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Article ; Online: Peripartum Lipid Apheresis: Novel Management of Familial Hyperlipidemia in Pregnancy.

Shapero, Kayle / Countouris, Malamo / Chibisov, Irina / Jeyabalan, Arun / Berlacher, Kathryn

JACC. Case reports

2023 Volume 27, Page(s) 102052

Abstract: Familial hypercholesterolemia (FH) is a genetic lipid disorder associated with early-onset severe cardiovascular disease. Many FH therapeutics have not been studied in pregnancy, and management of patients with FH through pregnancy is limited. We present ...

Abstract	Familial hypercholesterolemia (FH) is a genetic lipid disorder associated with early-onset severe cardiovascular disease. Many FH therapeutics have not been studied in pregnancy, and management of patients with FH through pregnancy is limited. We present a patient with FH who was safely treated through pregnancy with combination therapy.
Language	English
Publishing date	2023-12-06
Publishing country	Netherlands
Document type	Case Reports
ISSN	2666-0849
ISSN (online)	2666-0849
DOI	10.1016/j.jaccas.2023.102052
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Outcomes of Endocarditis in Pregnancy: A Single-Center Experience.

Shapero, Kayle / El-Dalati, Sami / Berlacher, Kathryn / Megli, Christina

Open forum infectious diseases

2023 Volume 10, Issue 9, Page(s) ofad470

Abstract: Background: The incidence of infective endocarditis (IE) in pregnancy is rare (0.006%), with increasing prevalence during the opioid epidemic. IE in pregnancy is associated with high rates of mortality and morbidity, and existing data on outcomes in ... ...

Abstract	Background: The incidence of infective endocarditis (IE) in pregnancy is rare (0.006%), with increasing prevalence during the opioid epidemic. IE in pregnancy is associated with high rates of mortality and morbidity, and existing data on outcomes in pregnancy are limited. Our study compares the outcomes of pregnant patients with IE with those of nonpregnant patients. Methods: Patients diagnosed with IE during pregnancy and 30 days postpartum between 2014 and 2021 were identified by International Classification of Diseases, Clinical Modification, Ninth and Tenth Edition codes. Pregnant cases were matched to nonpregnant reproductive-age endocarditis patients in a 1:4 ratio. Data were collected and validated through chart review. Results: One hundred eighty patients with IE were identified; 34 were pregnant or within 30 days postpartum at diagnosis. There were higher rates of hepatitis C and opioid maintenance therapy in the pregnant patients. The etiology of IE in pregnant patients was predominantly Conclusions: We observed similar rates of mortality in the pregnant IE patients. We observed a microbial predilection for
Language	English
Publishing date	2023-09-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2757767-3
ISSN	2328-8957
ISSN	2328-8957
DOI	10.1093/ofid/ofad470
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Article ; Online: Subaortic Stenosis With Elevated Aortic Gradients in a Pregnant Patient.

Shapero, Kayle S / Chou, Josephine C

JACC. Case reports

2020 Volume 2, Issue 1, Page(s) 131–134

Abstract: Subaortic stenosis is an obstructive lesion that may be exacerbated by pregnancy. We describe the management of a 39-year-old woman presenting at 37 weeks of pregnancy with a murmur who is found to have a subaortic membrane with severely elevated left ... ...

Abstract	Subaortic stenosis is an obstructive lesion that may be exacerbated by pregnancy. We describe the management of a 39-year-old woman presenting at 37 weeks of pregnancy with a murmur who is found to have a subaortic membrane with severely elevated left ventricular outflow gradients. (
Language	English
Publishing date	2020-01-15
Publishing country	Netherlands
Document type	Case Reports
ISSN	2666-0849
ISSN (online)	2666-0849
DOI	10.1016/j.jaccas.2019.11.054
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Article ; Online: Exertional Syncope in College Varsity Athletes.

Gier, Chad / Shapero, Kayle / Lynch, Mathew / Spatz, Erica S / Young, Lawrence / Arlis-Mayor, Stephanie / Lampert, Rachel

JACC. Clinical electrophysiology

2023 Volume 9, Issue 8 Pt 2, Page(s) 1596–1597

MeSH term(s)	Humans ; Athletes ; Sports ; Syncope/diagnosis ; Syncope/epidemiology ; Syncope/etiology
Language	English
Publishing date	2023-05-24
Publishing country	United States
Document type	Letter
ZDB-ID	2846739-5
ISSN	2405-5018 ; 2405-500X ; 2405-500X
ISSN (online)	2405-5018 ; 2405-500X
ISSN	2405-500X
DOI	10.1016/j.jacep.2023.04.004
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Article: Management of infective endocarditis in pregnancy by a multidisciplinary team: a case series.

