LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 711

Search options

  1. Article ; Online: Re: Ithaar H. Derweesh, Rana R. McKay, Aditya Bagrodia. Primary Cytoreductive Nephrectomy: Standing the Test of Time? Eur Urol. 2023;83:152-3.

    Mejean, Arnaud

    European urology

    2023  Volume 83, Issue 5, Page(s) e135

    MeSH term(s) Humans ; Animals ; Cytoreduction Surgical Procedures ; Kidney Neoplasms/surgery ; Carcinoma, Renal Cell/surgery ; Nephrectomy ; Ranidae
    Language English
    Publishing date 2023-02-11
    Publishing country Switzerland
    Document type Letter ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2022.12.039
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1247: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 294: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: Actualisation 2020–2022 des recommandations françaises du Comité de cancérologie de l’AFU – Éditorial.

    Méjean, A

    Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie

    2020  Volume 30, Issue 12S, Page(s) S1

    Title translation Update 2020-2022 of French ccAFU guidelines - Editorial.
    Language French
    Publishing date 2020-12-21
    Publishing country France
    Document type Editorial
    ZDB-ID 1186190-3
    ISSN 1166-7087
    ISSN 1166-7087
    DOI 10.1016/S1166-7087(20)30748-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3959: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Primum Non Nocere: When Nephrectomy Becomes a Selective Approach in Metastatic Renal Cell Carcinoma.

    Méjean, Arnaud

    European urology oncology

    2020  Volume 3, Issue 2, Page(s) 174–175

    MeSH term(s) Carcinoma, Renal Cell/surgery ; Cytoreduction Surgical Procedures ; Humans ; Kidney Neoplasms/surgery ; Nephrectomy ; Prospective Studies ; Vascular Endothelial Growth Factor A
    Chemical Substances Vascular Endothelial Growth Factor A
    Language English
    Publishing date 2020-03-20
    Publishing country Netherlands
    Document type Editorial ; Comment
    ISSN 2588-9311
    ISSN (online) 2588-9311
    DOI 10.1016/j.euo.2020.02.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Cytoreductive Nephrectomy: Still Necessary in 2021.

    Méjean, Arnaud / Bex, Axel

    European urology open science

    2022  Volume 36, Page(s) 49–50

    Language English
    Publishing date 2022-01-06
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-1683
    ISSN (online) 2666-1683
    DOI 10.1016/j.euros.2021.08.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: Progrès dans les traitements des cancers du rein.

    Méjean, Arnaud

    Nephrologie & therapeutique

    2017  Volume 13, Issue 3, Page(s) 154–159

    Abstract: Partial nephrectomy is the gold standard for the renal tumours less than 7 to 10cm whenever feasible in order to preserve renal function. The extension of nephron-sparing surgery using a mini-invasive approach is possible by robotic surgery. Radical ... ...

    Title translation Advancement in the treatment of renal carcinoma.
    Abstract Partial nephrectomy is the gold standard for the renal tumours less than 7 to 10cm whenever feasible in order to preserve renal function. The extension of nephron-sparing surgery using a mini-invasive approach is possible by robotic surgery. Radical nephrectomy is mandatory in the other situations and especially in case of locally advanced renal carcinoma. The place of cytoreductive nephrectomy in metastatic renal cell carcinoma is the purpose of the CARMENA trial. Tyrosine kinase inhibitors are currently the first line treatment; but in the near future new immunotherapy by checkpoints molecules could crucially change the treatment of metastatic renal cell carcinoma. Numerous trials in a neoadjuvant or adjuvant settings are ongoing.
    Language French
    Publishing date 2017-05
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 2229575-6
    ISSN 1872-9177 ; 1769-7255
    ISSN (online) 1872-9177
    ISSN 1769-7255
    DOI 10.1016/j.nephro.2017.02.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6298: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Biosynthesis of Cylindrospermopsin in Cyanobacteria: Characterization of CyrJ the Sulfotransferase.

    Méjean, Annick / Ploux, Olivier

    Journal of natural products

    2021  Volume 84, Issue 2, Page(s) 408–416

    Abstract: 7-Deoxy-desulfo-cylindrospermopsin was purified at small-scale from the supernatant of a culture of the ... ...

    Abstract 7-Deoxy-desulfo-cylindrospermopsin was purified at small-scale from the supernatant of a culture of the cyanobacterium
    MeSH term(s) Alkaloids/biosynthesis ; Amino Acid Sequence ; Molecular Structure ; Oscillatoria/chemistry ; Oscillatoria/enzymology ; Sulfotransferases/genetics
    Chemical Substances Alkaloids ; cylindrospermopsin (2JIZ556BA3) ; Sulfotransferases (EC 2.8.2.-)
    Language English
    Publishing date 2021-01-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.0c01089
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1144: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Primary angiosarcoma of the kidney: A challenging diagnosis.

