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Article: Lung transplantation during COVID-19 outbreak in mainland China.

Ju, Chun-Rong / Guan, Wei-Jie / He, Jian-Xing

2020 Volume 12, Issue 10, Page(s) 6132–6135

Language	English
Publishing date	2020-10-30
Publishing country	China
Document type	Journal Article
ZDB-ID	2573571-8
ISSN	2077-6624 ; 2072-1439
ISSN (online)	2077-6624
ISSN	2072-1439
DOI	10.21037/jtd-20-1948
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Clinical characteristics and treatment strategy of nocardiosis in lung transplant recipients: A single-center experience.

Xu, Yu / Lian, Qiao-Yan / Chen, Ao / Zhang, Jian-Heng / Xu, Xin / Huang, Dan-Xia / He, Jian-Xing / Ju, Chun-Rong

IDCases

2023 Volume 32, Page(s) e01758

Abstract: Objective: Nocardia: Methods: This retrospective study reviewed the clinical data of adult lung transplant recipients who were complicated with nocardiosis between January 2018 and December 2021 at the largest lung transplant center in South China.!## ...

Abstract	Objective: Nocardia Methods: This retrospective study reviewed the clinical data of adult lung transplant recipients who were complicated with nocardiosis between January 2018 and December 2021 at the largest lung transplant center in South China. Results: The incidence of nocardiosis was 4.2% (13/316), including 9 cases of pulmonary nocardiosis and 4 disseminated nocardiosis (blood, pulmonary and intracranial). The accuracy in diagnosing nocardiosis was 77.8% by culture and 100% by metagenomic next-generation sequencing (mNGS). Conclusions: mNGS is more accurate than culture in diagnosing nocardiosis. Most patients responded well to the antibiotic therapy with combined antibiotics at the initial stage followed by a single antibiotic treatment.
Language	English
Publishing date	2023-03-31
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2745454-X
ISSN	2214-2509
ISSN	2214-2509
DOI	10.1016/j.idcr.2023.e01758
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Article ; Online: Lung transplantation for anti-MDA5-positive dermatomyositis-associated rapid progressive interstitial lung disease: report of two cases and review of the literature

Lian, Qiao-yan / Chen, Ao / Zhang, Jian-heng / Xu, Xin / Huang, Dan-xia / Luo, Qun / He, Jian-xing / Ju, Chun-rong

Clin Rheumatol. 2023 Mar., v. 42, no. 3, p. 941-947

2023 , Page(s) 941–947

Abstract: Lung transplantation is an ultimate lifesaving treatment for many patients with end-stage lung disease, whereas whether it is an optional intervention for the anti-melanoma differentiation-associated gene 5 (anti-MDA5)-positive dermatomyositis (DM)- ... ...

Abstract	Lung transplantation is an ultimate lifesaving treatment for many patients with end-stage lung disease, whereas whether it is an optional intervention for the anti-melanoma differentiation-associated gene 5 (anti-MDA5)-positive dermatomyositis (DM)-associated rapid progressive interstitial lung disease (RP-ILD) remain controversial. We report two patients diagnosed with anti-MDA5-positive DM-associated RP-ILD, who were both bridging to lung transplant with extracorporeal membrane oxygenation (ECMO) after failing to respond to extensive immunosuppressants. The first patient received full rehabilitation, but the second patient died of DM flare at the early-stage post-lung transplantation. Most of the clinical information was parallel in these two patients except the anti-MDA5 antibody level, which gradually decreased and became negative in the first patient but always hovering in high titers in the second patient, although both of the two patients received standard immunosuppressive regimen for prevention of rejection after lung transplantation. A total of 11 patients with anti-MDA5-positive DM-associated RP-ILD who underwent lung transplantation from the literature were identified. Most patients (10/11, 90.1%) were successfully discharged and without DM flare during the follow-up period post-lung transplantation. Nine of them were followed up more than 1 year, and anti-MDA-5 antibody was reported to be negative in four patients, whereas the others were unavailable. Combined with the case series in the literature, our limited experience suggests that lung transplantation is a promising therapeutic option for end-stage patients with anti-MDA5-positive DM-associated RP-ILD, with ECMO as a bridge to lung transplantation, if necessary. However, clearance or a downtrend of anti-MDA5 antibody may be required pre-transplant to avoid DM flare and recurrent RP-ILD post-transplantation.
Keywords	antibodies ; dermatomyositis ; genes ; immunosuppression ; immunosuppressive agents ; lungs ; patients ; respiratory tract diseases ; therapeutics
Language	English
Dates of publication	2023-03
Size	p. 941-947
Publishing place	Springer International Publishing
Document type	Article ; Online
Note	Review
ZDB-ID	604755-5
ISSN	0770-3198
ISSN	0770-3198
DOI	10.1007/s10067-022-06422-6
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Metagenomic Next-Generation Sequencing for Diagnosing Infections in Lung Transplant Recipients: A Retrospective Study.

