiveness to T cells. Matrisome analysis of the HIMF-derived ECM revealed collagen VI as a major culprit for differences in T cell adhesion. Collagen VI knockdown in HIMF reduced adhesion T cell as did the blockage of integrin αvβ1. Elevated gene expression of collagen VI in biopsies of pediatric CD patients was linked to risk for future stricturing disease. Conclusion: HIMF-derived ECM in IBD binds a remarkably enhanced number of T cells, which is dependent on Collagen VI and integrin αvβ1. Collagen VI expression is a risk factor for a future complicated CD course. Blocking immune cells retention may represent a novel approach to treatment in IBD.
MeSH term(s)	Child ; Humans ; Myofibroblasts/metabolism ; Adhesiveness ; T-Lymphocytes/pathology ; Collagen/metabolism ; Inflammatory Bowel Diseases ; Inflammation/metabolism
Chemical Substances	Collagen (9007-34-5)
Language	English
Publishing date	2022-09-13
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1183793-7
ISSN	1569-1802 ; 0945-053X
ISSN (online)	1569-1802
ISSN	0945-053X
DOI	10.1016/j.matbio.2022.09.001
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Article ; Online: Children's Oncology Group Trial AALL1231: A Phase III Clinical Trial Testing Bortezomib in Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia and Lymphoma.

Teachey, David T / Devidas, Meenakshi / Wood, Brent L / Chen, Zhiguo / Hayashi, Robert J / Hermiston, Michelle L / Annett, Robert D / Archer, J Hunter / Asselin, Barbara L / August, Keith J / Cho, Steve Y / Dunsmore, Kimberly P / Fisher, Brian T / Freedman, Jason L / Galardy, Paul J / Harker-Murray, Paul / Horton, Terzah M / Jaju, Alok I / Lam, Allison /

Messinger, Yoav H / Miles, Rodney R / Okada, Maki / Patel, Samir I / Schafer, Eric S / Schechter, Tal / Singh, Neelam / Steele, Amii C / Sulis, Maria Luisa / Vargas, Sarah L / Winter, Stuart S / Wood, Charlotte / Zweidler-McKay, Patrick / Bollard, Catherine M / Loh, Mignon L / Hunger, Stephen P / Raetz, Elizabeth A

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2022 Volume 40, Issue 19, Page(s) 2106–2118

Abstract: Purpose: To improve the outcomes of patients with T-cell acute lymphoblastic leukemia (T-ALL) and ... lymphoblastic lymphoma (T-LL), the proteasome inhibitor bortezomib was examined in the Children's Oncology Group ... radiation (CRT) in newly diagnosed T-ALL.: Patients and methods: Children and young adults with T-ALL/T ...

Abstract	Purpose: To improve the outcomes of patients with T-cell acute lymphoblastic leukemia (T-ALL) and lymphoblastic lymphoma (T-LL), the proteasome inhibitor bortezomib was examined in the Children's Oncology Group phase III clinical trial AALL1231, which also attempted to reduce the use of prophylactic cranial radiation (CRT) in newly diagnosed T-ALL. Patients and methods: Children and young adults with T-ALL/T-LL were randomly assigned to a modified augmented Berlin-Frankfurt-Münster chemotherapy regimen with/without bortezomib during induction and delayed intensification. Multiple modifications were made to the augmented Berlin-Frankfurt-Münster backbone used in the predecessor trial, AALL0434, including using dexamethasone instead of prednisone and adding two extra doses of pegaspargase in an attempt to eliminate CRT in most patients. Results: AALL1231 accrued 824 eligible and evaluable patients from 2014 to 2017. The 4-year event-free survival (EFS) and overall survival (OS) for arm A (no bortezomib) versus arm B (bortezomib) were 80.1% ± 2.3% versus 83.8% ± 2.1% (EFS, Conclusion: Patients with T-LL had significantly improved EFS and OS with bortezomib on the AALL1231 backbone. Systemic therapy intensification allowed elimination of CRT in more than 90% of patients with T-ALL without excess relapse.
MeSH term(s)	Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Bortezomib/adverse effects ; Child ; Disease-Free Survival ; Humans ; Infant ; Lymphoma/drug therapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; T-Lymphocytes ; Young Adult
Chemical Substances	Bortezomib (69G8BD63PP)
Language	English
Publishing date	2022-03-10
Publishing country	United States
Document type	Clinical Trial, Phase III ; Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.21.02678
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Zs.A 1847: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 650: Show issues

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Article ; Online: CD8 cytotoxic T-cell infiltrates and cellular damage in the hypothalamus in human obesity.

