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Article: Retraction: Oral leukoplakia, a clinical-histopathological study in 412 patients.

Rubert, Andrea / Bagán, Leticia / Bagán, Jose V

Journal of clinical and experimental dentistry

2021 Volume 13, Issue 5, Page(s) e426–e432

Abstract: The authors detected some minor errors in the published manuscript (Rubert A, Bagán L, Bagán JV. Oral leukoplakia, a clinical-histopathological study in 412 patients. J Clin Exp Dent. 2020 Jun 1;12(6):e540-e546. doi: 10.4317/jced.57091. PMID: 32665812; ... ...

Abstract	The authors detected some minor errors in the published manuscript (Rubert A, Bagán L, Bagán JV. Oral leukoplakia, a clinical-histopathological study in 412 patients. J Clin Exp Dent. 2020 Jun 1;12(6):e540-e546. doi: 10.4317/jced.57091. PMID: 32665812; PMCID: PMC7335600.) and have requested that the entire article be republished with these errors already rectified. Background: A retrospective clinical-histopathological study was made of the evolution of oral leukoplakia over time, staging the disease according to the classification of van der Waal. Material and methods: A study was made of 412 patients with oral leukoplakia, analyzing the corresponding clinical factors and histopathological findings; assessing associations between the different clinical presentations and epithelial dysplasia; and evaluating the factors influencing malignant transformation of the lesions. Results: Clinically, homogeneous presentations were seen to predominate (n = 336, 81.6%), while histologically most of the lesions exhibited no dysplastic changes (n = 271; 65.7%). Stage 1 of the van der Waal classification was the most common presentation (n = 214; 51.9%). The lesion malignization rate was 8.5%, and the factors associated to a significantly increased malignization risk were non-homogeneous OL lesions ( Conclusions: In our series of patients with oral leukoplakia, malignization was associated to the less common clinical presentations of the disease, i.e., non-homogeneous lesions, and the latter tended to exhibit high grade epithelial dysplasia.
Language	English
Publishing date	2021-05-01
Publishing country	Spain
Document type	Journal Article
ZDB-ID	2586647-3
ISSN	1989-5488
ISSN	1989-5488
DOI	10.4317/jced.532746
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Osteonecrosis of the jaws associated with denosumab: Study of clinical and radiographic characteristics in a series of clinical cases.

Tofé, Victoria I / Bagán, Leticia / Bagán, José V

Journal of clinical and experimental dentistry

2020 Volume 12, Issue 7, Page(s) e676–e681

Abstract: Background: The objective of this study was to describe the clinical and radiographic characteristics of our series of medication-related osteonecrosis of the jaws (ONJ) associated with denosumab.: Material and methods: We presented 15 cases of ONJ ... ...

Abstract	Background: The objective of this study was to describe the clinical and radiographic characteristics of our series of medication-related osteonecrosis of the jaws (ONJ) associated with denosumab. Material and methods: We presented 15 cases of ONJ associated with denosumab; 11 received treatment for their osteoporosis and four for cancer treatments. We recorded the most frequent clinical findings, symptoms and radiographic characteristics in our patient group, as well as local and systemic contributing factors. Results: The mean time of treatment with denosumab was 23.83 ± 12.84 months. 40% of the patients had a previous history of treatment with bisphosphonates. The most common local factor was tooth extraction (11 cases; 73.3%), and in most cases there was necrotic bone exposure (13/15, 86.67%). Osteolysis, bone sclerosis and cortical erosion were the most common radiographic findings. Stage 1 was the most frequent, present in 60% of the cases. Conclusions: In our patient group, most were in the early stages of ONJ.
Language	English
Publishing date	2020-07-01
Publishing country	Spain
Document type	Journal Article
ZDB-ID	2586647-3
ISSN	1989-5488
ISSN	1989-5488
DOI	10.4317/jced.57019
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Article: Oral leukoplakia, a clinical-histopathological study in 412 patients.

Rubert, Andrea / Bagán, Leticia / Bagán, Jose V

Journal of clinical and experimental dentistry

2020 Volume 12, Issue 6, Page(s) e540–e546

Abstract: Background: A retrospective clinical-histopathological study was made of the evolution of oral leukoplakia over time, staging the disease according to the classification of van der Waal.: Material and methods: A study was made of 412 patients with ... ...

