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  1. Book ; Conference proceedings: Proceedings of the European Research Project SMT4-CT96-2072 "Development of methods to identify foods produced by means of genetic engineering"

    Barallon, Rita / Zagon, Jutta

    (BgVV-Hefte ; 1999,5)

    1999  

    Author's details ed. by J. Zagon ... With contributions of R. Barallon
    Series title BgVV-Hefte ; 1999,5
    Collection
    Keywords Lebensmittel ; Gentechnologie ; Nachweis ; Forschungsprojekt
    Subject Test ; Nachweisverfahren ; Nachweismethode ; Gentechnik ; Genchirurgie ; Genetic engineering ; Genetische Manipulation ; Genetische Technik ; Genmanipulation ; Nahrungsmittel ; Nahrung für Menschen ; Forschungsvorhaben ; Forschung und Entwicklung ; Forschungsprojekte
    Language English
    Size 83 S. : Ill.
    Publisher Bundesinst. für Gesundheitlichen Verbraucherschutz und Veterinärmed
    Publishing place Berlin
    Document type Book ; Conference proceedings
    HBZ-ID HT010746303
    ISBN 3-931675-44-0 ; 978-3-931675-44-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 1425 -1999,5- verfügbar in Königswinter Königswinter

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  2. Book ; Conference proceedings: Proceedings of the European Research Project SMT4-CT96-2072 "Development of methods to identify foods produced by means of genetic engineering"

    Barallon, Rita / Zagon, Jutta

    (BgVV-Hefte ; 1999,5)

    1999  

    Author's details ed. by J. Zagon ... With contributions of R. Barallon
    Series title BgVV-Hefte ; 1999,5
    Collection
    Keywords Lebensmittel ; Gentechnologie ; Nachweis ; Forschungsprojekt
    Subject Test ; Nachweisverfahren ; Nachweismethode ; Gentechnik ; Genchirurgie ; Genetic engineering ; Genetische Manipulation ; Genetische Technik ; Genmanipulation ; Nahrungsmittel ; Nahrung für Menschen ; Forschungsvorhaben ; Forschung und Entwicklung ; Forschungsprojekte
    Language English
    Size 83 S. : Ill.
    Publisher Bundesinst. für Gesundheitlichen Verbraucherschutz und Veterinärmed
    Publishing place Berlin
    Document type Book ; Conference proceedings
    HBZ-ID HT010746303
    ISBN 3-931675-44-0 ; 978-3-931675-44-8
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    994/1506 available for loan (reading room) Freihandmagazin (U1)

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  3. Book ; Conference proceedings: Proceedings of the European Research Project SMT4-CT96-2072: "Development of methods to identify foods produced by means of genetic engineering"

    Barallon, Rita / Zagon, Jutta

    (BgVV-Hefte / Bundesinstitut für gesundheitlichen Verbraucherschutz und Veterinärmedizin ; 05/1999)

    1999  

    Author's details ed. by J. Zagon... ; with contrib. of R. Barallon
    Series title BgVV-Hefte / Bundesinstitut für gesundheitlichen Verbraucherschutz und Veterinärmedizin <Berlin> ; 05/1999
    Keywords novel foods ; Lebensmittel, gentechnisch veränderte ; Lebensmittelanalytik
    Language German
    Size 83 S
    Publisher Bundesinstitut für gesundheitlichen Verbraucherschutz und Veterinärmedizin
    Publishing place Berlin
    Document type Book ; Conference proceedings
    ISBN 3931675440 ; 9783931675448
    Database Federal Institute for Risk Assessment

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  4. Book ; Conference proceedings: Proceedings of the European research project SMT4-CT96-2072 "Development of methods to identify foods produced by means of genetic engineering"

    Barallon, Rita / Zagon, Jutta

    (BgVV-Hefte / Bundesinstitut für Gesundheitlichen Verbraucherschutz und Veterinärmedizin ; 1999,5)

