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  1. Article ; Online: FLASHlab@PITZ: New R&D platform with unique capabilities for electron FLASH and VHEE radiation therapy and radiation biology under preparation at PITZ.

    Stephan, Frank / Gross, Matthias / Grebinyk, Anna / Aboulbanine, Zakaria / Amirkhanyan, Zohrab / Budach, Volker / Ehrhardt, Vincent Henrique / Faus-Golfe, Angeles / Frohme, Marcus / Germond, Jean-Francois / Good, James David / Grüner, Florian / Kaul, David / Krasilnikov, Mikhail / Leavitt, Ron / Leemans, Wim / Li, Xiangkun / Loisch, Gregor / Müller, Frieder /
    Müller, Georg / Obier, Frank / Oppelt, Anne / Philipp, Sebastian / Qian, Houjun / Reindl, Judith / Riemer, Felix / Sack, Martin / Schmitz, Michael / Schnautz, Tobias / Schüller, Andreas / Staufer, Theresa / Stegmann, Christian / Tsakanova, Gohar / Vozenin, Marie-Catherine / Weise, Hans / Worm, Steven / Zips, Daniel

    Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)

    2022  Volume 104, Page(s) 174–187

    Abstract: At the Photo Injector Test facility at DESY in Zeuthen (PITZ), an R&D platform for electron FLASH ...

    Abstract At the Photo Injector Test facility at DESY in Zeuthen (PITZ), an R&D platform for electron FLASH and very high energy electron radiation therapy and radiation biology is being prepared (FLASHlab@PITZ). The beam parameters available at PITZ are worldwide unique. They are based on experiences from 20 + years of developing high brightness beam sources and an ultra-intensive THz light source demonstrator for ps scale electron bunches with up to 5 nC bunch charge at MHz repetition rate in bunch trains of up to 1 ms length, currently 22 MeV (upgrade to 250 MeV planned). Individual bunches can provide peak dose rates up to 10
    MeSH term(s) Humans ; Electrons ; Radiobiology ; Neoplasms
    Language English
    Publishing date 2022-12-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1122650-x
    ISSN 1724-191X ; 1120-1797
    ISSN (online) 1724-191X
    ISSN 1120-1797
    DOI 10.1016/j.ejmp.2022.10.026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Expression of TCF3 target genes defines a subclass of diffuse large B-cell lymphoma characterized by up-regulation of MYC target genes and poor clinical outcome following R-CHOP therapy.

    Tyryshkin, Kathrin / Moore, Alison / Good, David / Popov, Jesse / Crocker, Susan / Rauh, Michael J / Baetz, Tara / LeBrun, David P

    Leukemia & lymphoma

    2022  Volume 64, Issue 1, Page(s) 119–129

    Abstract: TCF3 is a lymphopoietic transcription factor that acquires somatic driver mutations in diffuse large B-cell lymphoma (DLBCL). Hypothesizing that expression patterns of TCF3-regulated genes can inform clinical management, we found that unsupervised ... ...

    Abstract TCF3 is a lymphopoietic transcription factor that acquires somatic driver mutations in diffuse large B-cell lymphoma (DLBCL). Hypothesizing that expression patterns of TCF3-regulated genes can inform clinical management, we found that unsupervised clustering analysis with 15 TCF3-regulated genes and eight additional ones resolved local DLBCL cases into two main clusters, denoted Groups A and B, of which Group A manifested inferior overall survival (OS,
    MeSH term(s) Humans ; Antibodies, Monoclonal, Murine-Derived/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Cyclophosphamide/therapeutic use ; Doxorubicin/therapeutic use ; Lymphoma, Large B-Cell, Diffuse/diagnosis ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Lymphoma, Large B-Cell, Diffuse/genetics ; Prednisone/therapeutic use ; Prognosis ; Rituximab/therapeutic use ; Up-Regulation ; Vincristine/therapeutic use
    Chemical Substances Antibodies, Monoclonal, Murine-Derived ; Basic Helix-Loop-Helix Transcription Factors ; Cyclophosphamide (8N3DW7272P) ; Doxorubicin (80168379AG) ; Prednisone (VB0R961HZT) ; Rituximab (4F4X42SYQ6) ; TCF3 protein, human ; Vincristine (5J49Q6B70F)
    Language English
    Publishing date 2022-11-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2022.2136968
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Introduction to statistics through resampling methods and R

    Good, Phillip I

    2013  

    Abstract: Intended for class use or self-study, the second addition of this text aspires like the first to introduce statistical methodology to a wide audience, simply and intuitively, through resampling from the data at hand. The methodology proceeds from ... ...

