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  1. Article ; Online: Synthesis and bioevaluation of water-soluble

    LiWen, Hua / Yanliang, Yi / Tretyakova, Elena V / Smirnova, Anna A / Kazakova, Oxana B / Xiao, Sulong

    Natural product research

    2024  , Page(s) 1–9

    Abstract: ... A series ... ...

    Abstract A series of
    Language English
    Publishing date 2024-04-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2024.2347449
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  2. Article ; Online: Evaluation of A-ring hydroxymethylene-amino- triterpenoids as inhibitors of SARS-CoV-2 spike pseudovirus and influenza H1N1.

    Kazakova, Oxana / Ma, Xinyuan / Tretyakova, Elena / Smirnova, Irina / Slita, Alexander / Sinegubova, Ekaterina / Zarubaev, Vladimir / Jin, Hongwei / Zhou, Demin / Xiao, Sulong

    The Journal of antibiotics

    2023  Volume 77, Issue 1, Page(s) 39–49

    Abstract: A set of triterpene A-ring hydroxymethylene-amino-derivatives was synthesized and their antiviral activity was studied. The synthesized compounds were tested for their potential inhibition of SARS-CoV-2 pseudovirus in BHK-21-hACE2 cells and influenza A/ ... ...

    Abstract A set of triterpene A-ring hydroxymethylene-amino-derivatives was synthesized and their antiviral activity was studied. The synthesized compounds were tested for their potential inhibition of SARS-CoV-2 pseudovirus in BHK-21-hACE2 cells and influenza A/PuertoRico/8/34 (H1N1) virus in MDCK cell culture. Compounds 6, 8 and 19 showed significant anti-SARS-CoV-2 pseudovirus activity with EC
    MeSH term(s) Humans ; COVID-19 ; Influenza A Virus, H1N1 Subtype ; Influenza, Human ; SARS-CoV-2 ; Triterpenes/pharmacology ; Molecular Docking Simulation ; Protein Binding ; Antiviral Agents/pharmacology
    Chemical Substances Triterpenes ; Antiviral Agents
    Language English
    Publishing date 2023-11-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 390800-8
    ISSN 1881-1469 ; 0021-8820 ; 0368-3532
    ISSN (online) 1881-1469
    ISSN 0021-8820 ; 0368-3532
    DOI 10.1038/s41429-023-00677-0
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 207: Show issues Location:
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  3. Article ; Online: Corrigendum to "Inhibition of influenza virus infection by multivalent pentacyclic triterpene-functionalized per-O-methylated cyclodextrin conjugates" [Eur. J. Med. Chem. 134(2017) 133-139].

    Tian, Zhenyu / Si, Longlong / Meng, Kun / Zhou, Xiaoshu / Zhang, Yongmin / Zhou, Demin / Xiao, Sulong

    European journal of medicinal chemistry

    2021  Volume 223, Page(s) 113647

    Language English
    Publishing date 2021-06-18
    Publishing country France
    Document type Published Erratum
    ZDB-ID 188597-2
    ISSN 1768-3254 ; 0009-4374 ; 0223-5234
    ISSN (online) 1768-3254
    ISSN 0009-4374 ; 0223-5234
    DOI 10.1016/j.ejmech.2021.113647
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 784: Show issues Location:
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  4. Article ; Online: Antiviral opportunities of Mannich bases derived from triterpenic N-propargylated indoles.

    Petrova, Anastasiya / Tretyakova, Elena / Khusnutdinova, Elmira / Kazakova, Oxana / Slita, Alexander / Zarubaev, Vladimir / Ma, Xinyuan / Jin, Hongwei / Xu, Huan / Xiao, Sulong

    Chemical biology & drug design

    2023  Volume 103, Issue 1, Page(s) e14370

    Abstract: Oleanolic and glycyrrhetic acids alkyne derivatives were synthesized as a result of propargylation of the indole NH-group condensed with the triterpene A-ring, the following aminomethylation led to a series of Mannich bases. The synthesized compounds ... ...

