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  1. Article: Listeria monocytogenes

    Mejía, Lorena / Espinosa-Mata, Estefanía / Freire, Ana Lucía / Zapata, Sonia / González-Candelas, Fernando

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1278860

    Abstract: ... Listeria ... ...

    Abstract Listeria monocytogenes
    Language English
    Publishing date 2023-12-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1278860
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Genomic Surveillance of

    Sánchez-Serrano, Andrea / Mejía, Lorena / Camaró, Maria Luisa / Ortolá-Malvar, Susana / Llácer-Luna, Martín / García-González, Neris / González-Candelas, Fernando

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 5

    Abstract: Salmonella ... ...

    Abstract Salmonella enterica
    Language English
    Publishing date 2023-05-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12050883
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Genomic analysis of the initial dissemination of carbapenem-resistant

    Garcia-Gonzalez, Neris / Fuster, Begoña / Tormo, Nuria / Salvador, Carme / Gimeno, Concepcion / Gonzalez-Candelas, Fernando

    Microbial genomics

    2023  Volume 9, Issue 6

    Abstract: Carbapenem- ... ...

    Abstract Carbapenem-resistant
    MeSH term(s) Humans ; Klebsiella pneumoniae/genetics ; beta-Lactamases/genetics ; Tertiary Care Centers ; Klebsiella Infections/epidemiology ; Carbapenem-Resistant Enterobacteriaceae/genetics ; Carbapenems/pharmacology ; Genomics ; Clone Cells
    Chemical Substances beta-Lactamases (EC 3.5.2.6) ; Carbapenems
    Language English
    Publishing date 2023-06-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2835258-0
    ISSN 2057-5858 ; 2057-5858
    ISSN (online) 2057-5858
    ISSN 2057-5858
    DOI 10.1099/mgen.0.001032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Comparative genomics and evolutionary analysis of

    Francés-Cuesta, Carlos / Ansari, Iván / Fernández-Garayzábal, José Francisco / Gibello, Alicia / González-Candelas, Fernando

    Microbial genomics

    2022  Volume 8, Issue 2

    Abstract: Lactococcus ... ...

    Abstract Lactococcus garvieae
    MeSH term(s) Animals ; Biological Evolution ; Endocarditis ; Genomics/methods ; Humans ; Lactococcus/genetics ; Mammals
    Language English
    Publishing date 2022-02-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2835258-0
    ISSN 2057-5858 ; 2057-5858
    ISSN (online) 2057-5858
    ISSN 2057-5858
    DOI 10.1099/mgen.0.000771
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Genetic determinants of host tropism in Klebsiella phages.

    Beamud, Beatriz / García-González, Neris / Gómez-Ortega, Mar / González-Candelas, Fernando / Domingo-Calap, Pilar / Sanjuan, Rafael

    Cell reports

    2023  Volume 42, Issue 2, Page(s) 112048

    Abstract: Bacteriophages play key roles in bacterial ecology and evolution and are potential antimicrobials. However, the determinants of phage-host specificity remain elusive. Here, we isolate 46 phages to challenge 138 representative clinical isolates of ... ...

    Abstract Bacteriophages play key roles in bacterial ecology and evolution and are potential antimicrobials. However, the determinants of phage-host specificity remain elusive. Here, we isolate 46 phages to challenge 138 representative clinical isolates of Klebsiella pneumoniae, a widespread opportunistic pathogen. Spot tests show a narrow host range for most phages, with <2% of 6,319 phage-host combinations tested yielding detectable interactions. Bacterial capsule diversity is the main factor restricting phage host range. Consequently, phage-encoded depolymerases are key determinants of host tropism, and depolymerase sequence types are associated with the ability to infect specific capsular types across phage families. However, all phages with a broader host range found do not encode canonical depolymerases, suggesting alternative modes of entry. These findings expand our knowledge of the complex interactions between bacteria and their viruses and point out the feasibility of predicting the first steps of phage infection using bacterial and phage genome sequences.
    MeSH term(s) Humans ; Klebsiella/genetics ; Bacteriophages/genetics ; Viral Tropism ; Klebsiella pneumoniae/genetics ; Genome, Viral
    Language English
    Publishing date 2023-02-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.112048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Impact of time elapsed since full vaccination on SARS-CoV-2 RNA load in Delta-variant breakthrough COVID-19.

    de Michelena, Paula / Torres, Ignacio / Albert, Eliseo / Bracho, Alma / González-Candelas, Fernando / Navarro, David

    The Journal of infection

    2022  Volume 84, Issue 4, Page(s) 579–613

    MeSH term(s) COVID-19/prevention & control ; Humans ; RNA, Viral/genetics ; SARS-CoV-2/genetics ; Serologic Tests ; Vaccination
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2022-01-10
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2022.01.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1501: Show issues Location:
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  7. Article ; Online: Homologous recombination as a mechanism of genetic changes in bovine parainfluenza-3 virus.