Shapero, Kayle S / Nauriyal, Varidhi / Megli, Christina / Berlacher, Kathryn / El-Dalati, Sami

Therapeutic advances in infectious disease

2022 Volume 9, Page(s) 20499361221080644

Abstract: Introduction: The incidence of infective endocarditis (IE) in pregnancy is rare and has been increasing during the opioid epidemic. IE in pregnancy is associated with high rates of maternal and fetal morbidity and mortality. Multidisciplinary ... ...

Abstract	Introduction: The incidence of infective endocarditis (IE) in pregnancy is rare and has been increasing during the opioid epidemic. IE in pregnancy is associated with high rates of maternal and fetal morbidity and mortality. Multidisciplinary endocarditis teams for management of IE have been shown to reduce in-hospital and 1-year mortality. We present a single-center experience managing IE in pregnancy utilizing a multidisciplinary endocarditis team. Methods: Patients diagnosed with IE while pregnant or within 30 days post-partum were identified. All patients discussed at the institution's weekly multidisciplinary endocarditis meeting were included. Demographic and clinical data and outcome-related variables were retrospectively reviewed and recorded. Results: Between 1 October 2020 and 1 June 2021 6 pregnant or 30-day post-partum patients with IE were identified. All patients had co-morbid injection drug use; Discussion: In a small retrospective cases series, coordination of care by a multidisciplinary endocarditis team led to a high-rate of surgical intervention with no patient-directed discharges and no in-hospital or 90-day mortality. Conclusion: Multidisciplinary endocarditis teams are a low-risk intervention that may improve outcomes in pregnant patients with IE.
Language	English
Publishing date	2022-02-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2728410-4
ISSN	2049-937X ; 2049-9361
ISSN (online)	2049-937X
ISSN	2049-9361
DOI	10.1177/20499361221080644
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Article ; Online: Endovascular Treatment of Inferior Vena Cava Thrombosis in Metastatic Malignancy: A Case Report and Review of Literature.

Shapero, Kayle S / Jelani, Qurat-Ul-Ain / Mena, Carlos

Vascular and endovascular surgery

2019 Volume 53, Issue 6, Page(s) 507–511

Abstract: Inferior vena cava (IVC) thrombosis is a specific form of thromboembolism that occurs at a rate of 1.5% in all patients hospitalized with a deep vein thrombosis. Malignant IVC thrombosis may occur due to compression from a tumor mass or metastasis or may ...

Abstract	Inferior vena cava (IVC) thrombosis is a specific form of thromboembolism that occurs at a rate of 1.5% in all patients hospitalized with a deep vein thrombosis. Malignant IVC thrombosis may occur due to compression from a tumor mass or metastasis or may also occur through tumor invasion of the venous vasculature. Obstruction of the IVC can lead to IVC syndrome, marked by ascites, lower extremity edema, and even congestive hepatic failure. We present a case of extensive IVC thrombosis in a 69-year-old female with metastatic adrenal cell carcinoma, presenting with severe bilateral lower extremity edema and ascites. Computed tomography showed IVC compression by the caudate lobe due to a metastatic liver mass and extensive clot burden of the IVC extending from the renal veins to the right atrium (RA). She underwent percutaneous IVC stenting with 4 stents placed in tandem from the IVC to the RA. Her hospital course was complicated by gastrointestinal bleed requiring clipping, acute liver failure, and hypophysitis due to trial therapy. Although her IVC symptoms were partially relieved with percutaneous intervention, her acute liver failure worsened and she was ultimately transitioned to hospice care.
MeSH term(s)	Adrenal Cortex Neoplasms/complications ; Adrenal Cortex Neoplasms/diagnostic imaging ; Adrenal Cortex Neoplasms/pathology ; Adrenocortical Carcinoma/complications ; Adrenocortical Carcinoma/diagnostic imaging ; Adrenocortical Carcinoma/secondary ; Aged ; Computed Tomography Angiography ; Endovascular Procedures/instrumentation ; Female ; Humans ; Phlebography/methods ; Stents ; Treatment Outcome ; Ultrasonography, Interventional ; Vena Cava, Inferior/diagnostic imaging ; Vena Cava, Inferior/surgery ; Venous Thrombosis/diagnostic imaging ; Venous Thrombosis/etiology ; Venous Thrombosis/surgery
Language	English
Publishing date	2019-06-19
Publishing country	United States
Document type	Case Reports ; Journal Article ; Review ; Video-Audio Media
ZDB-ID	2076272-0
ISSN	1938-9116 ; 1538-5744
ISSN (online)	1938-9116
ISSN	1538-5744
DOI	10.1177/1538574419857992
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Zs.A 622: Show issues

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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Outcomes of mechanical circulatory support for acute myocardial infarction complicated by cardiogenic shock.

