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  1. Article ; Online: Transplant rejection and paradigms lost.

    Strom, Terry B

    The Journal of clinical investigation

    2013  Volume 123, Issue 6, Page(s) 2360–2362

    Abstract: During transplant rejection, migrating T cells infiltrate the grafted organ, but the signals that direct this migration are incompletely understood. In this issue of the JCI, Walch et al. debunk two classical paradigms concerning transplant rejection, ... ...

    Abstract During transplant rejection, migrating T cells infiltrate the grafted organ, but the signals that direct this migration are incompletely understood. In this issue of the JCI, Walch et al. debunk two classical paradigms concerning transplant rejection, with important consequences for the design of antirejection therapeutics.
    MeSH term(s) Animals ; Antigen Presentation ; CD8-Positive T-Lymphocytes/physiology ; Heart Transplantation/immunology ; Kidney Transplantation/immunology ; Transendothelial and Transepithelial Migration/immunology
    Language English
    Publishing date 2013-05-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI69385
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Conference proceedings: Proceedings of a Symposium on Optimization of Immunosuppressive Therapy while Minimizing Infection in Renal Transplantation Striking a Balance

    Strom, Terry B.

    Boca Raton, Fla., March 25 - 26, 1988

    (Transplantation proceedings ; 20,6, Suppl. 8)

    1988  

    Title variant Optimization of immunosuppressive therapy while minimizing infection in renal transplantation striking a balance
    Event/congress Symposium on Optimization of Immunosuppressive Therapy while Minimizing Infection in Renal Transplantation Striking a Balance (1988, BocaRatonFla.)
    Author's details chairman and guest ed. Terry B. Strom
    Series title Transplantation proceedings ; 20,6, Suppl. 8
    Collection
    Keywords Kidney Transplantation / congresses ; Infection / prevention & control / congresses ; Immunosuppressive Agents / adverse effects / congresses
    Language English
    Size 53 S. : graph. Darst.
    Publisher Grune & Stratton
    Publishing place Philadelphia, Pa
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT003271679
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Zs A 835 -20,6,Suppl.8- verfügbar in Königswinter Königswinter

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  3. Article ; Online: Can childhood viral infection protect from type 1 diabetes?

    Strom, Terry B

    The Journal of clinical investigation

    2009  Volume 119, Issue 6, Page(s) 1458–1461

    Abstract: While many candidate type 1 diabetes (T1D) susceptibility genes have been identified, evidence suggests that environmental stimuli, such as viral infections, may also be involved in T1D pathogenesis. However, how viral infections may prevent or trigger ... ...

    Abstract While many candidate type 1 diabetes (T1D) susceptibility genes have been identified, evidence suggests that environmental stimuli, such as viral infections, may also be involved in T1D pathogenesis. However, how viral infections may prevent or trigger the diabetogenic process remains unclear. In this issue of the JCI, Filippi et al. show that infection of NOD mice with Coxsackie virus B3 or lymphocytic choriomeningitis virus, neither of which directly destroys insulin-secreting pancreatic beta cells, triggers the activation of two distinct immunoregulatory mechanisms, involving both the innate and adaptive immune system, that protect against the development of T1D in these animals (see the related article beginning on page 1515).
    MeSH term(s) Animals ; Autoimmunity/immunology ; Coxsackievirus Infections/immunology ; Coxsackievirus Infections/prevention & control ; Cytomegalovirus Infections/immunology ; Cytomegalovirus Infections/prevention & control ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/immunology ; Insulin-Secreting Cells/immunology ; Insulin-Secreting Cells/metabolism ; Interferon-beta/metabolism ; T-Lymphocytes/immunology ; Transforming Growth Factor beta/immunology
    Chemical Substances Transforming Growth Factor beta ; Interferon-beta (77238-31-4)
    Language English
    Publishing date 2009-06-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/jci39565
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: 2006 Homer W. Smith Lecture: taming T cells.

    Strom, Terry B

    Journal of the American Society of Nephrology : JASN

    2007  Volume 18, Issue 11, Page(s) 2824–2832

    MeSH term(s) Humans ; Immune Tolerance/physiology ; Interleukin-2/physiology ; Lymphocyte Activation/physiology ; T-Lymphocytes/physiology ; Transplantation Immunology/physiology
    Chemical Substances Interleukin-2
    Language English
    Publishing date 2007-10-17
    Publishing country United States
    Document type Lecture ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2007070832
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3344: Show issues Location:
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  5. Article ; Online: Transplantation: a new molecular approach to the diagnosis of acute rejection.

    Chandraker, Anil / Strom, Terry B

    Nature reviews. Nephrology

    2013  Volume 9, Issue 11, Page(s) 631–632

    Abstract: Renal biopsy is the gold standard for detection of rejection in kidney transplant recipients, but is not considered until evidence of renal dysfunction is apparent. Now, Suthanthiran and colleagues suggest that mRNA levels in urinary cells from these ... ...

    Abstract Renal biopsy is the gold standard for detection of rejection in kidney transplant recipients, but is not considered until evidence of renal dysfunction is apparent. Now, Suthanthiran and colleagues suggest that mRNA levels in urinary cells from these patients might be diagnostic and prognostic of acute cellular rejection.
    MeSH term(s) Acute Disease ; Biopsy ; Graft Rejection/genetics ; Graft Rejection/pathology ; Humans ; Kidney Transplantation/adverse effects ; Prognosis ; RNA, Messenger/metabolism
    Chemical Substances RNA, Messenger
    Language English
    Publishing date 2013-10-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/nrneph.2013.199
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    Zs.MG 107: Show issues

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  6. Article: Saving islets from allograft rejection.

