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  1. Article: Editorial: Structural and functional venomics as a powerful approach for drug discovery and development.

    Abdel-Rahman, Mohamed A / Cao, Zhijian / Abd El-Aziz, Tarek Mohamed / Strong, Peter N / Sabatier, Jean-Marc

    Frontiers in pharmacology

    2024  Volume 15, Page(s) 1405681

    Language English
    Publishing date 2024-04-10
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1405681
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  2. Article ; Online: Snake Venom: A Promising Source of Neurotoxins Targeting Voltage-Gated Potassium Channels.

    AlShammari, Altaf K / Abd El-Aziz, Tarek Mohamed / Al-Sabi, Ahmed

    Toxins

    2023  Volume 16, Issue 1

    Abstract: The venom derived from various sources of snakes represents a vast collection of predominantly protein-based toxins that exhibit a wide range of biological actions, including but not limited to inflammation, pain, cytotoxicity, cardiotoxicity, and ... ...

    Abstract The venom derived from various sources of snakes represents a vast collection of predominantly protein-based toxins that exhibit a wide range of biological actions, including but not limited to inflammation, pain, cytotoxicity, cardiotoxicity, and neurotoxicity. The venom of a particular snake species is composed of several toxins, while the venoms of around 600 venomous snake species collectively encompass a substantial reservoir of pharmacologically intriguing compounds. Despite extensive research efforts, a significant portion of snake venoms remains uncharacterized. Recent findings have demonstrated the potential application of neurotoxins derived from snake venom in selectively targeting voltage-gated potassium channels (Kv). These neurotoxins include BPTI-Kunitz polypeptides, PLA
    MeSH term(s) Humans ; Neurotoxins/toxicity ; Potassium Channels, Voltage-Gated ; Snake Venoms ; Neurotoxicity Syndromes ; Cardiotoxicity
    Chemical Substances Neurotoxins ; Potassium Channels, Voltage-Gated ; Snake Venoms
    Language English
    Publishing date 2023-12-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518395-3
    ISSN 2072-6651 ; 2072-6651
    ISSN (online) 2072-6651
    ISSN 2072-6651
    DOI 10.3390/toxins16010012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Optogenetic Control of PIP2 Interactions Shaping ENaC Activity.

    Abd El-Aziz, Tarek Mohamed / Kaur, Amanpreet / Shapiro, Mark S / Stockand, James D / Archer, Crystal R

    International journal of molecular sciences

    2022  Volume 23, Issue 7

    Abstract: The activity of the epithelial ... ...

    Abstract The activity of the epithelial Na
    MeSH term(s) Binding Sites ; Epithelial Sodium Channels/metabolism ; Optogenetics ; Phosphatidylinositol 4,5-Diphosphate/metabolism ; Phosphatidylinositols/metabolism ; Sodium/metabolism
    Chemical Substances Epithelial Sodium Channels ; Phosphatidylinositol 4,5-Diphosphate ; Phosphatidylinositols ; Sodium (9NEZ333N27)
    Language English
    Publishing date 2022-03-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23073884
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  4. Article ; Online: MITOCHONDRIA: The dual function of the transient receptor potential melastatin 2 channels from cytomembrane to mitochondria.

    Zhang, Xiao-Min / Song, Ying / Zhu, Xin-Yi / Wang, Wen-Jun / Fan, Xu-Li / El-Aziz, Tarek Mohamed Abd

    The international journal of biochemistry & cell biology

    2023  Volume 157, Page(s) 106374

    Abstract: Mitochondria are closely related to oxidative stress and play an important role in maintaining cell functional homeostasis and meeting cell energy demand. The transient receptor potential melastatin 2 (TRPM2) channel affects the occurrence and ... ...

