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Article ; Online: A Fluorous Peptide Amphiphile with Potent Antimicrobial Activity for the Treatment of MRSA-induced Sepsis and Chronic Wound Infection.

Hu, Jingjing / Liu, Nan / Fan, Qianqian / Gu, Yunqing / Chen, Sijia / Zhu, Fang / Cheng, Yiyun

Angewandte Chemie (International ed. in English)

2024 , Page(s) e202403140

Abstract: The rising prevalence of global antibiotic resistance evokes the urgent need for novel antimicrobial candidates. Cationic lipopeptides have attracted much attention due to their strong antimicrobial activity, broad-spectrum and low resistance tendency. ... ...

Abstract	The rising prevalence of global antibiotic resistance evokes the urgent need for novel antimicrobial candidates. Cationic lipopeptides have attracted much attention due to their strong antimicrobial activity, broad-spectrum and low resistance tendency. Herein, a library of fluoro-lipopeptide amphiphiles was synthesized by tagging a series of cationic oligopeptides with a fluoroalkyl tail via a disulfide spacer. Among the lipopeptide candidates, R6F bearing six arginine moieties and a fluorous tag shows the highest antibacterial activity, and it exhibits an interesting fluorine effect as compared to the non-fluorinated lipopeptides. The high antibacterial activity of R6F is attributed to its excellent bacterial membrane permeability, which further disrupts the respiratory chain redox stress and cell wall biosynthesis of the bacteria. By co-assembling with lipid nanoparticles, R6F showed high therapeutic efficacy and minimal adverse effects in the treatment of MRSA-induced sepsis and chronic wound infection. This work provides a novel strategy to design highly potent antibacterial peptide amphiphiles for the treatment of drug-resistant bacterial infections.
Language	English
Publishing date	2024-02-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202403140
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Tribological Properties of Blocky Composites with Carbon Nanotubes.

Hu, Chaoxiang / Gu, Yunqing / Qiu, Qianfeng / Ding, Hongxin / Mou, Jiegang / Wu, Denghao / Ma, Longbiao / Xu, Maosen / Mou, Chengqi

International journal of molecular sciences

2024 Volume 25, Issue 7

Abstract: A large amount of primary energy is lost due to friction, and the study of new additive materials to improve friction performance is in line with the concept of low carbon. Carbon nanotubes (CNTs) have advantages in drag reduction and wear resistance ... ...

Abstract	A large amount of primary energy is lost due to friction, and the study of new additive materials to improve friction performance is in line with the concept of low carbon. Carbon nanotubes (CNTs) have advantages in drag reduction and wear resistance with their hollow structure and self-lubricating properties. This review investigated the mechanism of improving friction properties of blocky composites (including polymer, metal, and ceramic-based composites) with CNTs' incorporation. The characteristic tubular structure and the carbon film make low wear rate and friction coefficient on the surface. In addition, the effect of CNTs' aggregation and interfacial bond strength on the wear resistance was analyzed. Within an appropriate concentration range of CNTs, the blocky composites exhibit better wear resistance properties. Based on the differences in drag reduction and wear resistance in different materials and preparation methods, further research directions of CNTs have been suggested.
MeSH term(s)	Nanotubes, Carbon ; Ceramics ; Friction ; Polymers ; Software
Chemical Substances	Nanotubes, Carbon ; Polymers
Language	English
Publishing date	2024-04-01
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25073938
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Article ; Online: A polymyxin and cellulase based smart hydrogel for localized infection treatment and biofilm eradication

Yongxin Yang / Yunqing Gu / Kunyu Chen / Jiajia Luo / Zijuan Cheng / Yiyun Cheng / Jingjing Hu

Giant, Vol 16, Iss , Pp 100187- (2023)

2023

Abstract: Polymyxins are credited as the last line of defense against the clinical multi-resistant Gram-negative pathogen infections. However, their clinical use is limited by high nephrotoxicity and neurotoxicity, and less effectiveness against mature biofilms. ... ...

Abstract	Polymyxins are credited as the last line of defense against the clinical multi-resistant Gram-negative pathogen infections. However, their clinical use is limited by high nephrotoxicity and neurotoxicity, and less effectiveness against mature biofilms. In this work, the polymyxins including polymyxin B and polymyxin E were crosslinked with oxidized dextran via the acid labile Schiff base linkage. The generated hydrogel can release the polymyxins upon bacterial infection in an on-demand manner, which may alleviate adverse effects of the antibiotics. Moreover, a multifunctional hydrogel is generated by introducing the enzyme cellulase into the polymyxin hydrogel via the same Schiff base chemistry. The prepared gel can effectively degrade the mature biofilm, sensitizing the polymyxins in the treatment of biofilm-associated infections both in vitro and in vivo. This study provides an effective strategy to reduce the side effects of polymyxins and enhance their sensitivity against the mature biofilm-associated localized infections.
Keywords	Polymyxin ; On-demand release ; Antibacterial hydrogel ; Hydrogels ; Biofilm ; Science (General) ; Q1-390
Subject code	616
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Effect of Bionic Nonsmooth Surface Vane on the Antiwear Characteristics of Double-Vane Pump.

