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Article ; Online: Hurdles for adopting mobile learning devices at the outset of clinical courses.

Folger, Daniel / Merenmies, Jussi / Sjöberg, Lena / Pyörälä, Eeva

2021 Volume 21, Issue 1, Page(s) 594

Abstract: Background: Mobile devices provide medical students with easy access to medical information and educational resources. Since 2013, we have followed the study use of iPads among medical students. In 2016, we observed a notable drop in the mobile device ... ...

Abstract	Background: Mobile devices provide medical students with easy access to medical information and educational resources. Since 2013, we have followed the study use of iPads among medical students. In 2016, we observed a notable drop in the mobile device usage in the first cohort of medical students entering their clinical courses. Methods: The aim of the study was to identify the hurdles for adopting mobile devices at the beginning of the clinical courses. We examined how students evaluated their own and the clinical teachers' ability to use the iPad, how the study assignments fit into digital learning, and how students used the mobile device with patients. The data were collected with online surveys among three consecutive student cohorts and the distributions of closed-ended questions analyzed. Results: Response rates ranged from 67.5 to 90.8%. Students evaluated their own ability to use the iPad as good or excellent and teachers' skills as relatively poor and wanted more digitally tailored assignments. They reported negative attitudes towards mobile device use in the clinical setting and were hesitant to use them in patient contact. Teachers seldom communicated suitable quality medical applications to students. Conclusions: Clinical teachers need support and training to implement a learning environment and assignments appropriate for mobile devices. Both students and teachers were concerned about using these devices with patients. To achieve the full potential of digitalisation in clinical courses, their use should be developed collectively with students.
MeSH term(s)	Cohort Studies ; Computers, Handheld ; Humans ; Learning ; Students, Medical ; Surveys and Questionnaires
Language	English
Publishing date	2021-11-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2044473-4
ISSN	1472-6920 ; 1472-6920
ISSN (online)	1472-6920
ISSN	1472-6920
DOI	10.1186/s12909-021-03008-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Recurrent Mild Acute Rejections and Donor-specific Antibodies as Risk Factors for Cardiac Allograft Vasculopathy in a National Pediatric Heart Transplant Cohort.

Kaskinen, Anu K / Tainio, Juuso / Pihkala, Jaana I / Peräsaari, Juha P / Lauronen, Jouni / Raissadati, Alireza / Merenmies, Jussi M / Jalanko, Hannu J / Jahnukainen, Timo

Transplantation direct

2023 Volume 9, Issue 10, Page(s) e1534

Abstract: Background: Immune-mediated factors such as acute cellular rejections and donor-specific antibodies (DSAs) are risk factors for cardiac allograft vasculopathy (CAV). We studied a national cohort with a unified setting and thorough protocol ... ...

Abstract	Background: Immune-mediated factors such as acute cellular rejections and donor-specific antibodies (DSAs) are risk factors for cardiac allograft vasculopathy (CAV). We studied a national cohort with a unified setting and thorough protocol endomyocardial biopsy (EMB) data for an association between cellular rejections, especially when mild and recurrent, and DSAs with CAV in pediatric heart transplant (HTx) patients. Methods: This is a retrospective, national cohort study of 94 pediatric HTxs performed between 1991 and 2019 and followed until December 31, 2020. Diagnosis of CAV was based on reevaluation of angiographies. Protocol and indication EMB findings with other patient data were collected from medical records. Associations between nonimmune and immune-mediated factors and CAV were analyzed with univariable and multivariable Cox regression analyses. Results: Angiographies performed on 76 patients revealed CAV in 23 patients (30%). Altogether 1138 EMBs (92% protocol biopsies) were performed on 78 patients (83%). During the first posttransplant year, grade 1 rejection (G1R) appeared in 45 patients (58%), and recurrent (≥2) G1R findings in 14 patients (18%). Pretransplant DSAs occurred in 13 patients (17%) and posttransplant DSAs in 37 patients (39%). In univariable analysis, pretransplant DSAs, appearance and recurrence of G1R findings, and total rejection score during the first posttransplant year, as well as recurrent G1R during follow-up, were all associated with CAV. In multivariable analysis, pretransplant DSAs and recurrent G1R during the first posttransplant year were found to be associated with CAV. Conclusions: Our results indicate that pretransplant DSA and recurrent G1R findings, especially during the first posttransplant year, are associated with CAV after pediatric HTx.
Language	English
Publishing date	2023-09-20
Publishing country	United States
Document type	Journal Article
ISSN	2373-8731
ISSN	2373-8731
DOI	10.1097/TXD.0000000000001534
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Donor-specific HLA antibodies in predicting crossmatch outcome: Comparison of three different laboratory techniques.