    Abstract Mitochondria are closely related to oxidative stress and play an important role in maintaining cell functional homeostasis and meeting cell energy demand. The transient receptor potential melastatin 2 (TRPM2) channel affects the occurrence and progression of diseases by regulating mitochondrial function. TRPM2 channel promotes Ca
    MeSH term(s) Reactive Oxygen Species/metabolism ; TRPM Cation Channels/genetics ; TRPM Cation Channels/metabolism ; Transient Receptor Potential Channels/metabolism ; Oxidative Stress ; Mitochondria/metabolism ; Calcium/metabolism
    Chemical Substances Reactive Oxygen Species ; TRPM Cation Channels ; Transient Receptor Potential Channels ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2023-01-25
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1228429-4
    ISSN 1878-5875 ; 1357-2725
    ISSN (online) 1878-5875
    ISSN 1357-2725
    DOI 10.1016/j.biocel.2023.106374
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    Zs.A 431: Show issues Location:
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  5. Article ; Online: Recent progress and challenges in drug development against COVID-19 coronavirus (SARS-CoV-2) - an update on the status.

    Abd El-Aziz, Tarek Mohamed / Stockand, James D

    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

    2020  Volume 83, Page(s) 104327

    Abstract: Coronaviruses are a large group of viruses known to cause illnesses that vary between the common cold and more severe diseases to include severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). A novel coronavirus was ... ...

    Abstract Coronaviruses are a large group of viruses known to cause illnesses that vary between the common cold and more severe diseases to include severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). A novel coronavirus was identified in December 2019 in Wuhan city, Hubei province, China. This virus represents a new strain that has not been previously identified in humans. The virus is now known as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the resulting disease is called coronavirus disease 2019 (COVID-19). The World Health Organization (WHO) declared the novel coronavirus outbreak a global pandemic in March 2020. Despite rigorous global containment and quarantine efforts, the incidence of COVID-19 continues to rise, with more than 1,948,617 laboratory-confirmed cases and over 121,846 deaths worldwide. Currently, no specific medication is recommended to treat COVID-19 patients. However, governments and pharmaceutical companies are struggling to quickly find an effective drug to defeat the coronavirus. In the current review, we summarize the existing state of knowledge about COVID-19, available medications, and treatment options. Favilavir is an antiviral drug that is approved in Japan for common influenza treatment and is now approved to treat symptoms of COVID-19 in China. Moreover, Chloroquine and hydroxychloroquine, drugs used to treat malaria and arthritis, respectively, were recommended by the National Health Commission of the People's Republic of China for treatment of COVID-19. Presently, chloroquine and hydroxychloroquine are under investigation by the US Food and Drug Administration (FDA) as a treatment for COVID-19. The first COVID-19 vaccine is not expected to be ready for clinical trials before the end of the year.
    MeSH term(s) Animals ; Antiviral Agents/pharmacology ; Betacoronavirus/physiology ; COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Coronavirus Infections/pathology ; Drug Development ; Humans ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/pathology ; SARS-CoV-2 ; Zoonoses
    Chemical Substances Antiviral Agents
    Keywords covid19
    Language English
    Publishing date 2020-04-19
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2037068-4
    ISSN 1567-7257 ; 1567-1348
    ISSN (online) 1567-7257
    ISSN 1567-1348
    DOI 10.1016/j.meegid.2020.104327
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5645: Show issues Location:
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  6. Article ; Online: P2Y2 receptor decreases blood pressure by inhibiting ENaC.

    Soares, Antonio G / Contreras, Jorge / Mironova, Elena / Archer, Crystal R / Stockand, James D / Abd El-Aziz, Tarek Mohamed

    JCI insight

    2023  Volume 8, Issue 14

    Abstract: Stimulating the Gq-coupled P2Y2 receptor (P2ry2) lowers blood pressure. Global knockout of P2ry2 increases blood pressure. Vascular and renal mechanisms are believed to participate in P2ry2 effects on blood pressure. To isolate the role of the kidneys in ...

