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  1. Article ; Online: Comparison of BD Bactec Plus Aerobic/F medium to VersaTREK Redox 1 blood culture medium for detection of Candida spp. in seeded blood culture specimens containing therapeutic levels of antifungal agents.

    Riedel, Stefan / Eisinger, Stephen W / Dam, Lisa / Stamper, Paul D / Carroll, Karen C

    Journal of clinical microbiology

    2011  Volume 49, Issue 4, Page(s) 1524–1529

    Abstract: Recovery of Candida spp. using the BD Bactec FX blood culture (BC) system (Bactec Plus Aerobic/F ...

    Abstract Recovery of Candida spp. using the BD Bactec FX blood culture (BC) system (Bactec Plus Aerobic/F medium) and the VersaTREK system (aerobic Redox medium) was evaluated using seeded BC bottles with and without the addition of commonly used antifungal agents. BC bottles (n = 1,442) were each inoculated with 10 ml human whole blood and 0.1 ml of suspensions of Candida spp., with or without antifungal agents. BC bottles were incubated in the corresponding system for a maximum of 5 days. In the absence of antifungal agents, Bactec FX recovered 97.4% of Candida spp., and VersaTREK recovered 99.1% (P = 0.154). With regard to length of time to detection (LTD) and overall recovery, both systems had various levels of effectiveness in recovering C. glabrata. In bottles containing antifungal agents, Bactec FX recovered 83.1% of isolates, whereas VersaTREK recovered 50.7% of Candida spp. (P < 0.001). For BC bottles without the addition of antifungal agents, the median LTD for VersaTREK was 2.2 h faster than that of Bactec FX (P < 0.001). In the presence of antifungal agents, the Bactec FX recovery time was significantly faster than that of VersaTREK (median difference of 10.8 h, P < 0.001). We conclude that both systems have comparable abilities to recover Candida spp. from seeded blood cultures in the absence of antifungal agents. In the presence of therapeutic levels of commonly used antifungal agents, the Bactec FX system demonstrated a significantly greater recovery of various Candida spp., as well as a shorter LTD.
    MeSH term(s) Antifungal Agents/administration & dosage ; Blood/microbiology ; Candida/isolation & purification ; Candidemia/diagnosis ; Culture Media/chemistry ; Humans ; Microbiological Techniques/methods
    Chemical Substances Antifungal Agents ; Culture Media
    Language English
    Publishing date 2011-01-26
    Publishing country United States
    Document type Comparative Study ; Evaluation Study ; Journal Article
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/JCM.02260-10
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Knowledge-Based Cancer Control.

    Eisinger, François

    Current oncology reports

    2018  Volume 20, Issue Suppl 1, Page(s) 19

    MeSH term(s) Female ; Health Knowledge, Attitudes, Practice ; Humans ; Neoplasms/prevention & control ; Surveys and Questionnaires
    Language English
    Publishing date 2018-03-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2057359-5
    ISSN 1534-6269 ; 1523-3790
    ISSN (online) 1534-6269
    ISSN 1523-3790
    DOI 10.1007/s11912-017-0651-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Fluorinated vitamin b(12) analogs are cofactors of corrinoid-dependent enzymes: a f-labeled nuclear magnetic resonance probe for identifying corrinoid-protein interactions.

    Stupperich, E / Eisinger, H J / Kerssebaum, R / Nexø, E

    Applied and environmental microbiology

    2005  Volume 59, Issue 2, Page(s) 599–603

    Abstract: ... possible to use F-labeled nuclear magnetic resonance spectroscopy for analyses of protein-bound cobamides. ...

