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Article ; Online: Systemic Therapy for Advanced Hepatocellular Carcinoma: ASCO Guideline Update Clinical Insights.

Rose, Michal G / Kennedy, Erin B / Abou-Alfa, Ghassan K / Finn, Richard S / Gade, Terence / Kelley, R Kate / Taddei, Tamar / Gordan, John D

JCO oncology practice

2024 , Page(s) OP2400189

Language	English
Publishing date	2024-04-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	3028198-2
ISSN	2688-1535 ; 2688-1527
ISSN (online)	2688-1535
ISSN	2688-1527
DOI	10.1200/OP.24.00189
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Book: The Skadar/Shkodra Lake environment

Barović, Goran / Pešić, Vladimir / Karaman, Gordan S. / Kostjanoj, Andrej Gennadʹevič

(The handbook of environmental chemistry ; volume 80)

2018

Author's details	volume editors: Vladimir Pešić, Gordan Karaman, Andrey G. Kostianoy ; with contributions by G. Barović [und 49 weiteren]
Series title	The handbook of environmental chemistry ; volume 80
Collection
Keywords	Environmental chemistry ; Sedimentology ; Aquatic biology ; Nationalpark Skutarisee ; Ökosystem ; Klimaänderung
Subject	Klima ; Klimawandel ; Klimaveränderung ; Klimawechsel ; Biosystem ; Ökosysteme
Subject code	577.14
Language	English
Size	xiii, 508 Seiten, Illustrationen, Diagramme, Karten
Publisher	Springer
Publishing place	Cham
Publishing country	Switzerland
Document type	Book
HBZ-ID	HT019861113
ISBN	978-3-319-99249-5 ; 9783319992501 ; 3-319-99249-X ; 3319992503
Database	Catalogue ZB MED Nutrition, Environment, Agriculture

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188/608	available for loan (reading room)	Freihandmagazin (U1)

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Article ; Online: The dynamic brain N-glycome.

Klarić, Thomas S / Lauc, Gordan

Glycoconjugate journal

2022 Volume 39, Issue 3, Page(s) 443–471

Abstract: The attachment of carbohydrates to other macromolecules, such as proteins or lipids, is an important regulatory mechanism termed glycosylation. One subtype of protein glycosylation is asparagine-linked glycosylation (N-glycosylation) which plays a key ... ...

Abstract	The attachment of carbohydrates to other macromolecules, such as proteins or lipids, is an important regulatory mechanism termed glycosylation. One subtype of protein glycosylation is asparagine-linked glycosylation (N-glycosylation) which plays a key role in the development and normal functioning of the vertebrate brain. To better understand the role of N-glycans in neurobiology, it's imperative we analyse not only the functional roles of individual structures, but also the collective impact of large-scale changes in the brain N-glycome. The systematic study of the brain N-glycome is still in its infancy and data are relatively scarce. Nevertheless, the prevailing view has been that the neuroglycome is inherently restricted with limited capacity for variation. The development of improved methods for N-glycomics analysis of brain tissue has facilitated comprehensive characterisation of the complete brain N-glycome under various experimental conditions on a larger scale. Consequently, accumulating data suggest that it's more dynamic than previously recognised and that, within a general framework, it has a given capacity to change in response to both intrinsic and extrinsic stimuli. Here, we provide an overview of the many factors that can alter the brain N-glycome, including neurodevelopment, ageing, diet, stress, neuroinflammation, injury, and disease. Given this emerging evidence, we propose that the neuroglycome has a hitherto underappreciated plasticity and we discuss the therapeutic implications of this regarding the possible reversal of pathological changes via interventions. We also briefly review the merits and limitations of N-glycomics as an analytical method before reflecting on some of the outstanding questions in the field.
MeSH term(s)	Brain/metabolism ; Glycomics ; Glycosylation ; Polysaccharides/chemistry
Chemical Substances	Polysaccharides
Language	English
Publishing date	2022-03-25
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	283770-5
ISSN	1573-4986 ; 0282-0080
ISSN (online)	1573-4986
ISSN	0282-0080
DOI	10.1007/s10719-022-10055-x
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Article: Long-term follow-up of complete remission in a patient with advanced hepatocellular carcinoma treated with sorafenib: a case report.