    1999  

    Institution Bundesinstitut für Gesundheitlichen Verbraucherschutz und Veterinärmedizin
    Author's details [Bundesinstitut für Gesundheitlichen Verbraucherschutz und Veterinärmedizin]. Ed. by J. Zagon ... With contributions of R. Barallon
    Series title BgVV-Hefte / Bundesinstitut für Gesundheitlichen Verbraucherschutz und Veterinärmedizin ; 1999,5
    Language German
    Size 83 S, Ill., graph. Darst, 30 cm
    Publisher BgVV
    Publishing place Berlin
    Document type Book ; Conference proceedings
    Note Literaturangaben
    ISBN 3931675440 ; 9783931675448
    Database Federal Office of Consumer Protection and Food Safety

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  5. Book ; Conference proceedings: Proceedings of the European research project SMT4-CT96-2072 "Development of methods to identify foods produced by means of genetic engineering"

    Barallon, Rita / Zagon, Jutta

    (BgVV-Hefte / Bundesinstitut für Gesundheitlichen Verbraucherschutz und Veterinärmedizin ; 1999,5)

    1999  

    Institution Bundesinstitut für Gesundheitlichen Verbraucherschutz und Veterinärmedizin
    Author's details [Bundesinstitut für Gesundheitlichen Verbraucherschutz und Veterinärmedizin]. Ed. by J. Zagon ... With contributions of R. Barallon
    Series title BgVV-Hefte / Bundesinstitut für Gesundheitlichen Verbraucherschutz und Veterinärmedizin ; 1999,5
    Language German
    Size 83 S, Ill., graph. Darst, 30 cm
    Publisher BgVV
    Publishing place Berlin
    Document type Book ; Conference proceedings
    Note Literaturangaben
    ISBN 3931675440 ; 9783931675448
    Database Max Rubner-Institute, Federal Research Institute of Nutrition and Food

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  6. Book ; Conference proceedings: Proceedings of the European research project SMT4-CT96-2072 "Development of methods to identify foods produced by means of genetic engineering"

    Barallon, Rita / Zagon, Jutta

    (BgVV-Hefte / Bundesinstitut für Gesundheitlichen Verbraucherschutz und Veterinärmedizin ; 1999,5)

    1999  

    Institution Bundesinstitut für Gesundheitlichen Verbraucherschutz und Veterinärmedizin
    Author's details [Bundesinstitut für Gesundheitlichen Verbraucherschutz und Veterinärmedizin]. Ed. by J. Zagon ... With contributions of R. Barallon
    Series title BgVV-Hefte / Bundesinstitut für Gesundheitlichen Verbraucherschutz und Veterinärmedizin ; 1999,5
    Language German
    Size 83 S, Ill., graph. Darst, 30 cm
    Publisher BgVV
    Publishing place Berlin
    Document type Book ; Conference proceedings
    Note Literaturangaben
    ISBN 3931675440 ; 9783931675448
    Database Special collection on veterinary medicine and general parasitology

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  7. Article ; Online: Comparative analysis of human mitochondrial DNA from World War I bone samples by DNA sequencing and ESI-TOF mass spectrometry.

    Howard, Rebecca / Encheva, Vesela / Thomson, Jim / Bache, Katherine / Chan, Yuen-Ting / Cowen, Simon / Debenham, Paul / Dixon, Alan / Krause, Jens-Uwe / Krishan, Elaina / Moore, Daniel / Moore, Victoria / Ojo, Michael / Rodrigues, Sid / Stokes, Peter / Walker, James / Zimmermann, Wolfgang / Barallon, Rita

    Forensic science international. Genetics

    2013  Volume 7, Issue 1, Page(s) 1–9

    Abstract: Mitochondrial DNA is commonly used in identity testing for the analysis of old or degraded samples or to give evidence of familial links. The Abbott T5000 mass spectrometry platform provides an alternative to the more commonly used Sanger sequencing for ... ...