    Abstract The homoacetogenic bacterium Sporomusa ovata synthesized the vitamin B(12) analog phenolyl cobamide or 4-fluorophenolyl cobamide when the methanol medium of growing cells was supplemented with 10 mM phenol or 5 mM 4-fluorophenol. Phenol and, presumably, 4-fluorophenol were specifically incorporated into these cobamides, since phenol was not metabolized significantly into amino acids or into acetic acid, the product of the catabolism. The phenol-containing cobamides contributed up to 90% of the protein-bound cobamides of the 1,300 to 1,900 nmol of corrinoid per g of dry cell material formed. Fluorine-19 nuclear magnetic resonance spectroscopy of 4-fluorophenolyl cobamide exhibited a resonance near 30 ppm. An additional signal emerged at 25 ppm when 4-fluorophenolyl cobamide was investigated as the cofactor of a corrinoid-dependent protein. The two resonances indicated distinct cofactor arrangements within the protein's active site. A 5-ppm high-field shift change suggested van der Waal's interactions between the fluorinated nucleotide of the cofactor and adjacent amino acid residues of the enzyme. Similarly, Propionibacterium freudenreichii and Methanobacterium thermoautotrophicum synthesized 5-fluorobenzimidazolyl cobamide. The human corrinoid binders intrinsic factor, transcobalamin, and haptocorrin recognized this corrinoid like vitamin B(12). Hence, it is possible to use F-labeled nuclear magnetic resonance spectroscopy for analyses of protein-bound cobamides.
    Language English
    Publishing date 2005-12-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 223011-2
    ISSN 1098-5336 ; 0099-2240
    ISSN (online) 1098-5336
    ISSN 0099-2240
    DOI 10.1128/aem.59.2.599-603.1993
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: 60-jähriger Mann mit unklarer Proteinurie und auffälligen Strukturen in der Niere.

    Eisinger, Felix / Artunc, Ferruh / Bohnert, Bernhard N

    Deutsche medizinische Wochenschrift (1946)

    2023  Volume 148, Issue 19, Page(s) 1225–1226

    Title translation 60-year-old man with proteinuria of unknown origin and unusual structures in the kidney.
    MeSH term(s) Male ; Humans ; Middle Aged ; Kidney/diagnostic imaging ; Proteinuria/etiology
    Language German
    Publishing date 2023-10-04
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/a-2088-0616
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  5. Article ; Online: Angelina and Brad effect.

    Eisinger, Francois

    Familial cancer

    2016  Volume 15, Issue 4, Page(s) 541–542

    Language English
    Publishing date 2016-10
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1502496-9
    ISSN 1573-7292 ; 1389-9600
    ISSN (online) 1573-7292
    ISSN 1389-9600
    DOI 10.1007/s10689-016-9908-2
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  6. Article ; Online: Cancer screening: continuing instability.

    Eisinger, François

    European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)

    2015  Volume 24 Suppl, Page(s) S65–7

    MeSH term(s) Breast Neoplasms/diagnosis ; Breast Neoplasms/epidemiology ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/epidemiology ; Early Detection of Cancer/economics ; Early Detection of Cancer/standards ; Early Detection of Cancer/trends ; Female ; Global Health/economics ; Global Health/standards ; Global Health/trends ; Humans ; Male
    Language English
    Publishing date 2015-06
    Publishing country England
    Document type Editorial ; Introductory Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1137033-6
    ISSN 1473-5709 ; 0959-8278
    ISSN (online) 1473-5709
    ISSN 0959-8278
    DOI 10.1097/CEJ.0000000000000147
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: 60-jähriger Mann mit unklarer Proteinurie und auffälligen Strukturen in der Niere

    Eisinger, Felix / Artunc, Ferruh / Bohnert, Bernhard N.

    DMW - Deutsche Medizinische Wochenschrift

    2023  Volume 148, Issue 19, Page(s) 1225–1226

    Language German
    Publishing date 2023-09-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 200446-x
    ISSN 1439-4413 ; 0012-0472
    ISSN (online) 1439-4413
    ISSN 0012-0472
    DOI 10.1055/a-2088-0616
    Database Thieme publisher's database

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  8. Article ; Online: The Mutual Relation of Platelet Activation and Innate Immunity.

    Eisinger, Felix / Langer, Harald F

    Hamostaseologie

    2018  Volume 38, Issue 4, Page(s) 186–202

    Abstract: Platelets are known to be central regulators of haemostasis, inflammation and immune response. Formed by megakaryocytes in the bone marrow and the lungs, platelets express a broad range of adhesion ... ...