Adžić, Gordan / Prejac, Juraj / Pleština, Stjepko

Frontiers in oncology

2023 Volume 13, Page(s) 1260989

Abstract: Introduction: Hepatocellular carcinoma (HCC) accounts for approximately 90% of primary liver cancer and can be caused by well-known risk factors, including infection with hepatitis B and C viruses, alcohol intake, and metabolic syndrome. The overall ... ...

Abstract	Introduction: Hepatocellular carcinoma (HCC) accounts for approximately 90% of primary liver cancer and can be caused by well-known risk factors, including infection with hepatitis B and C viruses, alcohol intake, and metabolic syndrome. The overall prognosis remains poor with a median survival of 1 year for symptomatic advanced-stage cases treated with systemic therapies. Case description: In July 2020, a 73-year-old male patient presented at our institution with mild abdominal pain and an attack of intense cold. After a radiological workup, the diagnosis of HCC located in the caudate lobe was established. The patient underwent atypical caudate lobe resection, and pathology confirmed the diagnosis of grade 3 HCC. Postoperative MRI showed a new metastasis in the 6th liver segment 1.3 cm in diameter, and a PVT progression which now affected the whole right lobe. The patient was started on sorafenib and demonstrated a complete response which still lasts for more than two years. Conclusion: We present a rare case of a patient who demonstrated a complete response to sorafenib treatment in advanced HCC with unfavorable prognostic factors.
Language	English
Publishing date	2023-10-10
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1260989
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Article ; Online: Anticholinergic Toxidrome as a Possible Explanation for Methylene Blue Toxicity.

Aldeghaither, Saud / Deschênes, Patrick Jean Francesco / Samoukovic, Gordan

The American journal of case reports

2023 Volume 24, Page(s) e941453

Abstract: BACKGROUND Methylene blue has multiple uses in medicine. It is generally used to treat refractory vasoplegia and methemoglobin toxicity, and can be used as a dye to localize the parathyroid glands intra-operatively. In refractory vasoplegia, methylene ... ...

Abstract	BACKGROUND Methylene blue has multiple uses in medicine. It is generally used to treat refractory vasoplegia and methemoglobin toxicity, and can be used as a dye to localize the parathyroid glands intra-operatively. In refractory vasoplegia, methylene blue inhibits endothelial nitric oxide and guanylate cyclase, causing vasoconstriction and potentially stabilizing blood pressure. Multiple complications have been associated with the use of methylene blue. These are related to either the sole effect of methylene blue or the combined effect of methylene blue and certain antidepressants, such as selective serotonin reuptake inhibitors (SSRIs). To the best of our knowledge, in the setting of post-cardiac surgery vasoplegia, there have been no reports of the neurological toxicity of methylene blue in the absence of SSRI use. In this case report, we describe the anticholinergic manifestations associated with the use of methylene blue in post-cardiac surgery vasoplegia. CASE REPORT A male patient in his mid-sixties with severe mitral regurgitation underwent elective mitral valve replacement. Postoperatively, he was hypotensive and required a high dose of vasopressors. Methylene blue was administered to treat refractory vasoplegia. The patient became anuric and febrile, with bilateral mydriasis. Internal cooling and continuous renal replacement therapy were initiated, and symptoms rapidly resolved. The patient was discharged after prolonged hospitalization with a permanent catheter for hemodialysis. CONCLUSIONS Anticholinergic toxidrome may explain the neurological adverse effects associated with high doses of methylene blue. Physicians should be cautious when using methylene blue in combination with other anticholinergic drugs and in conditions of renal failure. The development of methylene blue toxicity warrants the urgent discontinuation of the agent and early drug elimination.
MeSH term(s)	Humans ; Male ; Methylene Blue/therapeutic use ; Methylene Blue/pharmacology ; Vasoplegia/drug therapy ; Vasoplegia/chemically induced ; Cardiac Surgical Procedures ; Hypotension ; Heart
Chemical Substances	Methylene Blue (T42P99266K)
Language	English
Publishing date	2023-11-15
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2517183-5
ISSN	1941-5923 ; 1941-5923
ISSN (online)	1941-5923
ISSN	1941-5923
DOI	10.12659/AJCR.941453
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Article ; Online: Recruitment of BAG2 to DNAJ-PKAc scaffolds promotes cell survival and resistance to drug-induced apoptosis in fibrolamellar carcinoma.