Ahrendsen, Jared T / Nong, Yi / Huo, Yuda / Steele, Jasmine / Anderson, Matthew P

Acta neuropathologica communications

2023 Volume 11, Issue 1, Page(s) 163

Abstract: ... non-obese human post-mortem brains. We report that CD8-positive cytotoxic T-cells are increased ... compared to non-obese patients, but not in other hypothalamic nuclei or brain regions. CD8 T-cells were ... most abundant in individuals with concurrent obesity and diabetes. Markers of cytotoxic T-cell induced ...

Abstract	Rare cases of paraneoplastic obesity in children suggest sporadic obesity might also arise from an adaptive immune cell-mediated mechanism. Since the hypothalamus is a central regulator of feeding behavior and energy expenditure, we quantified lymphocytic inflammation in this region in a cohort of obese and non-obese human post-mortem brains. We report that CD8-positive cytotoxic T-cells are increased in hypothalamic median eminence/arcuate nucleus (ME/Arc) and bed nucleus of the stria terminalis in 40% of obese compared to non-obese patients, but not in other hypothalamic nuclei or brain regions. CD8 T-cells were most abundant in individuals with concurrent obesity and diabetes. Markers of cytotoxic T-cell induced damage, activated caspase 3 and poly-ADP ribose, were also elevated in the ME/Arc of obese patients. To provoke CD8 cytotoxic T-cell infiltrates in ventromedial region of hypothalamus in mice we performed stereotactic injections of an adeno-associated virus expressing immunogenic green fluorescent protein or saline. AAV but not saline injections triggered hypothalamic CD8 T-cell infiltrates associated with a rapid weight gain in mice recapitulating the findings in human obesity. This is the first description of the neuropathology of human obesity and when combined with its reconstitution in a mouse model suggests adaptive immunity may drive as much as 40% of the human condition.
MeSH term(s)	Animals ; Humans ; Mice ; Arcuate Nucleus of Hypothalamus/metabolism ; CD8-Positive T-Lymphocytes ; Hypothalamus/metabolism ; Pediatric Obesity/metabolism ; T-Lymphocytes
Language	English
Publishing date	2023-10-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2715589-4
ISSN	2051-5960 ; 2051-5960
ISSN (online)	2051-5960
ISSN	2051-5960
DOI	10.1186/s40478-023-01659-x
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Article ; Online: Programme of self-reactive innate-like T cell-mediated cancer immunity.

Chou, Chun / Zhang, Xian / Krishna, Chirag / Nixon, Briana G / Dadi, Saida / Capistrano, Kristelle J / Kansler, Emily R / Steele, Miranda / Han, Jian / Shyu, Amy / Zhang, Jing / Stamatiades, Efstathios G / Liu, Ming / Li, Shun / Do, Mytrang H / Edwards, Chaucie / Kang, Davina S / Chen, Chin-Tung / Wei, Iris H /

Pappou, Emmanouil P / Weiser, Martin R / Garcia-Aguilar, J / Smith, J Joshua / Leslie, Christina S / Li, Ming O

Nature

2022 Volume 605, Issue 7908, Page(s) 139–145

Abstract: Cellular transformation induces phenotypically diverse populations of tumour-infiltrating T cells ...

Abstract	Cellular transformation induces phenotypically diverse populations of tumour-infiltrating T cells
MeSH term(s)	Animals ; Cell Differentiation ; Immunity, Innate ; Interleukin-15 ; Mice ; Neoplasms/metabolism ; Receptors, Antigen, T-Cell/metabolism ; T-Lymphocytes, Cytotoxic/metabolism
Chemical Substances	Interleukin-15 ; Receptors, Antigen, T-Cell
Language	English
Publishing date	2022-04-20
Publishing country	England
Document type	Journal Article
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-022-04632-1
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Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: T cell egress via lymphatic vessels is tuned by antigen encounter and limits tumor control.