Abstract	Background: A retrospective clinical-histopathological study was made of the evolution of oral leukoplakia over time, staging the disease according to the classification of van der Waal. Material and methods: A study was made of 412 patients with oral leukoplakia, analyzing the corresponding clinical factors and histopathological findings; assessing associations between the different clinical presentations and epithelial dysplasia; and evaluating the factors influencing malignant transformation of the lesions. Results: Clinically, homogeneous presentations were seen to predominate (n = 336, 81.6%), while histologically most of the lesions exhibited no dysplastic changes (n = 271; 65.7%). Stage 1 of the van der Waal classification was the most common presentation (n = 214; 51.9%). The lesion malignization rate was 8.3%, and the factors associated to a significantly increased malignization risk were non-homogeneous OL lesions ( Conclusions: In our series of patients with oral leukoplakia, malignization was associated to the less common clinical presentations of the disease, i.e., non-homogeneous lesions, and the latter tended to exhibit high grade epithelial dysplasia.
Language	English
Publishing date	2020-06-01
Publishing country	Spain
Document type	Journal Article
ZDB-ID	2586647-3
ISSN	1989-5488
ISSN	1989-5488
DOI	10.4317/jced.57091
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Article ; Online: Recurrences following treatment of proliferative verrucous leukoplakia: A systematic review and meta-analysis.

Proaño-Haro, Alex / Bagan, Leticia / Bagan, Jose V

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

2021 Volume 50, Issue 8, Page(s) 820–828

Abstract: Background: A systematic review and meta-analysis were made of the incidence of recurrences in patients with proliferative verrucous leukoplakia (PVL) subjected to different types of treatment.: Methods: The study was carried out following the ... ...

Abstract	Background: A systematic review and meta-analysis were made of the incidence of recurrences in patients with proliferative verrucous leukoplakia (PVL) subjected to different types of treatment. Methods: The study was carried out following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement guidelines. A literature search was made in the Medline (PubMed), EMBASE, and Web of Science databases, together with a manual search, covering the period from 1985 to January 2020, with no language restrictions. Studies were included if they described treatments applied to at least 10 patients with the corresponding outcomes. Methodological quality was evaluated using Jadad scale and Newcastle-Ottawa tool. Global incidence was calculated by random effects meta-analysis using the Comprehensive Meta-analysis version 3.0 software. Publication bias was assessed using funnel plots and the Duval and Tweedie trim and fill method. Results: Of the 922 identified articles, 12 were found to meet the inclusion criteria. Most of them presented moderate or low risk of bias. A total of 397 patients were analyzed. The mean age was 62.34 years and 248 were women (62.5%). The mean follow-up was 79.3 months. The most frequent treatment was surgical removal with a cold scalpel or laser (339 patients). A total of 232 subjects presented lesion recurrence. The combination of proportions global effect meta-analysis yielded a recurrence rate of 67.2% (95% CI: 48.3-81.8), with the absence of publication bias. Conclusions: There is not enough scientific evidence to conclude that any treatment strategy is able to reduce the recurrence in PVL.
MeSH term(s)	Female ; Humans ; Incidence ; Leukoplakia, Oral/therapy ; Middle Aged ; Neoplasm Recurrence, Local
Language	English
Publishing date	2021-04-13
Publishing country	Denmark
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	1021270-x
ISSN	1600-0714 ; 0904-2512
ISSN (online)	1600-0714
ISSN	0904-2512
DOI	10.1111/jop.13178
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Zs.A 825: Show issues

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Article ; Online: Claves para el diagnóstico diferencial del dolor odontogénico mediante un soporte audiovisual

Maria Margaix-Muñoz / Leticia Bagán Debón / Yolanda Jiménez Soriano / María Gracia Sarrión Pérez / José Bagán / Rafael Poveda-Roda

Educación Médica, Vol 24, Iss 5, Pp 100846- (2023)

metodologías alternativas de aprendizaje

2023

Abstract: Resumen: Antecedentes: el odontólogo juega un papel fundamental en el diagnóstico y tratamiento del dolor orofacial, sobre todo en el dolor de origen pulpar o periodontal (odontogénico). En el caso del dolor clasificado habitualmente como crónico (no ... ...

