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Book ; Online ; E-Book: Immunotherapy for head and neck cancer

Chan, Anthony T. C. / Ma, Brigette B.Y.

(Cancer immunotherapy ; 1)

2023

Author's details	Anthony T. C. Chan, Brigette B.Y. Ma editors
Series title	Cancer immunotherapy ; 1
Collection
Keywords	Immunotherapy ; Oncology ; Radiation Oncology ; Surgery ; Otorhinolaryngology ; Medical radiology
Subject code	615.37 ; 571.96
Language	English
Size	1 Online-Ressource (VIII, 147 Seiten), Illustrationen
Publisher	Springer
Publishing place	Cham
Publishing country	Switzerland
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT030702740
ISBN	978-3-031-29223-1 ; 9783031292255 ; 3-031-29223-5 ; 3031292251
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Hot on the trail in the TME: Clues from a trilogy of checkpoint inhibitor trials in nasopharyngeal cancer.

Ma, Brigette B Y / Thu Le, Quynh

Cancer cell

2023 Volume 41, Issue 6, Page(s) 1006–1008

Abstract: In this issue of Cancer Cell, Yang et al. report the third in a series of phase III trials that demonstrates the survival benefit of combining a PD-1 inhibitor with chemotherapy in nasopharyngeal cancer. A gene expression analysis identifies "hot" and " ... ...

Abstract	In this issue of Cancer Cell, Yang et al. report the third in a series of phase III trials that demonstrates the survival benefit of combining a PD-1 inhibitor with chemotherapy in nasopharyngeal cancer. A gene expression analysis identifies "hot" and "cold" tumor signatures with prognostic and predictive significance.
MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Lung Neoplasms/genetics ; Nasopharyngeal Neoplasms/drug therapy ; Nasopharyngeal Neoplasms/genetics ; Prognosis ; B7-H1 Antigen/genetics ; Tumor Microenvironment
Chemical Substances	B7-H1 Antigen
Language	English
Publishing date	2023-05-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	2078448-X
ISSN	1878-3686 ; 1535-6108
ISSN (online)	1878-3686
ISSN	1535-6108
DOI	10.1016/j.ccell.2023.04.013
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Article ; Online: Trends in phase 1 oncology drug development in East-Asia and Australia.

Ma, Brigette B Y

Chinese clinical oncology

2019 Volume 8, Issue 3, Page(s) 22

MeSH term(s)	Australia ; Drug Development/trends ; Far East ; Humans
Language	English
Publishing date	2019-07-15
Publishing country	China
Document type	Clinical Trial, Phase I ; Journal Article
ZDB-ID	2828547-5
ISSN	2304-3873 ; 2304-3865
ISSN (online)	2304-3873
ISSN	2304-3865
DOI	10.21037/cco.2019.06.04
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Article ; Online: Global Implementation of Precision Oncology.

Yam, Clinton / Ma, Brigette B Y / Yap, Timothy A

JCO precision oncology

2021 Volume 5

MeSH term(s)	Data Collection ; Humans ; Medical Oncology ; Neoplasms/diagnosis ; Precision Medicine
Language	English
Publishing date	2021-05-18
Publishing country	United States
Document type	Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
ISSN	2473-4284
ISSN (online)	2473-4284
DOI	10.1200/PO.21.00001
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Article ; Online: Targeting the PD-1/ PD-L1 interaction in nasopharyngeal carcinoma.

Johnson, David / Ma, Brigette B Y

Oral oncology

2021 Volume 113, Page(s) 105127

Abstract: Upregulation of the programmed cell death receptor-1 and ligand (PD-1/PD-L1) pathway is one of many possible mechanisms of immune-evasion relevant to Epstein-Barr virus (EBV)- associated nasopharyngeal cancer (NPC). The therapeutic targeting of the PD-1/ ...

