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  1. Article ; Online: Editorial to accompany exchange of views: Role of exercise pressor reflex in control of ventilation during exercise.

    Fadel, Paul J

    Experimental physiology

    2020  Volume 105, Issue 12, Page(s) 2258–2259

    MeSH term(s) Exercise ; Muscles ; Reflex
    Language English
    Publishing date 2020-11-20
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1016295-1
    ISSN 1469-445X ; 0958-0670
    ISSN (online) 1469-445X
    ISSN 0958-0670
    DOI 10.1113/EP089124
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  2. Article ; Online: Nitric Oxide and Cardiovascular Regulation: Beyond the Endothelium.

    Fadel, Paul J

    Hypertension (Dallas, Tex. : 1979)

    2017  Volume 69, Issue 5, Page(s) 778–779

    Language English
    Publishing date 2017-05
    Publishing country United States
    Document type Editorial
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.117.08999
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  3. Article ; Online: Characterizing participants who respond to text, email, phone calls, or postcards in a SARS-CoV-2 prevalence study.

    Duszynski, Thomas J / Fadel, William / Dixon, Brian / Yiannoutsos, Constantin T / Halverson, Paul / Menachemi, Nir

    BMC public health

    2024  Volume 24, Issue 1, Page(s) 1113

    Abstract: Introduction: Multiple modalities and frequencies of contact are needed to maximize recruitment in many public health surveys. The purpose of this analysis is to characterize respondents to a statewide SARS-CoV-2 testing study whose participation ... ...

    Abstract Introduction: Multiple modalities and frequencies of contact are needed to maximize recruitment in many public health surveys. The purpose of this analysis is to characterize respondents to a statewide SARS-CoV-2 testing study whose participation followed either postcard, phone outreach or electronic means of invitation. In addition, we examine how participant characteristics differ based upon the number of contacts needed to elicit participation.
    Methods: This is a cross-sectional analysis of survey data collected from participants who were randomly selected to represent Indiana residents and were invited to be tested for Covid-19 in April 2020. Participants received invitations via postcard, text/emails, and/or robocalls/texts based upon available contact information. The modality, and frequency of contacts, that prompted participation was determined by when the notification was sent and when the participant responded and subsequently registered to participate in the study. Chi square analyses were used to determine differences between groups and significant findings were analyzed using multinomial logistic regression.
    Results: Respondents included 3,658 individuals and were stratified by postcards (7.9%), text/emails (26.5%), and robocalls/text (65.7%) with 19.7% registering after 1 contact, 47.9% after 2 contacts, and 32.4% after 3 contacts encouraging participation. Females made up 54.6% of the sample and responded at a higher rate for postcards (8.2% vs. 7.5%) and text/emails (28.1 vs. 24.6%) as compared to males (χ
    Discussion: Researchers should be aware that the modality of contact as well as the number of prompts used could influence differential participation in public health studies. Our findings can inform researchers developing studies that rely on selective participation by study subjects. We explore how to increase participation within targeted demographic groups using specific modalities and examining frequency of contact.
    MeSH term(s) Humans ; Male ; Female ; COVID-19/epidemiology ; Cross-Sectional Studies ; Adult ; Middle Aged ; Indiana/epidemiology ; Young Adult ; Adolescent ; Aged ; SARS-CoV-2 ; Prevalence ; Telephone ; Electronic Mail/statistics & numerical data ; Text Messaging/statistics & numerical data ; Surveys and Questionnaires ; COVID-19 Testing/statistics & numerical data ; Contact Tracing/statistics & numerical data ; Postal Service ; Patient Selection
    Language English
    Publishing date 2024-04-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041338-5
    ISSN 1471-2458 ; 1471-2458
    ISSN (online) 1471-2458
    ISSN 1471-2458
    DOI 10.1186/s12889-024-18550-6
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  4. Article ; Online: Sympathetic transduction: let's not forget about the physiology.

    Fadel, Paul J / Young, Benjamin E / Keller, David M

    American journal of physiology. Regulatory, integrative and comparative physiology

    2021  Volume 321, Issue 4, Page(s) R634–R635

    Language English
    Publishing date 2021-10-04
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 603839-6
    ISSN 1522-1490 ; 0363-6119
    ISSN (online) 1522-1490
    ISSN 0363-6119
    DOI 10.1152/ajpregu.00212.2021
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  5. Article ; Online: Cardiac autonomic function is preserved in young adults with major depressive disorder.

