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  1. Article ; Online: Ensembles of Metal Triflate Additives in Gold(I)-Catalyzed Formal [2 + 2 + 2] Cycloaddition of Carbonyls with Activated Terminal Alkynes: One-Pot Synthesis of 2

    Sung, Dan-Bi / Lee, Jong Seok

    Organic letters

    2023  Volume 25, Issue 39, Page(s) 7110–7114

    Abstract: Herein, we describe a gold(I)-catalyzed intermolecular formal [2 + 2 + 2] cycloaddition of a carbonyl compound and a propiolate. A series of highly substituted ... ...

    Abstract Herein, we describe a gold(I)-catalyzed intermolecular formal [2 + 2 + 2] cycloaddition of a carbonyl compound and a propiolate. A series of highly substituted 2
    Language English
    Publishing date 2023-09-08
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.3c02536
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  2. Article ; Online: Putative role of endothelin receptor B in the development and maintenance of taste buds within the circumvallate papillae.

    Lee, Jong-Min / Jung, Han-Sung

    Journal of oral biosciences

    2024  Volume 66, Issue 1, Page(s) 249–252

    Abstract: This study aimed to achieve a better understanding of taste receptor cell development relative to endothelin receptor B (ETB) in circumvallate papillae (CVP). ETB localization was assessed by immunohistochemistry during tongue development of the mouse. ... ...

    Abstract This study aimed to achieve a better understanding of taste receptor cell development relative to endothelin receptor B (ETB) in circumvallate papillae (CVP). ETB localization was assessed by immunohistochemistry during tongue development of the mouse. Co-localization of ETB with taste receptor type III cell marker, Synaptosomal-Associated Protein 25 kDa (SNAP25), was evident in both the developing and adult CVP. ETB was strongly localized in the stromal core region. As development progressed, ETB became localized in the CVP mesenchyme and partially in the epithelium. ETB and SNAP25 co-localization indicates that ETB may regulate innervation from the CVP mesenchyme to taste buds.
    MeSH term(s) Animals ; Mice ; Epithelium ; Immunohistochemistry ; Nervous System Physiological Phenomena ; Taste Buds/metabolism
    Chemical Substances EDNRB protein, mouse
    Language English
    Publishing date 2024-01-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2218267-6
    ISSN 1880-3865 ; 1349-0079
    ISSN (online) 1880-3865
    ISSN 1349-0079
    DOI 10.1016/j.job.2024.01.005
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  3. Article ; Online: Natural-product-based fluorescent probes: recent advances and applications.

    Sung, Dan-Bi / Lee, Jong Seok

    RSC medicinal chemistry

    2022  Volume 14, Issue 3, Page(s) 412–432

    Abstract: Fluorescent probes are attractive tools for biology, drug discovery, disease diagnosis, and environmental analysis. In bioimaging, these easy-to-operate and inexpensive probes can be used to detect biological substances, obtain detailed cell images, ... ...

    Abstract Fluorescent probes are attractive tools for biology, drug discovery, disease diagnosis, and environmental analysis. In bioimaging, these easy-to-operate and inexpensive probes can be used to detect biological substances, obtain detailed cell images, track
    Language English
    Publishing date 2022-12-20
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2632-8682
    ISSN (online) 2632-8682
    DOI 10.1039/d2md00376g
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  4. Article ; Online: Retraction notice to "Preclinical metabolism of LB42908, a novel farnesyl transferase inhibitor, and its effects on the cytochrome P450 isozyme activities" [Bioorg. Med. Chem. Lett. 22(9) (2012) 3067-3071].

    Chang, Minsun / Lee, Sung-Hak / Kim, Ho Jun / Koh, Jong-Sung / Kim, Aeri

    Bioorganic & medicinal chemistry letters

    2024  Volume 104, Page(s) 129734

    Language English
    Publishing date 2024-04-10
    Publishing country England
    Document type Journal Article ; Retraction of Publication
    ZDB-ID 1063195-1
    ISSN 1464-3405 ; 0960-894X
    ISSN (online) 1464-3405
    ISSN 0960-894X
    DOI 10.1016/j.bmcl.2024.129734
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    Zs.A 3203: Show issues Location:
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  5. Article: Antioxidant and Antimelanogenic Activities of

    Lee, Yeon-Ji / Choi, Joo-Hee / Kang, Kyung-Ku / Sung, Soo-Eun / Lee, Sijoon / Sung, Minkyoung / Seo, Min-Soo / Park, Jong-Hwan

    Microorganisms

    2024  Volume 12, Issue 1

    Abstract: Excessive reactive oxygen species production can detrimentally impact skin cell physiology, resulting in cell growth arrest, melanogenesis, and aging. Recent clinical studies have found that lactic acid bacteria have a special effect directly or ... ...