Abstract	Upregulation of the programmed cell death receptor-1 and ligand (PD-1/PD-L1) pathway is one of many possible mechanisms of immune-evasion relevant to Epstein-Barr virus (EBV)- associated nasopharyngeal cancer (NPC). The therapeutic targeting of the PD-1/ PD-L1 axis is an area of active research in NPC and at least 8 monoclonal or bi-specific antibodies targeting this axis are currently under clinical evaluation in some of the following clinical settings: (1) palliative treatment of recurrent and/or metastatic (R/M) disease; (2) radical treatment of locoregionally advanced disease in adjunct to conventional chemoradiotherapy; (3) local/ regional recurrence. PD-1 antibodies as monotherapy has been reported to yield an overall objective response in around 20-30% of patients with R/M NPC in single-armed phase II trials, and the predictive role of PD-L1 expression in NPC remains to be defined. As with other solid tumors, combinatorial strategies with cytotoxic chemotherapy, radiotherapy or other immunotherapeutic agents (such as other immune-checkpoint inhibitors, EBV-targeting cellular therapy and other immune-modulating agents) and vascular endothelial growth factor/receptor antibodies are actively being evaluated in clinical trials with single-armed or randomized designs. This article will review the scientific rationale of targeting the PD1/PD-L1 axis in NPC, and summarizes the latest trials involving these agents and predictive biomarkers of response to PD-1/PD-L1 antibodies in NPC.
MeSH term(s)	Humans ; Immune Checkpoint Inhibitors/pharmacology ; Immune Checkpoint Inhibitors/therapeutic use ; Nasopharyngeal Carcinoma/drug therapy ; Nasopharyngeal Carcinoma/pathology ; Programmed Cell Death 1 Receptor/antagonists & inhibitors
Chemical Substances	Immune Checkpoint Inhibitors ; Programmed Cell Death 1 Receptor
Language	English
Publishing date	2021-01-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1120465-5
ISSN	1879-0593 ; 0964-1955 ; 1368-8375
ISSN (online)	1879-0593
ISSN	0964-1955 ; 1368-8375
DOI	10.1016/j.oraloncology.2020.105127
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Article ; Online: The expanding universe of checkpoint inhibitors for nasopharyngeal cancer.

Ma, Brigette B Y / Hui, Edwin P / Chan, Anthony T C

Nature medicine

2021 Volume 27, Issue 9, Page(s) 1512–1513

MeSH term(s)	Humans ; Nasopharyngeal Carcinoma/drug therapy ; Nasopharyngeal Neoplasms/drug therapy
Language	English
Publishing date	2021-09-13
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1220066-9
ISSN	1546-170X ; 1078-8956
ISSN (online)	1546-170X
ISSN	1078-8956
DOI	10.1038/s41591-021-01482-8
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Article ; Online: Current advances in targeted therapy for metastatic colorectal cancer - Clinical translation and future directions.

Johnson, David / Chee, Cheng Ean / Wong, Wesley / Lam, Rachel C T / Tan, Iain Bee Huat / Ma, Brigette B Y

Cancer treatment reviews

2024 Volume 125, Page(s) 102700

Abstract: The last two decades have witnessed major breakthroughs in the development of targeted therapy for patients with metastatic colorectal cancer (mCRC), an achievement which stems largely from advances in translational research. Precision medicine is now ... ...

