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  1. Article ; Online: The refusal of the Society to accept antibiotic toxicity: missing opportunities for therapy of severe infections.

    Rolain, J M / Baquero, F

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2016  Volume 22, Issue 5, Page(s) 423–427

    Abstract: Over the last decade the emergence and spread of antibiotic resistance in bacteria has led to a new fear in the scientific and medical communities as well as among members of the general public. Due to the lack of development of new antibiotics, there is ...

    Abstract Over the last decade the emergence and spread of antibiotic resistance in bacteria has led to a new fear in the scientific and medical communities as well as among members of the general public. Due to the lack of development of new antibiotics, there is a need to reconsider old drugs or dosages rejected because of their toxicity. As a society, if we tolerate the potential toxicity of other drugs, such as anticancer drugs, why do we refuse to accept the use of toxic but effective antibiotics in life-threatening infections? The aim of this review is to provide insight into the reasons why the medical community remains unjustifiably unwilling to accept the risk of toxicity and the adverse effects of antibiotics that, nonetheless, might be required to treat severe infections, including those due to multidrug-resistant bacteria.
    MeSH term(s) Anti-Bacterial Agents/adverse effects ; Anti-Bacterial Agents/therapeutic use ; Attitude of Health Personnel ; Bacterial Infections/drug therapy ; Humans
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2016-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2016.03.026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4541: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 284: Show issues

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  2. Article: First detection of

    Cherak, Z / Bendjama, E / Moussi, A / Benbouza, A / Grainat, N / Rolain, J-M / Loucif, L

    New microbes and new infections

    2022  Volume 47, Page(s) 100977

    Abstract: ... ...

    Abstract Enterococcus
    Language English
    Publishing date 2022-04-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2750179-6
    ISSN 2052-2975
    ISSN 2052-2975
    DOI 10.1016/j.nmni.2022.100977
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Whole genome sequencing for deciphering the resistome of Chryseobacterium indologenes, an emerging multidrug-resistant bacterium isolated from a cystic fibrosis patient in Marseille, France.

    Cimmino, T / Rolain, J-M

    New microbes and new infections

    2016  Volume 12, Page(s) 35–42

    Abstract: We decipher the resistome of Chryseobacterium indologenes MARS15, an emerging multidrug-resistant clinical strain, using the whole genome sequencing strategy. The bacterium was isolated from the sputum of a hospitalized patient with cystic fibrosis in ... ...

    Abstract We decipher the resistome of Chryseobacterium indologenes MARS15, an emerging multidrug-resistant clinical strain, using the whole genome sequencing strategy. The bacterium was isolated from the sputum of a hospitalized patient with cystic fibrosis in the Timone Hospital in Marseille, France. Genome sequencing was done with Illumina MiSeq using a paired-end strategy. The in silico analysis was done by RAST, the resistome by the ARG-ANNOT database and detection of polyketide synthase (PKS) by ANTISMAH. The genome size of C. indologenes MARS15 is 4 972 580 bp with 36.4% GC content. This multidrug-resistant bacterium was resistant to all β-lactams, including imipenem, and also to colistin. The resistome of C. indologenes MARS15 includes Ambler class A and B β-lactams encoding bla CIA and bla IND-2 genes and MBL (metallo-β-lactamase) genes, the CAT (chloramphenicol acetyltransferase) gene and the multidrug efflux pump AcrB. Specific features include the presence of an urease operon, an intact prophage and a carotenoid biosynthesis pathway. Interestingly, we report for the first time in C. indologenes a PKS cluster that might be responsible for secondary metabolite biosynthesis, similar to erythromycin. The whole genome sequence analysis provides insight into the resistome and the discovery of new details, such as the PKS cluster.
    Language English
    Publishing date 2016-04-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2750179-6
    ISSN 2052-2975
    ISSN 2052-2975
    DOI 10.1016/j.nmni.2016.03.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Characterization of a Novel Pathogen in Immunocompromised Patients:

    Yasmin, Mohamad / Rojas, Laura J / Marshall, Steven H / Hujer, Andrea M / Cmolik, Anna / Marshall, Emma / Boucher, Helen W / Vila, Alejandro J / Soldevila, Maxime / Diene, Seydina M / Rolain, Jean-Marc / Bonomo, Robert A

    Open forum infectious diseases

    2023  Volume 10, Issue 2, Page(s) ofad014

    Abstract: Background: Elizabethkingia anophelis: Methods: Whole-genome sequencing (WGS) was conducted to accurately identify isolate species and elucidate the determinants of β-lactam resistance. Antimicrobial susceptibility testing was performed using broth ... ...

    Abstract Background: Elizabethkingia anophelis
    Methods: Whole-genome sequencing (WGS) was conducted to accurately identify isolate species and elucidate the determinants of β-lactam resistance. Antimicrobial susceptibility testing was performed using broth microdilution and disk diffusion assays. To assess the functional contribution of the major metallo-β-lactamase (MBL) encoding genes to the resistance profile,
    Results: WGS identified the organism as
    Conclusions: Using WGS, we accurately identified and characterized an extensively drug-resistant
    Language English
    Publishing date 2023-01-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofad014
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  5. Article ; Online: Are we living in an antibiotic resistance nightmare?

    Abat, C / Raoult, D / Rolain, J-M

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2018  Volume 24, Issue 6, Page(s) 568–569

    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Bacterial Infections/drug therapy ; Bacterial Infections/microbiology ; Bacterial Infections/mortality ; Drug Resistance, Multiple, Bacterial ; Hospitalization/statistics & numerical data ; Humans
    Chemical Substances Anti-Bacterial Agents
    Keywords covid19
    Language English
    Publishing date 2018-01-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2018.01.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4541: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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    Zs.MO 284: Show issues

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  6. Article: Investigations by the Institut Hospitalo-Universitaire Méditerranée Infection of food and food-borne infections in the Mediterranean Basin and in sub-Saharan Africa.