    Peyrottes, Arthur / Bodard, Sylvain / Timsit, Marc-Olivier / Méjean, Arnaud / Panthier, Frederic / Audenet, François

    The French journal of urology

    2024  Volume 34, Issue 4, Page(s) 102609

    Abstract: Angiosarcoma is a rare malignancy derived from endothelial cells, which behaves aggressively. Primary angiosarcoma of the kidney is even rarer, and its clinical and radiological presentations do not differ from clear cells renal cell carcinoma (ccRCC). ... ...

    Abstract Angiosarcoma is a rare malignancy derived from endothelial cells, which behaves aggressively. Primary angiosarcoma of the kidney is even rarer, and its clinical and radiological presentations do not differ from clear cells renal cell carcinoma (ccRCC). Management protocols are not standardized, although nephrectomy is usually performed. Subsequent treatments (chemotherapy, radiotherapy, and lately, targeted therapies) vary considerably. Herein, we report the case of a middle-aged patient harboring primary angiosarcoma of the left kidney and discuss its presentation and management in light of current guidelines. The case is described for its rarity and masquerading nature.
    Language English
    Publishing date 2024-03-08
    Publishing country France
    Document type Journal Article
    ISSN 2950-3930
    ISSN (online) 2950-3930
    DOI 10.1016/j.fjurol.2024.102609
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  8. Article: Biosynthesis of Cylindrospermopsin in Cyanobacteria: Characterization of CyrJ the Sulfotransferase

    Méjean, Annick / Ploux, Olivier

    Journal of natural products. 2021 Jan. 13, v. 84, no. 2

    2021  

    Abstract: 7-Deoxy-desulfo-cylindrospermopsin was purified at small-scale from the supernatant of a culture of the cyanobacterium Oscillatoria sp. PCC 10702. This metabolite was obtained in a pure form using a three-step chromatographic procedure, and its identity ... ...

    Abstract 7-Deoxy-desulfo-cylindrospermopsin was purified at small-scale from the supernatant of a culture of the cyanobacterium Oscillatoria sp. PCC 10702. This metabolite was obtained in a pure form using a three-step chromatographic procedure, and its identity was confirmed by liquid chromatography–tandem mass spectrometry (LC–MS/MS). LC–MS quantification showed that this metabolite was excreted in the culture medium of Oscillatoria sp. PCC 10702. Isotopic incorporation studies using [2-¹³C,¹⁵N]glycine, a cylindrospermopsin precursor, and Oscillatoria sp. PCC 10702 cells showed that glycine was incorporated into 7-deoxy-desulfo-cylindrospermopsin, 7-deoxy-cylindrospermopsin, 7-epi-cylindrospermopsin, and cylindrospermopsin. The isotopic incorporation rate was consistent with the following metabolic flux: 7-deoxy-desulfo-cylindrospermopsin → 7-deoxy-cylindrospermopsin → 7-epi-cylindrospermopsin and cylindrospermopsin. We have cloned the cyrJ gene into an expression vector and overproduced the putative sulfotransferase CyrJ in Escherichia coli. The purified protein CyrJ catalyzed, in vitro, the transfer of a sulfonate group from 3′-phosphoadenosine-5′-phosphosulfate (PAPS) to 7-deoxy-desulfo-cylindrospermopsin to give 7-deoxy-cylindrospermopsin. Kinetic analysis afforded the following apparent constants: KM ₐₚₚ. (PAPS) = 0.12 μM, Vₘₐₓ ₐₚₚ. = 20 nM/min, KM ₐₚₚ. (7-deoxy-desulfo-cylindrospermopsin) = 0.12 μM, and KI ₐₚₚ. (7-deoxy-desulfo-cylindrospermopsin) = 4.1 μM. Preliminary data suggested that CyrJ catalyzed the reaction through a ternary-complex kinetic mechanism. All these data confirmed that CyrJ catalyzed a sulfotransfer during the penultimate step of the biosynthesis of cylindrospermopsin.
    Keywords Escherichia coli ; Oscillatoria ; biosynthesis ; culture media ; cylindrospermopsin ; genes ; genetic vectors ; kinetics ; liquid chromatography ; metabolites ; sulfonates ; tandem mass spectrometry
    Language English
    Dates of publication 2021-0113
    Size p. 408-416.
    Publishing place American Chemical Society and American Society of Pharmacognosy
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.0c01089
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1144: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Identification of 7-Deoxy-desulfo-argino-cylindrospermopsin, the Missing Piece in Cylindrospermopsin Biosynthesis.