Abstract	The last two decades have witnessed major breakthroughs in the development of targeted therapy for patients with metastatic colorectal cancer (mCRC), an achievement which stems largely from advances in translational research. Precision medicine is now widely practiced in routine oncological care, where systemic therapy is individualized based on clinical factors such as primary tumor sidedness, location and number of metastases, as well as molecular factors such as the RAS and BRAF mutation status, mismatch repair / microsatellite status and presence of other actionable genomic alterations in the tumor. The optimal selection of patients with RAS and BRAF-wild type (WT), left-sided primary tumor for treatment with epidermal growth factor receptor (EGFR) and chemotherapy (chemo) has markedly improved survival in the first-line setting. The pivotal trials of cetuximab in combination with BRAF/ MEK inhibitor for BRAF V600E mutant mCRC, and panitumumab with KRAS G12C inhibitor in KRAS(G12C)-mutant mCRC have been practice-changing. Anti-HER2 small molecular inhibitor, antibodies and antibody-drug conjugates have significantly improved the treatment outcome of patients with HER2 amplified mCRC. Anti-angiogenesis agents are now used across all lines of treatment and novel combinations with immune-checkpoint inhibitors are under active investigation in MSS mCRC. The non-invasive monitoring of molecular resistance to targeted therapies using Next Generation Sequencing analysis of circulating tumor-derived DNA (ctDNA) and captured sequencing of tumors have improved patient selection for targeted therapies. This review will focus on how latest advances, challenges and future directions in the development of targeted therapies in mCRC.
MeSH term(s)	Humans ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Proto-Oncogene Proteins B-raf/genetics ; Proto-Oncogene Proteins p21(ras) ; Panitumumab/therapeutic use ; Cetuximab/therapeutic use ; Colonic Neoplasms ; Rectal Neoplasms
Chemical Substances	Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2) ; Panitumumab (6A901E312A) ; Cetuximab (PQX0D8J21J)
Language	English
Publishing date	2024-02-24
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	125102-8
ISSN	1532-1967 ; 0305-7372
ISSN (online)	1532-1967
ISSN	0305-7372
DOI	10.1016/j.ctrv.2024.102700
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Article ; Online: The emerging data on choice of optimal therapy for locally advanced nasopharyngeal carcinoma.

Hui, Edwin Pun / Ma, Brigette B Y / Chan, Anthony T C

Current opinion in oncology

2020 Volume 32, Issue 3, Page(s) 187–195

Abstract: Purpose of review: We focus on the emerging data from randomized clinical trials for optimal integration of induction, concurrent, and/or adjuvant chemotherapy with intensity-modulated radiotherapy in locally advanced nasopharyngeal carcinoma (NPC), and ...

Abstract	Purpose of review: We focus on the emerging data from randomized clinical trials for optimal integration of induction, concurrent, and/or adjuvant chemotherapy with intensity-modulated radiotherapy in locally advanced nasopharyngeal carcinoma (NPC), and the use of plasma Epstein-Barr virus (EBV) DNA for risk stratification. Recent findings: Several phase 3 trials have shown that induction chemotherapy followed by concurrent chemoradiation (CRT) improved overall survival or disease-free survival when compared to CRT alone in stage III/IV NPC who is at high risk of distant metastases. The benefit of adjuvant chemotherapy following CRT when compared to CRT alone is uncertain. There are increasing clinical data supporting the use of plasma EBV DNA for risk stratification. There are growing clinical data supporting the integration of immune checkpoint inhibitors into the induction, concurrent, and/or adjuvant/maintenance phase of treatment in locally advanced NPC. Summary: Concurrent chemoradiation remains the standard treatment backbone in locally advanced NPC. There is level 1 evidence for induction chemotherapy followed by CRT in stage III/IV NPC. There is increasing evidence against the indiscriminate use of adjuvant chemotherapy following CRT. With the increasing treatment intensification, future treatment algorithm in NPC should incorporate plasma EBV DNA and other biomarkers for risk stratification and treatment selection.
MeSH term(s)	Chemoradiotherapy ; Clinical Trials, Phase III as Topic ; Humans ; Induction Chemotherapy ; Nasopharyngeal Neoplasms/drug therapy ; Nasopharyngeal Neoplasms/pathology ; Nasopharyngeal Neoplasms/radiotherapy ; Neoplasm Staging ; Radiotherapy, Intensity-Modulated ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2020-01-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1049384-0
ISSN	1531-703X ; 1040-8746
ISSN (online)	1531-703X
ISSN	1040-8746
DOI	10.1097/CCO.0000000000000622
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Article ; Online: Opportunities and challenges in combining immunotherapy and radiotherapy in head and neck cancers.

Wong, Kenneth C W / Johnson, David / Hui, Edwin P / Lam, Rachel C T / Ma, Brigette B Y / Chan, Anthony T C

Cancer treatment reviews

2022 Volume 105, Page(s) 102361

Abstract: Locally advanced and recurrent/ metastatic (R/M) head and neck cancers have poor prognosis generally. Radiotherapy (RT) is known to have multiple immunomodulatory effects, and various immune checkpoint inhibitors (ICIs) have been shown to be efficacious ... ...

