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  1. Article: Sex-related differences in incidence, phenotype and risk of sudden cardiac death in inherited arrhythmia syndromes.

    Asatryan, Babken / Barth, Andreas S

    Frontiers in cardiovascular medicine

    2023  Volume 9, Page(s) 1010748

    Abstract: Inherited Arrhythmia Syndromes (IAS) including long QT and Brugada Syndrome, are characterized by life-threatening arrhythmias in the absence of apparent structural heart disease and are caused by pathogenic variants in genes encoding cardiac ion ... ...

    Abstract Inherited Arrhythmia Syndromes (IAS) including long QT and Brugada Syndrome, are characterized by life-threatening arrhythmias in the absence of apparent structural heart disease and are caused by pathogenic variants in genes encoding cardiac ion channels or associated proteins. Studies of large pedigrees of families affected by IAS have demonstrated incomplete penetrance and variable expressivity. Biological sex is one of several factors that have been recognized to modulate disease severity in IAS. There is a growing body of evidence linking sex hormones to the susceptibility to arrhythmias, yet, many sex-specific disease aspects remain underrecognized as female sex and women with IAS are underinvestigated and findings from male-predominant cohorts are often generalized to both sexes with minimal to no consideration of relevant sex-associated differences in prevalence, disease manifestations and outcome. In this review, we highlight current knowledge of sex-related biological differences in normal cardiac electrophysiology and sex-associated factors that influence IAS phenotypes.
    Language English
    Publishing date 2023-01-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.1010748
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Unraveling Complexities in Genetically Elusive Long QT Syndrome.

    Asatryan, Babken / Murray, Brittney / Gasperetti, Alessio / McClellan, Rebecca / Barth, Andreas S

    Circulation. Arrhythmia and electrophysiology

    2024  Volume 17, Issue 2, Page(s) e012356

    Abstract: Genetic testing has become standard of care for patients with long QT syndrome (LQTS), providing diagnostic, prognostic, and therapeutic information for both probands and their family members. However, up to a quarter of patients with LQTS do not have ... ...

    Abstract Genetic testing has become standard of care for patients with long QT syndrome (LQTS), providing diagnostic, prognostic, and therapeutic information for both probands and their family members. However, up to a quarter of patients with LQTS do not have identifiable Mendelian pathogenic variants in the currently known LQTS-associated genes. This absence of genetic confirmation, intriguingly, does not lessen the severity of LQTS, with the prognosis in these gene-elusive patients with unequivocal LQTS mirroring genotype-positive patients in the limited data available. Such a conundrum instigates an exploration into the causes of corrected QT interval (QTc) prolongation in these cases, unveiling a broad spectrum of potential scenarios and mechanisms. These include multiple environmental influences on QTc prolongation, exercise-induced repolarization abnormalities, and the profound implications of the constantly evolving nature of genetic testing and variant interpretation. In addition, the rapid advances in genetics have the potential to uncover new causal genes, and polygenic risk factors may aid in the diagnosis of high-risk patients. Navigating this multifaceted landscape requires a systematic approach and expert knowledge, integrating the dynamic nature of genetics and patient-specific influences for accurate diagnosis, management, and counseling of patients. The role of a subspecialized expert cardiogenetic clinic is paramount in evaluation to navigate this complexity. Amid these intricate aspects, this review outlines potential causes of gene-elusive LQTS. It also provides an outline for the evaluation of patients with negative and inconclusive genetic test results and underscores the need for ongoing adaptation and reassessment in our understanding of LQTS, as the complexities of gene-elusive LQTS are increasingly deciphered.
    MeSH term(s) Humans ; Electrocardiography ; Long QT Syndrome/diagnosis ; Long QT Syndrome/genetics ; Long QT Syndrome/therapy ; Genotype ; Risk Factors ; Genetic Testing
    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2426129-4
    ISSN 1941-3084 ; 1941-3149
    ISSN (online) 1941-3084
    ISSN 1941-3149
    DOI 10.1161/CIRCEP.123.012356
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6667: Show issues Location:
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  3. Article: Catheter Ablation for Channelopathies: When Is Less More?

    Mehta, Adhya / Chandiramani, Rishi / Ghosh, Binita / Asatryan, Babken / Hajra, Adrija / Barth, Andreas S

    Journal of clinical medicine

    2024  Volume 13, Issue 8

    Abstract: Ventricular fibrillation (VF) is a common cause of sudden cardiac death in patients with channelopathies, particularly in the young population. Although pharmacological treatment, cardiac sympathectomy, and implantable cardioverter defibrillators (ICD) ... ...