    Méjean, Annick / Lequin, Olivier / Ploux, Olivier

    Journal of the American Chemical Society

    2022  Volume 144, Issue 32, Page(s) 14627–14637

    Abstract: Cylindrospermopsin, a major cyanotoxin, is produced by freshwater cyanobacteria. Its biosynthesis starts from arginine and glycine and involves five polyketide synthases and several tailoring enzymes. We report the identification of 7-deoxy-desulfo- ... ...

    Abstract Cylindrospermopsin, a major cyanotoxin, is produced by freshwater cyanobacteria. Its biosynthesis starts from arginine and glycine and involves five polyketide synthases and several tailoring enzymes. We report the identification of 7-deoxy-desulfo-argino-cylindrospermopsin in several cylindrospermopsin-producing cyanobacteria using mass spectrometry experiments. We have purified this new metabolite and established its structure by 1D and 2D NMR spectroscopy using scalar-based
    MeSH term(s) Arginine/metabolism ; Bacterial Toxins/chemistry ; Cyanobacteria/metabolism ; Cyanobacteria Toxins ; Polyketide Synthases/metabolism ; Uracil/chemistry ; Zinc/metabolism
    Chemical Substances Bacterial Toxins ; Cyanobacteria Toxins ; Uracil (56HH86ZVCT) ; Polyketide Synthases (79956-01-7) ; Arginine (94ZLA3W45F) ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2022-08-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.2c03932
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 4' 55/32: Show issues
    Z 7.3: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Article: Identification of 7-Deoxy-desulfo-argino-cylindrospermopsin, the Missing Piece in Cylindrospermopsin Biosynthesis

    Méjean, Annick / Lequin, Olivier / Ploux, Olivier

    Journal of the American Chemical Society. 2022 Aug. 02, v. 144, no. 32

    2022  

    Abstract: Cylindrospermopsin, a major cyanotoxin, is produced by freshwater cyanobacteria. Its biosynthesis starts from arginine and glycine and involves five polyketide synthases and several tailoring enzymes. We report the identification of 7-deoxy-desulfo- ... ...

    Abstract Cylindrospermopsin, a major cyanotoxin, is produced by freshwater cyanobacteria. Its biosynthesis starts from arginine and glycine and involves five polyketide synthases and several tailoring enzymes. We report the identification of 7-deoxy-desulfo-argino-cylindrospermopsin in several cylindrospermopsin-producing cyanobacteria using mass spectrometry experiments. We have purified this new metabolite and established its structure by 1D and 2D NMR spectroscopy using scalar-based ¹H-¹H, ¹H-¹³C, and ¹H-¹⁵N as well as 2D ¹H-¹H ROESY correlation experiments. Using labeled arginines in isotopic incorporation experiments, we have shown that arginine is fully incorporated into 7-deoxy-desulfo-argino-cylindrospermopsin and that the uracil ring of cylindrospermopsin originates from the guanidino moiety of arginine, thus solving a long-standing puzzling question. CyrG and CyrH from the cylindrospermopsin-producing Oscillatoria sp. PCC 6506 were overproduced in Escherichia coli and purified to homogeneity. We showed that CyrG is a zinc-dependent hydrolase, homologous to adenosine deaminases, that transforms 7-deoxy-desulfo-argino-cylindrospermopsin into 7-deoxy-desulfo-cylindrospermopsin and ornithine, with the following kinetic parameters: KM = 0.21 ± 0.05 μM and kcₐₜ = 0.19 ± 0.02 min–¹. CyrG contained 0.55 mol of zinc per mol of monomer but could be activated by Feᴵᴵ or Coᴵᴵ. CyrH contained almost no metal and showed no such activity even in the presence of excess metal. Using structure-based alignments and secondary structure predictions, we propose that the fifth and last polyketide synthase CyrF in cylindrospermopsin biosynthesis contains an unprecedented C-terminal domain homologous to N-acetyltransferases. We suggest that this domain catalyzes the condensation of the CyrF product with arginine to give 7-deoxy-desulfo-argino-cylindrospermopsin. This would be an unprecedented termination step for a polyketide synthase.
    Keywords Escherichia coli ; Oscillatoria ; acetyltransferases ; adenosine deaminase ; amino acid sequences ; arginine ; biosynthesis ; cylindrospermopsin ; freshwater ; mass spectrometry ; metabolites ; moieties ; nuclear magnetic resonance spectroscopy ; ornithine ; polyketide synthases ; uracil ; zinc
    Language English
    Dates of publication 2022-0802
    Size p. 14627-14637.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.2c03932
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 4' 55/32: Show issues
    Z 7.3: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top