    Title translation Introduction to statistics through resampling methods and R/S-PLUS
    Author's details Phillip I. Good
    Abstract "Intended for class use or self-study, the second addition of this text aspires like the first to introduce statistical methodology to a wide audience, simply and intuitively, through resampling from the data at hand. The methodology proceeds from chapter to chapter from the simple to the complex"--
    Keywords Resampling (Statistics)
    Language English
    Size XII, 210 S., 24 cm
    Edition 2. ed.
    Publisher Wiley
    Publishing place Hoboken, NJ
    Document type Book
    Note Includes index
    ISBN 9781118428214 ; 1118428218
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  4. Book ; Online: Introduction to statistics through resampling methods and R

    Good, Phillip I

    2013  

    Abstract: Intended for class use or self-study, the second addition of this text aspires like the first to introduce statistical methodology to a wide audience, simply and intuitively, through resampling from the data at hand. The methodology proceeds from ... ...

    Title translation Introduction to statistics through resampling methods and R/S-PLUS
    Author's details Phillip I. Good
    Abstract "Intended for class use or self-study, the second addition of this text aspires like the first to introduce statistical methodology to a wide audience, simply and intuitively, through resampling from the data at hand. The methodology proceeds from chapter to chapter from the simple to the complex"--
    Keywords Resampling (Statistics)
    Language English
    Size Online-Ressource (1 online resource)
    Edition Second edition
    Document type Book ; Online
    Note Includes indexes
    ISBN 9781118428214 ; 9781118497562 ; 9781118497579 ; 9781118497678 ; 9781118428214 ; 1118428218 ; 1118497562 ; 1118497570 ; 1118497678 ; 1118428218
    DOI 10.1002/9781118497593
    Database Former special subject collection: coastal and deep sea fishing

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  5. Article ; Online: Ten simple rules for cultivating open science and collaborative R&D.

    Masum, Hassan / Rao, Aarthi / Good, Benjamin M / Todd, Matthew H / Edwards, Aled M / Chan, Leslie / Bunin, Barry A / Su, Andrew I / Thomas, Zakir / Bourne, Philip E

    PLoS computational biology

    2013  Volume 9, Issue 9, Page(s) e1003244

    MeSH term(s) Cooperative Behavior ; Research ; Science
    Language English
    Publishing date 2013-09-26
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2193340-6
    ISSN 1553-7358 ; 1553-734X
    ISSN (online) 1553-7358
    ISSN 1553-734X
    DOI 10.1371/journal.pcbi.1003244
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: [11C](R)-PK11195 PET imaging of microglial activation in multiple system atrophy.

    Gerhard, A / Banati, R B / Goerres, G B / Cagnin, A / Myers, R / Gunn, R N / Turkheimer, F / Good, C D / Mathias, C J / Quinn, N / Schwarz, J / Brooks, D J

    Neurology

    2003  Volume 61, Issue 5, Page(s) 686–689

    Abstract: Microglia, the brain's intrinsic macrophages, bind (R)-PK11195 when activated by neuronal injury ... The authors used [11C](R)-PK11195 PET to localize in vivo microglial activation in patients ... with multiple system atrophy (MSA). Increased [11C](R)-PK11195 binding was primarily found in the dorsolateral ...

    Abstract Microglia, the brain's intrinsic macrophages, bind (R)-PK11195 when activated by neuronal injury. The authors used [11C](R)-PK11195 PET to localize in vivo microglial activation in patients with multiple system atrophy (MSA). Increased [11C](R)-PK11195 binding was primarily found in the dorsolateral prefrontal cortex, putamen, pallidum, pons, and substantia nigra, reflecting the known distribution of neuropathologic changes in MSA. Providing an indicator of disease activity, [11C](R)-PK11195 PET can thus be used to characterize the in vivo neuropathology of MSA.
    MeSH term(s) Aged ; Carbon Radioisotopes ; Humans ; Isoquinolines ; Male ; Microglia/diagnostic imaging ; Middle Aged ; Multiple System Atrophy/diagnostic imaging ; Tomography, Emission-Computed
    Chemical Substances Carbon Radioisotopes ; Isoquinolines ; PK 11195 (YNF83VN1RL)
    Language English
    Publishing date 2003-04-02
    Publishing country United States
    Document type Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/01.wnl.0000078192.95645.e6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Ten simple rules for cultivating open science and collaborative R&D.