    Alatorre-García, Thalia A / Fonseca-Coronado, Salvador / González-Candelas, Fernando

    Veterinary microbiology

    2021  Volume 261, Page(s) 109185

    Abstract: Bovine parainfluenza-3 virus (BPIV-3) is one of the main viruses associated with bovine respiratory disease complex (BRDC) worldwide. BPIV-3 infect the bovine respiratory tract causing from subclinical infections to severe pneumonia with significant ... ...

    Abstract Bovine parainfluenza-3 virus (BPIV-3) is one of the main viruses associated with bovine respiratory disease complex (BRDC) worldwide. BPIV-3 infect the bovine respiratory tract causing from subclinical infections to severe pneumonia with significant economic losses in the cattle industry. BPIV-3 is a RNA virus with high genetic variability, nevertheless, the contribution of recombination events to its variability has not been assessed so far. In this study the 25 complete genome sequences (CGS) reported so far and 215 partial sequences of different viral genes of BPIV-3 were analyzed to determine their genotypes and subgenotypes, distribution, and the existence of potential recombination events. Based on the analysis of the HN, M, N, and P genes one hypothetical subgenotype was found (subgenotype A4). Four recombination events between sequences of swine and cattle were detected by RDP4 analysis in conjunction with phylogenetic incongruences in the L gene. In addition, 9 sequences reported from Argentina were found to be miss-classified. These results reveal that homologous recombination events have a relevant role in the evolution of BPIV-3 and highlight the importance of implement advanced molecular characterization to better understand the variability and evolution of BPIV-3 as a component of BRDC.
    MeSH term(s) Animals ; Cattle ; Cattle Diseases/virology ; Genetic Variation/genetics ; Genotype ; Homologous Recombination/genetics ; Parainfluenza Virus 3, Bovine/classification ; Parainfluenza Virus 3, Bovine/genetics ; Phylogeny ; Respirovirus Infections/virology ; Sheep ; Sheep Diseases/virology ; Viral Proteins/genetics
    Chemical Substances Viral Proteins
    Language English
    Publishing date 2021-07-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 753154-0
    ISSN 1873-2542 ; 0378-1135
    ISSN (online) 1873-2542
    ISSN 0378-1135
    DOI 10.1016/j.vetmic.2021.109185
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2917: Show issues Location:
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  8. Article ; Online: SARS-CoV-2 RNA load in nasopharyngeal specimens from outpatients with breakthrough COVID-19 due to Omicron BA.1 and BA.2.

    de Michelena, Paula / Olea, Beatriz / Torres, Ignacio / González-Candelas, Fernando / Navarro, David

    Journal of medical virology

    2022  Volume 94, Issue 12, Page(s) 5836–5840

    Abstract: This retrospective observational study compared severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA load in nasopharyngeal specimens (NPs) from patients with breakthrough coronavirus disease 2019 (COVID-19) caused by the Omicron BA.1 or BA.2 ...

    Abstract This retrospective observational study compared severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA load in nasopharyngeal specimens (NPs) from patients with breakthrough coronavirus disease 2019 (COVID-19) caused by the Omicron BA.1 or BA.2 sublineages. The convenience sample was composed of 277 outpatients (176 female/112 male; median age, 48 years; range, 12-97) with breakthrough COVID-19 (n = 130 due to BA.1 and n = 147 due to BA.2). All participants had completed a full vaccination schedule and 56% had received a booster vaccine dose at the time of COVID-19 breakthrough microbiological diagnosis. NPs were collected within 7 days (median 2 days) after symptom onset. The TaqPath COVID-19 Combo Kit (Thermo Fisher Scientific) was used to estimate viral loads in NPs. Overall, viral RNA loads in NPs were comparable (p = 0.31) for BA.1 (median, 7.1 log
    MeSH term(s) COVID-19/diagnosis ; COVID-19 Vaccines ; Female ; Humans ; Male ; Middle Aged ; Outpatients ; RNA, Viral/genetics ; SARS-CoV-2/genetics
    Chemical Substances COVID-19 Vaccines ; RNA, Viral
    Language English
    Publishing date 2022-08-29
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.28079
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    Zs.A 1320: Show issues Location:
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  9. Article ; Online: The impact of genetic recombination on pathogenic Leptospira.