Ju, Chun-Rong / Lian, Qiao-Yan / Guan, Wei-Jie / Chen, Ao / Zhang, Jian-Heng / Xu, Xin / Chen, Rong-Chang / Li, Shi-Yue / He, Jian-Xing

Transplant international : official journal of the European Society for Organ Transplantation

2022 Volume 35, Page(s) 10265

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	High-Throughput Nucleotide Sequencing/methods ; Humans ; Lung ; Retrospective Studies ; Sensitivity and Specificity ; Transplant Recipients
Language	English
Publishing date	2022-02-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	639435-8
ISSN	1432-2277 ; 0934-0874
ISSN (online)	1432-2277
ISSN	0934-0874
DOI	10.3389/ti.2022.10265
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Zs.A 2358: Show issues

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Article ; Online: The egg ribonuclease SjCP1412 accelerates liver fibrosis caused by

Li, Qi-Feng / Li, Yi-Xin / Yang, Ying-Ying / Dong, Pan-Pan / Mei, Cong-Jin / Lu, Ju-Lu / Zhang, Jian-Feng / Hua, Hai-Yong / Xiong, Chun-Rong / Yu, Chuan-Xin / Song, Li-Jun / Yang, Kun

Parasitology

2023 Volume 151, Issue 3, Page(s) 260–270

Abstract: Schistosomiasis, a parasite infectious disease caused ... ...

Abstract	Schistosomiasis, a parasite infectious disease caused by
MeSH term(s)	Humans ; Mice ; Animals ; Schistosomiasis japonica/complications ; Schistosomiasis japonica/parasitology ; Ribonucleases/metabolism ; Ribonucleases/pharmacology ; Endothelial Cells ; Liver Cirrhosis/parasitology ; Liver Cirrhosis/pathology ; Schistosoma japonicum ; Liver/pathology ; Inflammation/pathology
Chemical Substances	Ribonucleases (EC 3.1.-)
Language	English
Publishing date	2023-12-18
Publishing country	England
Document type	Journal Article
ZDB-ID	207627-5
ISSN	1469-8161 ; 0031-1820
ISSN (online)	1469-8161
ISSN	0031-1820
DOI	10.1017/S0031182023001361
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Article ; Online: Lung transplantation for anti-MDA5-positive dermatomyositis-associated rapid progressive interstitial lung disease: report of two cases and review of the literature.

Lian, Qiao-Yan / Chen, Ao / Zhang, Jian-Heng / Xu, Xin / Huang, Dan-Xia / Luo, Qun / He, Jian-Xing / Ju, Chun-Rong

Clinical rheumatology

2022 Volume 42, Issue 3, Page(s) 941–947

Abstract	Lung transplantation is an ultimate lifesaving treatment for many patients with end-stage lung disease, whereas whether it is an optional intervention for the anti-melanoma differentiation-associated gene 5 (anti-MDA5)-positive dermatomyositis (DM)-associated rapid progressive interstitial lung disease (RP-ILD) remain controversial. We report two patients diagnosed with anti-MDA5-positive DM-associated RP-ILD, who were both bridging to lung transplant with extracorporeal membrane oxygenation (ECMO) after failing to respond to extensive immunosuppressants. The first patient received full rehabilitation, but the second patient died of DM flare at the early-stage post-lung transplantation. Most of the clinical information was parallel in these two patients except the anti-MDA5 antibody level, which gradually decreased and became negative in the first patient but always hovering in high titers in the second patient, although both of the two patients received standard immunosuppressive regimen for prevention of rejection after lung transplantation. A total of 11 patients with anti-MDA5-positive DM-associated RP-ILD who underwent lung transplantation from the literature were identified. Most patients (10/11, 90.1%) were successfully discharged and without DM flare during the follow-up period post-lung transplantation. Nine of them were followed up more than 1 year, and anti-MDA-5 antibody was reported to be negative in four patients, whereas the others were unavailable. Combined with the case series in the literature, our limited experience suggests that lung transplantation is a promising therapeutic option for end-stage patients with anti-MDA5-positive DM-associated RP-ILD, with ECMO as a bridge to lung transplantation, if necessary. However, clearance or a downtrend of anti-MDA5 antibody may be required pre-transplant to avoid DM flare and recurrent RP-ILD post-transplantation.
MeSH term(s)	Humans ; Dermatomyositis ; Autoantibodies ; Interferon-Induced Helicase, IFIH1 ; Immunosuppressive Agents/therapeutic use ; Lung Diseases, Interstitial/complications ; Lung Diseases, Interstitial/surgery ; Lung Diseases, Interstitial/diagnosis ; Lung Transplantation
Chemical Substances	Autoantibodies ; Interferon-Induced Helicase, IFIH1 (EC 3.6.4.13) ; Immunosuppressive Agents
Language	English
Publishing date	2022-11-28
Publishing country	Germany
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	604755-5
ISSN	1434-9949 ; 0770-3198
ISSN (online)	1434-9949
ISSN	0770-3198
DOI	10.1007/s10067-022-06422-6
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Article: Development and feasibility of a virtual reality-based exergaming program to enhance cardiopulmonary fitness in children with developmental coordination disorder.