Abstract	Resumen: Antecedentes: el odontólogo juega un papel fundamental en el diagnóstico y tratamiento del dolor orofacial, sobre todo en el dolor de origen pulpar o periodontal (odontogénico). En el caso del dolor clasificado habitualmente como crónico (no odontogénico), un elevado porcentaje de estudiantes de Odontología se sienten «en absoluto» o «algo» preparados para afrontar su diagnóstico y tratamiento. Objetivo: proponer una breve guía para diferenciar clínicamente el dolor odontogénico del dolor orofacial, que sea de utilidad tanto para el estudiante de Odontología como para el profesional. Material y método: se elaboró un vídeo educativo de apoyo a la docencia dentro de un proyecto de innovación docente de la Universidad de Valencia titulado «El dolor orofacial para estudiantes del grado de Odontología: dolor agudo frente a dolor crónico» (UV-SFPIE_PID-1640062. Núm. Registro: 64155). Se establecieron 11 características fundamentales del dolor odontogénico y otras 11 del no odontogénico, que pretenden servir de orientación para el diagnóstico en situaciones en las que el dolor no presenta las características habituales. Resultados: la proyección del vídeo tuvo una buena acogida por parte de los estudiantes, entendiéndolo como una herramienta atractiva de aprendizaje que favorece la motivación y la adquisición de responsabilidades. El 75,3% consideró que era «muy interesante», otorgando la máxima puntuación. Conclusión: con los datos disponibles actualmente en la literatura científica en relación a las características del dolor facial atípico, consideramos que la guía aportada en este proyecto puede ser de utilidad en el diagnóstico de estos procesos. Abstract: Background: Dentists play a fundamental role in the diagnosis and treatment of orofacial pain, especially in pain of pulp or periodontal (odontogenic) origin. In the case of pain usually classified as chronic (non-odontogenic), a high percentage of dental students feel “not at all” or “somewhat” prepared to carry out a diagnosis and treatment. Objective: ...
Keywords	Orofacial pain ; Atypical orofacial pain ; Odontogenic ; Non-odontogenic ; Differential diagnosis ; Medical education ; Education (General) ; L7-991 ; Medicine (General) ; R5-920
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effect of clinical and histologic features on time to malignancy in 224 cases of oral leukoplakia treated by surgery.

Bagan, Jose / Martorell, Miguel / Cebrián, Jose L / Rubert, Andrea / Bagán, Leticia / Mezquida, Carlos / Hervás, David

Clinical oral investigations

2022 Volume 26, Issue 8, Page(s) 5181–5188

Abstract: Objectives: Our main purpose and research question were to analyze and quantify whether there were significant differences in the time to develop cancer among patients with oral leukoplakia (OL), comparing the more susceptible cases to those with the ... ...

Abstract	Objectives: Our main purpose and research question were to analyze and quantify whether there were significant differences in the time to develop cancer among patients with oral leukoplakia (OL), comparing the more susceptible cases to those with the least susceptibility to malignancy. Materials and methods: We followed 224 cases of OL after surgical or CO Results: Histology type (moderate or severe dysplasia) and tongue location showed hazard ratios (HR) of 3.19 (95% CI [1.05-8.59]) and 4.78 (95% CI [1.6-16.61]), respectively. Both variables increased the risk of malignant transformation, thus identifying a susceptible subpopulation with reduced time required to develop cancer, as with non-homogeneous leukoplakias. The median time for cancer development was 4 years and 5 months, with a minimum of 9 months after the diagnosis of OL and a maximum of 15 years and 2 months. Conclusions: Susceptible patients with non-homogeneous leukoplakia, dysplasia, or leukoplakia in the tongue develop cancer earlier than those with homogeneous OL and those without dysplasia. Clinical relevance: The novel contribution of this research is that, until now, the time it took for oral leukoplakias to develop cancer based on whether they were homogeneous or non-homogeneous, and if they have or not epithelial dysplasia, had not been comparatively described and quantified. As a final result, the time to malignant transformation in non-homogeneous and dysplastic leukoplakias is significantly shorter.
MeSH term(s)	Bayes Theorem ; Cell Transformation, Neoplastic/pathology ; Humans ; Hyperplasia ; Lasers, Gas/therapeutic use ; Leukoplakia, Oral/epidemiology ; Leukoplakia, Oral/surgery
Language	English
Publishing date	2022-04-26
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1364490-7
ISSN	1436-3771 ; 1432-6981
ISSN (online)	1436-3771
ISSN	1432-6981
DOI	10.1007/s00784-022-04486-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 4788: Show issues

