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Article ; Online: Impact on the time elapsed since SARS-CoV-2 infection, vaccination history, and number of doses, on protection against reinfection.

Sánchez-de Prada, Laura / Martínez-García, Ana María / González-Fernández, Belén / Gutiérrez-Ballesteros, Javier / Rojo-Rello, Silvia / Garcinuño-Pérez, Sonsoles / Álvaro-Meca, Alejandro / Ortiz De Lejarazu, Raúl / Sanz-Muñoz, Iván / Eiros, José M

Scientific reports

2024 Volume 14, Issue 1, Page(s) 353

Abstract: SARS-CoV-2 reinfections have been frequent, even among those vaccinated. The aim of this study is to know if hybrid immunity (infection + vaccination) is affected by the moment of vaccination and number of doses received. We conducted a retrospective ... ...

Abstract	SARS-CoV-2 reinfections have been frequent, even among those vaccinated. The aim of this study is to know if hybrid immunity (infection + vaccination) is affected by the moment of vaccination and number of doses received. We conducted a retrospective study in 746 patients with a history of COVID-19 reinfection and recovered the dates of infection and reinfection and vaccination status (date and number of doses). To assess differences in the time to reinfection(t
MeSH term(s)	Humans ; COVID-19/epidemiology ; COVID-19/prevention & control ; SARS-CoV-2 ; Reinfection/epidemiology ; Reinfection/prevention & control ; Retrospective Studies ; Vaccination
Language	English
Publishing date	2024-01-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-50335-6
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Article ; Online: Survey of neurocritical patient care in Spain. Part 2: Cerebrovascular disease.

Llompart-Pou, J A / Barea-Mendoza, J A / Pérez-Bárcena, J / Sánchez-Casado, M / Ballesteros-Sanz, M Á / Chico-Fernández, M

Medicina intensiva

2021 Volume 45, Issue 7, Page(s) e1–e3

MeSH term(s)	Cerebrovascular Disorders/therapy ; Critical Care ; Humans ; Intensive Care Units ; Spain ; Surveys and Questionnaires
Language	English
Publishing date	2021-07-01
Publishing country	Spain
Document type	Case Reports
ISSN	2173-5727
ISSN (online)	2173-5727
DOI	10.1016/j.medine.2021.06.001
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Article ; Online: CAR Immunotherapy for the treatment of infectious diseases: a systematic review.

Morte-Romea, Elena / Pesini, Cecilia / Pellejero-Sagastizábal, Galadriel / Letona-Giménez, Santiago / Martínez-Lostao, Luis / Aranda, Silvia Loscos / Toyas, Carla / Redrado, Sergio / Dolader-Ballesteros, Elena / Arias, Maykel / Galvez, Eva M / Sanz-Pamplona, Rebeca / Pardo, Julián / Paño-Pardo, Jose Ramón / Ramírez-Labrada, Ariel

Frontiers in immunology

2024 Volume 15, Page(s) 1289303

Abstract: Immunotherapy treatments aim to modulate the host's immune response to either mitigate it in inflammatory/autoimmune disease or enhance it against infection or cancer. Among different immunotherapies reaching clinical application during the last years, ... ...

Abstract	Immunotherapy treatments aim to modulate the host's immune response to either mitigate it in inflammatory/autoimmune disease or enhance it against infection or cancer. Among different immunotherapies reaching clinical application during the last years, chimeric antigen receptor (CAR) immunotherapy has emerged as an effective treatment for cancer where different CAR T cells have already been approved. Yet their use against infectious diseases is an area still relatively poorly explored, albeit with tremendous potential for research and clinical application. Infectious diseases represent a global health challenge, with the escalating threat of antimicrobial resistance underscoring the need for alternative therapeutic approaches. This review aims to systematically evaluate the current applications of CAR immunotherapy in infectious diseases and discuss its potential for future applications. Notably, CAR cell therapies, initially developed for cancer treatment, are gaining recognition as potential remedies for infectious diseases. The review sheds light on significant progress in CAR T cell therapy directed at viral and opportunistic fungal infections.
MeSH term(s)	Humans ; Receptors, Chimeric Antigen ; Immunotherapy ; Immunotherapy, Adoptive ; Neoplasms/therapy ; Communicable Diseases/therapy
Chemical Substances	Receptors, Chimeric Antigen
Language	English
Publishing date	2024-01-30
Publishing country	Switzerland
Document type	Systematic Review ; Research Support, Non-U.S. Gov't ; Journal Article
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2024.1289303
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Article ; Online: Intrapleural hematoma and hyperinsuflation of the native lung in lung transplant recipients.