    Abstract Mitochondrial DNA is commonly used in identity testing for the analysis of old or degraded samples or to give evidence of familial links. The Abbott T5000 mass spectrometry platform provides an alternative to the more commonly used Sanger sequencing for the analysis of human mitochondrial DNA. The robustness of the T5000 system has previously been demonstrated using DNA extracted from volunteer buccal swabs but the system has not been tested using more challenging sample types. For mass spectrometry to be considered as a valid alternative to Sanger sequencing it must also be demonstrated to be suitable for use with more limiting sample types such as old teeth, bone fragments, and hair shafts. In 2009 the Commonwealth War Graves Commission launched a project to identify the remains of 250 World War I soldiers discovered in a mass grave in Fromelles, France. This study characterises the performance of both Sanger sequencing and the T5000 platform for the analysis of the mitochondrial DNA extracted from 225 of these remains, both in terms of the ability to amplify and characterise DNA regions of interest and the relative information content and ease-of-use associated with each method.
    MeSH term(s) Bone and Bones/metabolism ; DNA, Mitochondrial/genetics ; Humans ; Polymerase Chain Reaction ; Reproducibility of Results ; Sequence Analysis, DNA ; Spectrometry, Mass, Electrospray Ionization/methods ; World War I
    Chemical Substances DNA, Mitochondrial
    Language English
    Publishing date 2013-01
    Publishing country Netherlands
    Document type Comparative Study ; Journal Article
    ZDB-ID 2493339-9
    ISSN 1878-0326 ; 1872-4973
    ISSN (online) 1878-0326
    ISSN 1872-4973
    DOI 10.1016/j.fsigen.2011.05.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6764: Show issues Location:
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  8. Article ; Online: Genotyping for CYP2C9 and VKORC1 alleles by a novel point of care assay with HyBeacon® probes.

    Howard, Rebecca / Leathart, Julian B S / French, David J / Krishan, Elaina / Kohnke, Hugo / Wadelius, Mia / van Schie, Rianne / Verhoef, Talitha / Maitland-van der Zee, Anke-Hilse / Daly, Ann K / Barallon, Rita

    Clinica chimica acta; international journal of clinical chemistry

    2011  Volume 412, Issue 23-24, Page(s) 2063–2069

    Abstract: Background: Coumarin anticoagulants such as warfarin are used to treat and prevent thromboembolic events in patients. The required dosage is difficult to predict and the risk of over or under anticoagulation are dependent on several environmental and ... ...

    Abstract Background: Coumarin anticoagulants such as warfarin are used to treat and prevent thromboembolic events in patients. The required dosage is difficult to predict and the risk of over or under anticoagulation are dependent on several environmental and clinical factors, such as concurrent medication, diet, age and genotype for polymorphisms in two genes CYP2C9 and VKORC1.
    Methods: A novel fluorescent PCR genotyping assay using HyBeacon® probes, was developed to enable clinical staff to genotype the CYP2C9*2 and CYP2C9*3 alleles and the VKORC1 G-1639A polymorphism directly from unextracted blood samples. A prototype PCR instrument, Genie 1, suitable for point of care use was developed to carry out the assays. The panel of tests was validated by analysing blood samples from 156 individuals and comparing genotypes with data obtained using DNA samples from the same individuals. The accuracy of genotypes obtained with the Genie 1 was compared against results from well validated real time PCR and PCR-restriction fragment length polymorphism analysis.
    Results: Identical results were obtained for the newly developed HyBeacon® method and the validation method in all cases except for one where no result was obtained for the VKORC1 polymorphism on the Genie instrument. The samples used for validation represented all six possible *2 and *3 allele-related CYP2C9 genotypes and all three VKORC1 G-1639A genotypes.
    Conclusions: We observed excellent accuracy for the newly developed method which can determine genotype in less than 2 h.
    MeSH term(s) Alleles ; Aryl Hydrocarbon Hydroxylases/genetics ; Base Sequence ; Cytochrome P-450 CYP2C9 ; DNA Primers ; Genotype ; Humans ; Mixed Function Oxygenases/genetics ; Point-of-Care Systems ; Polymerase Chain Reaction ; Polymorphism, Genetic ; Vitamin K Epoxide Reductases
    Chemical Substances DNA Primers ; Mixed Function Oxygenases (EC 1.-) ; CYP2C9 protein, human (EC 1.14.13.-) ; Cytochrome P-450 CYP2C9 (EC 1.14.13.-) ; Aryl Hydrocarbon Hydroxylases (EC 1.14.14.1) ; VKORC1 protein, human (EC 1.17.4.4) ; Vitamin K Epoxide Reductases (EC 1.17.4.4)
    Language English
    Publishing date 2011-11-20
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Validation Studies
    ZDB-ID 80228-1
    ISSN 1873-3492 ; 0009-8981
    ISSN (online) 1873-3492
    ISSN 0009-8981
    DOI 10.1016/j.cca.2011.07.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.173: Show issues Location:
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  9. Article ; Online: Match criteria for human cell line authentication: where do we draw the line?