Ma, Longbiao / Gu, Yunqing / Xia, Ke / Mou, Jiegang / Wu, Denghao / Yan, Muhan

Applied bionics and biomechanics

2022 Volume 2022, Page(s) 4442417

Abstract: In order to improve the antiwear characteristics of the double-vane self-priming pump, the surface structure of ... ...

Abstract	In order to improve the antiwear characteristics of the double-vane self-priming pump, the surface structure of the
Language	English
Publishing date	2022-04-20
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2179924-6
ISSN	1754-2103 ; 1176-2322
ISSN (online)	1754-2103
ISSN	1176-2322
DOI	10.1155/2022/4442417
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Article ; Online: Longitudinal Relationship between Bullying Victimization and Non-Suicidal Self-Injury among Chinese Adolescents: The Buffering Roles of Gratitude and Parental Autonomy Support.

Wu, Nini / Mo, Jianhong / Wen, Anluan / Ou, Haoer / Gu, Weixin / Qiu, Yunqing / Yuan, Lixin / Lan, Xiaoyu

International journal of environmental research and public health

2023 Volume 20, Issue 2

Abstract: Drawing on the resilience-oriented socioecological framework, the current study contributes to scarce scholarship by exploring intrapersonal (i.e., gratitude) and interpersonal (i.e., parental autonomy support) factors in the longitudinal association ... ...

Abstract	Drawing on the resilience-oriented socioecological framework, the current study contributes to scarce scholarship by exploring intrapersonal (i.e., gratitude) and interpersonal (i.e., parental autonomy support) factors in the longitudinal association between bullying victimization and adolescent non-suicidal self-injury (NSSI). Participants were 238 Chinese adolescents (
MeSH term(s)	Male ; Female ; Humans ; Adolescent ; East Asian People ; Self-Injurious Behavior/epidemiology ; Bullying ; Crime Victims ; Adolescent Behavior
Language	English
Publishing date	2023-01-12
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20021440
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Article ; Online: A Stacked FKM/PU Triboelectric Nanogenerator for Discrete Mechanical Energy Harvesting.

Su, Yuxiang / Liu, Anguo / Feng, Wuwei / Gu, Yunqing / Su, Xiaonan / Dai, Guanyu / Shao, Yilei / Wan, Liping / Fang, Haohan / Li, Zhenhua

ACS omega

2023 Volume 8, Issue 21, Page(s) 18823–18829

Abstract: To combine the advantages of elastic and nonelastic triboelectric materials, this work proposes a new type of triboelectric nanogenerator (TENG) based on stacking -the stacked FKM/PU TENG. By stacking the elastomer polyurethane (PU) and the nonelastomer ... ...

Abstract	To combine the advantages of elastic and nonelastic triboelectric materials, this work proposes a new type of triboelectric nanogenerator (TENG) based on stacking -the stacked FKM/PU TENG. By stacking the elastomer polyurethane (PU) and the nonelastomer fluororubber (FKM), the FKM/PU TENG combines the inherent triboelectric characteristics of both materials and the unique elasticity of PU to achieve an output performance that is much higher than that of the FKM-TENG or the PU-TENG. The maximum instantaneous open-circuit voltage and short-circuit current of the FKM/PU TENG reach 661 V and 71.2 μA, respectively. Under the limiting conditions of 3 Hz and maximum compression, this device can attain a maximum power density of 49.63 W/m
Language	English
Publishing date	2023-05-18
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c00970
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Article ; Online: Preparation and Modification Technology Analysis of Ionic Polymer-Metal Composites (IPMCs)

Chendong He / Yunqing Gu / Junjun Zhang / Longbiao Ma / Muhan Yan / Jiegang Mou / Yun Ren

International Journal of Molecular Sciences, Vol 23, Iss 3522, p

2022 Volume 3522

Abstract: As a new type of flexible smart material, ionic polymer-metal composite (IPMC) has the advantages of being lightweight and having fast responses, good flexibility, and large deformation ranges. However, IPMC has the disadvantages of a small driving force ...

Abstract	As a new type of flexible smart material, ionic polymer-metal composite (IPMC) has the advantages of being lightweight and having fast responses, good flexibility, and large deformation ranges. However, IPMC has the disadvantages of a small driving force and short lifespan. Based on this, this paper firstly analyzes the driving mechanism of IPMC. Then, it focuses on the current preparation technology of IPMC from the aspects of electroless plating and mechanical plating. The advantages and disadvantages of various preparation methods are analyzed. Due to the special driving mechanism of IPMC, there is a problem of short non-aqueous working time. Therefore, the modification research of IPMC is reviewed from the aspects of the basement membrane, working medium, and electrode materials. Finally, the current challenges and future development prospects of IPMC are discussed.
Keywords	IPMC ; smart materials ; driving mechanism ; preparation technology ; modification research ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	600
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Preparation and Modification Technology Analysis of Ionic Polymer-Metal Composites (IPMCs).