Lauer, Sophia M / Omar, Mitchell H / Golkowski, Martin G / Kenerson, Heidi L / Lee, Kyung-Soon / Pascual, Bryan C / Lim, Huat C / Forbush, Katherine / Smith, F Donelson / Gordan, John D / Ong, Shao-En / Yeung, Raymond S / Scott, John D

Cell reports

2024 Volume 43, Issue 2, Page(s) 113678

Abstract: The DNAJ-PKAc fusion kinase is a defining feature of fibrolamellar carcinoma (FLC). FLC tumors are notoriously resistant to standard chemotherapies, with aberrant kinase activity assumed to be a contributing factor. By combining proximity proteomics, ... ...

Abstract	The DNAJ-PKAc fusion kinase is a defining feature of fibrolamellar carcinoma (FLC). FLC tumors are notoriously resistant to standard chemotherapies, with aberrant kinase activity assumed to be a contributing factor. By combining proximity proteomics, biochemical analyses, and live-cell photoactivation microscopy, we demonstrate that DNAJ-PKAc is not constrained by A-kinase anchoring proteins. Consequently, the fusion kinase phosphorylates a unique array of substrates, including proteins involved in translation and the anti-apoptotic factor Bcl-2-associated athanogene 2 (BAG2), a co-chaperone recruited to the fusion kinase through association with Hsp70. Tissue samples from patients with FLC exhibit increased levels of BAG2 in primary and metastatic tumors. Furthermore, drug studies implicate the DNAJ-PKAc/Hsp70/BAG2 axis in potentiating chemotherapeutic resistance. We find that the Bcl-2 inhibitor navitoclax enhances sensitivity to etoposide-induced apoptosis in cells expressing DNAJ-PKAc. Thus, our work indicates BAG2 as a marker for advanced FLC and a chemotherapeutic resistance factor in DNAJ-PKAc signaling scaffolds.
MeSH term(s)	Humans ; Cell Survival ; Carcinoma, Hepatocellular/drug therapy ; Apoptosis ; HSP70 Heat-Shock Proteins ; Proto-Oncogene Proteins c-bcl-2 ; Molecular Chaperones
Chemical Substances	HSP70 Heat-Shock Proteins ; Proto-Oncogene Proteins c-bcl-2 ; BAG2 protein, human ; Molecular Chaperones
Language	English
Publishing date	2024-01-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2024.113678
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Article ; Online: Association of age at menopause and age at menarche with later-life skeletal fragility fractures in Bosnian postmenopausal women.

Kapetanović, Amila / Bajić, Gordan / Sarić, Sabina / Alimanović-Alagić, Rubina / Bonić, Martina / Pleho, Dženan

Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina

2024 Volume 21, Issue 1, Page(s) 154–158

Abstract: Aim To investigate the effects of estrogen-related events (age at menopause, age at menarche) on later-life skeletal fragility in Bosnian postmenopausal women. Methods A total of 100 postmenopausal Bosnian women, aged between 55 and 75 years, were ... ...