    Abstract Ventricular fibrillation (VF) is a common cause of sudden cardiac death in patients with channelopathies, particularly in the young population. Although pharmacological treatment, cardiac sympathectomy, and implantable cardioverter defibrillators (ICD) have been the mainstay in the management of VF in patients with channelopathies, they are associated with significant adverse effects and complications, leading to poor quality of life. Given these drawbacks, catheter ablation has been proposed as a therapeutic option for patients with channelopathies. Advances in imaging techniques and modern mapping technologies have enabled increased precision in identifying arrhythmia triggers and substrate modification. This has aided our understanding of the underlying pathophysiology of ventricular arrhythmias in channelopathies, highlighting the roles of the Purkinje network and the epicardial right ventricular outflow tract in arrhythmogenesis. This review explores the role of catheter ablation in managing the most common channelopathies (Brugada syndrome, congenital long QT syndrome, short QT syndrome, and catecholaminergic polymorphic ventricular tachycardia). While the initial results for ablation in Brugada syndrome are promising, the long-term efficacy and durability of ablation in different channelopathies require further investigation. Given the genetic and phenotypic heterogeneity of channelopathies, future studies are needed to show whether catheter ablation in patients with channelopathies is associated with a reduction in VF, and psychological distress stemming from recurrent ICD shocks, particularly relative to other available therapeutic options (e.g., quinidine in high-risk Brugada patients).
    Language English
    Publishing date 2024-04-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13082384
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  4. Article ; Online: Increased risk of myocarditis and arrythmias in anti-Ku positive scleroderma-myositis overlap patients: a case series.

    Bhalodia, Aashik / Bermea, Kevin / Schmidt, Jen / Gilotra, Nisha / Barth, Andreas S / Adamo, Luigi / Paik, Julie J

    Rheumatology (Oxford, England)

    2024  

    Language English
    Publishing date 2024-03-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/keae199
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 240: Show issues Location:
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    Zs.MO 497: Show issues

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  5. Article: CME: Plantarfasziitis.

    Barth, Sebastian / Zeller, Andreas

    Praxis

    2022  Volume 110, Issue 4, Page(s) 224–231

    Abstract: CME: Plantar ... ...

    Title translation CME: Plantar fasciitis.
    Abstract CME: Plantar fasciitis
    MeSH term(s) Fasciitis, Plantar/diagnosis ; Fasciitis, Plantar/therapy ; Humans
    Language German
    Publishing date 2022-02-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 209026-0
    ISSN 1661-8165 ; 1661-8157 ; 0369-8394
    ISSN (online) 1661-8165
    ISSN 1661-8157 ; 0369-8394
    DOI 10.1024/1661-8157/a003836
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    Zs.MO 12: Show issues

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  6. Article: Left bundle pacing in a patient with atrioventricular canal defect presenting with atrial standstill and junctional bradycardia.

    Aronis, Konstantinos N / Yang, Eunice / Barnes, Benjamin T / Cedars, Ari / De La Uz, Caridad M / Barth, Andreas S

    HeartRhythm case reports

    2023  Volume 9, Issue 5, Page(s) 314–318

    Language English
    Publishing date 2023-02-23
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834871-0
    ISSN 2214-0271
    ISSN 2214-0271
    DOI 10.1016/j.hrcr.2023.02.009
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  7. Article ; Online: How and Why to Organise Family-Based Screening Clinics for Hypertrophic Cardiomyopathy.

    Rivers, Bryana J / Carrick, Richard T / Muller, Steven A / Barth, Andreas S / Madrazo, Jose A / James, Cynthia A

    The Canadian journal of cardiology

    2023  

    Language English
    Publishing date 2023-10-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2023.09.027
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    Zs.A 2150: Show issues Location:
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  8. Article ; Online: 13

    Paul, Suman / Jeništová, Adéla / Vosough, Faraz / Berntsson, Elina / Mörman, Cecilia / Jarvet, Jüri / Gräslund, Astrid / Wärmländer, Sebastian K T S / Barth, Andreas

    Communications chemistry

    2023  Volume 6, Issue 1, Page(s) 163

    Abstract: Interactions between molecules are fundamental in biology. They occur also between amyloidogenic peptides or proteins that are associated with different amyloid diseases, which makes it important to study the mutual influence of two polypeptides on each ... ...

    Abstract Interactions between molecules are fundamental in biology. They occur also between amyloidogenic peptides or proteins that are associated with different amyloid diseases, which makes it important to study the mutual influence of two polypeptides on each other's properties in mixed samples. However, addressing this research question with imaging techniques faces the challenge to distinguish different polypeptides without adding artificial probes for detection. Here, we show that nanoscale infrared spectroscopy in combination with
    Language English
    Publishing date 2023-08-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2929562-2
    ISSN 2399-3669 ; 2399-3669
    ISSN (online) 2399-3669
    ISSN 2399-3669
    DOI 10.1038/s42004-023-00955-w
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  9. Article ; Online: Filling in the gaps: deciphering the function of noncoding DNA.

    Barth, Andreas S

    Circulation. Cardiovascular genetics

    2012  Volume 5, Issue 1, Page(s) 151–152

    Language English
    Publishing date 2012-02-01
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 2477394-3
    ISSN 1942-3268 ; 1942-325X
    ISSN (online) 1942-3268
    ISSN 1942-325X
    DOI 10.1161/CIRCGENETICS.111.962670
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    Zs.A 6731: Show issues Location:
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  10. Article ; Online: Prolonged asystole during REM sleep: A case report and review of the literature.

    Sampognaro, James R / Barth, Andreas S / Jun, Jonathan C / Chrispin, Jonathan / Berger, Ronald D / Love, Charles J / Eddy, Courtney / Calkins, Hugh

    Heart rhythm O2

    2022  Volume 3, Issue 5, Page(s) 613–619

    Language English
    Publishing date 2022-07-22
    Publishing country United States
    Document type Case Reports
    ISSN 2666-5018
    ISSN (online) 2666-5018
    DOI 10.1016/j.hroo.2022.07.007
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