Steele, Maria M / Jaiswal, Abhinav / Delclaux, Ines / Dryg, Ian D / Murugan, Dhaarini / Femel, Julia / Son, Sunny / du Bois, Haley / Hill, Cameron / Leachman, Sancy A / Chang, Young H / Coussens, Lisa M / Anandasabapathy, Niroshana / Lund, Amanda W

Nature immunology

2023 Volume 24, Issue 4, Page(s) 664–675

Abstract: Antigen-specific ... ...

Abstract	Antigen-specific CD8
MeSH term(s)	Humans ; CD8-Positive T-Lymphocytes ; Receptors, CXCR4/metabolism ; Neoplasms/therapy ; Neoplasms/pathology ; Lymphatic Vessels/metabolism ; Immunotherapy
Chemical Substances	Receptors, CXCR4
Language	English
Publishing date	2023-02-27
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2016987-5
ISSN	1529-2916 ; 1529-2908
ISSN (online)	1529-2916
ISSN	1529-2908
DOI	10.1038/s41590-023-01443-y
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Zs.A 5294: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 42: Show issues

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Article ; Online: Myeloid-derived suppressor cells and T cell populations in children with Multisystem Inflammatory Syndrome.

Bline, Katherine E / Wilt, Anna L / Alexander, Robin N / Andrews, Angel N / Mertz, Sara E / Ye, Fang / Steele, Lisa M / Wolfe, Amber L / Mejias, Asuncion / Ramilo, Octavio

Pediatric research

2023 Volume 95, Issue 5, Page(s) 1288–1294

Abstract: ... an immunosuppressive cell population that expands under inflammatory conditions and suppresses T cell function ... with T cell lymphopenia.: Methods: We conducted a prospective, observational study. Initial ... once. MDSC and T cell populations were identified by flow cytometric methods.: Results: We enrolled 22 ...

Abstract	Background: Multisystem inflammatory syndrome in children (MIS-C) represents a hyperinflammatory state that can result in multi-organ dysfunction and death. Myeloid-derived suppressor cells (MDSC) are an immunosuppressive cell population that expands under inflammatory conditions and suppresses T cell function. We hypothesized that MDSC would be increased in children with MIS-C and that MDSC expansion would be associated with T cell lymphopenia. Methods: We conducted a prospective, observational study. Initial blood samples were collected within 48 h of admission. Age-matched healthy controls underwent sampling once. MDSC and T cell populations were identified by flow cytometric methods. Results: We enrolled 22 children with MIS-C (12 ICU, 10 ward) and 21 healthy controls (HC). Children with MIS-C demonstrated significantly higher MDSC compared to HC, and MDSC expansion persisted for >3 weeks in the ICU group. Children with MIS-C admitted to the ICU demonstrated significantly lower absolute numbers of T cells and natural killer cells. There were no significant associations between MDSC and cardiac dysfunction, duration of hospitalization, or vasoactive inotrope score. Conclusions: Our study suggests that children critically ill with MIS-C have expansion of MDSC and associated decreased T cell and NK cell populations. Our results did not demonstrate associations between MDSC and clinical outcomes. Impact: Multisystem inflammatory syndrome in children (MIS-C) is a dysregulated immune response occurring several weeks after SARS-CoV-2 infection that can result in multi-organ dysfunction and death. Children severely ill with MIS-C demonstrated increased myeloid-derived suppressor cells and decreased absolute numbers of CD4+ and CD8 + T cells and NK cells compared to healthy controls. There was no significant association between MDSC numbers and clinical outcomes; including cardiac dysfunction, length of stay, or requirement of vasoactive support, in children with MIS-C.
MeSH term(s)	Humans ; Systemic Inflammatory Response Syndrome/immunology ; Systemic Inflammatory Response Syndrome/blood ; Prospective Studies ; Female ; Male ; Child ; Myeloid-Derived Suppressor Cells/immunology ; COVID-19/immunology ; COVID-19/complications ; COVID-19/blood ; Child, Preschool ; T-Lymphocytes/immunology ; Adolescent ; Case-Control Studies ; Infant ; Lymphopenia/immunology ; Lymphopenia/blood ; Killer Cells, Natural/immunology ; Flow Cytometry
Language	English
Publishing date	2023-12-02
Publishing country	United States
Document type	Journal Article ; Observational Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	4411-8
ISSN	1530-0447 ; 0031-3998
ISSN (online)	1530-0447
ISSN	0031-3998
DOI	10.1038/s41390-023-02919-1
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Zs.A 564: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 373: Show issues

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Article ; Online: Author Correction: T cell egress via lymphatic vessels is tuned by antigen encounter and limits tumor control.