    Abstract Oleanolic and glycyrrhetic acids alkyne derivatives were synthesized as a result of propargylation of the indole NH-group condensed with the triterpene A-ring, the following aminomethylation led to a series of Mannich bases. The synthesized compounds were tested for their potential inhibition of influenza A/PuertoRico/8/34 (H1N1) virus in Madin-Darby canine kidney (MDCK) cell culture and SARS-CoV-2 pseudovirus in baby hamster kidney-21-human angiotensin-converting enzyme 2 (BHK-21-hACE2) cells. Mannich bases of oleanolic and glycyrrhetic acids N-propargylated indoles 7, 8, and 12 were the most efficacious against influenza virus A with IC
    MeSH term(s) Cricetinae ; Animals ; Dogs ; Humans ; Influenza A Virus, H1N1 Subtype ; Molecular Docking Simulation ; Mannich Bases ; Oleanolic Acid/pharmacology ; SARS-CoV-2 ; Antiviral Agents/pharmacology ; Antiviral Agents/chemistry ; Indoles/pharmacology
    Chemical Substances Mannich Bases ; Oleanolic Acid (6SMK8R7TGJ) ; Antiviral Agents ; Indoles
    Language English
    Publishing date 2023-10-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2216600-2
    ISSN 1747-0285 ; 1747-0277
    ISSN (online) 1747-0285
    ISSN 1747-0277
    DOI 10.1111/cbdd.14370
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  5. Article ; Online: Author Correction: An engineered influenza virus to deliver antigens for lung cancer vaccination.

    Ji, Dezhong / Zhang, Yuanjie / Sun, Jiaqi / Zhang, Bo / Ma, Wenxiao / Cheng, Boyang / Wang, Xinchen / Li, Yuanhao / Mu, Yu / Xu, Huan / Wang, Qi / Zhang, Chuanling / Xiao, Sulong / Zhang, Lihe / Zhou, Demin

    Nature biotechnology

    2023  Volume 42, Issue 3, Page(s) 529

    Language English
    Publishing date 2023-07-14
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 1311932-1
    ISSN 1546-1696 ; 1087-0156
    ISSN (online) 1546-1696
    ISSN 1087-0156
    DOI 10.1038/s41587-023-01884-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2167: Show issues Location:
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    Zs.MO 137: Show issues
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  6. Article: Novel

    Liang, Shuobin / Ma, Xinyuan / Li, Man / Yi, Yanliang / Gao, Qianqian / Zhang, Yongmin / Zhang, Lihe / Zhou, Demin / Xiao, Sulong

    Frontiers in chemistry

    2022  Volume 10, Page(s) 836955

    Abstract: In our continuing efforts toward the design of novel pentacyclic triterpene derivatives as potential anti-influenza virus entry inhibitors, a series of homogeneous heptavalent glycyrrhetinic acid derivatives based ... ...

    Abstract In our continuing efforts toward the design of novel pentacyclic triterpene derivatives as potential anti-influenza virus entry inhibitors, a series of homogeneous heptavalent glycyrrhetinic acid derivatives based on
    Language English
    Publishing date 2022-04-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711776-5
    ISSN 2296-2646
    ISSN 2296-2646
    DOI 10.3389/fchem.2022.836955
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  7. Article ; Online: Abietic, maleopimaric and quinopimaric dipeptide Ugi-4CR derivatives and their potency against influenza A and SARS-CoV-2.

    Tretyakova, Elena V / Ma, Xinyuan / Kazakova, Oxana B / Shtro, Anna A / Petukhova, Galina D / Smirnova, Anna A / Xu, Huan / Xiao, Sulong

    Natural product research

    2022  Volume 37, Issue 12, Page(s) 1954–1960

    Abstract: A set of 12 abietane diterpene derivatives have been synthesised by the Ugi-four component reaction (Ugi-4CR) and tested for cytotoxicity and activity against influenza virus A/Puerto Rico/8/34 (H1N1) and SARS-CoV-2 pseudovirus. Five dipeptide ... ...