Kim, Yeunjung / Shapero, Kayle / Ahn, Shawn S / Goldsweig, Andrew M / Desai, Nihar / Altin, S Elissa

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

2021 Volume 99, Issue 3, Page(s) 658–663

Abstract: Background: Mechanical circulatory support (MCS) with the Impella device (Abiomed, Danvers, MA) has been associated with higher in-hospital mortality than intra-aortic balloon pump (IABP) in the Premier Healthcare Database and National Cardiovascular ... ...

Abstract	Background: Mechanical circulatory support (MCS) with the Impella device (Abiomed, Danvers, MA) has been associated with higher in-hospital mortality than intra-aortic balloon pump (IABP) in the Premier Healthcare Database and National Cardiovascular Data Registry. Methods: The objective of this retrospective cohort study was to describe trends and outcomes of Impella usage in acute myocardial infarction complicated by cardiogenic shock (AMICS) treated with MCS (Impella or IABP) using real-world observational data from the National Inpatient Sample (NIS) including hospitalizations for AMICS managed with MCS between January 2012 to December 2017. The primary outcomes included in-hospital mortality, transfusion, acute kidney injury, stroke, total costs, and length of stay. Propensity score matching was performed with hierarchical models using risk factor and Elixhauser comorbidity variables. Results and conclusion: We identified 54,480 hospitalizations for AMICS managed with MCS including 5750 (10.5%) utilizing Impella. Throughout the study period, Impella usage increased yearly to 19.9% of AMICS cases in 2017. After propensity score matching, Impella was associated with higher in-hospital mortality (odds ratio [OR] 1.74, 95% confidence interval [CI] 1.41-2.13) and transfusions (OR 1.97, 95% CI 1.40-2.78) than IABP, without association with acute kidney injury or stroke. Impella use was associated with higher hospital costs (mean difference $22,416.80 [95% CI $17,029-27,804]). Impella usage for AMICS increased significantly from 2012 to 2017 and was associated with increased in-hospital mortality and costs. Randomized controlled trials are urgently needed to assess the safety and efficacy of Impella.
MeSH term(s)	Heart-Assist Devices/adverse effects ; Humans ; Intra-Aortic Balloon Pumping ; Myocardial Infarction/complications ; Myocardial Infarction/diagnosis ; Myocardial Infarction/therapy ; Retrospective Studies ; Shock, Cardiogenic/diagnosis ; Shock, Cardiogenic/etiology ; Shock, Cardiogenic/therapy ; Treatment Outcome
Language	English
Publishing date	2021-06-22
Publishing country	United States
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	1459995-8
ISSN	1522-726X ; 1522-1946
ISSN (online)	1522-726X
ISSN	1522-1946
DOI	10.1002/ccd.29834
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Zs.A 1226: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Experiences of athletes with arrhythmogenic cardiac conditions in returning to play.

Shapero, Kayle / Gier, Chad / Briske, Kaylie / Spatz, Erica S / Wasfy, Meagan / Baggish, Aaron L / Pierce, Stacey / Ackerman, Michael J / Lampert, Rachel

Heart rhythm O2

2022 Volume 3, Issue 2, Page(s) 133–140

Abstract: Background: Recommendations for return to play (RTP) for athletes with genetic (or congenital) heart diseases (GHD) predisposing to sudden cardiac death (SCD) have evolved from an initially paternalistic and conservative approach, to supporting a more ... ...

Abstract	Background: Recommendations for return to play (RTP) for athletes with genetic (or congenital) heart diseases (GHD) predisposing to sudden cardiac death (SCD) have evolved from an initially paternalistic and conservative approach, to supporting a more flexible approach to decision-making. The experiences of athletes and their families during the RTP process are unknown. Objective: To understand current RTP processes. Methods: We administered a mixed-methods telephone interview combining quantitative and qualitative components to 30 athletes with a GHD who had RTP, and 23 parents. Participants were identified from the Yale ICD Sports registry and Mayo Clinic's Windland Smith Rice Genetic Heart Rhythm Clinic. Qualitative data were analyzed using a grounded theory approach to identify common themes. Results: Most common diagnoses were long QT syndrome and hypertrophic cardiomyopathy and most common sports, soccer, basketball, and football. Twenty-three athletes encountered ≥1 perceived barrier(s) to RTP: 17 were restricted by their first cardiologist; 6 were required to meet with school administrators, 4 signed waivers, and 3 hired lawyers. Common themes expressed by athletes and their parents were frustration with poor communication, perceived lack of physician knowledge of their diagnosis, and unilateral, paternalistic decision-making, as well as cynicism that physicians and schools were primarily concerned with liability. After RTP, 26 athletes had some form of emergency action plan, although responsibility was often left to the family. Conclusion: Many perceived barriers exist for athletes with GHD who wish to RTP after their diagnoses. Shared decision-making from the onset is critical for RTP.
Language	English
Publishing date	2022-01-25
Publishing country	United States
Document type	Journal Article
ISSN	2666-5018
ISSN (online)	2666-5018
DOI	10.1016/j.hroo.2022.01.009
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Article ; Online: Effect of institutional transcatheter aortic valve replacement volume on mortality: A systematic review and meta-analysis.