Peräsaari, J P / Jaatinen, T / Merenmies, J

Transplant immunology

2017 Volume 46, Page(s) 23–28

Abstract: The virtual crossmatch, which is based on single antigen bead technology, is used in the prediction of crossmatch results. However, this assay differs in sensitivity and specificity from crossmatch methods. In our study, the results of physical ... ...

Abstract	The virtual crossmatch, which is based on single antigen bead technology, is used in the prediction of crossmatch results. However, this assay differs in sensitivity and specificity from crossmatch methods. In our study, the results of physical crossmatches, performed with three different methods, were assessed against virtual crossmatch results. The aim was to determine the potential cut-off values for donor specific antibodies (DSA) that would predict the crossmatch results obtained by different methods. The results of different crossmatch techniques were correlated with the virtual crossmatch. The receiver operating characteristic (ROC) analysis revealed the Flow cytometric crossmatch (FCXM) and Luminex crossmatch (LXM) to be the most accurate, with area under curve (AUC) values of 0.861 and 0.805, respectively. While we found that the virtual crossmatch correlated well with all the crossmatch results, FCXM produced the best results (83% of the DSA detected). LXM outperformed the other tests in terms of the accuracy in separating class II DSA.
MeSH term(s)	Blood Grouping and Crossmatching/methods ; Flow Cytometry ; Graft Rejection/diagnosis ; Graft Rejection/prevention & control ; HLA Antigens/immunology ; Histocompatibility Testing ; Humans ; Kidney Transplantation ; Microspheres ; Predictive Value of Tests ; Prognosis ; ROC Curve ; Sensitivity and Specificity ; Tissue Donors ; Ureohydrolases/blood
Chemical Substances	HLA Antigens ; Ureohydrolases (EC 3.5.3.-) ; allantoicase (EC 3.5.3.4)
Language	English
Publishing date	2017-11-20
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1160846-8
ISSN	1878-5492 ; 0966-3274
ISSN (online)	1878-5492
ISSN	0966-3274
DOI	10.1016/j.trim.2017.11.002
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Article: Käänteinen oppiminen lääketieteen peruskoulutuksessa.

Merenmies, Jussi / Niemi-Murola, Leila / Pyörälä, Eeva

Duodecim; laaketieteellinen aikakauskirja

2015 Volume 131, Issue 21, Page(s) 2009–2015

Abstract: Medical education is facing changes in order to improve young doctors' competency to respond better to current needs of the patients and the society. Both curriculum content and teaching methods are revised. In addition to vibrant research in academic ... ...

Title translation	Flipped classroom in basic medical education.
Abstract	Medical education is facing changes in order to improve young doctors' competency to respond better to current needs of the patients and the society. Both curriculum content and teaching methods are revised. In addition to vibrant research in academic medical education, teachers are supported by the improved web-based learning environments and novel technical tools. Flipped classroom, a new paradigm that benefits from technical development, provides many opportunities for medical education. This teaching method always consists of two mutually complementary parts. The first part of the learning action takes place independently off classroom with video lectures or other stimuli for learning. The second part takes place in conjunction with the teacher and other students, and requires student group interactions.
MeSH term(s)	Clinical Competence ; Curriculum/trends ; Education, Medical, Undergraduate/trends ; Humans ; Internet ; Problem-Based Learning ; Teaching/trends ; Video Recording
Language	Finnish
Publishing date	2015
Publishing country	Finland
Document type	English Abstract ; Journal Article
ZDB-ID	127604-9
ISSN	0012-7183
ISSN	0012-7183
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Article: Valmistuvan Iääkärin toimenpidetaidot - kohti sulautuvaa opetusta.

Niemi-Murola, Leila / Karppinen, Helena / Kaila, Minna / Merenmies, Jussi

Duodecim; laaketieteellinen aikakauskirja

2016 Volume 132, Issue 3, Page(s) 260–265

Abstract: Medical students feel that their ability to carry out procedures is lower than desired. Whereas supervised learning is easily arranged at scheduled appointment clinics, experience in emergency procedures often accumulates only during practical training. ... ...