Location:
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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: On the Oral Microbiome of Oral Potentially Malignant and Malignant Disorders: Dysbiosis, Loss of Diversity, and Pathogens Enrichment.

Herreros-Pomares, Alejandro / Hervás, David / Bagan-Debón, Leticia / Jantus-Lewintre, Eloísa / Gimeno-Cardona, Concepción / Bagan, José

International journal of molecular sciences

2023 Volume 24, Issue 4

Abstract: The role of dysbiosis in the development and progression of oral potentially malignant disorders (OPMDs) remains largely unknown. Here, we aim to characterize and compare the oral microbiome of homogeneous leucoplakia (HL), proliferative verrucous ... ...

Abstract	The role of dysbiosis in the development and progression of oral potentially malignant disorders (OPMDs) remains largely unknown. Here, we aim to characterize and compare the oral microbiome of homogeneous leucoplakia (HL), proliferative verrucous leukoplakia (PVL), oral squamous cell carcinoma (OSCC), and OSCC preceded by PVL (PVL-OSCC). Fifty oral biopsies from HL (
MeSH term(s)	Humans ; Mouth Neoplasms/pathology ; Carcinoma, Squamous Cell/pathology ; Dysbiosis ; RNA, Ribosomal, 16S/genetics ; Leukoplakia, Oral ; Microbiota
Chemical Substances	RNA, Ribosomal, 16S
Language	English
Publishing date	2023-02-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24043466
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Article ; Online: Prediction of the risk of cancer and the grade of dysplasia in leukoplakia lesions using deep learning.

Ferrer-Sánchez, Antonio / Bagan, Jose / Vila-Francés, Joan / Magdalena-Benedito, Rafael / Bagan-Debon, Leticia

Oral oncology

2022 Volume 132, Page(s) 105967

Abstract: Objectives: To estimate the probability of malignancy of an oral leukoplakia lesion using Deep Learning, in terms of evolution to cancer and high-risk dysplasia.: Materials and methods: A total of 261 oral leukoplakia lesions with a mean of 5.5 years ...

Abstract	Objectives: To estimate the probability of malignancy of an oral leukoplakia lesion using Deep Learning, in terms of evolution to cancer and high-risk dysplasia. Materials and methods: A total of 261 oral leukoplakia lesions with a mean of 5.5 years follow-up were analysed from standard digital photographs. A deep learning pipeline composed by a U-Net based segmentation of the lesion followed by a multi-task CNN classifier was used to predict the malignant transformation and the risk of dysplasia of the lesion. An explainability heatmap is constructed using LIME in order to interpret the decision of the model for each output. Results: A Dice coefficient of 0.561 was achieved on the segmentation task. For the prediction of a malignant transformation, the model provided a sensitivity of 1 with a specificity of 0.692. For the prediction of high-risk dysplasia, the model achieved a specificity of 0.740 and a sensitivity of 0.928. Conclusion: The proposed model using deep learning can be a helpful tool for predicting the possible malignant evolution of oral leukoplakias. The generated heatmap provides a high confidence on the output of the model and enables its interpretability.
MeSH term(s)	Cell Transformation, Neoplastic/pathology ; Deep Learning ; Humans ; Hyperplasia ; Leukoplakia, Oral/pathology
Language	English
Publishing date	2022-06-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1120465-5
ISSN	1879-0593 ; 0964-1955 ; 1368-8375
ISSN (online)	1879-0593
ISSN	0964-1955 ; 1368-8375
DOI	10.1016/j.oraloncology.2022.105967
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Zs.A 4869: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.A 456: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Oral cancers preceded by proliferative verrucous leukoplakia exhibit distinctive molecular features.