    Darling, Ashley M / Dominguez, Cynthia M / Skow, Rachel J / Mogle, Jacqueline / Saunders, Erika F H / Fadel, Paul J / Greaney, Jody L

    American journal of physiology. Heart and circulatory physiology

    2024  Volume 326, Issue 3, Page(s) H648–H654

    Abstract: The prevalence of major depressive disorder (MDD) is highest in young adults and contributes to an increased risk of developing future cardiovascular disease (CVD). However, the underlying mechanisms remain unclear. The studies examining cardiac ... ...

    Abstract The prevalence of major depressive disorder (MDD) is highest in young adults and contributes to an increased risk of developing future cardiovascular disease (CVD). However, the underlying mechanisms remain unclear. The studies examining cardiac autonomic function that have included young unmedicated adults with MDD report equivocal findings, and few have considered the potential influence of disease severity or duration. We hypothesized that heart rate variability (HRV) and cardiac baroreflex sensitivity (BRS) would be reduced in young unmedicated adults with MDD (18-30 yr old) compared with healthy nondepressed young adults (HA). We further hypothesized that greater symptom severity would be related to poorer cardiac autonomic function in young adults with MDD. Heart rate and beat-to-beat blood pressure were continuously recorded during 10 min of supine rest to assess HRV and cardiac BRS in 28 HA (17 female, 22 ± 3 yr old) and 37 adults with MDD experiencing current symptoms of mild-to-moderate severity (unmedicated; 28 female, 20 ± 3 yr old). Neither HRV [root mean square of successive differences between normal heartbeats (RMSSD): 63 ± 34 HA vs. 79 ± 36 ms MDD;
    MeSH term(s) Humans ; Female ; Young Adult ; Depressive Disorder, Major/diagnosis ; Autonomic Nervous System ; Heart ; Autonomic Nervous System Diseases ; Blood Pressure/physiology ; Heart Diseases ; Baroreflex/physiology ; Heart Rate/physiology
    Language English
    Publishing date 2024-01-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603838-4
    ISSN 1522-1539 ; 0363-6135
    ISSN (online) 1522-1539
    ISSN 0363-6135
    DOI 10.1152/ajpheart.00762.2023
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  6. Article ; Online: Aging and sympathetic transduction to blood pressure in humans: methodological and physiological considerations.

    Bigalke, Jeremy A / Young, Benjamin E / Cleveland, Emily L / Fadel, Paul J / Carter, Jason R

    American journal of physiology. Heart and circulatory physiology

    2023  Volume 326, Issue 1, Page(s) H148–H157

    Abstract: Recent reports suggest that quantification of signal-averaged sympathetic transduction is influenced by resting muscle sympathetic nerve activity (MSNA) and burst occurrence relative to the average mean arterial pressure (MAP). Herein, we asked how these ...

    Abstract Recent reports suggest that quantification of signal-averaged sympathetic transduction is influenced by resting muscle sympathetic nerve activity (MSNA) and burst occurrence relative to the average mean arterial pressure (MAP). Herein, we asked how these findings may influence age-related reductions in sympathetic transduction. Beat-to-beat blood pressure and MSNA were recorded during 5 min of rest in 27 younger (13 females: age, 25 ± 5 yr; BMI, 25 ± 4 kg/m
    MeSH term(s) Female ; Humans ; Aged ; Young Adult ; Adult ; Middle Aged ; Blood Pressure/physiology ; Heart Rate/physiology ; Muscle, Skeletal/innervation ; Aging/physiology ; Sympathetic Nervous System/physiology
    Language English
    Publishing date 2023-11-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603838-4
    ISSN 1522-1539 ; 0363-6135
    ISSN (online) 1522-1539
    ISSN 0363-6135
    DOI 10.1152/ajpheart.00359.2023
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  7. Article ; Online: Inflammation as a mediator of arterial ageing.

    Trott, Daniel W / Fadel, Paul J

    Experimental physiology

    2019  Volume 104, Issue 10, Page(s) 1455–1471

    Abstract: New findings: What is the topic of this review? This review summarizes and synthesizes what is known about the contribution of inflammation to age-related arterial dysfunction. What advances does it highlight? This review details observational evidence ... ...

