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  1. Article ; Conference proceedings: Fallbericht zur Behandlung eines NSCLC Patienten und aktivierender p.G469A BRAF-Mutation mit Dabrafenib und Trametinib

    Olive, E / Grohé, C / Sänger, K / Lamping, M / Leyvraz, S / Ochsenreither, S / Keilholz, U / Tessmer, A

    Pneumologie

    2018  Volume 72, Issue S 01

    Event/congress 59. Kongress der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin e.V., Dresden, 2018-03-14
    Language German
    Publishing date 2018-02-21
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 607630-0
    ISSN 1438-8790 ; 0934-8387
    ISSN (online) 1438-8790
    ISSN 0934-8387
    DOI 10.1055/s-0037-1619263
    Database Thieme publisher's database

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  2. Article ; Online: An examination of the resonances in modern flutes with ergonomically angled headjoints.

    Saenger, Katherine L

    The Journal of the Acoustical Society of America

    2022  Volume 151, Issue 1, Page(s) 256

    Abstract: ... pressure waves (with amplitudes P ...

    Abstract This paper investigates the passive resonance spectra of a modern Boehm flute body outfitted with a variety of transverse and end-blown ergonomic headjoints in an attempt to determine if there is anything intrinsic to the acoustics of these instruments that keeps them from being as good as the same flute with a standard headjoint. With the exception of a commercial U-shaped, recurved headjoint, the ergonomic headjoints examined were all home-built from plastic pipe Tees connected to the flute body by means of a modular jointed neck. Spectra were collected with a pressure-based method that uses a localized sound source placed just outside the flute's embouchure hole to generate forward-going and backward-going pressure waves (with amplitudes P
    Language English
    Publishing date 2022-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 219231-7
    ISSN 1520-8524 ; 0001-4966
    ISSN (online) 1520-8524
    ISSN 0001-4966
    DOI 10.1121/10.0009182
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Turner Syndrome: An Update.

    Steiner, Margaret / Saenger, Paul

    Advances in pediatrics

    2022  Volume 69, Issue 1, Page(s) 177–202

    Abstract: Turner syndrome is the most common sex chromosome abnormality in women. Infertility and short stature are the most striking findings seen in these patients. Unfortunately, many girls are still being diagnosed too late and therefore early diagnosis and ... ...

    Abstract Turner syndrome is the most common sex chromosome abnormality in women. Infertility and short stature are the most striking findings seen in these patients. Unfortunately, many girls are still being diagnosed too late and therefore early diagnosis and treatment key. Turner syndrome affects many systems of the body; therefore, a comprehensive approach is key for therapeutic intervention.
    MeSH term(s) Dwarfism ; Female ; Humans ; Turner Syndrome/diagnosis ; Turner Syndrome/epidemiology ; Turner Syndrome/genetics
    Language English
    Publishing date 2022-06-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 210524-x
    ISSN 1878-1926 ; 0065-3101
    ISSN (online) 1878-1926
    ISSN 0065-3101
    DOI 10.1016/j.yapd.2022.03.004
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  4. Article ; Online: A pressure-based transfer matrix method and measurement technique for studying resonances in flutes and other open-input resonators.

    Saenger, Katherine L

    The Journal of the Acoustical Society of America

    2019  Volume 147, Issue 4, Page(s) 2556

    Abstract: ... the quantities being evaluated are the acoustic pressure P and the acoustic flow U; in the present pressure-based ... evaluated are the amplitudes of the forward-going and backward-going pressure waves, P ...

    Abstract This paper provides an alternative formulation of a transfer matrix method (TMM) long used for modeling the passive resonances of wind instruments. In the conventional, impedance-based TMMs, the quantities being evaluated are the acoustic pressure P and the acoustic flow U; in the present pressure-based TMM (a variation of the Heavens matrix method developed for thin film optics), the quantities being evaluated are the amplitudes of the forward-going and backward-going pressure waves, P
    Language English
    Publishing date 2019-12-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 219231-7
    ISSN 1520-8524 ; 0001-4966
    ISSN (online) 1520-8524
    ISSN 0001-4966
    DOI 10.1121/10.0001102
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  5. Article ; Online: Ten years of biosimilar recombinant human growth hormone in Europe.