    Abstract Stimulating the Gq-coupled P2Y2 receptor (P2ry2) lowers blood pressure. Global knockout of P2ry2 increases blood pressure. Vascular and renal mechanisms are believed to participate in P2ry2 effects on blood pressure. To isolate the role of the kidneys in P2ry2 effects on blood pressure and to reveal the molecular and cellular mechanisms of this action, we test here the necessity of the P2ry2 and the sufficiency of Gq-dependent signaling in renal principal cells to the regulation of the epithelial Na+ channel (ENaC), sodium excretion, and blood pressure. Activating P2ry2 in littermate controls but not principal cell-specific P2ry2-knockout mice decreased the activity of ENaC in renal tubules. Moreover, deletion of P2ry2 in principal cells abolished increases in sodium excretion in response to stimulation of P2ry2 and compromised the normal ability to excrete a sodium load. Consequently, principal cell-specific knockout of P2ry2 prevented decreases in blood pressure in response to P2ry2 stimulation in the deoxycorticosterone acetate-salt (DOCA-salt) model of hypertension. In wild-type littermate controls, such stimulation decreased blood pressure in this model of hypertension by promoting a natriuresis. Pharmacogenetic activation of Gq exclusively in principal cells using targeted expression of Gq-designer receptors exclusively activated by designer drugs and clozapine N-oxide decreased the activity of ENaC in renal tubules, promoting a natriuresis that lowered elevated blood pressure in the DOCA-salt model of hypertension. These findings demonstrate that the kidneys play a major role in decreasing blood pressure in response to P2ry2 activation and that inhibition of ENaC activity in response to P2ry2-mediated Gq signaling lowered blood pressure by increasing renal sodium excretion.
    MeSH term(s) Mice ; Animals ; Blood Pressure/physiology ; Receptors, Purinergic P2Y2/genetics ; Desoxycorticosterone Acetate ; Sodium/metabolism ; Hypertension/metabolism ; Mice, Knockout
    Chemical Substances Receptors, Purinergic P2Y2 ; Desoxycorticosterone Acetate (6E0A168OB8) ; Sodium (9NEZ333N27)
    Language English
    Publishing date 2023-07-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2379-3708
    ISSN (online) 2379-3708
    DOI 10.1172/jci.insight.167704
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  7. Article ; Online: Human recombinant soluble ACE2 (hrsACE2) shows promise for treating severe COVID-19.

    Abd El-Aziz, Tarek Mohamed / Al-Sabi, Ahmed / Stockand, James D

    Signal transduction and targeted therapy

    2020  Volume 5, Issue 1, Page(s) 258

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Peptidyl-Dipeptidase A ; Pneumonia, Viral ; SARS-CoV-2
    Chemical Substances Peptidyl-Dipeptidase A (EC 3.4.15.1)
    Keywords covid19
    Language English
    Publishing date 2020-11-03
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-020-00374-6
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  8. Article ; Online: Advances in venomics: Modern separation techniques and mass spectrometry.

    Abd El-Aziz, Tarek Mohamed / Soares, Antonio G / Stockand, James D

    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

    2020  Volume 1160, Page(s) 122352

    Abstract: Snake venoms are complex chemical mixtures of biologically active proteins and non-protein components. Toxins have a wide range of targets and effects to include ion channels and membrane receptors, and platelet aggregation and platelet plug formation. ... ...