Title translation	Procedural skills of students qualifying as a doctor - towards blended learning.
Abstract	Medical students feel that their ability to carry out procedures is lower than desired. Whereas supervised learning is easily arranged at scheduled appointment clinics, experience in emergency procedures often accumulates only during practical training. A large part of the students had turned to the internet in search for advice or repetition about typical emergency procedures. With the growing yearly intake by the faculties it will be difficult to increase contact teaching at the clinical stage, but it is possible to improve its quality through flipped classroom. Procedural videos found in the internet are well suited for stimuli prior to contact teaching.
MeSH term(s)	Clinical Competence ; Education, Medical, Undergraduate/methods ; Emergency Medicine/education ; Humans ; Internet ; Teaching Materials
Language	Finnish
Publishing date	2016
Publishing country	Finland
Document type	English Abstract ; Journal Article
ZDB-ID	127604-9
ISSN	0012-7183
ISSN	0012-7183
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Kystinen munuaissairaus ja diabetes--alidiagnosoitu yksigeeninen kehityshäiriö.

Merenmies, Jussi / Ala-Houhala, Marja / Tuomi, Tiinamaija

Duodecim; laaketieteellinen aikakauskirja

2012 Volume 128, Issue 19, Page(s) 1999–2006

Abstract: Heterozygous mutations in the TCF2 gene encoding the transcription factor HNF-11 cause a dominantly inherited developmental disorder that may be associated with various dysplastic and cystic lesions of the kidneys and renal insufficiency, disorder of ... ...

Title translation	Cystic kidney disease and diabetes--an underdiagnosed monogenic developmental disorder.
Abstract	Heterozygous mutations in the TCF2 gene encoding the transcription factor HNF-11 cause a dominantly inherited developmental disorder that may be associated with various dysplastic and cystic lesions of the kidneys and renal insufficiency, disorder of pancreatic development and insulin-deficient MODY diabetes, aberrant hepatic enzyme levels, gout and genital anomalies. Symptoms and findings vary in their degree of severity. When an isolated abnormality is detected, recognition of the syndrome is essential in order to diagnose the other organ manifestations. Since the mid-2000's, 10 to 20 patients have been diagnosed in Finland.
MeSH term(s)	Diabetes Mellitus/epidemiology ; Diabetes Mellitus/genetics ; Finland/epidemiology ; Hepatocyte Nuclear Factor 1-beta/genetics ; Heterozygote ; Humans ; Kidney Diseases, Cystic/epidemiology ; Kidney Diseases, Cystic/genetics ; Mutation
Chemical Substances	HNF1B protein, human ; Hepatocyte Nuclear Factor 1-beta (138674-15-4)
Language	Finnish
Publishing date	2012
Publishing country	Finland
Document type	English Abstract ; Journal Article
ZDB-ID	127604-9
ISSN	0012-7183
ISSN	0012-7183
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Article ; Online: Serum neutrophil gelatinase-associated lipocalin and recovery of kidney graft function after transplantation.

Hollmen, Maria E / Kyllönen, Lauri E / Merenmies, Jussi / Salmela, Kaija T

BMC nephrology

2014 Volume 15, Page(s) 123

Abstract: Background: Neutrophil gelatinase-associated lipocalin (NGAL) is a marker for acute kidney injury. We studied whether serum NGAL predicts delayed graft function (DGF) and recovery of kidney function after transplantation.: Methods: Serum NGAL was ... ...

Abstract	Background: Neutrophil gelatinase-associated lipocalin (NGAL) is a marker for acute kidney injury. We studied whether serum NGAL predicts delayed graft function (DGF) and recovery of kidney function after transplantation. Methods: Serum NGAL was analyzed using commercial ELISA and point-of-care (POC) (Triage®, Biosite) methods. Serum samples were collected from 176 consecutive, deceased-donor kidney recipients just before transplant surgery and on day 1 and 14 after transplantation. The first 132 samples were analyzed with both methods and the remaining samples with the POC method. Results: The correlation between the ELISA and POC methods was 0.89, p < 0.0001 and hence the POC method was used for the remaining analyses. DGF was seen in 66/176 patients. Day 1 sNGAL was significantly higher in DGF (588 ng/ml, SD 189.6) compared to early graft function (355 ng/ml, SD 166.2, p < 0.0001) and this difference persisted on day 14. Day 1 sNGAL predicted DGF with an area under the curve (AUC) of 0.853 (CI 0.792-0.914, p < 0.0001). At the optimal cutoff level of 423 ng/ml the sensitivity was 87% and the specificity 77%. In a multivariate analysis, day 1 sNGAL emerged as an independent predictor of DGF. The sNGAL also predicted DGF lasting longer than 14 days with an AUC of 0.825 (CI 0.751-0.899, p < 0.0001). At the optimal cutoff level of 486 ng/ml, the sensitivity was 80% and specificity 75%. Conclusion: Serum NGAL predicts clinically significant DGF and is useful in the care of kidney transplant recipients.
MeSH term(s)	Acute-Phase Proteins ; Aged ; Biomarkers/blood ; Delayed Graft Function/blood ; Delayed Graft Function/diagnosis ; Female ; Humans ; Kidney Transplantation/trends ; Lipocalin-2 ; Lipocalins/blood ; Male ; Middle Aged ; Proto-Oncogene Proteins/blood ; Tissue Donors
Chemical Substances	Acute-Phase Proteins ; Biomarkers ; LCN2 protein, human ; Lipocalin-2 ; Lipocalins ; Proto-Oncogene Proteins
Language	English
Publishing date	2014-07-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041348-8
ISSN	1471-2369 ; 1471-2369
ISSN (online)	1471-2369
ISSN	1471-2369
DOI	10.1186/1471-2369-15-123
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Cell density-dependent expression of heparin-binding growth-associated molecule (HB-GAM, p18) and its down-regulation by fibroblast growth factors.