Arlabán Carpintero, M / Sánchez Arguiano, J / Ballesteros Sanz, M A

Medicina intensiva

2018 Volume 43, Issue 5, Page(s) 326

Title translation	Hematoma intrapleural e hiperinsuflación del pulmón nativo en paciente con trasplante pulmonar.
MeSH term(s)	Air ; Hematoma/diagnostic imaging ; Humans ; Lung Diseases/diagnostic imaging ; Lung Transplantation ; Middle Aged ; Pleural Diseases/diagnostic imaging ; Postoperative Complications/diagnostic imaging
Language	Spanish
Publishing date	2018-07-09
Publishing country	Spain
Document type	Case Reports ; Journal Article
ISSN	2173-5727
ISSN (online)	2173-5727
DOI	10.1016/j.medin.2018.05.006
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Article ; Online: Severe traumatic disease register in Spain.

Chico-Fernández, M / Llompart-Pou, J A / Sánchez-Casado, M / Ballesteros-Sanz, M Á

Medicina intensiva

2017 Volume 41, Issue 5, Page(s) 324–325

Title translation	Registro de enfermedad traumática grave en España.
Language	Spanish
Publishing date	2017-06
Publishing country	Spain
Document type	Letter
ZDB-ID	731753-0
ISSN	1578-6749 ; 0210-5691
ISSN (online)	1578-6749
ISSN	0210-5691
DOI	10.1016/j.medin.2017.02.011
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Article ; Online: Encuesta de atención al paciente neurocrítico en España. Parte 1: Traumatismos del sistema nervioso central.

Llompart-Pou, J A / Barea-Mendoza, J A / Pérez-Bárcena, J / Sánchez-Casado, M / Ballesteros-Sanz, M A / Chico-Fernández, M

Medicina intensiva

2019 Volume 45, Issue 4, Page(s) 250–252

Title translation	Survey of the neurocritical patient care in Spain. Part 1: Trauma of the central nervous system.
Language	Spanish
Publishing date	2019-10-11
Publishing country	Spain
Document type	Case Reports
ISSN	2173-5727
ISSN (online)	2173-5727
DOI	10.1016/j.medin.2019.09.001
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Article ; Online: Is peritoneal dialysis suitable technique CKD patients over 65 years? A prospective multicenter study.

Portolés, Jose / Vega, Almudena / Lacoba, Enrique / López-Sánchez, Paula / Botella, Mario / Yuste, Claudia / Martín Cleary, Catalina / Sanz Ballesteros, Sandra / González Sanchidrian, Silvia / Sánchez García, Luisa / Carreño, Agustín / Bajo, M Auxiliadora / Janeiro, Darío

Nefrologia

2021 Volume 41, Issue 5, Page(s) 529–538

Abstract: Background: Chronic kidney disease (CKD) is increasing in patients older than 65 years and is related to morbidity, frailty, and dependence. Peritoneal dialysis (PD) has classically been associated with young patients with an active life.: Hypothesis!# ...