    Abstract Platelets are known to be central regulators of haemostasis, inflammation and immune response. Formed by megakaryocytes in the bone marrow and the lungs, platelets express a broad range of adhesion receptors
    MeSH term(s) Animals ; Blood Platelets/immunology ; Complement System Proteins/immunology ; Humans ; Immunity, Innate ; Infection/immunology ; Inflammation/immunology ; Neoplasms/immunology ; Platelet Activation
    Chemical Substances Complement System Proteins (9007-36-7)
    Language English
    Publishing date 2018-09-25
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 801512-0
    ISSN 2567-5761 ; 0720-9355
    ISSN (online) 2567-5761
    ISSN 0720-9355
    DOI 10.1055/s-0038-1669450
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  9. Article ; Online: Re: Performance of first mammography examination in women younger than 40 years.

    Eisinger, Francois

    Journal of the National Cancer Institute

    2010  Volume 102, Issue 22, Page(s) 1742; author reply 1742, 1742–3

    MeSH term(s) Adult ; Age Factors ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/prevention & control ; Early Detection of Cancer ; Female ; Humans ; Mammography ; Mass Screening/methods ; Mass Screening/statistics & numerical data ; Predictive Value of Tests ; Quality-Adjusted Life Years ; Risk Assessment ; Sensitivity and Specificity ; United States/epidemiology
    Language English
    Publishing date 2010-11-17
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2992-0
    ISSN 1460-2105 ; 0027-8874 ; 0198-0157
    ISSN (online) 1460-2105
    ISSN 0027-8874 ; 0198-0157
    DOI 10.1093/jnci/djq396
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  10. Article: Mechanisms and predictors of menses resumption once normal weight is reached in anorexia nervosa.

    Galusca, Bogdan / Gay, Aurélia / Belleton, Gwenaëlle / Eisinger, Martin / Massoubre, Catherine / Lang, François / Grouselle, Dominique / Estour, Bruno / Germain, Natacha

    Journal of eating disorders

    2023  Volume 11, Issue 1, Page(s) 172

    Abstract: Background: In cases of Anorexia Nervosa (AN), achieving weight gain recovery beyond the lower limits set by the World Health Organization and normalizing classical nutritional markers appears to be essential for most patients. However, this is not ... ...

    Abstract Background: In cases of Anorexia Nervosa (AN), achieving weight gain recovery beyond the lower limits set by the World Health Organization and normalizing classical nutritional markers appears to be essential for most patients. However, this is not always adequate to restore menstrual cycles. This discrepancy can cause concern for both patients and healthcare providers, and can impact the medical management of these individuals. Thus, the purpose of this study was to assess the ability of anthropometric and hormonal factors to predict the resumption of menstrual cycles in individuals with anorexia nervosa upon reaching a normal body weight.
    Method: Patients with AN who had achieved a normal Body Mass Index but had not yet resumed their menstrual cycles (referred to as ANRec) were evaluated on two occasions: first at visit 1 and then again 6 months later, provided their body weight remained stable over this period (visit 2). Among the 46 ANRec patients who reached visit 2, they were categorized into two groups: 20 with persistent amenorrhea (PA-ANRec) and 26 who had regained their menstrual cycles (RM-ANRec). Anthropometric measurements, several hormone levels, Luteinizing Hormone (LH) pulsatility over a 4-h period, and LH response to gonadotropin-releasing hormone injection (LH/GnRH) were then compared between the two groups at visit 1.
    Results: Patients in the RM-ANRec group exhibited higher levels of follicular stimulating hormone, estradiol, inhibin B, LH/GnRH, and lower levels of ghrelin compared to those in the PA-ANRec group. Analysis of Receiver Operating Characteristic curves indicated that having ≥ 2 LH pulses over a 4-h period, LH/GnRH levels ≥ 33 IU/l, and inhibin B levels > 63 pg/ml predicted the resumption of menstrual cycles with a high degree of specificity (87%, 100%, and 100%, respectively) and sensitivity (82%, 80%, and 79%, respectively).
    Conclusions: These three hormonal tests, of which two are straightforward to perform, demonstrated a high predictive accuracy for the resumption of menstrual cycles. They could offer valuable support for the management of individuals with AN upon achieving normalized weight. Negative results from these tests could assist clinicians and patients in maintaining their efforts to attain individualized metabolic targets.
    Trial registration: IORG0004981.
    Language English
    Publishing date 2023-09-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2699357-0
    ISSN 2050-2974
    ISSN 2050-2974
    DOI 10.1186/s40337-023-00893-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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