    Mejía, Lorena / Prado, Belén / Cárdenas, Paúl / Trueba, Gabriel / González-Candelas, Fernando

    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases

    2022  Volume 102, Page(s) 105313

    Abstract: Leptospirosis is the most common zoonosis worldwide, and is increasingly common in poor urban communities, where there is inadequate sewage disposal and abundance of domestic and peridomestic animals. There are many risk factors associated with the ... ...

    Abstract Leptospirosis is the most common zoonosis worldwide, and is increasingly common in poor urban communities, where there is inadequate sewage disposal and abundance of domestic and peridomestic animals. There are many risk factors associated with the disease, such as contaminated water exposure, close contact with animals, floods, recreational activities related to water, wet agriculture. The symptoms of leptospirosis are common to other infectious diseases and, if not treated, it can lead to meningitis, liver failure, kidney damage and death. Leptospirosis is caused by 38 pathogenic species of Leptospira, which are divided in almost 30 serogroups and more than 300 serovars. The serological classification (serogroups and serovars) is based on the expression of distinct lipopolysaccharide (LPS) antigens. These antigens are also associated to protective immunity; antibodies against a serovar protect from any member of the same serovar. Serologic and phylogenetic analyses are not congruent probably due to genetic recombination of LPS genes among different leptospiral species. To analyze the importance of recombination in leptospiral evolution, we performed a gene-by-gene tree topology comparison on closed genomes available in public databases at two levels: among core genomes of pathogenic species (34 recombinant among 1213 core genes), and among core genomes of L. interrogans isolates (178/798). We found that most recombinant genes code for proteins involved in translation, ribosomal structure and biogenesis, but also for cell wall, membrane and envelope biogenesis. Besides, our final results showed that half of LPS genes are recombinant (18/36). This is relevant because serovar classification and vaccine development are based on these epitopes. The frequent recombination of LPS-associated genes suggests that natural selection is promoting the survival of recombinant lineages. These results may help understanding the factors that make Leptospira a successful pathogen.
    MeSH term(s) Animals ; Leptospira/genetics ; Leptospirosis ; Lipopolysaccharides ; Phylogeny ; Recombination, Genetic ; Water
    Chemical Substances Lipopolysaccharides ; Water (059QF0KO0R)
    Language English
    Publishing date 2022-06-07
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2037068-4
    ISSN 1567-7257 ; 1567-1348
    ISSN (online) 1567-7257
    ISSN 1567-1348
    DOI 10.1016/j.meegid.2022.105313
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    Zs.A 5645: Show issues Location:
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  10. Article ; Online: Redefining the treponemal history through pre-Columbian genomes from Brazil.

    Majander, Kerttu / Pla-Díaz, Marta / du Plessis, Louis / Arora, Natasha / Filippini, Jose / Pezo-Lanfranco, Luis / Eggers, Sabine / González-Candelas, Fernando / Schuenemann, Verena J

    Nature

    2024  Volume 627, Issue 8002, Page(s) 182–188

    Abstract: The origins of treponemal diseases have long remained unknown, especially considering the sudden onset of the first syphilis epidemic in the late 15th century in Europe and its hypothesized arrival from the Americas with Columbus' ... ...

    Abstract The origins of treponemal diseases have long remained unknown, especially considering the sudden onset of the first syphilis epidemic in the late 15th century in Europe and its hypothesized arrival from the Americas with Columbus' expeditions
    MeSH term(s) Humans ; Brazil/epidemiology ; Brazil/ethnology ; Europe/epidemiology ; Evolution, Molecular ; Genome, Bacterial/genetics ; History, 15th Century ; History, Ancient ; Syphilis/epidemiology ; Syphilis/history ; Syphilis/microbiology ; Syphilis/transmission ; Treponema pallidum/classification ; Treponema pallidum/genetics ; Treponema pallidum/isolation & purification ; Treponemal Infections/epidemiology ; Treponemal Infections/history ; Treponemal Infections/microbiology ; Treponemal Infections/transmission
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-023-06965-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 26: Show issues Location:
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    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

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