Abstract	Aim To investigate the effects of estrogen-related events (age at menopause, age at menarche) on later-life skeletal fragility in Bosnian postmenopausal women. Methods A total of 100 postmenopausal Bosnian women, aged between 55 and 75 years, were included. The women in the study group (n=50) had fragility fractures, and in the control group (n=50) were without fragility fractures. Bone mineral density (BMD) was measured using Dual Energy X-ray Absorptiometry (DXA) on the lumbar spine (L2-L4) and proximal femur. Results No statistically significant difference relating to the age between the groups was found. The average age at menopause was 44.70 years in women with fragility fractures and 51.76 years in women without fragility fracture (p=0.0001). The average age at menarche was 14.30 years in women with fragility fractures and 13.70 years in women without fragility fractures (p=0.140). T score of ≤-2.5 SD was found in 40 (80%) women in the study group, and in eight (16%) women in the control group (p=0.0001). Conclusions Age at menopause, but not age at menarche, was risk factors for later-life fragility fracture in postmenopausal Bosnian women. In addition, fragility fractures correlated with low BMD in this population group.
Language	English
Publishing date	2024-02-01
Publishing country	Bosnia and Herzegovina
Document type	Journal Article
ZDB-ID	2378942-6
ISSN	1840-2445 ; 1840-2445
ISSN (online)	1840-2445
ISSN	1840-2445
DOI	10.17392/1692-23
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Article ; Online: Determination of multi-class pesticides residues of cow and human milk samples from Iran using UHPLC-MS/MS and GC-ECD: A probabilistic health risk assessment.

Ramezani, Sara / Mahdavi, Vahideh / Gordan, Hasti / Rezadoost, Hasan / Oliver Conti, Gea / Mousavi Khaneghah, Amin

Environmental research

2022 Volume 208, Page(s) 112730

Abstract: Raw, pasteurized, powdered cow milk and human milk samples from Tehran, Iran were investigated for the residual of fifty pesticides with the aid of gas chromatography coupled with electron capture detector (GC-ECD) and mass detector for confirmation; and ...

Abstract	Raw, pasteurized, powdered cow milk and human milk samples from Tehran, Iran were investigated for the residual of fifty pesticides with the aid of gas chromatography coupled with electron capture detector (GC-ECD) and mass detector for confirmation; and ultra-high performance liquid chromatography-tandem mass spectroscopy (UHPLC-MS/MS). No pesticide residue was determined in more than 91% of examined samples. However, the dimethoate residue was detected in 3 raw milk samples in levels higher than EU recommended MRL. While in 3 human milk samples, organochlorine pesticides residue, p,p'-DDT, and p,p'-DDD was recognized below MRLs, only in 1 human sample residue of p,p'-DDE was more than CODEX recommended MRL. HI in adults and children were 0.72 and 3.55, respectively. However, the health risk assessment based on HI demonstrated that adult consumers are not at considerable risk. The HI, higher than 1 in children, confirms the risks raised due to ingestion of organochlorine (OCP) and organophosphorus (OPP) pesticides via milk consumption. In addition, no carcinogenic risk to milk consumers was calculated. Therefore, implementation of good farming practices on farms, improving the knowledge and consciousness of pesticide users, use other safe methods for pest control such as biotechnology-based, and use a rational program for application of pesticides, continuous monitoring of pesticides in crops, and strict government regulations on pesticide residues in food are recommended.
MeSH term(s)	Animals ; Cattle ; Chromatography, Gas ; Chromatography, High Pressure Liquid ; Electrons ; Female ; Food Contamination/analysis ; Humans ; Hydrocarbons, Chlorinated/analysis ; Iran ; Milk/chemistry ; Milk, Human/chemistry ; Pesticide Residues/analysis ; Pesticides/analysis ; Risk Assessment ; Tandem Mass Spectrometry/methods
Chemical Substances	Hydrocarbons, Chlorinated ; Pesticide Residues ; Pesticides
Language	English
Publishing date	2022-01-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2022.112730
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Article ; Online: Impact of a Best Practices Program in Patients with Relapsed/Refractory Multiple Myeloma Receiving Selinexor.

Gordan, Lucio N / Ray, David / Ijioma, Stephen C / Dranitsaris, George / Warner, Amanda / Heritage, Trevor / Fink, Matthew / Wenk, David / Chadwick, Paul / Khrystolubova, Natasha / Peles, Shachar

Current oncology (Toronto, Ont.)

2024 Volume 31, Issue 1, Page(s) 501–510

Abstract: Best practice (BP) in cancer care consists of a multifaceted approach comprising individualized treatment plans, evidence-based medicine, the optimal use of supportive care and patient education. We investigated the impact of a BP program in patients ... ...

