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  1. Article ; Online: Chromium (VI) promotes lung cancer initiation by activating EGF/ALDH1A1 signalling.

    Metropulos, Anastasia E / Becker, Jeffrey H / Principe, Daniel R

    Clinical and translational discovery

    2022  Volume 2, Issue 4

    Abstract: Lung cancer is the leading cause of cancer-related death worldwide and is strongly associated with tobacco smoke exposure. Though smoking remains the most important and best studied risk factor, recent data suggests that several other carcinogens have a ... ...

    Abstract Lung cancer is the leading cause of cancer-related death worldwide and is strongly associated with tobacco smoke exposure. Though smoking remains the most important and best studied risk factor, recent data suggests that several other carcinogens have a driving role in lung cancer development, particularly in select populations at risk of high or prolonged exposure. Hexavalent chromium [Cr(VI)] is a known carcinogen that is widely used in the manufacturing industry. While the link between Cr(VI) and lung cancer incidence is well-accepted, the mechanisms through which Cr(VI) promotes lung cancer development are poorly understood. In the present study by Ge and colleagues published in
    Language English
    Publishing date 2022-12-14
    Publishing country United States
    Document type Journal Article ; Comment
    ISSN 2768-0622
    ISSN (online) 2768-0622
    DOI 10.1002/ctd2.155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Correction: Prioritizing surveillance of Nipah virus in India.

    Plowright, Raina K / Becker, Daniel J / Crowley, Daniel E / Washburne, Alex D / Huang, Tao / Nameer, P O / Gurley, Emily S / Han, Barbara A

    PLoS neglected tropical diseases

    2023  Volume 17, Issue 2, Page(s) e0011126

    Abstract: This corrects the article DOI: 10.1371/journal.pntd.0007393.]. ...

    Abstract [This corrects the article DOI: 10.1371/journal.pntd.0007393.].
    Language English
    Publishing date 2023-02-10
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2735
    ISSN (online) 1935-2735
    ISSN 1935-2735
    DOI 10.1371/journal.pntd.0011126
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: A paired analysis of mercury among non-invasive tissues to inform bat conservation monitoring.

    Simonis, Molly C / Whitmore, Kimberlee / Dyer, Kristin E / Allira, Meagan / Demory, Bret / Chumchal, Matthew M / Becker, Daniel J

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Contaminant exposure can harm wildlife. However, measuring contaminant exposure in wildlife can be challenging due to accessibility of species and/or sampling tissue matrices needed to answer research questions regarding exposure. For example, in bats ... ...

    Abstract Contaminant exposure can harm wildlife. However, measuring contaminant exposure in wildlife can be challenging due to accessibility of species and/or sampling tissue matrices needed to answer research questions regarding exposure. For example, in bats and other taxa that roost, it may be best to collect pooled feces from colonies for minimal disturbance to species of conservation concern, but fecal contaminant concentrations do not provide contaminant bioaccumulation estimates. Thus, there is a need for quantifying relationships between sample matrices for measuring contaminant exposure to answer research questions pertaining to wildlife health and addressing conservation needs. Our goal was to determine relationships between fecal and fur total mercury (THg). To do so, we collected paired feces and fur from Mexican free-tailed bats (
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.31.587502
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Post-graduation career pathways: a nationwide survey among dental students in Germany.

    Thiem, Daniel G E / Puladi, Behrus / Seifert, Lukas / Becker, Philipp / Bjelopavlovic, Monika / Magennis, Patrick / Wiltfang, Jörg / Warwas, Felix Benjamin

    Clinical oral investigations

    2024  Volume 28, Issue 2, Page(s) 134

    Abstract: Objectives: Oral and maxillofacial surgery (OMFS) has to compete with other specialties for the best candidates. With the upcoming change of generations (Z and Alpha) and the movement toward gender parity of dentistry, understanding changing preferences ...

