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  1. Article ; Online: The different flavors and splices of MCL.

    Weigert, Oliver

    Blood

    2020  Volume 136, Issue 5, Page(s) 526–527

    MeSH term(s) Chromosome Mapping ; Exome ; Flavoring Agents ; Humans ; Lymphoma, Mantle-Cell ; Taste
    Chemical Substances Flavoring Agents
    Language English
    Publishing date 2020-07-30
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2020005591
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  2. Article ; Online: The clinical and molecular taxonomy of t(14;18)-negative follicular lymphomas.

    Salaverria, Itziar / Weigert, Oliver / Quintanilla-Martinez, Leticia

    Blood advances

    2023  Volume 7, Issue 18, Page(s) 5258–5271

    Abstract: Follicular lymphoma (FL) is a neoplasm derived from germinal center B cells, composed of centrocytes and centroblasts, with at least a focal follicular growth pattern. The t(14;18) translocation together with epigenetic deregulation through recurrent ... ...

    Abstract Follicular lymphoma (FL) is a neoplasm derived from germinal center B cells, composed of centrocytes and centroblasts, with at least a focal follicular growth pattern. The t(14;18) translocation together with epigenetic deregulation through recurrent genetic alterations are now recognized as the hallmark of FL. Nevertheless, FL is a heterogeneous disease, clinically, morphologically, and biologically. The existence of FL lacking the t(14;18) chromosomal alteration highlights the complex pathogenesis of FL, and indicates that there are alternative pathogenetic mechanisms that can induce a neoplasm with follicular center B-cell phenotype. Based on their clinical presentation, t(14;18)-negative FLs can be divided into 3 broad groups: nodal presentation, extranodal presentation, and those affecting predominantly children and young adults. Recent studies have shed some light into the genetic alterations of t(14;18)-negative FL. Within the group of t(14;18)-negative FL with nodal presentation, cases with STAT6 mutations are increasingly recognized as a distinctive molecular subgroup, often cooccurring with CREBBP and/or TNFRSF14 mutations. FL with BCL6 rearrangement shows clinicopathological similarities to its t(14;18)-positive counterpart. In contrast, t(14;18)-negative FL in extranodal sites is characterized mainly by TNFRSF14 mutations in the absence of chromatin modifying gene mutations. FL in children have a unique molecular landscape when compared with those in adults. Pediatric-type FL (PTFL) is characterized by MAP2K1, TNFRSF14, and/or IRF8 mutations, whereas large B-cell lymphoma with IRF4 rearrangement is now recognized as a distinct entity, different from PTFL. Ultimately, a better understanding of FL biology and heterogeneity should help to understand the clinical differences and help guide patient management and treatment decisions.
    MeSH term(s) Child ; Young Adult ; Humans ; Lymphoma, Follicular/diagnosis ; Lymphoma, Follicular/genetics ; Translocation, Genetic ; Mutation ; B-Lymphocytes/pathology ; Germinal Center/pathology
    Language English
    Publishing date 2023-08-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2022009456
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online ; Thesis: Functional characterization of ARID1A mutations in follicular lymphoma

    Antoniolli, Martina [Verfasser] / Weigert, Oliver [Akademischer Betreuer]

    2023  

    Author's details Martina Antoniolli ; Betreuer: Oliver Weigert
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
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  4. Book ; Online ; Thesis: The molecular ontogeny of follicular lymphoma

    Keay, William David [Verfasser] / Weigert, Oliver [Akademischer Betreuer]

    identification and functional characterization of selected truncal gene mutations

    2023  

    Author's details William David Keay ; Betreuer: Oliver Weigert
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
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  5. Article: Neue Therapien für Patienten mit Non-Hodgkin-Lymphomen

    Gaitzsch, Erik / Weigert, Oliver

    TumorDiagnostik & Therapie

    2020  Volume 41, Issue 04, Page(s) 240–245

    Language German
    Publishing date 2020-05-01
    Publisher © Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2072365-9
    ISSN 1439-1279 ; 0722-219X
    ISSN (online) 1439-1279
    ISSN 0722-219X
    DOI 10.1055/a-1103-8770
    Database Thieme publisher's database

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  6. Article: Follikuläres Lymphom - Pathogenese, Diagnostik und Therapie

    Adolph, Louisa / Weigert, Oliver

    Trillium-Krebsmedizin

    2020  Volume 29, Issue 7, Page(s) 485

    Language German
    Document type Article
    ZDB-ID 2768536-6
    ISSN 2198-9818
    Database Current Contents Medicine

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  7. Book ; Online ; Thesis: Validierung und funktionelle Charakterisierung einer Cathepsin S - Gain-of-Function Mutation im Follikulären Lymphom

    Stolz, Sebastian [Verfasser] / Weigert, Oliver [Akademischer Betreuer]

    2021  

    Author's details Sebastian Stolz ; Betreuer: Oliver Weigert
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek der Ludwig-Maximilians-Universität
    Publishing place München
    Document type Book ; Online ; Thesis
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  8. Article ; Online: It's a long way to the top (if you want to personalize immunotherapy).

    Haebe, Sarah / Weigert, Oliver

    Journal for immunotherapy of cancer

    2017  Volume 5, Page(s) 6

    Abstract: Harnessing the immune system to attack tumor cells by targeting tumor-associated or -preferably- tumor-specific antigens has emerged as a promising but challenging treatment option for malignant lymphomas. Follicular lymphoma is among the most common ... ...