    Capes-Davis, Amanda / Reid, Yvonne A / Kline, Margaret C / Storts, Douglas R / Strauss, Ethan / Dirks, Wilhelm G / Drexler, Hans G / MacLeod, Roderick A F / Sykes, Gregory / Kohara, Arihiro / Nakamura, Yukio / Elmore, Eugene / Nims, Raymond W / Alston-Roberts, Christine / Barallon, Rita / Los, Georgyi V / Nardone, Roland M / Price, Paul J / Steuer, Anton /
    Thomson, Jim / Masters, John R W / Kerrigan, Liz

    International journal of cancer

    2013  Volume 132, Issue 11, Page(s) 2510–2519

    Abstract: Continuous human cell lines have been used extensively as models for biomedical research. In working with these cell lines, researchers are often unaware of the risk of cross-contamination and other causes of misidentification. To reduce this risk, there ...

    Abstract Continuous human cell lines have been used extensively as models for biomedical research. In working with these cell lines, researchers are often unaware of the risk of cross-contamination and other causes of misidentification. To reduce this risk, there is a pressing need to authenticate cell lines, comparing the sample handled in the laboratory to a previously tested sample. The American Type Culture Collection Standards Development Organization Workgroup ASN-0002 has developed a Standard for human cell line authentication, recommending short tandem repeat (STR) profiling for authentication of human cell lines. However, there are known limitations to the technique when applied to cultured samples, including possible genetic drift with passage. In our study, a dataset of 2,279 STR profiles from four cell banks was used to assess the effectiveness of the match criteria recommended within the Standard. Of these 2,279 STR profiles, 1,157 were grouped into sets of related cell lines-duplicate holdings, legitimately related samples or misidentified cell lines. Eight core STR loci plus amelogenin were used to unequivocally authenticate 98% of these related sets. Two simple match algorithms each clearly discriminated between related and unrelated samples, with separation between related samples at ≥80% match and unrelated samples at <50% match. A small degree of overlap was noted at 50-79% match, mostly from cell lines known to display variable STR profiles. These match criteria are recommended as a simple and effective way to interpret results from STR profiling of human cell lines.
    MeSH term(s) Algorithms ; Cell Line ; Gene Expression Profiling/methods ; Genotyping Techniques/standards ; Humans ; Microsatellite Repeats/genetics ; Polymerase Chain Reaction
    Language English
    Publishing date 2013-06-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218257-9
    ISSN 1097-0215 ; 0020-7136
    ISSN (online) 1097-0215
    ISSN 0020-7136
    DOI 10.1002/ijc.27931
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 478: Show issues Location:
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    Zs.MO 576: Show issues

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  10. Article ; Online: A randomized trial of genotype-guided dosing of acenocoumarol and phenprocoumon.