    Abstract Objectives: Oral and maxillofacial surgery (OMFS) has to compete with other specialties for the best candidates. With the upcoming change of generations (Z and Alpha) and the movement toward gender parity of dentistry, understanding changing preferences and misconceptions is essential.
    Material and methods: An online survey was conducted by the German-Association-of-Oral-and-Maxillofacial-Surgery (DGMKG) across German dental schools. The survey collected demographic data, academic background, and career aspirations, with a focus on OMFS. The dental student survey results were compared to a survey given to OMFS Specialists.
    Results: 637 dental students, mainly female (70%), from 30 German universities participated. 27% had defined career aspirations post-graduation, with self-employment and academia being popular choices. 67% were unsure. Specializations leaned towards restorative dentistry (41%), orthodontics (36%), and prosthodontics (31%). While 73% showed interest in surgical practices, 20% were attracted in specializing in OMFS. Of those averse to OMFS, 78% cited long training duration as the deterrent, 12% were put off by perceived unattractive working hours. Other reasons included negative undergraduate experiences, scarcity of part-time positions, and perceived inadequate earnings.
    Conclusion: Accurate data is crucial for career decisions. OMFS societies must proactively share accurate information and guide students. OMFS offers family-friendly hours, and while its training might be longer than dental specialties, it is on par with other surgical professions.
    Clinical relevance: Dental students consistently regard OMFS as commendable career path. To guarantee sustained OMFS expertise, it is imperative to nurture this interest through dedicated academic mentorship and innovative education, thereby solidifying their professional direction.
    MeSH term(s) Humans ; Female ; Male ; Students, Dental ; Career Choice ; Surgery, Oral/education ; Orthodontics ; Surveys and Questionnaires ; Germany
    Language English
    Publishing date 2024-02-05
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1364490-7
    ISSN 1436-3771 ; 1432-6981
    ISSN (online) 1436-3771
    ISSN 1432-6981
    DOI 10.1007/s00784-024-05535-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4788: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Quantitative description of the phase-separation behavior of the multivalent SLP65-CIN85 complex.

    Maier, Joachim / Sieme, Daniel / Wong, Leo E / Dar, Furqan / Wienands, Jürgen / Becker, Stefan / Griesinger, Christian

    PNAS nexus

    2024  Volume 3, Issue 3, Page(s) pgae079

    Abstract: Biomolecular condensates play a major role in cell compartmentalization, besides membrane-enclosed organelles. The multivalent SLP65 and CIN85 proteins are proximal B-cell antigen receptor (BCR) signal effectors and critical for proper immune responses. ... ...

    Abstract Biomolecular condensates play a major role in cell compartmentalization, besides membrane-enclosed organelles. The multivalent SLP65 and CIN85 proteins are proximal B-cell antigen receptor (BCR) signal effectors and critical for proper immune responses. In association with intracellular vesicles, the two effector proteins form phase separated condensates prior to antigen stimulation, thereby preparing B lymphocytes for rapid and effective activation upon BCR ligation. Within this tripartite system, 6 proline-rich motifs (PRMs) of SLP65 interact promiscuously with 3 SH3 domains of the CIN85 monomer, establishing 18 individual SH3-PRM interactions whose individual dissociation constants we determined. Based on these 18 dissociation constants, we measured the phase-separation properties of the natural SLP65/CIN85 system as well as designer constructs that emphasize the strongest SH3/PRM interactions. By modeling these various SLP65/CIN85 constructs with the program LASSI (LAttice simulation engine for Sticker and Spacer Interactions), we reproduced the observed phase-separation properties. In addition, LASSI revealed a deviation in the experimental measurement, which was independently identified as a previously unknown intramolecular interaction. Thus, thermodynamic properties of the individual PRM/SH3 interactions allow us to model the phase-separation behavior of the SLP65/CIN85 system faithfully.
    Language English
    Publishing date 2024-02-14
    Publishing country England
    Document type Journal Article
    ISSN 2752-6542
    ISSN (online) 2752-6542
    DOI 10.1093/pnasnexus/pgae079
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  6. Article ; Online: Coronavirus sampling and surveillance in bats from 1996-2019: a systematic review and meta-analysis.

    Cohen, Lily E / Fagre, Anna C / Chen, Binqi / Carlson, Colin J / Becker, Daniel J

    Nature microbiology

    2023  Volume 8, Issue 6, Page(s) 1176–1186

    Abstract: The emergence of SARS-CoV-2 highlights a need for evidence-based strategies to monitor bat viruses. We performed a systematic review of coronavirus sampling (testing for RNA positivity) in bats globally. We identified 110 studies published between 2005 ... ...

    Abstract The emergence of SARS-CoV-2 highlights a need for evidence-based strategies to monitor bat viruses. We performed a systematic review of coronavirus sampling (testing for RNA positivity) in bats globally. We identified 110 studies published between 2005 and 2020 that collectively reported positivity from 89,752 bat samples. We compiled 2,274 records of infection prevalence at the finest methodological, spatiotemporal and phylogenetic level of detail possible from public records into an open, static database named datacov, together with metadata on sampling and diagnostic methods. We found substantial heterogeneity in viral prevalence across studies, reflecting spatiotemporal variation in viral dynamics and methodological differences. Meta-analysis identified sample type and sampling design as the best predictors of prevalence, with virus detection maximized in rectal and faecal samples and by repeat sampling of the same site. Fewer than one in five studies collected and reported longitudinal data, and euthanasia did not improve virus detection. We show that bat sampling before the SARS-CoV-2 pandemic was concentrated in China, with research gaps in South Asia, the Americas and sub-Saharan Africa, and in subfamilies of phyllostomid bats. We propose that surveillance strategies should address these gaps to improve global health security and enable the origins of zoonotic coronaviruses to be identified.
    MeSH term(s) Animals ; Humans ; Chiroptera ; Phylogeny ; SARS-CoV-2/genetics ; COVID-19/epidemiology ; China
    Language English
    Publishing date 2023-05-25
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 2058-5276
    ISSN (online) 2058-5276
    DOI 10.1038/s41564-023-01375-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Evaluation of Medication-Related Osteonecrosis of the Jaw (MRONJ) in Terms of Staging and Treatment Strategies by Dental Students at Different Educational Levels.