Kir, Devika / Shapero, Kayle / Chatterjee, Saurav / Grimshaw, Alyssa / Oddleifson, August / Spatz, Erica S / Goldsweig, Andrew M / Desai, Nihar R

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

2021 Volume 98, Issue 3, Page(s) E453–E461

Abstract: Objective: We sought to conduct a systematic review and network meta-analysis to examine the association between institutional transcatheter aortic valve replacement (TAVR) volume and all-cause mortality.: Background: Since inception in 2011, there ... ...

Abstract	Objective: We sought to conduct a systematic review and network meta-analysis to examine the association between institutional transcatheter aortic valve replacement (TAVR) volume and all-cause mortality. Background: Since inception in 2011, there has been an exponential increase in the number of TAVR centers across the world. Multiple studies have questioned if a relationship exists between institutional TAVR volume and patient outcomes. Methods: We performed a systematic literature search for relevant articles using a combination of free text terms in the title/abstract related to volume, TAVR, and patient outcomes. Two reviewers independently screened all titles/abstracts for eligibility based on pre-specified criteria. All-cause mortality data was pooled from eligible studies and centers were categorized as low-(30-50 cases), intermediate-, or high-volume (75-130 cases) based on their annual TAVR volumes. Results: Our search yielded an initial list of 11,153 citations, 120 full text studies were reviewed and 7 studies met all inclusion and exclusion criteria, yielding a total of 1,93,498 TAVRs. Categorized according to center's annual volume; 25,062 TAVRs were performed in low-, 77,093 in intermediate- and 91,343 in high-volume centers. Network meta-analysis showed a relative reduction in mortality rates of 37%, 23% and 19%, for high volume versus low volume centers, high volume versus intermediate volume centers and intermediate versus low volume centers, respectively. Conclusions: Existing research clearly shows an inverse relationship between annual TAVR procedural volume and all-cause mortality. We need to focus on development of strong referral networks and consolidation rather than expansion of existing TAVR centers to improve patient outcomes, while ensuring adequate access-to-care.
MeSH term(s)	Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/surgery ; Humans ; Risk Factors ; Transcatheter Aortic Valve Replacement/adverse effects ; Treatment Outcome
Language	English
Publishing date	2021-02-10
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
ZDB-ID	1459995-8
ISSN	1522-726X ; 1522-1946
ISSN (online)	1522-726X
ISSN	1522-1946
DOI	10.1002/ccd.29502
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Zs.A 1226: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Cardio-obstetrics: Recognizing and managing cardiovascular complications of pregnancy.

Shapero, Kayle S / Desai, Nihar R / Elder, Robert W / Lipkind, Heather S / Chou, Josephine C / Spatz, Erica S

Cleveland Clinic journal of medicine

2020 Volume 87, Issue 1, Page(s) 43–52

Abstract: Pregnancy can exacerbate known cardiovascular disorders and unmask previously unrecognized problems. Patients with congenital heart disorders, valvular disease, primary pulmonary hypertension, hypertensive disorders of pregnancy, and acquired peripartum ... ...

Abstract	Pregnancy can exacerbate known cardiovascular disorders and unmask previously unrecognized problems. Patients with congenital heart disorders, valvular disease, primary pulmonary hypertension, hypertensive disorders of pregnancy, and acquired peripartum cardiomyopathy need a collaborative interdisciplinary team that includes a cardiologist with specialty training in obstetrics.
MeSH term(s)	Cardiology/methods ; Cardiomyopathies/therapy ; Female ; Humans ; Hypertension, Pregnancy-Induced/therapy ; Obstetrics/methods ; Patient Care Team ; Pregnancy ; Pregnancy Complications, Cardiovascular/therapy ; Prenatal Care/methods
Language	English
Publishing date	2020-01-02
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	639116-3
ISSN	1939-2869 ; 0891-1150
ISSN (online)	1939-2869
ISSN	0891-1150
DOI	10.3949/ccjm.87a.18137
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