Ju, Ya-Ju / Du, Yi-Chun / Huang, Hsien-Chun / Hu Kao, Po-Sen / Cherng, Rong-Ju

Frontiers in pediatrics

2023 Volume 11, Page(s) 1238471

Abstract: Introduction: Developmental coordination disorder (DCD) is a neurodevelopmental disorder characterized by motor skill deficits. Such deficits often limit children's participation in physical activities, further affecting their overall health, including ... ...

Abstract	Introduction: Developmental coordination disorder (DCD) is a neurodevelopmental disorder characterized by motor skill deficits. Such deficits often limit children's participation in physical activities, further affecting their overall health, including through reduced cardiopulmonary fitness. Because virtual reality (VR) devices offer interactive games and activities that require various movements and coordination, they can serve as motivating and enjoyable means for children to perform physical exercise. In this study, we developed a VR-based exergaming system and tested its ability to enhance the cardiopulmonary fitness of children with DCD. Materials and methods: A total of 13 children with DCD and 10 young adults were recruited in phase I to examine the test-retest reliability and concurrent validity of our system (including a custom-made heart rate monitor) with a commercial heart rate device. In phase II, we included an additional 13 children with DCD to test the feasibility of the system. We tested the outcomes using the enjoyment rating scale, intrinsic motivation inventory (IMI), and 20-m shuttle run test (20mSRT). Results: In phase I, test-retest reliability was good to excellent in the static task and moderate to good in the dynamic task. Concurrent validity was excellent in both tasks. In phase II, more than half of the children (18 out of 26) assigned the maximum rating for their enjoyment of the game; they also had high average scores on the IMI. Furthermore, after the 8-week training using the VR program, the average running distance of the 26 children in the 20mSRT had increased significantly from 129.23 m to 176.92 m ( Conclusion: Our VR-based exergaming program can serve as an alternative intervention for enhancing cardiopulmonary fitness in children with DCD.
Language	English
Publishing date	2023-12-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2023.1238471
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Article: [Correlation of sperm nuclear maturity with the outcomes of in vitro fertilization].

Li, Jie / Rong, Chun-Hao / Hu, Ju-Wei / Zhou, Li-Ming

Zhonghua nan ke xue = National journal of andrology

2023 Volume 27, Issue 12, Page(s) 1075–1080

Abstract: Objective: To investigate the correlation between sperm nuclear maturity and the outcomes of in vitro fertilization (IVF).: Methods: We retrospectively analyzed the clinical data on 1 393 cycles of IVF in our center from September 2018 to May 2020. ... ...