    Heimes, Diana / Mark, Nicolas Alexander / Kuchen, Robert / Pabst, Andreas / Becker, Philipp / Kyyak, Solomiya / Thiem, Daniel G E / Schulze, Ralf / Kämmerer, Peer W

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 2

    Abstract: ... ...

    Abstract Background
    MeSH term(s) Humans ; Bisphosphonate-Associated Osteonecrosis of the Jaw/diagnosis ; Bisphosphonate-Associated Osteonecrosis of the Jaw/epidemiology ; Bisphosphonate-Associated Osteonecrosis of the Jaw/prevention & control ; Bone Density Conservation Agents/therapeutic use ; Cross-Sectional Studies ; Students, Dental ; Educational Status ; Diphosphonates
    Chemical Substances Bone Density Conservation Agents ; Diphosphonates
    Language English
    Publishing date 2023-01-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59020252
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6270: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Correction

    Raina K Plowright / Daniel J Becker / Daniel E Crowley / Alex D Washburne / Tao Huang / P O Nameer / Emily S Gurley / Barbara A Han

    PLoS Neglected Tropical Diseases, Vol 17, Iss 2, p e

    Prioritizing surveillance of Nipah virus in India.

    2023  Volume 0011126

    Abstract: This corrects the article DOI:10.1371/journal.pntd.0007393.]. ...

    Abstract [This corrects the article DOI:10.1371/journal.pntd.0007393.].
    Keywords Arctic medicine. Tropical medicine ; RC955-962 ; Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  9. Article ; Online: Detection of Trypanosoma cruzi in the saliva of diverse neotropical bats.

    Bergner, Laura M / Becker, Daniel J / Tello, Carlos / Carrera, Jorge E / Streicker, Daniel G

    Zoonoses and public health

    2021  Volume 68, Issue 3, Page(s) 271–276

    Abstract: Trypanosoma cruzi is widely reported in bats, yet transmission routes remain unclear. We present evidence from metagenomic sequence data that T. cruzi occurs in the saliva of diverse Neotropical bats. Phylogenetic analyses demonstrated that the bat- ... ...

    Abstract Trypanosoma cruzi is widely reported in bats, yet transmission routes remain unclear. We present evidence from metagenomic sequence data that T. cruzi occurs in the saliva of diverse Neotropical bats. Phylogenetic analyses demonstrated that the bat-associated T. cruzi sequences described here formed part of a bat-specific clade, suggesting an independent transmission cycle. Our results highlight the value in repurposing metagenomic data generated for viral discovery to reveal insights into the biology of other parasites. Evaluating whether the presence of T. cruzi in the saliva of two hematophagous bat species represents an ecological route for zoonotic transmission of Chagas disease is an interesting avenue for future research.
    MeSH term(s) Animals ; Chiroptera/virology ; Peru ; Phylogeny ; Saliva/virology ; Trypanosoma cruzi/genetics ; Trypanosoma cruzi/isolation & purification
    Language English
    Publishing date 2021-01-23
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2271118-1
    ISSN 1863-2378 ; 1863-1959
    ISSN (online) 1863-2378
    ISSN 1863-1959
    DOI 10.1111/zph.12808
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Bat cellular immunity varies by year and dietary habit amidst land conversion.

    DeAnglis, Isabella K / Andrews, Benjamin R / Lock, Lauren R / Dyer, Kristin E / Yang, Anni / Volokhov, Dmitriy V / Fenton, M Brock / Simmons, Nancy B / Downs, Cynthia J / Becker, Daniel J

    Conservation physiology

    2024  Volume 12, Issue 1, Page(s) coad102

    Abstract: Monitoring the health of wildlife populations is essential in the face of increased agricultural expansion and forest fragmentation. Loss of habitat and habitat degradation can negatively affect an animal's physiological state, possibly resulting in ... ...

    Abstract Monitoring the health of wildlife populations is essential in the face of increased agricultural expansion and forest fragmentation. Loss of habitat and habitat degradation can negatively affect an animal's physiological state, possibly resulting in immunosuppression and increased morbidity or mortality. We sought to determine how land conversion may differentially impact cellular immunity and infection risk in Neotropical bats species regularly infected with bloodborne pathogens, and to evaluate how effects may vary over time and by dietary habit. We studied common vampire bats (
    Language English
    Publishing date 2024-01-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2721508-8
    ISSN 2051-1434
    ISSN 2051-1434
    DOI 10.1093/conphys/coad102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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