    Abstract Excessive reactive oxygen species production can detrimentally impact skin cell physiology, resulting in cell growth arrest, melanogenesis, and aging. Recent clinical studies have found that lactic acid bacteria have a special effect directly or indirectly on skin organs, but the exact mechanism has not been elucidated. In this study, we investigated the mechanisms underlying the antioxidant protective effect and the inhibitory effect on melanin synthesis of
    Language English
    Publishing date 2024-01-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms12010188
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  6. Article ; Online: Multiorgan-on-a-chip for realization of gut-skin axis.

    Lee, Hye Ri / Sung, Jong Hwan

    Biotechnology and bioengineering

    2022  Volume 119, Issue 9, Page(s) 2590–2601

    Abstract: The concept of physiological link between the gut and the skin, known as the gut-skin axis, has been gaining more evidence recently. Although experimental data from animal and human studies support the existence of the gut-skin axis, in vitro model ... ...

    Abstract The concept of physiological link between the gut and the skin, known as the gut-skin axis, has been gaining more evidence recently. Although experimental data from animal and human studies support the existence of the gut-skin axis, in vitro model platforms that can test the hypothesis are lacking. Organ-on-a-chip offers the possibility of connecting different tissues and recapitulating interactions between them. In this study, we report a multiorgan chip that can capture the basic interorgan communication between the gut and the skin. Its modular design enables separate culture and differentiation of the gut and skin tissues, and after assembly the two organs are connected via microfluidic channels than enables perfusion and mass transfer. We showed that the impairment of the gut barrier function exacerbated the adverse effect of fatty acids on skin cells, with decreased viability, increased level of cytokine secretion and human beta defensin-2 (hBD-2), an inflammatory dermal disease marker. Based on these results, we believe that our multiorgan chip can be a novel in vitro platform for recapitulating complex mechanisms underlying the gut-skin axis.
    MeSH term(s) Animals ; Humans ; Lab-On-A-Chip Devices ; Skin
    Language English
    Publishing date 2022-07-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 280318-5
    ISSN 1097-0290 ; 0006-3592
    ISSN (online) 1097-0290
    ISSN 0006-3592
    DOI 10.1002/bit.28164
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  7. Article ; Online: Intensity-Modulated Radiation Therapy for Uterine Cervical Cancer to Reduce Toxicity and Enhance Efficacy - an Option or a Must?: A Narrative Review.

    Lee, Sea-Won / Kim, Aeran / Lee, Sung Jong / Kim, Sung Hwan / Lee, Jong Hoon

    Cancer research and treatment

    2023  Volume 56, Issue 1, Page(s) 1–17

    Abstract: Radiotherapy (RT) is a fundamental modality in treatment of cervical cancer. With advancement of technology, conventional RT used for external beam radiotherapy (EBRT) for over half a century has been rapidly replaced with intensity-modulated radiation ... ...

    Abstract Radiotherapy (RT) is a fundamental modality in treatment of cervical cancer. With advancement of technology, conventional RT used for external beam radiotherapy (EBRT) for over half a century has been rapidly replaced with intensity-modulated radiation therapy (IMRT) especially during the last decade. This newer technique is able to differentiate the intensity of radiation within the same field, thus reduces the inevitable exposure of radiation to normal organs and enables better dose delivery to tumors. Recently, the American Society for Radiation Oncology has released a guideline for RT in cervical cancer. Although a section of the guideline recommends IMRT for the purpose of toxicity reduction, a thorough review of the literature is necessary to understand the current status of IMRT in cervical cancer. This narrative review updates the recent high-level evidences regarding the efficacy and toxicity of IMRT and provides a better understanding of the most innovative techniques currently available for EBRT enabled by IMRT.
    MeSH term(s) Female ; Humans ; Radiotherapy, Intensity-Modulated/adverse effects ; Radiotherapy, Intensity-Modulated/methods ; Uterine Cervical Neoplasms/pathology ; Radiotherapy Dosage ; Radiotherapy, Conformal/methods
    Language English
    Publishing date 2023-08-30
    Publishing country Korea (South)
    Document type Review ; Journal Article
    ZDB-ID 2133613-1
    ISSN 2005-9256 ; 1598-2998
    ISSN (online) 2005-9256
    ISSN 1598-2998
    DOI 10.4143/crt.2023.562
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    Zs.A 7043: Show issues Location:
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  8. Article ; Online: A rare case of uterine endometrium granuloma presenting pyometra.