    Abstract Harnessing the immune system to attack tumor cells by targeting tumor-associated or -preferably- tumor-specific antigens has emerged as a promising but challenging treatment option for malignant lymphomas. Follicular lymphoma is among the most common lymphomas worldwide and remains incurable for most patients. Considered to be an immunogenic disease it represents an interesting disease entity for various immunotherapeutic approaches. In an article published in the May issue of
    Language English
    Publishing date 2017
    Publishing country England
    Document type Editorial
    ZDB-ID 2719863-7
    ISSN 2051-1426 ; 2051-1426
    ISSN (online) 2051-1426
    ISSN 2051-1426
    DOI 10.1186/s40425-016-0207-0
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  9. Article ; Online: The promises and challenges of using gene mutations for patient stratification in follicular lymphoma.

    Weigert, Oliver / Weinstock, David M

    Blood

    2017  Volume 130, Issue 13, Page(s) 1491–1498

    Abstract: Follicular lymphoma (FL) is a clinically and molecularly highly heterogeneous disease. Most patients achieve long-lasting remissions and have excellent overall survival (OS) with current treatment. However, ∼20% of patients have early progression of ... ...

    Abstract Follicular lymphoma (FL) is a clinically and molecularly highly heterogeneous disease. Most patients achieve long-lasting remissions and have excellent overall survival (OS) with current treatment. However, ∼20% of patients have early progression of disease and short OS. At present, therapies are not guided by individual risk or disease biology. Reliable tools for patient stratification are urgently needed to avoid overtreatment of low-risk patients and to prioritize alternative approaches in high-risk patients. A rapidly expanding repertoire of promising therapeutic options is available for clinical evaluation; however, the numbers of patients with FL and the resources to conduct adequately powered trials are limited. Recent studies have shown that gene mutations can serve as prognostic and/or predictive biomarkers, in particular when integrated into composite risk models. Before translating these findings into routine clinical practice, however, several challenges loom. We review aspects of "clinicogenetic" risk model development and validation that apply to FL and more generally to other cancers. Finally, we propose a crowdsourcing effort that could expedite the development, validation, refinement, and selection of risk models. A new era of collaboration and harmonization is required if we hope to transition from empiric selection of therapeutics to risk-based, biology-guided treatment of patients with FL.
    MeSH term(s) Biomarkers ; Humans ; Lymphoma, Follicular/genetics ; Lymphoma, Follicular/pathology ; Mutation ; Prognosis ; Risk Assessment
    Chemical Substances Biomarkers
    Language English
    Publishing date 2017-08-07
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2017-07-737353
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Relevance of different prognostic scores in primary CNS lymphoma in the era of intensified treatment regimens: A retrospective, multicenter analysis of 174 patients.

    Zeremski, Vanja / Adolph, Louisa / Beer, Sina / Berisha, Mirjeta / Jacobs, Benedikt / Kahl, Christoph / Koenecke, Christian / Kropf, Siegfried / Panse, Jens / Petersen, Judith / Schmidt-Hieber, Martin / Schneider, Jessica / Vucinic, Vladan / Walter, Jeanette / Weigert, Oliver / Witte, Hanno M / Mougiakakos, Dimitrios

    European journal of haematology

    2024  Volume 112, Issue 4, Page(s) 641–649

    Abstract: Objectives: Treatment intensification (including consolidative high-dose chemotherapy with autologous stem cell transplantation [HDT-ASCT]) significantly improved outcome in primary central nervous system lymphoma (PCNSL) patients.: Methods: We ... ...

    Abstract Objectives: Treatment intensification (including consolidative high-dose chemotherapy with autologous stem cell transplantation [HDT-ASCT]) significantly improved outcome in primary central nervous system lymphoma (PCNSL) patients.
    Methods: We conducted a multicenter, retrospective analysis of newly diagnosed PCNSL patients, treated with intensified treatment regimens. The following scores were evaluated in terms of overall survival (OS) and progression-free survival (PFS): Memorial Sloan-Kettering Cancer Center (MSKCC), International Extranodal Lymphoma Study Group (IELSG), and three-factor (3F) prognostic score. Further, all scores were comparatively investigated for model quality and concordance.
    Results: Altogether, 174 PCNSL patients were included. One hundred and five patients (60.3%) underwent HDT-ASCT. Two-year OS and 2-year PFS for the entire population were 73.3% and 48.5%, respectively. The MSKCC (p = .003) and 3F score (p < .001), but not the IELSG score (p = .06), had the discriminatory power to identify different risk groups for OS. In regard to concordance, the 3F score (C-index [0.71]) outperformed both the MSKCC (C-index [0.64]) and IELSG (C-index [0.53]) score. Moreover, the superiority of the 3F score was shown for PFS, successfully stratifying patients in three risk groups, which also resulted in the highest C-index (0.66).
    Conclusion: The comparative analysis of established PCNSL risk scores affirm the clinical utility of the 3F score stratifying the widest prognostic spectrum among PCNSL patients treated with intensified treatment approaches.
    MeSH term(s) Humans ; Hematopoietic Stem Cell Transplantation/methods ; Prognosis ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Central Nervous System Neoplasms/therapy ; Central Nervous System Neoplasms/drug therapy ; Retrospective Studies ; Transplantation, Autologous ; Lymphoma/therapy ; Lymphoma/drug therapy
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Multicenter Study ; Journal Article
    ZDB-ID 392482-8
    ISSN 1600-0609 ; 0902-4441
    ISSN (online) 1600-0609
    ISSN 0902-4441
    DOI 10.1111/ejh.14159
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