    Saenger, Paul

    Drug design, development and therapy

    2017  Volume 11, Page(s) 1505–1507

    Abstract: Recombinant human growth hormone (rhGH) has been in clinical use for more than 30 years. With the expiration of patent exclusivity for the first wave of rhGH products and other biopharmaceuticals, the opportunity emerged for the development of biosimilar ...

    Abstract Recombinant human growth hormone (rhGH) has been in clinical use for more than 30 years. With the expiration of patent exclusivity for the first wave of rhGH products and other biopharmaceuticals, the opportunity emerged for the development of biosimilar medicines. A biosimilar is defined by the European Medicines Agency (EMA) as a biological medicine that is similar to another biological medicine that has already been authorized for use. The EMA led the way (well ahead of the Food and Drug Administration in the US) in developing the biosimilar concept, and the type of science-based regulatory framework required to ensure high-quality, safe, and effective biosimilar medicines; the provisions for approval of biosimilars have been in place in Europe since 2005. Under these provisions, Omnitrope
    MeSH term(s) Biosimilar Pharmaceuticals/administration & dosage ; Biosimilar Pharmaceuticals/adverse effects ; Child ; Decision Making ; Drug Approval ; Drug Design ; Europe ; Human Growth Hormone/administration & dosage ; Human Growth Hormone/adverse effects ; Humans ; Recombinant Proteins
    Chemical Substances Biosimilar Pharmaceuticals ; Recombinant Proteins ; Human Growth Hormone (12629-01-5)
    Language English
    Publishing date 2017-05-16
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2451346-5
    ISSN 1177-8881 ; 1177-8881
    ISSN (online) 1177-8881
    ISSN 1177-8881
    DOI 10.2147/DDDT.S130317
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Reference growth data in 46,XY disorders of sex development from a single center.

    Saenger, Paul

    Pediatric investigation

    2017  Volume 1, Issue 1, Page(s) 20

    Language English
    Publishing date 2017-12-27
    Publishing country United States
    Document type Editorial
    ISSN 2574-2272
    ISSN (online) 2574-2272
    DOI 10.1002/ped4.12012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Long-acting growth hormone in 2022.

    Steiner, Margaret / Frank, Jacklyn / Saenger, Paul

    Pediatric investigation

    2023  Volume 7, Issue 1, Page(s) 36–42

    Abstract: After the isolation of pituitary growth hormone (GH) in 1957, this form of GH, always in limited supply, was the only drug available for the treatment of GH deficiency. In 1985, recombinant GH became available, and the modalities of GH therapies changed ... ...

    Abstract After the isolation of pituitary growth hormone (GH) in 1957, this form of GH, always in limited supply, was the only drug available for the treatment of GH deficiency. In 1985, recombinant GH became available, and the modalities of GH therapies changed dramatically as the supply was unlimited. New indications for GH in pediatrics and adult medicine were developed. Treatment was daily. Now in 2021 long-acting GH (LAGH) became available the world over making GH therapy more patient-friendly and even showing slightly greater efficacy than daily GH therapy. We are now entering a new era of LAGH therapy for pediatric and adult use with new formulations of GH, which will predictably be the preferred form of GH therapy for years to come increasing adherence to GH therapy and possibly even efficacy, that is, better growth rate. The continued availability of new safety data will further solidify the use of LAGH in clinical medicine.
    Language English
    Publishing date 2023-01-03
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2574-2272
    ISSN (online) 2574-2272
    DOI 10.1002/ped4.12358
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Long acting growth hormone (LAGH), an update.

    Grillo, Margaret Steiner / Frank, Jacklyn / Saenger, Paul

    Frontiers in pediatrics

    2023  Volume 11, Page(s) 1254231

    Abstract: In 1957, Maurice Raben at Yale was able to isolate and purify growth hormone from cadaveric pituitary glands. Pituitary growth hormone was the only way to treat children with growth hormone (GH) deficiency, until 1985 when recombinant GH became available ...