Merenmies, J

FEBS letters

1992 Volume 307, Issue 3, Page(s) 297–300

Abstract: Heparin-binding growth-associated molecule (HB-GAM) is a developmentally regulated protein that is intensely expressed during the rapid postnatal growth phase of rat brain. The expression of HB-GAM studied in 12 cell lines was restricted to C6 rat glioma ...

Abstract	Heparin-binding growth-associated molecule (HB-GAM) is a developmentally regulated protein that is intensely expressed during the rapid postnatal growth phase of rat brain. The expression of HB-GAM studied in 12 cell lines was restricted to C6 rat glioma cell line and BALB/c 3T3 cells. In BALB/c 3T3 cells the expression of HB-GAM was enhanced in confluent and quiescent cell cultures. When the confluent cultures were treated with bFGF the expression of HB-GAM mRNA was strongly reduced and the protein disappeared rapidly from proliferating cells. The data presented suggest involvement of HB-GAM in cell differentiation phenomena rather than in cell proliferation.
MeSH term(s)	3T3 Cells ; Animals ; Blotting, Western ; Carrier Proteins/biosynthesis ; Carrier Proteins/physiology ; Cell Count ; Cell Differentiation/physiology ; Cell Division/physiology ; Cytokines/biosynthesis ; Cytokines/physiology ; Down-Regulation ; Fibroblast Growth Factor 1/pharmacology ; Fibroblast Growth Factor 2/pharmacology ; Growth Substances/biosynthesis ; Growth Substances/genetics ; Growth Substances/physiology ; Mice ; Mice, Inbred BALB C ; RNA, Messenger/metabolism ; Rats ; Tumor Cells, Cultured
Chemical Substances	Carrier Proteins ; Cytokines ; Growth Substances ; RNA, Messenger ; Fibroblast Growth Factor 2 (103107-01-3) ; Fibroblast Growth Factor 1 (104781-85-3) ; pleiotrophin (134034-50-7)
Language	English
Publishing date	1992-08-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	212746-5
ISSN	1873-3468 ; 0014-5793
ISSN (online)	1873-3468
ISSN	0014-5793
DOI	10.1016/0014-5793(92)80699-h
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Thesis: Heparin-binding proteins amphoterin and HB-GAM in neuronal development

Merenmies, Jussi

(Commentationes physico-mathematicae et chemico-medicae ; 139)

1992

Author's details	Jussi Merenmies
Series title	Commentationes physico-mathematicae et chemico-medicae ; 139
Language	English
Size	64 S., graph. Darst.
Publisher	Finnish Society of Sciences and Letters
Publishing place	Helsinki
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Univ., Diss.--Helsinki, 1992
ISBN	9516532470 ; 9789516532472
Database	Former special subject collection: coastal and deep sea fishing

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Book ; Thesis: Heparin-binding proteins amphoterin and HB-GAM in neuronal development

Merenmies, Jussi

(Commentationes physico-mathematicae et chemico-medicae ; 139)

1992

Author's details	Jussi Merenmies
Series title	Commentationes physico-mathematicae et chemico-medicae ; 139
Language	English
Size	64 S., graph. Darst.
Publisher	Finnish Society of Sciences and Letters
Publishing place	Helsinki
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Univ., Diss.--Helsinki, 1992
ISBN	9516532470 ; 9789516532472
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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