    Abstract A set of 12 abietane diterpene derivatives have been synthesised by the Ugi-four component reaction (Ugi-4CR) and tested for cytotoxicity and activity against influenza virus A/Puerto Rico/8/34 (H1N1) and SARS-CoV-2 pseudovirus. Five dipeptide derivatives demonstrated a selectivity index (SI) higher than 10 and IC
    MeSH term(s) Humans ; SARS-CoV-2 ; Influenza A Virus, H1N1 Subtype ; COVID-19 ; Abietanes/pharmacology ; Abietanes/chemistry ; Diterpenes
    Chemical Substances Abietanes ; Diterpenes
    Language English
    Publishing date 2022-08-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2022.2112040
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  8. Article ; Online: Discovery of Pentacyclic Triterpenoid PROTACs as a Class of Effective Hemagglutinin Protein Degraders.

    Li, Haiwei / Wang, Shouxin / Ma, Wenxiao / Cheng, Boyang / Yi, Yanliang / Ma, Xinyuan / Xiao, Sulong / Zhang, Lihe / Zhou, Demin

    Journal of medicinal chemistry

    2022  Volume 65, Issue 10, Page(s) 7154–7169

    Abstract: Influenza hemagglutinin that drives viral entry into cells via the membrane fusion process is an up-and-coming antiviral drug target. Herein, we described for the first time the design, synthesis, and biological characteristics of a new class of ... ...

    Abstract Influenza hemagglutinin that drives viral entry into cells via the membrane fusion process is an up-and-coming antiviral drug target. Herein, we described for the first time the design, synthesis, and biological characteristics of a new class of pentacyclic triterpenoid-based proteolysis targeting chimeras (PROTACs) to enhance the degradation of hemagglutinin target. Among these PROTACs,
    MeSH term(s) Animals ; Chimera/metabolism ; Hemagglutinins ; Humans ; Influenza, Human/drug therapy ; Intercellular Signaling Peptides and Proteins ; Mice ; Proteins/metabolism ; Proteolysis ; Triterpenes/chemistry
    Chemical Substances Hemagglutinins ; Intercellular Signaling Peptides and Proteins ; Proteins ; Triterpenes ; snake venom protein C activator
    Language English
    Publishing date 2022-05-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.1c02013
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 151: Show issues Location:
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  9. Article: hMOF induces cisplatin resistance of ovarian cancer by regulating the stability and expression of MDM2.

    Cai, Mingbo / Xu, Sulong / Jin, Yuxi / Yu, Jingjing / Dai, Shan / Shi, Xiao-Jing / Guo, Ruixia

    Cell death discovery

    2023  Volume 9, Issue 1, Page(s) 179

    Abstract: Histone acetyltransferase human males absent on the first (hMOF) is a member of MYST family which participates in posttranslational chromatin modification by controlling the acetylation level of histone H4K16. Abnormal activity of hMOF occurs in multiple ...

