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  1. Article ; Online: Novel cutting edge nano-strategies to address old long-standing complications in cardiovascular diseases. A comprehensive review.

    Tesoro, Laura / Hernandez, Ignacio / Saura, Marta / Badimón, Lina / Zaragoza, Carlos

    European journal of clinical investigation

    2024  , Page(s) e14208

    Abstract: Background: Cardiovascular diseases (CVD) impact a substantial portion of the global population and represent a significant threat to experiencing life-threatening outcomes, such as atherosclerosis, myocardial infarction, stroke and heart failure. ... ...

    Abstract Background: Cardiovascular diseases (CVD) impact a substantial portion of the global population and represent a significant threat to experiencing life-threatening outcomes, such as atherosclerosis, myocardial infarction, stroke and heart failure. Despite remarkable progress in pharmacology and medical interventions, CVD persists as a major public health concern, and now ranks as the primary global cause of death and the highest consumer of global budgets. Ongoing research endeavours persist in seeking novel therapeutic avenues and interventions to deepen our understanding of CVD, enhance prevention measures, and refine treatment strategies.
    Methods: Nanotechnology applied to the development of new molecular probes with diagnostic and theranostic properties represents one of the greatest technological challenges in preclinical and clinical research.
    Results: The application of nanotechnology in cardiovascular medicine holds great promise for advancing our understanding of CVDs and revolutionizing their diagnosis and treatment strategies, ultimately improving patient care and outcomes. In addition, the capacity of drug encapsulation in nanoparticles has significantly bolstered their biological safety, bioavailability and solubility. In combination with imaging technologies, molecular imaging has emerged as a pivotal therapeutic tool, offering insight into the molecular events underlying disease and facilitating targeted treatment approaches.
    Conclusion: Here, we present a comprehensive overview of the recent advancements in targeted nanoparticle approaches for diagnosing CVDs, encompassing molecular imaging techniques, underscoring the significant progress in theranostic, as a novel and promising therapeutic strategy.
    Language English
    Publishing date 2024-04-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 186196-7
    ISSN 1365-2362 ; 0014-2972 ; 0960-135X
    ISSN (online) 1365-2362
    ISSN 0014-2972 ; 0960-135X
    DOI 10.1111/eci.14208
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    In stock of ZB MED Cologne/Königswinter

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  2. Article: Corrigendum: Preclinical models of congestive heart failure, advantages and limitations for application in clinical practice.

    Saura, Marta / Zamorano, Jose Luis / Zaragoza, Carlos

    Frontiers in physiology

    2022  Volume 13, Page(s) 1045550

    Abstract: This corrects the article DOI: 10.3389/fphys.2022.850301.]. ...

    Abstract [This corrects the article DOI: 10.3389/fphys.2022.850301.].
    Language English
    Publishing date 2022-10-10
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.1045550
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  3. Article ; Online: miR-16 induces endoplasmic reticulum stress in ischemic dilated cardiomyopathy.

    Sánchez-Esteban, Sandra / Zaragoza, Carlos / Saura, Marta

    Revista espanola de cardiologia (English ed.)

    2021  Volume 74, Issue 9, Page(s) 732–733

    Language Spanish
    Publishing date 2021-03-26
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 2592481-3
    ISSN 1885-5857 ; 1885-5857
    ISSN (online) 1885-5857
    ISSN 1885-5857
    DOI 10.1016/j.rec.2021.03.003
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  4. Article: Preclinical models of congestive heart failure, advantages, and limitations for application in clinical practice.

    Saura, Marta / Zamorano, Jose Luis / Zaragoza, Carlos

    Frontiers in physiology

    2022  Volume 13, Page(s) 850301

    Abstract: Congestive heart failure (CHF) has increased over the years, in part because of recent progress in the management of chronic diseases, thus contributing to the maintenance of an increasingly aging population. CHF represents an unresolved health problem ... ...