Nature immunology

2023 Volume 24, Issue 4, Page(s) 729

Language	English
Publishing date	2023-03-16
Publishing country	United States
Document type	Published Erratum
ZDB-ID	2016987-5
ISSN	1529-2916 ; 1529-2908
ISSN (online)	1529-2916
ISSN	1529-2908
DOI	10.1038/s41590-023-01491-4
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Zs.A 5294: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Persistence of SARS-CoV-2-specific B and T cell responses in convalescent COVID-19 patients 6-8 months after the infection.

Sherina, Natalia / Piralla, Antonio / Du, Likun / Wan, Hui / Kumagai-Braesch, Makiko / Andréll, Juni / Braesch-Andersen, Sten / Cassaniti, Irene / Percivalle, Elena / Sarasini, Antonella / Bergami, Federica / Di Martino, Raffaella / Colaneri, Marta / Vecchia, Marco / Sambo, Margherita / Zuccaro, Valentina / Bruno, Raffaele / Sachs, Michele / Oggionni, Tiberio /

Meloni, Federica / Abolhassani, Hassan / Bertoglio, Federico / Schubert, Maren / Byrne-Steele, Miranda / Han, Jian / Hust, Michael / Xue, Yintong / Hammarström, Lennart / Baldanti, Fausto / Marcotte, Harold / Pan-Hammarström, Qiang

Med (New York, N.Y.)

2021 Volume 2, Issue 3, Page(s) 281–295.e4

Abstract: ... 2 antibody (Ab) levels and specific memory B and T cell responses in convalescent coronavirus ... and specific memory B and T cell responses were tested in a subset of samples.: Findings: Anti-SARS ... in 80% of the samples collected at 6-8 months after symptom onset. SARS-CoV-2-specific memory B and T ...

Abstract	Background: Monitoring the adaptive immune responses during the natural course of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection provides useful information for the development of vaccination strategies against this virus and its emerging variants. We thus profiled the serum anti-SARS-CoV-2 antibody (Ab) levels and specific memory B and T cell responses in convalescent coronavirus disease 2019 (COVID-19) patients. Methods: A total of 119 samples from 88 convalescent donors who experienced mild to critical disease were tested for the presence of elevated anti-spike and anti-receptor binding domain Ab levels over a period of 8 months. In addition, the levels of SARS-CoV-2 neutralizing Abs and specific memory B and T cell responses were tested in a subset of samples. Findings: Anti-SARS-CoV-2 Abs were present in 85% of the samples collected within 4 weeks after the onset of symptoms in COVID-19 patients. Levels of specific immunoglobulin M (IgM)/IgA Abs declined after 1 month, while levels of specific IgG Abs and plasma neutralizing activities remained relatively stable up to 6 months after diagnosis. Anti-SARS-CoV-2 IgG Abs were still present, although at a significantly lower level, in 80% of the samples collected at 6-8 months after symptom onset. SARS-CoV-2-specific memory B and T cell responses developed with time and were persistent in all of the patients followed up for 6-8 months. Conclusions: Our data suggest that protective adaptive immunity following natural infection of SARS-CoV-2 may persist for at least 6-8 months, regardless of disease severity. Development of medium- or long-term protective immunity through vaccination may thus be possible. Funding: This project was supported by the European Union's Horizon 2020 research and innovation programme (ATAC, no. 101003650), the Italian Ministry of Health (Ricerca Finalizzata grant no. GR-2013-02358399), the Center for Innovative Medicine, and the Swedish Research Council. J.A. was supported by the SciLifeLab/KAW national COVID-19 research program project grant 2020.
MeSH term(s)	Antibodies, Viral ; COVID-19 ; Humans ; Immunoglobulin A ; Immunoglobulin G ; SARS-CoV-2 ; T-Lymphocytes
Chemical Substances	Antibodies, Viral ; Immunoglobulin A ; Immunoglobulin G
Language	English
Publishing date	2021-02-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2666-6340
ISSN (online)	2666-6340
DOI	10.1016/j.medj.2021.02.001
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