    Strom, Terry B

    Proceedings of the National Academy of Sciences of the United States of America

    2005  Volume 102, Issue 36, Page(s) 12651–12652

    MeSH term(s) Animals ; Graft Rejection/immunology ; Humans ; Inflammation/immunology ; Ischemia/immunology ; Islets of Langerhans/immunology ; Islets of Langerhans/surgery ; Islets of Langerhans Transplantation/immunology ; Transplantation, Homologous/immunology ; alpha 1-Antitrypsin/immunology
    Chemical Substances alpha 1-Antitrypsin
    Language English
    Publishing date 2005-09-06
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.0506079102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Rejection--more than the eye can see.

    Strom, Terry B

    The New England journal of medicine

    2005  Volume 353, Issue 22, Page(s) 2394–2396

    MeSH term(s) Acute Disease ; Biomarkers/urine ; CD3 Complex/genetics ; CD3 Complex/urine ; Forkhead Transcription Factors/genetics ; Forkhead Transcription Factors/urine ; Gene Expression ; Graft Rejection/diagnosis ; Graft Rejection/urine ; Humans ; Kidney Transplantation ; Lymphocyte Activation ; RNA, Messenger/urine ; Receptors, Interleukin-2/genetics ; T-Lymphocytes/physiology
    Chemical Substances Biomarkers ; CD3 Complex ; FOXP3 protein, human ; Forkhead Transcription Factors ; RNA, Messenger ; Receptors, Interleukin-2
    Language English
    Publishing date 2005-12-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe058257
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  8. Article ; Online: Immunogenetics and transplantation.

    Kirk, Allan / Strom, Terry B

    Current opinion in immunology

    2010  Volume 22, Issue 5, Page(s) 631–633

    MeSH term(s) Animals ; Humans ; Immunogenetics ; Transplantation Immunology ; Transplantation, Homologous/immunology
    Language English
    Publishing date 2010-10-08
    Publishing country England
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2010.09.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Tolerance--is it worth it?

    Finger, Erik B / Strom, Terry B / Matas, Arthur J

    Cold Spring Harbor perspectives in medicine

    2014  Volume 4, Issue 2

    Abstract: We are entering an exciting time in the study of immunologic tolerance. Several cellular and molecular strategies have been developed that show promise in nonhuman transplant models and these approaches are just now appearing in clinical trials. ... ...

    Abstract We are entering an exciting time in the study of immunologic tolerance. Several cellular and molecular strategies have been developed that show promise in nonhuman transplant models and these approaches are just now appearing in clinical trials. Tolerance strategies that prevent immune rejection and obviate the need for immunosuppressive medications (with inherent risk of cancer, infection, and organ toxicity) would improve both graft and patient survival. Each tolerance protocol brings its own set of associated risks. As the results of these trials become available, we must continue to evaluate their successes and failures. The balance of these outcomes will help us answer the question: "Tolerance-Is it worth it?"
    MeSH term(s) Costimulatory and Inhibitory T-Cell Receptors/antagonists & inhibitors ; Costs and Cost Analysis ; Graft Rejection/genetics ; Graft Rejection/immunology ; Humans ; Immunosuppression/adverse effects ; Immunosuppression/methods ; Immunosuppressive Agents/adverse effects ; Stem Cell Transplantation/adverse effects ; T-Lymphocytes, Regulatory/immunology ; Transplantation Chimera/immunology ; Transplantation Conditioning/methods ; Transplantation Tolerance/drug effects ; Transplantation Tolerance/immunology
    Chemical Substances Costimulatory and Inhibitory T-Cell Receptors ; Immunosuppressive Agents
    Language English
    Publishing date 2014-02-01
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2157-1422
    ISSN (online) 2157-1422
    DOI 10.1101/cshperspect.a015594
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Is transplantation tolerable?

    Strom, Terry B

    The Journal of clinical investigation

    2004  Volume 113, Issue 12, Page(s) 1681–1683

    Abstract: To test the hypothesis that chronic stimulation of T cells with a weak agonistic antigen will generate regulatory T cells and immune tolerance, a study reported in this issue employed the redesign of a minor histocompatibility antigen. Using knowledge of ...

    Abstract To test the hypothesis that chronic stimulation of T cells with a weak agonistic antigen will generate regulatory T cells and immune tolerance, a study reported in this issue employed the redesign of a minor histocompatibility antigen. Using knowledge of residues at which the antigen contacts the T cell receptor, a weak agonist was produced. Pretreatment with this altered antigen produced transplant tolerance, generation of regulatory T cells, and a loss of many antigen-reactive T cells.
    MeSH term(s) Animals ; Female ; Immune Tolerance/physiology ; Mice ; Minor Histocompatibility Antigens/genetics ; Minor Histocompatibility Antigens/immunology ; Organ Transplantation ; Receptors, Antigen, T-Cell/metabolism ; T-Lymphocyte Subsets ; T-Lymphocytes/immunology
    Chemical Substances Minor Histocompatibility Antigens ; Receptors, Antigen, T-Cell
    Language English
    Publishing date 2004-06-15
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI22153
    Database MEDical Literature Analysis and Retrieval System OnLINE

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