Abstract	Locally advanced and recurrent/ metastatic (R/M) head and neck cancers have poor prognosis generally. Radiotherapy (RT) is known to have multiple immunomodulatory effects, and various immune checkpoint inhibitors (ICIs) have been shown to be efficacious in the R/M setting in recent years. Hence, it is logical to combine RT and ICIs to improve the outlook for such patients, especially in view of the promising pre-clinical data on this novel combination. In this review, we highlighted the key mechanisms underlying the immunostimulatory and immunoinhibitory effects of RT, with a view to suggesting strategies to overcome radioresistance. We also discussed how the unique immune landscapes of virus-induced cancers, namely Epstein-Barr virus-induced nasopharyngeal carcinoma and human papillomavirus-mediated oropharyngeal cancer, could be exploited with ICIs. The landmark clinical trials in both the locally advanced and R/M settings were reviewed, and these trials showed that the combination of RT and ICIs is generally well tolerated. The potential reasons behind the largely negative results of these studies were also explored, focusing on various parameters including dose fractionation, sequencing, irradiated volume and the use of predictive biomarkers.
MeSH term(s)	Epstein-Barr Virus Infections/complications ; Head and Neck Neoplasms/drug therapy ; Head and Neck Neoplasms/radiotherapy ; Herpesvirus 4, Human ; Humans ; Immunotherapy/methods ; Nasopharyngeal Neoplasms ; Neoplasm Recurrence, Local/drug therapy ; Squamous Cell Carcinoma of Head and Neck
Language	English
Publishing date	2022-02-16
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	125102-8
ISSN	1532-1967 ; 0305-7372
ISSN (online)	1532-1967
ISSN	0305-7372
DOI	10.1016/j.ctrv.2022.102361
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Article ; Online: Radiologic extranodal extension for nodal staging in nasopharyngeal carcinoma.

Ai, Qi Yong H / King, Ann D / Yuan, Hui / Vardhanabhuti, Varut / Mo, Frankie K F / Hung, Kuo Feng / Hui, Edwin P / Kwong, Dora Lai-Wan / Lee, Victor Ho-Fun / Ma, Brigette B Y

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

2023 Volume 191, Page(s) 110050

Abstract: Purpose: Extranodal extension (ENE) has the potential to add value to the current nodal staging system (N: Methods & materials: Pre-treatment MRI of 750 patients from the internal cohort were retrospectively reviewed. Predictive values of six ... ...

Abstract	Purpose: Extranodal extension (ENE) has the potential to add value to the current nodal staging system (N Methods & materials: Pre-treatment MRI of 750 patients from the internal cohort were retrospectively reviewed. Predictive values of six modified nodal staging systems that incorporated four patterns of ENE and two patterns of CNN to the current stage N3 for disease-free survival (DFS) were compared with that of N Results: Incorporation of advanced ENE, which infiltrates into adjacent muscle/skin/salivary glands outperformed the other five modifications for predicting outcomes (p < 0.01) and achieved a significantly higher c-index for 5-year DFS (0.69 vs 0.72) (p < 0.01) when compared with that of N Conclusion: Results from two centre cohorts confirmed that the radiological advanced ENE should be considered as a criterion for stage N3 disease in NPC.
MeSH term(s)	Humans ; Nasopharyngeal Carcinoma/diagnostic imaging ; Nasopharyngeal Carcinoma/pathology ; Retrospective Studies ; Extranodal Extension/pathology ; Neoplasm Staging ; Neoplasm Recurrence, Local/pathology ; Prognosis ; Nasopharyngeal Neoplasms/diagnostic imaging ; Nasopharyngeal Neoplasms/radiotherapy ; Lymph Nodes/diagnostic imaging ; Lymph Nodes/pathology
Language	English
Publishing date	2023-12-13
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	605646-5
ISSN	1879-0887 ; 0167-8140
ISSN (online)	1879-0887
ISSN	0167-8140
DOI	10.1016/j.radonc.2023.110050
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