    Abstract Congestive heart failure (CHF) has increased over the years, in part because of recent progress in the management of chronic diseases, thus contributing to the maintenance of an increasingly aging population. CHF represents an unresolved health problem and therefore the establishment of animal models that recapitulates the complexity of CHF will become a critical element to be addressed, representing a serious challenge given the complexity of the pathogenesis of CHF itself, which is further compounded by methodological biases that depend on the animal species in use. Animal models of CHF have been developed in many different species, with different surgical procedures, all with promising results but, for the moment, unable to fully recapitulate the human disease. Large animal models often provide a more promising reality, with all the difficulties that their use entails, and which limit their performance to fewer laboratories, the costly of animal housing, animal handling, specialized facilities, skilled methodological training, and reproducibility as another important limiting factor when considering a valid animal model versus potentially better performing alternatives. In this review we will discuss the different animal models of CHF, their advantages and, above all, the limitations of each procedure with respect to effectiveness of results in terms of clinical application.
    Language English
    Publishing date 2022-08-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.850301
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  5. Article ; Online: Indoxyl Sulfate-Induced Valve Endothelial Cell Endothelial-to-Mesenchymal Transition and Calcification in an Integrin-Linked Kinase-Dependent Manner.

    Delgado-Marin, Maria / Sánchez-Esteban, Sandra / Cook-Calvete, Alberto / Jorquera-Ortega, Sara / Zaragoza, Carlos / Saura, Marta

    Cells

    2024  Volume 13, Issue 6

    Abstract: Calcific Aortic Valve Disease (CAVD) is a significant concern for cardiovascular health and is closely associated with chronic kidney disease (CKD). Aortic valve endothelial cells (VECs) play a significant role in the onset and progression of CAVD. ... ...

    Abstract Calcific Aortic Valve Disease (CAVD) is a significant concern for cardiovascular health and is closely associated with chronic kidney disease (CKD). Aortic valve endothelial cells (VECs) play a significant role in the onset and progression of CAVD. Previous research has suggested that uremic toxins, particularly indoxyl sulfate (IS), induce vascular calcification and endothelial dysfunction, but the effect of IS on valve endothelial cells (VECs) and its contribution to CAVD is unclear. Our results show that IS reduced human VEC viability and increased pro-calcific markers RUNX2 and alkaline phosphatase (ALP) expression. Additionally, IS-exposed VECs cultured in pro-osteogenic media showed increased calcification. Mechanistically, IS induced endothelial-to-mesenchymal transition (EndMT), evidenced by the loss of endothelial markers and increased expression of mesenchymal markers. IS triggered VEC inflammation, as revealed by NF-kB activation, and decreased integrin-linked kinase (ILK) expression. ILK overexpression reversed the loss of endothelial phenotype and RUNX2, emphasizing its relevance in the pathogenesis of CAVD in CKD. Conversely, a lower dose of IS intensified some of the effects in EndMT caused by silencing ILK. These findings imply that IS affects valve endothelium directly, contributing to CAVD by inducing EndMT and calcification, with ILK acting as a crucial modulator.
    MeSH term(s) Humans ; Indican ; Core Binding Factor Alpha 1 Subunit/metabolism ; Endothelial Cells/metabolism ; Cells, Cultured ; Vascular Calcification/metabolism ; Renal Insufficiency, Chronic/pathology ; Aortic Valve/pathology ; Aortic Valve Stenosis ; Calcinosis ; Protein Serine-Threonine Kinases
    Chemical Substances integrin-linked kinase (EC 2.7.1.-) ; Indican (N187WK1Y1J) ; Core Binding Factor Alpha 1 Subunit ; Protein Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2024-03-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells13060481
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  6. Article ; Online: Cardiac microvasculature and adverse remodeling after acute myocardial infarction. New evidence on the use of VEGF as a therapeutic target.

    Zaragoza, Carlos / Saura, Marta / Ramírez-Carracedo, Rafael

    Revista espanola de cardiologia (English ed.)