    Abstract New findings: What is the topic of this review? This review summarizes and synthesizes what is known about the contribution of inflammation to age-related arterial dysfunction. What advances does it highlight? This review details observational evidence for the relationship of age-related inflammation and arterial dysfunction, insight from autoimmune inflammatory diseases and their effects on arterial function, interventional evidence linking inflammation and age-related arterial dysfunction, insight into age-related arterial inflammation from preclinical models and interventions to ameliorate age-related inflammation and arterial dysfunction.
    Abstract: Advanced age is a primary risk factor for cardiovascular disease, the leading cause of death in the industrialized world. Two major components of arterial ageing are stiffening of the large arteries and impaired endothelium-dependent dilatation in multiple vascular beds. These two alterations are major contributors to the development of overt cardiovascular disease. Increasing inflammation with advanced age is likely to play a role in this arterial dysfunction. The purpose of this review is to synthesize what is known about inflammation and its relationship to age-related arterial dysfunction. This review discusses both the initial observational evidence for the relationship of age-related inflammation and arterial dysfunction and the evidence that inflammatory autoimmune diseases are associated with a premature arterial ageing phenotype. We next discuss interventional and mechanistic evidence linking inflammation and age-related arterial dysfunction in older adults. We also attempt to summarize the relevant evidence from preclinical models. Lastly, we discuss interventions in both humans and animals that have been shown to ameliorate age-related arterial inflammation and dysfunction. The available evidence provides a strong basis for the role of inflammation in both large artery stiffening and impairment of endothelium-dependent dilatation; however, the specific inflammatory mediators, the initiating factors and the relative importance of the endothelium, smooth muscle cells, perivascular adipose tissue and immune cells in arterial inflammation are not well understood. With the expansion of the ageing population, ameliorating age-related arterial inflammation represents an important potential strategy for preserving vascular health in the elderly.
    MeSH term(s) Aging/pathology ; Animals ; Arteries/pathology ; Cardiovascular Diseases ; Endothelium, Vascular/pathology ; Humans ; Inflammation/pathology
    Language English
    Publishing date 2019-08-08
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1016295-1
    ISSN 1469-445X ; 0958-0670
    ISSN (online) 1469-445X
    ISSN 0958-0670
    DOI 10.1113/EP087499
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  8. Article ; Online: Commentary on "Acute Lower Leg Heating Increases Exercise Capacity in Patients With Peripheral Artery Disease".

    Young, Benjamin E / Fadel, Paul J

    The Journal of cardiovascular nursing

    2018  Volume 34, Issue 2, Page(s) 134–136

    MeSH term(s) Exercise ; Exercise Tolerance ; Heating ; Humans ; Peripheral Arterial Disease ; Regional Blood Flow
    Language English
    Publishing date 2018-10-25
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 639335-4
    ISSN 1550-5049 ; 0889-4655
    ISSN (online) 1550-5049
    ISSN 0889-4655
    DOI 10.1097/JCN.0000000000000547
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  9. Article ; Online: Potential for reducing resting sympathetic nerve activity with new classes of glucose-lowering drugs in heart failure with preserved ejection fraction.

    Washio, Takuro / Hissen, Sarah L / Takeda, Ryosuke / Akins, John D / Wakeham, Denis J / Brazile, Tiffany / Hearon, Christopher M / MacNamara, James P / Sarma, Satyam / Levine, Benjamin D / Fadel, Paul J / Fu, Qi

    Clinical autonomic research : official journal of the Clinical Autonomic Research Society

    2024  Volume 34, Issue 1, Page(s) 223–226

    MeSH term(s) Humans ; Glucose ; Stroke Volume ; Heart Failure/drug therapy ; Hypoglycemic Agents ; Diabetes Mellitus, Type 2
    Chemical Substances Glucose (IY9XDZ35W2) ; Hypoglycemic Agents
    Language English
    Publishing date 2024-01-29
    Publishing country Germany
    Document type Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1080007-4
    ISSN 1619-1560 ; 0959-9851
    ISSN (online) 1619-1560
    ISSN 0959-9851
    DOI 10.1007/s10286-023-01013-0
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  10. Article: Neural control of the circulation during exercise in health and disease.

    Fadel, Paul J

    Frontiers in physiology

    2013  Volume 4, Page(s) 224

    Language English
    Publishing date 2013-08-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2013.00224
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