Abstract	Objective: To investigate the correlation between sperm nuclear maturity and the outcomes of in vitro fertilization (IVF). Methods: We retrospectively analyzed the clinical data on 1 393 cycles of IVF in our center from September 2018 to May 2020. According to the high DNA stainability (HDS) of sperm, we divided the patients into a mature (HDS ≤ 10%) and an immature sperm nucleus group (HDS > 10%), compared the results of IVF, embryonic development and clinical outcomes between the two groups, and analyzed their correlation with HDS. Results: The rates of fertilization and normal fertilization were significantly higher and that of fertilization failure remarkably lower in the mature than in the immature sperm nuclear group (P < 0.05). There were no statistically significant differences between the two groups in the rates of cleavage, high-quality embryo, blastocyst formation, clinical pregnancy, miscarriage and live birth (P > 0.05). Univariate logistic regression analysis showed that HDS was correlated negatively with the rates of fertilization, normal fertilization and blastocyst formation (P < 0.05), positively with fertilization failure (P < 0.05), but not significantly with the rates of cleavage, high-quality embryo, clinical pregnancy, miscarriage and live birth (P > 0.05). After adjusting for confounding factors by multivariate logistic regression analysis, HDS was found correlated negatively with the fertilization rate (OR = 0.945, 95% CI: 0.918 to 0.972, P < 0.05), positively with fertilization failure (OR = 1.043, 95% CI: 1.010 to －1.078, P < 0.05), but not significantly with the rates of normal fertilization, cleavage, high-quality embryo, blastocyst formation, clinical pregnancy, miscarriage and live birth (P > 0.05). Conclusions: Sperm nuclear maturity significantly affects the rates of fertilization and fertilization failure in IVF patients. Taking sperm nuclear maturity indicators in consideration in the process of IVF may contribute to comprehensive evaluation of semen and male fertility and guide clinical decision-making.
Language	Chinese
Publishing date	2023-07-16
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2267480-9
ISSN	1009-3591
ISSN	1009-3591
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Article ; Online: Plasma myostatin levels are related to the extent of right ventricular dysfunction in exacerbation of chronic obstructive pulmonary disease.

Ju, Chun-Rong / Zhang, Jian-Heng / Chen, Miao / Chen, Rong-Chang

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals

2017 Volume 22, Issue 3-4, Page(s) 246–252

Abstract: Objective: To investigate the relationship between plasma myostatin levels and right ventricle (RV) dysfunction (RVD) in acute exacerbation of chronic obstructive pulmonary disease (AECOPD).: Methods: The study recruited 84 patients with AECOPD. ... ...

Abstract	Objective: To investigate the relationship between plasma myostatin levels and right ventricle (RV) dysfunction (RVD) in acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods: The study recruited 84 patients with AECOPD. Plasma myostatin was analyzed and tricuspid annular plane systolic excursion (TAPSE) < 16 mm was used as the main indicator for RVD. Results: Plasma myostatin levels were significantly higher in 47 patients with RVD than 37 ones without (P < 0.005). Multivariate regression analysis revealed that myostatin levels correlated significantly with TAPSE values and RV myocardial performance index (p < 0.001) among the study patients. Conclusion: Plasma myostatin is a potential biomarker for improving diagnosis of RVD in AECOPD.
MeSH term(s)	Aged ; Biomarkers/blood ; Case-Control Studies ; Female ; Humans ; Male ; Multivariate Analysis ; Myostatin/blood ; Pulmonary Disease, Chronic Obstructive/blood ; Pulmonary Disease, Chronic Obstructive/complications ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Tricuspid Valve/physiopathology ; Ventricular Dysfunction, Right/blood ; Ventricular Dysfunction, Right/diagnosis ; Ventricular Dysfunction, Right/etiology
Chemical Substances	Biomarkers ; MSTN protein, human ; Myostatin
Language	English
Publishing date	2017-05
Publishing country	England
Document type	Journal Article
ZDB-ID	1324372-x
ISSN	1366-5804 ; 1354-750X
ISSN (online)	1366-5804
ISSN	1354-750X
DOI	10.1080/1354750X.2016.1203999
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Article ; Online: The Airway Microbiota Signatures of Infection and Rejection in Lung Transplant Recipients.

Su, Jin / Li, Chun-Xi / Liu, Hai-Yue / Lian, Qiao-Yan / Chen, Ao / You, Zhi-Xuan / Li, Kun / Cai, Yu-Hang / Lin, Yan-Xia / Pan, Jian-Bing / Zhang, Guo-Xia / Ju, Chun-Rong / You, Chang-Xuan / He, Jian-Xing

Microbiology spectrum

2022 Volume 10, Issue 2, Page(s) e0034421

Abstract: Infection and rejection are the two most common complications after lung transplantation (LT) and are associated with increased morbidity and mortality. We aimed to examine the association between the airway microbiota and infection and rejection in lung ...

Abstract	Infection and rejection are the two most common complications after lung transplantation (LT) and are associated with increased morbidity and mortality. We aimed to examine the association between the airway microbiota and infection and rejection in lung transplant recipients (LTRs). Here, we collected 181 sputum samples (event-free,
MeSH term(s)	Humans ; Lung ; Lung Transplantation/adverse effects ; Microbiota ; RNA, Ribosomal, 16S/genetics ; Transplant Recipients
Chemical Substances	RNA, Ribosomal, 16S
Language	English
Publishing date	2022-04-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.00344-21
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