    2020  Volume 74, Issue 2, Page(s) 124–125

    MeSH term(s) Humans ; Microvessels ; Myocardial Infarction/drug therapy ; Vascular Endothelial Growth Factor A ; Ventricular Remodeling
    Chemical Substances Vascular Endothelial Growth Factor A
    Language Spanish
    Publishing date 2020-10-17
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 2592481-3
    ISSN 1885-5857 ; 1885-5857
    ISSN (online) 1885-5857
    ISSN 1885-5857
    DOI 10.1016/j.rec.2020.07.019
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  7. Article ; Online: Design Orientation Clusters in Design-Marketing Relationships

    Mónica Cantó-Primo / Marta Frasquet / Irene Gil-Saura / Brigitte Borja de Mozota

    She Ji: The Journal of Design, Economics and Innovation, Vol 9, Iss 3, Pp 379-

    A Survey of Spanish Companies

    2023  Volume 401

    Abstract: This article presents a segmentation analysis that categorizes industrial design firms based on levels of design orientation. It could serve as a useful framework for designers to tailor their marketing strategies to specific groups or companies. We ... ...

    Abstract This article presents a segmentation analysis that categorizes industrial design firms based on levels of design orientation. It could serve as a useful framework for designers to tailor their marketing strategies to specific groups or companies. We conducted both qualitative research involving experts, and quantitative research using a sample of 201 small and medium-sized enterprises (SMEs) in the Spanish furniture and lighting industries. The design capacity building approach of design orientation, which was determined by evaluating scores across seven dimensions of the design orientation scale, was adopted based on: 1) awareness of the benefits of design; 2) design sensibility; 3) basic design skills; 4) specialized design skills; 5) involving others; 6) design organization; and, 7) innovation skills. The results identified three clusters with different behaviors: “full design orientation” (Cluster 1), “design orientation from the top down” (Cluster 2), and “operational design orientation” (Cluster 3). This research provides a pragmatic tool for design service providers, linking design skills, design impact, and organizational performance.
    Keywords Design skills ; Design orientation ; Design management ; Design performance ; Competitive advantage ; Cluster analysis ; Technology (General) ; T1-995 ; Economics as a science ; HB71-74
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Combination of Bisphenol A and Its Emergent Substitute Molecules Is Related to Heart Disease and Exerts a Differential Effect on Vascular Endothelium.

    Moreno-Gómez-Toledano, Rafael / Delgado-Marín, María / Sánchez-Esteban, Sandra / Cook-Calvete, Alberto / Ortiz, Sara / Bosch, Ricardo J / Saura, Marta

    International journal of molecular sciences

    2023  Volume 24, Issue 15

    Abstract: Plastic production, disposal, and recycling systems represent one of the higher challenges for the planet's health. Its direct consequence is the release of endocrine disruptors, such as bisphenol A (BPA), and its emerging substitute molecules, bisphenol ...

    Abstract Plastic production, disposal, and recycling systems represent one of the higher challenges for the planet's health. Its direct consequence is the release of endocrine disruptors, such as bisphenol A (BPA), and its emerging substitute molecules, bisphenol F and S (BPF and BPS), into the environment. Consequently, bisphenols are usually present in human biological fluids. Since BPA, BPS, and BPF have structural analogies and similar hormonal activity, their combined study is urgently needed. The present manuscript studied the effect of the mixture of bisphenols (BP
    MeSH term(s) Humans ; Animals ; Mice ; Endocrine Disruptors/toxicity ; Endothelium, Vascular/metabolism ; Bayes Theorem ; Nutrition Surveys ; Benzhydryl Compounds/pharmacology ; Heart Diseases
    Chemical Substances bisphenol A (MLT3645I99) ; Endocrine Disruptors ; Benzhydryl Compounds
    Language English
    Publishing date 2023-07-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241512188
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  9. Article: Association between urinary concentrations of bisphenol A substitutes and diabetes in adults.

    Moreno-Gómez-Toledano, Rafael / Vélez-Vélez, Esperanza / Arenas, María I / Saura, Marta / Bosch, Ricardo J

    World journal of diabetes

    2022  Volume 13, Issue 7, Page(s) 521–531

    Abstract: Background: Due to new restrictions on the use of bisphenol A (BPA), industries are beginning to replace it with derived molecules such as bisphenol S and F (BPS and BPF). There is extensive evidence in the academic literature on the potential health ... ...