    Verhoef, Talitha I / Ragia, Georgia / de Boer, Anthonius / Barallon, Rita / Kolovou, Genovefa / Kolovou, Vana / Konstantinides, Stavros / Le Cessie, Saskia / Maltezos, Efstratios / van der Meer, Felix J M / Redekop, William K / Remkes, Mary / Rosendaal, Frits R / van Schie, Rianne M F / Tavridou, Anna / Tziakas, Dimitrios / Wadelius, Mia / Manolopoulos, Vangelis G / Maitland-van der Zee, Anke H

    The New England journal of medicine

    2013  Volume 369, Issue 24, Page(s) 2304–2312

    Abstract: Background: Observational evidence suggests that the use of a genotype-guided dosing algorithm may increase the effectiveness and safety of acenocoumarol and phenprocoumon therapy.: Methods: We conducted two single-blind, randomized trials comparing ... ...

    Abstract Background: Observational evidence suggests that the use of a genotype-guided dosing algorithm may increase the effectiveness and safety of acenocoumarol and phenprocoumon therapy.
    Methods: We conducted two single-blind, randomized trials comparing a genotype-guided dosing algorithm that included clinical variables and genotyping for CYP2C9 and VKORC1 with a dosing algorithm that included only clinical variables, for the initiation of acenocoumarol or phenprocoumon treatment in patients with atrial fibrillation or venous thromboembolism. The primary outcome was the percentage of time in the target range for the international normalized ratio (INR; target range, 2.0 to 3.0) in the 12-week period after the initiation of therapy. Owing to low enrollment, the two trials were combined for analysis. The primary outcome was assessed in patients who remained in the trial for at least 10 weeks.
    Results: A total of 548 patients were enrolled (273 patients in the genotype-guided group and 275 in the control group). The follow-up was at least 10 weeks for 239 patients in the genotype-guided group and 245 in the control group. The percentage of time in the therapeutic INR range was 61.6% for patients receiving genotype-guided dosing and 60.2% for those receiving clinically guided dosing (P=0.52). There were no significant differences between the two groups for several secondary outcomes. The percentage of time in the therapeutic range during the first 4 weeks after the initiation of treatment in the two groups was 52.8% and 47.5% (P=0.02), respectively. There were no significant differences with respect to the incidence of bleeding or thromboembolic events.
    Conclusions: Genotype-guided dosing of acenocoumarol or phenprocoumon did not improve the percentage of time in the therapeutic INR range during the 12 weeks after the initiation of therapy. (Funded by the European Commission Seventh Framework Programme and others; EU-PACT ClinicalTrials.gov numbers, NCT01119261 and NCT01119274.).
    MeSH term(s) Acenocoumarol/administration & dosage ; Aged ; Algorithms ; Anticoagulants/administration & dosage ; Aryl Hydrocarbon Hydroxylases/genetics ; Cytochrome P-450 CYP2C9 ; Female ; Follow-Up Studies ; Genotype ; Humans ; International Normalized Ratio ; Male ; Middle Aged ; Pharmacogenetics ; Phenprocoumon/administration & dosage ; Single-Blind Method ; Thromboembolism/chemically induced ; Treatment Failure ; Vitamin K Epoxide Reductases/genetics
    Chemical Substances Anticoagulants ; CYP2C9 protein, human (EC 1.14.13.-) ; Cytochrome P-450 CYP2C9 (EC 1.14.13.-) ; Aryl Hydrocarbon Hydroxylases (EC 1.14.14.1) ; VKORC1 protein, human (EC 1.17.4.4) ; Vitamin K Epoxide Reductases (EC 1.17.4.4) ; Acenocoumarol (I6WP63U32H) ; Phenprocoumon (Q08SIO485D)
    Language English
    Publishing date 2013-12-12
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMoa1311388
    Database MEDical Literature Analysis and Retrieval System OnLINE

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