    Abstract Snake venoms are complex chemical mixtures of biologically active proteins and non-protein components. Toxins have a wide range of targets and effects to include ion channels and membrane receptors, and platelet aggregation and platelet plug formation. Toxins target these effectors and effects at high affinity and selectivity. From a pharmacological perspective, snake venom compounds are a valuable resource for drug discovery and development. However, a major challenge to drug discovery using snake venoms is isolating and analyzing the bioactive proteins and peptides in these complex mixtures. Getting molecular information from complex mixtures such as snake venoms requires proteomic analyses, generally combined with transcriptomic analyses of venom glands. The present review summarizes current knowledge and highlights important recent advances in venomics with special emphasis on contemporary separation techniques and bioinformatics that have begun to elaborate the complexity of snake venoms. Several analytical techniques such as two-dimensional gel electrophoresis, RP-HPLC, size exclusion chromatography, ion exchange chromatography, MALDI-TOF-MS, and LC-ESI-QTOF-MS have been employed in this regard. The improvement of separation approaches such as multidimensional-HPLC, 2D-electrophoresis coupled to soft-ionization (MALDI and ESI) mass spectrometry has been critical to obtain an accurate picture of the startling complexity of venoms. In the case of bioinformatics, a variety of software tools such as PEAKS also has been used successfully. Such information gleaned from venomics is important to both predicting and resolving the biological activity of the active components of venoms, which in turn is key for the development of new drugs based on these venom components.
    MeSH term(s) Animals ; Arthropods ; Chromatography, Liquid ; Drug Discovery ; Electrophoresis, Gel, Two-Dimensional ; Mass Spectrometry ; Proteome/analysis ; Proteome/chemistry ; Proteome/isolation & purification ; Proteomics ; Snails ; Snakes ; Venoms/analysis ; Venoms/chemistry ; Venoms/isolation & purification
    Chemical Substances Proteome ; Venoms
    Language English
    Publishing date 2020-09-17
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1180823-8
    ISSN 1873-376X ; 0378-4347 ; 1570-0232 ; 1387-2273
    ISSN (online) 1873-376X
    ISSN 0378-4347 ; 1570-0232 ; 1387-2273
    DOI 10.1016/j.jchromb.2020.122352
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 813: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Investigating the structure-activity relationship of marine polycyclic batzelladine alkaloids as promising inhibitors for SARS-CoV-2 main protease (M

    Elgohary, Alaa M / Elfiky, Abdo A / Pereira, Florbela / Abd El-Aziz, Tarek Mohamed / Sobeh, Mansour / Arafa, Reem K / El-Demerdash, Amr

    Computers in biology and medicine

    2022  Volume 147, Page(s) 105738

    Abstract: Over a span of two years ago, since the emergence of the first case of the novel coronavirus (SARS-CoV-2) in China, the pandemic has crossed borders causing serious health emergencies, immense economic crisis and impacting the daily life worldwide. ... ...

    Abstract Over a span of two years ago, since the emergence of the first case of the novel coronavirus (SARS-CoV-2) in China, the pandemic has crossed borders causing serious health emergencies, immense economic crisis and impacting the daily life worldwide. Despite the discovery of numerous forms of precautionary vaccines along with other recently approved orally available drugs, yet effective antiviral therapeutics are necessarily needed to hunt this virus and its variants. Historically, naturally occurring chemicals have always been considered the primary source of beneficial medications. Considering the SARS-CoV-2 main protease (M
    MeSH term(s) Alkaloids/pharmacology ; Antiviral Agents/chemistry ; Coronavirus 3C Proteases ; Humans ; Ligands ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Protease Inhibitors/chemistry ; Protease Inhibitors/pharmacology ; SARS-CoV-2 ; Structure-Activity Relationship ; Viral Nonstructural Proteins/chemistry ; COVID-19 Drug Treatment
    Chemical Substances Alkaloids ; Antiviral Agents ; Ligands ; Protease Inhibitors ; Viral Nonstructural Proteins ; 3C-like proteinase, SARS-CoV-2 (EC 3.4.22.-) ; Coronavirus 3C Proteases (EC 3.4.22.28)
    Language English
    Publishing date 2022-06-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 127557-4
    ISSN 1879-0534 ; 0010-4825
    ISSN (online) 1879-0534
    ISSN 0010-4825
    DOI 10.1016/j.compbiomed.2022.105738
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    Zs.A 653: Show issues Location:
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  10. Article: Stimulation of the Epithelial Na

    Soares, Antonio G / Contreras, Jorge / Archer, Crystal R / Mironova, Elena / Berdeaux, Rebecca / Stockand, James D / Abd El-Aziz, Tarek Mohamed

    Frontiers in physiology

    2021  Volume 12, Page(s) 725782

    Abstract: The activity of the Epithelial ... ...

    Abstract The activity of the Epithelial Na
    Language English
    Publishing date 2021-08-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2021.725782
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