Abstract	Background: Chronic kidney disease (CKD) is increasing in patients older than 65 years and is related to morbidity, frailty, and dependence. Peritoneal dialysis (PD) has classically been associated with young patients with an active life. Hypothesis: PD should be offered to patients over 65 years. We search for any unfavorable results that may advice not to recommend PD therapy for this group. Objective: To describe PD treatment and outcomes in patients > 65 years, to compare their results with patients < 65 years and to identify areas with room for improvement in a real-life study. Study: Prospective, observational, and multicenter study performed in incident PD patients, from January 2003 until January 2018. Results: We included 2,435 PD patients, 31.9% were older than 65 years; there was a difference of 25 years between both groups. Median follow up was 2.1 years. Older than 65 years group had more comorbidity: Diabetes (29.5% vs 17.2%; p < 0.001), previous CV events 34.5% vs 14.0%; p < 0.001), Charlson index (3.8 vs 3.0; p < 0.001). We did not find differences in efficacy and PD adequacy objectives fulfillment, anaemia management or blood pressure during follow-up. Peritonitis rate was higher in older 65 years group (0.65 vs 0.45 episodes/patient/year; p < 0.001), but there was not differences in germs, admission rate and follow up. Mortality was higher in older 65 years group (28.4% vs 9.4%) as expected. PD permanence probability was similar (2.1 years). The main cause of PD withdrawal was transplant in group < 65 years (48.3%) and transfer to HD in group > 65 years. The main reason was caregiver or patient fatigue (20.2%), and not technique failure (7.3%). Multivariate Cox regression analysis showed a relation (HR [95%CI]) between mortality and age > 65 years 2.4 [1.9-3.0]; DM 1.6 [1.3-2.1]; CV events 2.1 [1.7-2.7]. Multivariate Cox regression analysis identify a relation between technique failure and age > 65 years 1.5 [1.3-1.9]; DM 1.6 [1.3-1.9] and previous transplant 1.5 [1.2-2.0]. Conclusion: Patients older than 65 years fulfilled PD adequacy criteria during the follow up. We believe PD is a valid option for patients older 65 years. It is necessary to try to prevent infections and patient/caregiver fatigue, to avoid HD transfer for reasons not related to technique failure.
MeSH term(s)	Aged ; Fatigue/complications ; Humans ; Kidney Failure, Chronic/therapy ; Peritoneal Dialysis/methods ; Prospective Studies ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/therapy
Language	English
Publishing date	2021-12-08
Publishing country	Spain
Document type	Journal Article ; Multicenter Study ; Observational Study
ZDB-ID	2837917-2
ISSN	2013-2514 ; 2013-2514
ISSN (online)	2013-2514
ISSN	2013-2514
DOI	10.1016/j.nefroe.2021.11.012
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Article ; Online: Coupled C, H, N, S and Fe biogeochemical cycles operating in the continental deep subsurface of the Iberian Pyrite Belt.

Environmental microbiology

2022 Volume 25, Issue 2, Page(s) 428–453

Abstract: ... the life support system of planet Earth. A 613 m deep geomicrobiological perforation and a systematic multi-analytical ...

Abstract	Microbial activity is a major contributor to the biogeochemical cycles that make up the life support system of planet Earth. A 613 m deep geomicrobiological perforation and a systematic multi-analytical characterization revealed an unexpected diversity associated with the rock matrix microbiome that operates in the subsurface of the Iberian Pyrite Belt (IPB). Members of 1 class and 16 genera were deemed the most representative microorganisms of the IPB deep subsurface and selected for a deeper analysis. The use of fluorescence in situ hybridization allowed not only the identification of microorganisms but also the detection of novel activities in the subsurface such as anaerobic ammonium oxidation (ANAMMOX) and anaerobic methane oxidation, the co-occurrence of microorganisms able to maintain complementary metabolic activities and the existence of biofilms. The use of enrichment cultures sensed the presence of five different complementary metabolic activities along the length of the borehole and isolated 29 bacterial species. Genomic analysis of nine isolates identified the genes involved in the complete operation of the light-independent coupled C, H, N, S and Fe biogeochemical cycles. This study revealed the importance of nitrate reduction microorganisms in the oxidation of iron in the anoxic conditions existing in the subsurface of the IPB.
MeSH term(s)	In Situ Hybridization, Fluorescence ; Bacteria/metabolism ; Iron/metabolism ; Microbiota/genetics ; Oxidation-Reduction
Chemical Substances	pyrite (132N09W4PR) ; Iron (E1UOL152H7)
Language	English
Publishing date	2022-12-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2020213-1
ISSN	1462-2920 ; 1462-2912
ISSN (online)	1462-2920
ISSN	1462-2912
DOI	10.1111/1462-2920.16291
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Article ; Online: Impact of Percutaneous Endoscopic Gastrostomy (PEG) on the Evolution of Disease in Patients with Amyotrophic Lateral Sclerosis (ALS).