    Lee, Chul Seung / Oh, Sujung / Lee, Ahwon / Lee, Sung Jong

    Asian journal of surgery

    2023  Volume 46, Issue 7, Page(s) 2910–2911

    MeSH term(s) Female ; Humans ; Pyometra/diagnosis ; Pyometra/diagnostic imaging ; Endometrium/surgery ; Uterus
    Language English
    Publishing date 2023-03-10
    Publishing country Netherlands
    Document type Case Reports ; Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2023.01.107
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    Zs.B 2831: Show issues Location:
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  9. Article ; Online: Relapsed Acute Myeloid Leukemia Presenting as Multiple Breast Masses: A Case Report.

    Sung, Pamela / Lee, Jong Yoon / Chu, A Jung

    Journal of the Korean Society of Radiology

    2023  Volume 84, Issue 2, Page(s) 454–459

    Abstract: Hematologic malignancy of the breast is very rare. Here, we report a case of relapsed acute myeloid leukemia (AML) presenting as multiple breast masses. A 77-year-old female visited an outpatient clinic reporting palpable masses in both breasts. She had ... ...

    Abstract Hematologic malignancy of the breast is very rare. Here, we report a case of relapsed acute myeloid leukemia (AML) presenting as multiple breast masses. A 77-year-old female visited an outpatient clinic reporting palpable masses in both breasts. She had a medical history of AML, which showed complete remission after nine cycles of chemotherapy. On mammography and ultrasonography, there were multiple masses correlated with her palpable symptoms accompanied by enlarged lymph nodes. Core needle biopsy immunohistochemistry (IHC) results indicated AML and blastic plasmacytoid dendritic cell neoplasm. AML was confirmed using bone marrow biopsy. Although very rare, when a patient with a history of hematologic malignancy presents a palpable mass in the breast, clinicians should conduct proper tissue analysis, including IHC stating for leukemic markers, to guide appropriate diagnosis and treatment.
    Language English
    Publishing date 2023-02-27
    Publishing country Korea (South)
    Document type Case Reports
    ISSN 2951-0805
    ISSN (online) 2951-0805
    DOI 10.3348/jksr.2022.0062
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  10. Article ; Online: Characteristics and functional outcomes of varus displaced proximal humerus fractures.

    Jung, Sung Weon / Jeon, Jong Min / Lee, Chul Ho

    Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association

    2024  

    Abstract: Background: The purpose of this study was to compare fracture characteristics and functional outcomes between patients with proximal humerus fractures with and without initial varus displacement.: Methods: A retrospective review of 325 patients with ... ...

    Abstract Background: The purpose of this study was to compare fracture characteristics and functional outcomes between patients with proximal humerus fractures with and without initial varus displacement.
    Methods: A retrospective review of 325 patients with proximal humerus fractures was performed. Patients with initial varus displacement were placed in Varus cohort and were age- and sex-matched 1:1 with a second cohort presenting proximal humerus fractures without varus displacement, referred to as Fracture cohort. Varus fracture displacement was defined when the most proximal aspect of humeral head was below the most proximal aspect of greater tuberosity on initial radiographs, and the head shaft angle was <130°.
    Results: There were 60 patients in V cohort and 60 patients in F cohort. Statistical analysis revealed that there were significant differences in initial horizontal offset (38.8 vs. 45.9 mm), initial anterior angulation angle (36.5° vs. 16.4°), postoperative head shaft angle (132.2° vs. 141.3°), last head shaft angle (122.2° vs. 138.5°), difference for head shaft angles (10.0° vs. 2.7°), postoperative horizontal offset (43.4 vs. 45.3 mm), last horizontal offset (38.4 vs. 42.8 mm), difference for offsets (4.9 vs. 2.5 mm), complications (15 vs. 7 cases), and revision surgery (7 vs. 1 case) between two cohorts. Overall satisfactory results were achieved in most patients regardless of varus displacement, pain-VAS and Constant scores in V cohort were inferior to the scores in F cohort. The cut-off value of postoperative head shaft angle for good/excellent outcomes was 135.5° using receiver operating characteristic curve analyses.
    Conclusion: Varus displaced proximal humerus fractures were accompanied by decreased horizontal offset and increased anterior angulation angle, and had a course of more varization and horizontal shortening compared with those without initial varus displacement. Patients with varus displaced fractures were associated with worse functional outcomes, and these factors might affect functional outcomes.
    Level of evidence: Prognostic, cohort study, Level III.
    Language English
    Publishing date 2024-02-28
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1314243-4
    ISSN 1436-2023 ; 0949-2658
    ISSN (online) 1436-2023
    ISSN 0949-2658
    DOI 10.1016/j.jos.2024.02.005
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    Zs.A 4484: Show issues Location:
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