He, Chendong / Gu, Yunqing / Zhang, Junjun / Ma, Longbiao / Yan, Muhan / Mou, Jiegang / Ren, Yun

International journal of molecular sciences

2022 Volume 23, Issue 7

Abstract	As a new type of flexible smart material, ionic polymer-metal composite (IPMC) has the advantages of being lightweight and having fast responses, good flexibility, and large deformation ranges. However, IPMC has the disadvantages of a small driving force and short lifespan. Based on this, this paper firstly analyzes the driving mechanism of IPMC. Then, it focuses on the current preparation technology of IPMC from the aspects of electroless plating and mechanical plating. The advantages and disadvantages of various preparation methods are analyzed. Due to the special driving mechanism of IPMC, there is a problem of short non-aqueous working time. Therefore, the modification research of IPMC is reviewed from the aspects of the basement membrane, working medium, and electrode materials. Finally, the current challenges and future development prospects of IPMC are discussed.
MeSH term(s)	Electrodes ; Ions ; Metals ; Polymers ; Technology
Chemical Substances	Ions ; Metals ; Polymers
Language	English
Publishing date	2022-03-24
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23073522
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Article ; Online: The Estimation of Centrifugal Pump Flow Rate Based on the Power–Speed Curve Interpolation Method

Yuezhong Wu / Denghao Wu / Minghao Fei / Gang Xiao / Yunqing Gu / Jiegang Mou

Processes, Vol 10, Iss 2163, p

2022 Volume 2163

Abstract: During the global energy crisis, it is essential to improve the energy efficiency of pumps by adjusting the pump’s control strategy according to the operational states. However, monitoring the pump’s operational states with the help of external sensors ... ...

Abstract	During the global energy crisis, it is essential to improve the energy efficiency of pumps by adjusting the pump’s control strategy according to the operational states. However, monitoring the pump’s operational states with the help of external sensors brings both additional costs and risks of failure. This study proposed an interpolation method based on PN curves (power–speed curves) containing information regarding motor shaft power, speed, and flow rate to achieve high accuracy in predicting the pump’s flow rates without flow sensors. The impact factors on the accuracy of the estimation method were analyzed. Measurements were performed to validate the feasibility and robustness of the PN curve interpolation method and compared with the QP and back-propagation neural network (BPNN) methods. The results indicated that the PN curve interpolation method has lower errors than the other two prediction models. Moreover, the average absolute errors of the PN curve interpolation method in the project applications at 47.5 Hz, 42.5 Hz, 37.5 Hz, and 32.5 Hz are 0.1442 m 3 /h, 0.2047 m 3 /h, 0.2197 m 3 /h, and 0.1979 m 3 /h. Additionally, the average relative errors are 2.0816%, 3.2875%, 3.6981%, and 2.9419%. Hence, this method fully meets the needs of centrifugal pump monitoring and control.
Keywords	centrifugal pump ; PN curves interpolation ; flow estimation ; sensorless ; Chemical technology ; TP1-1185 ; Chemistry ; QD1-999
Subject code	333
Language	English
Publishing date	2022-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Influence of Bionic Circular Groove Blade Surface on Wear Performance

Longbiao Ma / Yunqing Gu / Ke Xia / Chengqi Mou / Jiegang Mou / Denghao Wu / Muhan Yan

Lubricants, Vol 10, Iss 101, p

2022 Volume 101

Abstract: In order to improve the anti-wear performance of a double-vane self-priming centrifugal pump during two-phase flow transfer, the construction of a streamline groove structure at the outlet end of the suction side of the vane, based on the bionic ... ...

Abstract	In order to improve the anti-wear performance of a double-vane self-priming centrifugal pump during two-phase flow transfer, the construction of a streamline groove structure at the outlet end of the suction side of the vane, based on the bionic principle, is proposed. Different pump characteristics are analysed to investigate the effect of different bionic groove spacing on the resistance to particle wear and the mechanism of improvement of the bionic grooves. The results show that the effect of the bionic blades on the hydraulic characteristics of the pump is within the allowable error (±1.4%). The circular groove structure with different spacing produces a difference in the pressure distribution on the blade. At the same particle concentration, with the increase in the groove spacing distance, the average wear of the blades first decreases and then increases; the average wear rate at the spacing of 7 mm is the smallest. At a particle concentration of 90 kg/m 3 , the average wear rate at a groove spacing of 7 mm is ~0.63 × 10 −4 kg/s∙m 2 , and the wear area is mainly found in the middle of the blade. The reason why the bionic blade improves the anti-wear performance of the pump is due to the reverse vortex zone in the groove, which changes the particle trajectory and collision frequency. The bionic grooves with a diameter of 2 mm and a spacing of 7 mm significantly reduce the average wear rate of the pump at different particle concentrations, while maintaining hydraulic performance.
Keywords	double-vane pump ; bionic groove ; numerical simulation ; groove spacing ; anti-wear ; Science ; Q
Subject code	620
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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