    Hassan Masum / Aarthi Rao / Benjamin M Good / Matthew H Todd / Aled M Edwards / Leslie Chan / Barry A Bunin / Andrew I Su / Zakir Thomas / Philip E Bourne

    PLoS Computational Biology, Vol 9, Iss 9, p e

    2013  Volume 1003244

    Keywords Biology (General) ; QH301-705.5
    Language English
    Publishing date 2013-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell Lymphomas.

    Vaswani, Rishi G / Gehling, Victor S / Dakin, Les A / Cook, Andrew S / Nasveschuk, Christopher G / Duplessis, Martin / Iyer, Priyadarshini / Balasubramanian, Srividya / Zhao, Feng / Good, Andrew C / Campbell, Robert / Lee, Christina / Cantone, Nico / Cummings, Richard T / Normant, Emmanuel / Bellon, Steven F / Albrecht, Brian K / Harmange, Jean-Christophe / Trojer, Patrick /
    Audia, James E / Zhang, Ying / Justin, Neil / Chen, Shuyang / Wilson, Jon R / Gamblin, Steven J

    Journal of medicinal chemistry

    2016  Volume 59, Issue 21, Page(s) 9928–9941

    Abstract: Polycomb repressive complex 2 (PRC2) has been shown to play a major role in transcriptional silencing in part by installing methylation marks on lysine 27 of histone 3. Dysregulation of PRC2 function correlates with certain malignancies and poor ... ...

    Abstract Polycomb repressive complex 2 (PRC2) has been shown to play a major role in transcriptional silencing in part by installing methylation marks on lysine 27 of histone 3. Dysregulation of PRC2 function correlates with certain malignancies and poor prognosis. EZH2 is the catalytic engine of the PRC2 complex and thus represents a key candidate oncology target for pharmacological intervention. Here we report the optimization of our indole-based EZH2 inhibitor series that led to the identification of CPI-1205, a highly potent (biochemical IC
    MeSH term(s) Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Cell Proliferation/drug effects ; Clinical Trials, Phase I as Topic ; Dogs ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Histone Methyltransferases ; Histone-Lysine N-Methyltransferase/antagonists & inhibitors ; Histone-Lysine N-Methyltransferase/metabolism ; Humans ; Indoles/chemical synthesis ; Indoles/chemistry ; Indoles/pharmacology ; Lymphoma, B-Cell/drug therapy ; Models, Molecular ; Molecular Structure ; Neoplasms, Experimental/drug therapy ; Neoplasms, Experimental/pathology ; Piperidines/chemical synthesis ; Piperidines/chemistry ; Piperidines/pharmacology ; Rats ; Structure-Activity Relationship
    Chemical Substances Antineoplastic Agents ; Enzyme Inhibitors ; Indoles ; Piperidines ; (R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (455J2479FY) ; Histone Methyltransferases (EC 2.1.1.-) ; Histone-Lysine N-Methyltransferase (EC 2.1.1.43)
    Language English
    Publishing date 2016-10-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.6b01315
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: 32nd Critical Care Transport Medicine Conference.

    Good, Nikole R

    Air medical journal

    2023  Volume 43, Issue 1, Page(s) 14–18

    Language English
    Publishing date 2023-12-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2072853-0
    ISSN 1532-6497 ; 1067-991X
    ISSN (online) 1532-6497
    ISSN 1067-991X
    DOI 10.1016/j.amj.2023.12.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book: Introduction to statistics through resampling methods and R/S-PLUS

    Good, Phillip I

    2005  

    Author's details Phillip I. Good
    Keywords Anwendung ; Statistik ; S-PLUS ; R
    Language English
    Size XII, 229 S, graph. Darst, 23 cm
    Publisher Wiley-Interscience
    Publishing place Hoboken, NJ
    Document type Book
    Note Includes indexes
    ISBN 0471715751 ; 9780471715757
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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