    Abstract Background: Due to new restrictions on the use of bisphenol A (BPA), industries are beginning to replace it with derived molecules such as bisphenol S and F (BPS and BPF). There is extensive evidence in the academic literature on the potential health effects of BPA, which is known to be a diabetogenic molecule. However, there are few publications related to new compounds derived from BPA.
    Aim: To perform an epidemiological study of urinary BPS and BPF in the American National Health and Nutrition Examination Survey (NHANES) cohort, and analyze their possible relationship with diabetes mellitus.
    Methods: NHANES datasets from 2013 to 2016 were used due to the urinary BPF and BPS availability. Data from 3658 adults were analyzed to perform regression analysis exploring the possible relationship between BPA-derived compounds and diabetes.
    Results: Descriptive statistics, linear regression modeling, and logistic regression analysis revealed a significant relationship between urinary BPS, but not BPF, and diabetes risk. Additionally, a relationship was observed between both compounds and hypertension and a slight relationship between BPF and dyslipidemia.
    Conclusion: In the present study, a strong relationship between urinary BPS, not BPF, and diabetes risk has been determined. BPA substitute molecules do not exempt the population from potential health risks.
    Language English
    Publishing date 2022-08-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2583471-X
    ISSN 1948-9358
    ISSN 1948-9358
    DOI 10.4239/wjd.v13.i7.521
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  10. Article ; Online: Long-term effectiveness of a nurse-led smoking cessation clinic at a comprehensive cancer center.

    Martínez, Cristina / Castellano, Yolanda / Fu, Marcela / Riccobene, Anna / Enríquez, Marta / Narváez, Maite / Saura, Judith / Feliu, Arianda / Fernández, Esteve

    Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing

    2023  Volume 55, Issue 3, Page(s) 681–691

    Abstract: Purpose: Smoking cessation interventions should be promoted in cancer centers to improve clinical outcomes among cancer patients and the quality of life of cancer-free patients and survivors. The aim of the present study was to examine long-term ... ...

    Abstract Purpose: Smoking cessation interventions should be promoted in cancer centers to improve clinical outcomes among cancer patients and the quality of life of cancer-free patients and survivors. The aim of the present study was to examine long-term abstinence (1, 3, and 5 years) among smokers who received an intensive nurse-led smoking cessation intervention.
    Design: A prospective follow-up study was conducted in a smoking cessation clinic in Barcelona.
    Methods: The study included 479 smokers who received a nurse-led smoking cessation intervention that included motivational interviewing, psychological support, behavioral change counseling, promotion of smoke-free policies, and relapse-prevention strategies, as well as pharmacotherapy if necessary, for 12 months. We calculated overall and sex-specific 1-, 3-, and 5-year abstinence probabilities (Kaplan-Meier curves) and adjusted hazard ratios (aHRs) of relapse with 95% confidence intervals (CIs) using Cox regression.
    Findings: The overall probability of abstinence at 1 and 5 years was 0.561 (95% CI: 0.516-0.606) and 0.364 (95% CI: 0.311-0.417), respectively. Females had a higher, but not significant, hazard ratio for relapse compared to males (aHR = 1.180; 95% CI: 0.905-1.538). Attending <5 visits was the most remarkable determinant of relapsing compared to attending 5-9 visits or ≥10 visits, both overall and by sex (p for trend: overall, p < 0.001; males, p = 0.007; and females, p < 0.001).
    Conclusions: Abstinence probability decreased over the 5-year follow-up but was relatively high. Males had higher abstinence rates than females in all follow-up periods. Completeness of the intensive intervention was the main predictor of cessation.
    Clinical relevance: Smoking cessation interventions should consider sex and incorporate strategies to increase adherence to obtain higher long-term abstinence rates.
    MeSH term(s) Male ; Female ; Humans ; Smoking Cessation ; Follow-Up Studies ; Prospective Studies ; Nurse's Role ; Quality of Life ; Recurrence ; Neoplasms
    Language English
    Publishing date 2023-03-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2008214-9
    ISSN 1547-5069 ; 1527-6546
    ISSN (online) 1547-5069
    ISSN 1527-6546
    DOI 10.1111/jnu.12891
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2842: Show issues Location:
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