López-Gómez, Juan J / Ballesteros-Pomar, María D / Torres-Torres, Beatriz / Pintor-De la Maza, Begoña / Penacho-Lázaro, María A / Palacio-Mures, José M / Abreu-Padín, Cristina / Sanz-Gallego, Irene / De Luis-Román, Daniel A

Nutrients

2021 Volume 13, Issue 8

Abstract: ... both in BMI (kg/m ...

Abstract	Dysphagia is a highly prevalent symptom in Amyotrophic Lateral Sclerosis (ALS), and the implantation of a percutaneous endoscopic gastrostomy (PEG) is a very frequent event. The aim of this study was to evaluate the influence of PEG implantation on survival and complications in ALS. An interhospital registry of patients with ALS of six hospitals in the Castilla-León region (Spain) was created between January 2015 and December 2017. The data were compared for those in whom a PEG was implanted and those who it was not. A total of 93 patients were analyzed. The mean age of the patients was 64.63 (17.67) years. A total of 38 patients (38.8%) had a PEG implantation. An improvement in the anthropometric parameters was observed among patients who had a PEG from the beginning of nutritional follow-up compared to those who did not, both in BMI (kg/m
MeSH term(s)	Aged ; Amyotrophic Lateral Sclerosis/complications ; Amyotrophic Lateral Sclerosis/mortality ; Anthropometry ; Deglutition Disorders/etiology ; Deglutition Disorders/mortality ; Deglutition Disorders/surgery ; Endoscopy, Digestive System/methods ; Endoscopy, Digestive System/mortality ; Female ; Gastrostomy/methods ; Gastrostomy/mortality ; Humans ; Male ; Malnutrition/mortality ; Malnutrition/prevention & control ; Middle Aged ; Nutritional Status ; Prospective Studies ; Registries ; Spain ; Treatment Outcome
Language	English
Publishing date	2021-08-12
Publishing country	Switzerland
Document type	Journal Article ; Multicenter Study ; Observational Study
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13082765
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Article ; Online: Effect of the type of specialized nutrition support on the course of the patient with amyotrophic lateral sclerosis (ALS). Interhospital registry SCLEDyN.

López-Gómez, Juan José / Ballesteros-Pomar, María D / Gómez-Hoyos, Emilia / Pintor de la Maza, Begoña / Penacho-Lázaro, M Ángeles / Palacio-Mures, Jose María / Abreu-Padín, Cristina / Sanz Gallego, Irene / de Luis-Román, Daniel A

Endocrinologia, diabetes y nutricion

2021 Volume 68, Issue 10, Page(s) 699–707

Abstract: ... between the first and second visit [Start: 24.18 (3.29) kg/m: Conclusions: Patients with ALS present ...

Abstract	Introduction: Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease in which specialized nutritional support is essential. The objectives of our study were to describe nutritional support at the beginning of follow-up and its impact on anthropometry and survival. Methods: An interhospital registry was created for the hospitals of Castilla-León through a web platform designed for this purpose. An anamnesis was carried out on the evolution and nutritional history of the disease; and classical anthropometry was determined. The prescribed nutritional treatment was recorded. The parameters were measured at the beginning, at six and twelve months of nutritional follow-up. Results: A total of 93 patients [49 (52.7%) spinal; 44 (47.3%) bulbar)] were analyzed. The nutritional support route at the beginning was oral diet in 36 (38.7%) patients; oral nutritional supplementation (SON) in 46 (49.5%) patients; and in 11 (11.8%) patients percutaneous endoscopic gastrostomy (PEG). A decrease in the body mass index (BMI) was observed between the first and second visit [Start: 24.18 (3.29) kg/m Conclusions: Patients with ALS present a severe deterioration in nutritional status before the start of nutritional support. After the nutritional intervention, a slowdown in weight loss and nutritional deterioration was observed.
MeSH term(s)	Amyotrophic Lateral Sclerosis/therapy ; Gastrostomy ; Humans ; Neurodegenerative Diseases ; Nutritional Support ; Registries
Language	English
Publishing date	2021-12-08
Publishing country	Spain
Document type	Journal Article
ISSN	2530-0180
ISSN (online)	2530-0180
DOI	10.1016/j.endien.2021.11.032
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