Abstract	Best practice (BP) in cancer care consists of a multifaceted approach comprising individualized treatment plans, evidence-based medicine, the optimal use of supportive care and patient education. We investigated the impact of a BP program in patients with relapsed/refractory multiple myeloma (RRMM) receiving selinexor. Features of the BP program that were specific to selinexor were initiating selinexor at doses ≤80 mg once weekly and the upfront use of standardized antiemetics. Study endpoints included time to treatment failure (TTF), duration of therapy, dose limiting toxicities and overall survival. Comparative analysis on TTF and duration of therapy was conducted using a log-rank test and multivariate Cox proportional hazard regression. Over the ensuing 12-month post-BP period, 41 patients received selinexor-based therapy compared to 68 patients who received selinexor-based therapy pre-BP implementation. Patients treated in the post-BP period had reductions in TTF (hazard ratio [HR] = 0.50; 95% CI: 0.27 to 0.92). Patients in the pre-BP period were four times more likely to stop therapy than those in the post-period (odds ratio [OR] = 4.0, 95% CI: 1.75 to 9.3). The findings suggest a BP program tailored to selinexor could increase the time to treatment failure, increase treatment duration and lower the incidence of drug limiting toxicities.
MeSH term(s)	Humans ; Multiple Myeloma/drug therapy ; Hydrazines/therapeutic use ; Triazoles/therapeutic use ; Duration of Therapy
Chemical Substances	selinexor (31TZ62FO8F) ; Hydrazines ; Triazoles
Language	English
Publishing date	2024-01-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1236972-x
ISSN	1718-7729 ; 1198-0052
ISSN (online)	1718-7729
ISSN	1198-0052
DOI	10.3390/curroncol31010034
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Article ; Online: Transcriptome of bone marrow-Derived stem cells reveals new inflammatory mediators related to increased survival in patients with multiple myeloma.

Tagliari de Oliveira, Stefania / Binato, Renata / Ellen Broto, Geise / Tomie Takakura, Erika / Navarro Gordan Ferreira Martins, Leticia / Abdelhay, Eliana / Panis, Carolina

Cytokine

2024 Volume 179, Page(s) 156613

Abstract: Although multiple myeloma (MM) is a neoplasm that leads affected individuals to death, little is known about why some patients survive much longer than others. In this context, we investigated the transcriptomic profile of bone marrow hematopoietic stem ... ...

Abstract	Although multiple myeloma (MM) is a neoplasm that leads affected individuals to death, little is known about why some patients survive much longer than others. In this context, we investigated the transcriptomic profile of bone marrow hematopoietic stem cells obtained from MM patients and compared the clinical outcomes of death and survival six months after bone marrow transplantation. The leukapheresis products of 39 patients with MM eligible for autologous transplantation were collected and analyzed. After extraction, the RNA was analyzed using the GeneChip Human Exon 1.0 Array method. The transcriptome profile was analyzed in silico, and the differentially expressed signaling pathways of interest were validated. The results showed a difference in the expression of inflammation-related genes, immune response processes, and the oxidative stress pathway. The in silico study also pointed out the involvement of the NFκB transcription factor in the possible modulation of these genes. We chose to validate molecules participating in these processes, including the cytokines TNF-α, IFN-γ, and TGF-β1; in addition, we measured the levels of oxidative stress mediators (pro-oxidant profile and the total antioxidant capacity). TNF-α levels were significantly reduced in patients who died and were over 50 years old at diagnosis, as well as in patients with plasmacytoma. Increased TNF-α was detected in patients with very high levels of β2-microglobulin. IFN-γ reduction was observed in patients with a complete response to treatment compared to those with a very good response. Patients with plasmacytoma who died also had an increased pro-oxidant profile. These data show the profile of inflammatory response markers that are altered in patients with MM who die quickly and serve as a basis for the development of future studies of markers to predict better survival in this disease.
Language	English
Publishing date	2024-04-20
Publishing country	England
Document type	Journal Article
ZDB-ID	1018055-2
ISSN	1096-0023 ; 1043-4666
ISSN (online)	1096-0023
ISSN	1043-4666
DOI	10.1016/j.cyto.2024.156613
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