Herreros-Pomares, Alejandro / Hervás, David / Bagan-Debon, Leticia / Proaño, Alex / Garcia, Diana / Sandoval, Juan / Bagan, Jose

Oral diseases

2023

Abstract: Objective: Proliferative verrucous leukoplakia (PVL) has high rates of malignant transformation into oral squamous cell carcinoma (OSCC), but the clinical and evolutionary pattern of OSCC from PVL (PVL-OSCC) is more favorable than that of OSCC not ... ...

Abstract	Objective: Proliferative verrucous leukoplakia (PVL) has high rates of malignant transformation into oral squamous cell carcinoma (OSCC), but the clinical and evolutionary pattern of OSCC from PVL (PVL-OSCC) is more favorable than that of OSCC not preceded by PVL (OSCC). Here, we aimed to explore the pathophysiologic differences between PVL-OSCC and OSCC through transcriptomic and DNA methylation analyses. Materials and methods: In this case-control study, oral biopsies from 8 PVL-OSCC and 10 OSCC patients were obtained for global sequencing using RNAseq and a genome-wide DNA methylation analysis via the Infinium EPIC Platform (graphical abstract). Results: One hundred and thirty-three differentially expressed genes (DEGs) were detected, 94 of them upregulated in OSCC. Most of these genes were previously described in cancer and associated with prognosis. The integrative analysis revealed 26 DEGs, corresponding to 37 CpGs, whose promoters were regulated by DNA methylation. Twenty-nine of the CpGs were found as hypermethylated in PVL-OSCC. Only 5 of the genes that were aberrantly methylated and differentially expressed were upregulated in PVL-OSCC patients, whereas 21 were underexpressed. Conclusions: PVL-OSCC patients presented lower expression of cancer-related genes. Hypermethylation of the promoter region of many genes was also noticed, indicating that DNA methylation could be a regulatory mechanism.
Language	English
Publishing date	2023-03-09
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	1290529-x
ISSN	1601-0825 ; 1354-523X
ISSN (online)	1601-0825
ISSN	1354-523X
DOI	10.1111/odi.14550
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 4427: Show issues

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Article: Salivary Cytokines in patients with Head and Neck Cancer (HNC) treated with Radiotherapy.

Principe, Sara / Dikova, Valentina / Bagán, José

Journal of clinical and experimental dentistry

2019 Volume 11, Issue 11, Page(s) e1072–e1077

Abstract: Background: Head and Neck cancer (HNC) is the sixth most common cancer in the world. The 5-year survival rate depends on early diagnosis and appropriate therapy. Typically, late diagnosis requires not only surgical intervention, but also radiotherapy ... ...

Abstract	Background: Head and Neck cancer (HNC) is the sixth most common cancer in the world. The 5-year survival rate depends on early diagnosis and appropriate therapy. Typically, late diagnosis requires not only surgical intervention, but also radiotherapy treatment combined or not with chemotherapy. Ionizing radiation is known to increase the expression of a number of cytokines involved in inflammation, wound healing and toxicity areas. Salivary cytokines have promising features to be used as biomarkers for disease screening and outcome prediction in this malignancy. The aim of this article is to analyze the role of salivary inflammatory response elements in HNC patients treated with radiotherapy, their modulation and association with the treatment outcome. Material and methods: A bibliographical search was performed on Pubmed, Cochrane and Embase using the following keywords: cytokines, saliva, head and neck cancer, radiotherapy. The cut-off point for the research were scientific papers published over the last 10 years. After a two-step selection process, 15 articles were identified and subjected to review. Results: Radiotherapy treatment was shown to influence a number of salivary cytokines. A trend towards a growth of IL-1β, IL-6, IL-8, MCP-1, and TNF-α levels was observed and it correlated with the irradiation dose. Conclusions: The analysis of salivary cytokines could be a useful biomarker for predicting radiotherapy outcome in HNC. However, large-scale investigations are required to validate the use of these cytokines in predicting and diagnosing HNC, as well as evaluating the response to the treatment.
Language	English
Publishing date	2019-11-01
Publishing country	Spain
Document type	Journal Article ; Review
ZDB-ID	2586647-3
ISSN	1989-5488
ISSN	1989-5488
DOI	10.4317/jced.56318
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