    Abat, C / Rolain, J-M / Colson, P

    New microbes and new infections

    2018  Volume 26, Page(s) S37–S42

    Abstract: Food-borne infections are major causes of public health concern in developing and developed countries. During the past decade, the Institut Hospitalo-Universitaire Méditerranée Infection has conducted or been involved in multiple investigations that ... ...

    Abstract Food-borne infections are major causes of public health concern in developing and developed countries. During the past decade, the Institut Hospitalo-Universitaire Méditerranée Infection has conducted or been involved in multiple investigations that aimed at identifying the sources and strains responsible for food-borne diseases and therefore at improving the understanding, diagnosis, prevention and control of these infections. Investigations were conducted in the Mediterranean area and in sub-Saharan Africa on more than 15 food-borne agents, 17 food products and 14 antibiotic resistance-associated genes. Multiple sources, including unexpected ones, and pathogens, including emerging ones, were involved. Travelling in developing countries and zoonoses are major contributors to food-borne infections, while food-borne transmission of resistance-associated genes is increasingly reported. However, risk factors and pathogens associated with food-borne infections likely remain untapped and must be more extensively investigated, monitored and regularly reassessed. Diagnostic tests based on new technologies and real-time surveillance tools based on microbiology laboratory data are promising approaches to detect known food-borne infections and decipher new ones. Studies of the microbiota and its relationships with dietary patterns are also worth being conducted.
    Language English
    Publishing date 2018-09-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2750179-6
    ISSN 2052-2975
    ISSN 2052-2975
    DOI 10.1016/j.nmni.2018.08.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Genome analysis of

    Dandachi, I / Anani, H / Hadjadj, L / Brahimi, S / Lagier, J-C / Daoud, Z / Rolain, J-M

    New microbes and new infections

    2021  Volume 41, Page(s) 100863

    Abstract: Lachnoclostridium ... ...

    Abstract Lachnoclostridium phocaeense
    Language English
    Publishing date 2021-03-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2750179-6
    ISSN 2052-2975
    ISSN 2052-2975
    DOI 10.1016/j.nmni.2021.100863
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  8. Article ; Online: Carbapenemase genes and genetic platforms in Gram-negative bacilli: Enterobacteriaceae, Pseudomonas and Acinetobacter species.

    Diene, S M / Rolain, J-M

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2014  Volume 20, Issue 9, Page(s) 831–838

    Abstract: The emergence and rapid spread of carbapenemases in Enterobacteriaceae, Pseudomonas and Acinetobacter (EPA) species is becoming a major public health crisis worldwide, and is responsible for large number of hospital-acquired and nosocomial infections. In ...

    Abstract The emergence and rapid spread of carbapenemases in Enterobacteriaceae, Pseudomonas and Acinetobacter (EPA) species is becoming a major public health crisis worldwide, and is responsible for large number of hospital-acquired and nosocomial infections. In this article, we review the current knowledge on the classification, phylogeny and genetic platforms of the main carbapenemases already described in Gram-negative bacteria.
    MeSH term(s) Acinetobacter/enzymology ; Acinetobacter/genetics ; Bacterial Proteins/classification ; Bacterial Proteins/genetics ; Bacterial Proteins/secretion ; Cluster Analysis ; DNA, Bacterial/chemistry ; DNA, Bacterial/genetics ; Enterobacteriaceae/enzymology ; Enterobacteriaceae/genetics ; Genes, Bacterial ; Humans ; Phylogeny ; Pseudomonas/enzymology ; Pseudomonas/genetics ; beta-Lactamases/classification ; beta-Lactamases/genetics ; beta-Lactamases/secretion
    Chemical Substances Bacterial Proteins ; DNA, Bacterial ; beta-Lactamases (EC 3.5.2.6) ; carbapenemase (EC 3.5.2.6)
    Language English
    Publishing date 2014-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1111/1469-0691.12655
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4541: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 284: Show issues

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  9. Article ; Online: Carbapenemases in Enterobacteriaceae: the magnitude of a worldwide concern.

    Rolain, J M / Cornaglia, G

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2014  Volume 20, Issue 9, Page(s) 819–820

    MeSH term(s) Bacterial Proteins/secretion ; Enterobacteriaceae/enzymology ; Enterobacteriaceae/isolation & purification ; Enterobacteriaceae Infections/epidemiology ; Enterobacteriaceae Infections/microbiology ; Global Health ; Humans ; Pandemics ; beta-Lactamases/secretion
    Chemical Substances Bacterial Proteins ; beta-Lactamases (EC 3.5.2.6) ; carbapenemase (EC 3.5.2.6)
    Language English
    Publishing date 2014-09
    Publishing country England
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1111/1469-0691.12737
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4541: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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    Zs.MO 284: Show issues

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  10. Article: Emergence of plasmid-encoded VIM-2-producing

    Nawfal Dagher, T / Al-Bayssari, C / Diene, S M / Azar, E / Rolain, J-M

    New microbes and new infections

    2019  Volume 29, Page(s) 100521

    Abstract: The present study aimed to describe the emergence of carbapenem- ... ...

    Abstract The present study aimed to describe the emergence of carbapenem-resistant
    Language English
    Publishing date 2019-02-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2750179-6
    ISSN 2052-2975
    ISSN 2052-2975
    DOI 10.1016/j.nmni.2019.100521
    Database MEDical Literature Analysis and Retrieval System OnLINE

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