    Abstract Histone acetyltransferase human males absent on the first (hMOF) is a member of MYST family which participates in posttranslational chromatin modification by controlling the acetylation level of histone H4K16. Abnormal activity of hMOF occurs in multiple cancers and biological alteration of hMOF expression can affect diverse cellular functions including cell proliferation, cell cycle progression and embryonic stem cells (ESCs) self-renewal. The relationship between hMOF and cisplatin resistance was investigated in The Cancer Genome Atlas (TCGA) and Genomics of Drug Sensitivity in Cancer (GDSC) database. Lentiviral-mediated hMOF-overexpressed cells or hMOF-knockdown cells were established to investigate its role on cisplatin-based chemotherapy resistance in vitro ovarian cancer cells and animal models. Furthermore, a whole transcriptome analysis with RNA sequencing was used to explore the underlying molecular mechanism of hMOF affecting cisplatin-resistance in ovarian cancer. The data from TCGA analysis and IHC identification demonstrated that hMOF expression was closely associated with cisplatin-resistance in ovarian cancer. The expression of hMOF and cell stemness characteristics increased significantly in cisplatin-resistant OVCAR3/DDP cells. In the low hMOF expressing ovarian cancer OVCAR3 cells, overexpression of hMOF improved the stemness characteristics, inhibited cisplatin-induced apoptosis and mitochondrial membrane potential impairment, as well as reduced the sensitivity of OVCAR3 cells to cisplatin treatment. Moreover, overexpression of hMOF diminished tumor sensitivity to cisplatin in a mouse xenograft tumor model, accompanied by decrease in the proportion of cisplatin-induced apoptosis and alteration of mitochondrial apoptosis proteins. In addition, opposite phenotype and protein alterations were observed when knockdown of hMOF in the high hMOF expressing ovarian cancer A2780 cells. Transcriptomic profiling analysis and biological experimental verification orientated that MDM2-p53 apoptosis pathway was related to hMOF-modulated cisplatin resistance of OVCAR3 cells. Furthermore, hMOF reduced cisplatin-induced p53 accumulation by stabilizing MDM2 expression. Mechanistically, the increased stability of MDM2 was due to the inhibition of ubiquitinated degradation, which resulted by increased of MDM2 acetylation levels by its direct interaction with hMOF. Finally, genetic inhibition MDM2 could reverse hMOF-mediated cisplatin resistance in OVCAR3 cells with up-regulated hMOF expression. Meanwhile, treatment with adenovirus expressing shRNA of hMOF improved OVCAR3/DDP cell xenograft sensitivity to cisplatin in mouse. Collectively, the results of the study confirm that MDM2 as a novel non-histone substrate of hMOF, participates in promoting hMOF-modulated cisplatin chemoresistance in ovarian cancer cells. hMOF/MDM2 axis might be a potential target for the treatment of chemotherapy-resistant ovarian cancer.
    Language English
    Publishing date 2023-06-08
    Publishing country United States
    Document type Journal Article
    ISSN 2058-7716
    ISSN 2058-7716
    DOI 10.1038/s41420-023-01478-y
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  10. Article ; Online: Novel β-Cyclodextrin-Based Heptavalent Glycyrrhetinic Acid Conjugates

    Shuobin Liang / Xinyuan Ma / Man Li / Yanliang Yi / Qianqian Gao / Yongmin Zhang / Lihe Zhang / Demin Zhou / Sulong Xiao

    Frontiers in Chemistry, Vol

    Synthesis, Characterization, and Anti-Influenza Activity

    2022  Volume 10

    Abstract: In our continuing efforts toward the design of novel pentacyclic triterpene derivatives as potential anti-influenza virus entry inhibitors, a series of homogeneous heptavalent glycyrrhetinic acid derivatives based on β-cyclodextrin scaffold were designed ...

    Abstract In our continuing efforts toward the design of novel pentacyclic triterpene derivatives as potential anti-influenza virus entry inhibitors, a series of homogeneous heptavalent glycyrrhetinic acid derivatives based on β-cyclodextrin scaffold were designed and synthesized by click chemistry. The structure was unambiguously characterized by NMR, IR, and MALDI-TOF-MS measurements. Seven conjugates showed sufficient inhibitory activity against influenza virus infection based on the cytopathic effect reduction assay with IC50 values in the micromolar range. The interactions of conjugate 37, the most potent compound (IC50 = 2.86 μM, CC50 > 100 μM), with the influenza virus were investigated using the hemagglutination inhibition assay. Moreover, the surface plasmon resonance assay further confirmed that compound 37 bound to the influenza HA protein specifically with a dissociation constant of 5.15 × 10−7 M. Our results suggest the promising role of β-cyclodextrin as a scaffold for preparing a variety of multivalent compounds as influenza entry inhibitors.
    Keywords glycyrrhetinic acid ; β-cyclodextrin ; influenza virus ; multivalency ; hemagglutinin ; Chemistry ; QD1-999
    Subject code 540
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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