    Abstract In 1957, Maurice Raben at Yale was able to isolate and purify growth hormone from cadaveric pituitary glands. Pituitary growth hormone was the only way to treat children with growth hormone (GH) deficiency, until 1985 when recombinant GH became available for daily subcutaneous injection. For many years, the pediatric endocrine community longed for a long-acting recombinant GH formulation that would decrease the inconvenience of daily injections. Several mechanisms were employed to develop a GH that is rapidly absorbed into the blood stream after subcutaneous injection, but provides slow removal from the circulatory system to potentially optimize patient adherence to GH therapy. Four long-acting growth hormones are currently available in the world, or are close to regulatory approval. They are: (1) Pegylated formulations, (2) Prodrug formulations which are converted into active drug, (3) Nonvalent transient albumin binding GH compounds and (4) GH fusion proteins where a protein si fused with GH. All four formulations have undergone detailed phase 3 studies and were found to show non-inferiority in these clinical studies. All four demonstrate a safety and tolerability profile that is comparable to that of daily somatropin with an excellent adherence profile.
    Language English
    Publishing date 2023-09-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2023.1254231
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Oral testosterone undecanoate is an effective treatment for micropenis therapy.

    Saenger, Paul / Steiner, Margaret

    Pediatric investigation

    2021  Volume 5, Issue 4, Page(s) 323–324

    Language English
    Publishing date 2021-12-13
    Publishing country United States
    Document type Editorial
    ISSN 2574-2272
    ISSN (online) 2574-2272
    DOI 10.1002/ped4.12304
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Females show worse functional outcome and quality of life compared to males 2 years after meniscus surgery: Data analysis from the German Arthroscopy Registry.

    Mai, Celine / Mai, Patrick / Hinz, Maximilian / Saenger, Rebecca / Seil, Romain / Tischer, Thomas / Roessler, Philip P

    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

    2024  

    Abstract: Purpose: The purpose of this study was to investigate the impact of sex on knee function, activity and quality of life following meniscus surgery using data from the German Arthroscopy Registry.: Methods: This is a retrospective cohort study with ... ...

    Abstract Purpose: The purpose of this study was to investigate the impact of sex on knee function, activity and quality of life following meniscus surgery using data from the German Arthroscopy Registry.
    Methods: This is a retrospective cohort study with data collected between 2017 and 2022. Patient-reported outcome measures (PROMs), namely Knee Injury and Osteoarthritis Outcome Score (KOOS), EuroQol Visual Analogue Scale (EQ Scale), and Marx Activity Rating Scale (MARS), were collected preoperatively and at 6, 12 and 24 months postoperatively. Data were analysed to examine differences between male and female patients regarding PROMs, pre-existing conditions, meniscus lesion types and surgical treatments.
    Results: A total of 1106 female (36.6%) and 1945 male patients (63.7%) were included. Males were significantly younger than females and had a higher body mass index. Overall, there were four times more medial meniscus lesions (MMLs) (77.5%) than lateral meniscus lesions (LMLs) (27.9%). Degenerative LMLs were more frequent in females, while traumatic LMLs were more common in males. Frequencies of traumatic and degenerative MMLs were similar among males and females. Males had higher absolute KOOS irrespective of treatment or meniscus lesion type. Meniscus repair resulted in similar improvements in ΔKOOS for both sexes, while meniscus resection exhibited higher absolute KOOS for males at each time point. Males generally had higher EQ Scale and MARS than females.
    Conclusion: Greater improvements in knee function, activity and quality of life were observed in males. While MMLs appear to be comparable among sexes, the nature of LML differed significantly. These results may help surgeons to refine patient selection for specific treatments to improve overall clinical outcomes.
    Level of evidence: Level III.
    Language English
    Publishing date 2024-03-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1159064-6
    ISSN 1433-7347 ; 0942-2056
    ISSN (online) 1433-7347
    ISSN 0942-2056
    DOI 10.1002/ksa.12131
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