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  1. Article ; Online: "Why Won't They Believe Me?"

    Munetz, Mark R / Freedman, Lois S

    Psychiatric services (Washington, D.C.)

    2023  Volume 74, Issue 12, Page(s) 1294–1295

    Language English
    Publishing date 2023-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1220173-x
    ISSN 1557-9700 ; 1075-2730
    ISSN (online) 1557-9700
    ISSN 1075-2730
    DOI 10.1176/appi.ps.20230141
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 416: Show issues Location:
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  2. Article ; Online: Therapy with mesenchymal stem cell transplantation in multiple sclerosis is ready for prime time: No.

    Uccelli, Antonio / Freedman, Mark S

    Multiple sclerosis (Houndmills, Basingstoke, England)

    2022  Volume 28, Issue 9, Page(s) 1326–1328

    MeSH term(s) Humans ; Mesenchymal Stem Cell Transplantation ; Multiple Sclerosis/surgery
    Language English
    Publishing date 2022-07-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 1290669-4
    ISSN 1477-0970 ; 1352-4585
    ISSN (online) 1477-0970
    ISSN 1352-4585
    DOI 10.1177/13524585221095427
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    Zs.A 4428: Show issues Location:
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  3. Book ; Online: Multiple sclerosis and demyelinating diseases

    Freedman, Mark S.

    (Advances in neurology : v. 98 ; v. 98)

    2006  

    Author's details editor, Mark S. Freedman
    Series title Advances in neurology : v. 98 ; v. 98
    Keywords Multiple sclerosis ; Demyelinating diseases
    Language English
    Size 1 Online-Ressource (xvi, 375 Seiten), Illustrationen
    Publisher Lippincott Williams & Wilkins
    Publishing place Philadelphia
    Document type Book ; Online
    Note Includes bibliographical references and index
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 978-0-7817-5170-4 ; 0-7817-5170-5
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Book: Multiple sclerosis and demyelinating diseases

    Freedman, Mark S.

    (Advances in neurology ; 98)

    2006  

    Author's details ed. Mark S. Freeman
    Series title Advances in neurology ; 98
    Collection
    Keywords Multiple Sclerosis ; Demyelinating Diseases ; Multiple sclerosis ; Demyelination
    Subject code 616.834
    Language English
    Size XVI, 375 S. : Ill., graph. Darst.
    Publisher Lippincott Williams & Wilkins
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT014532549
    ISBN 0-7817-5170-5 ; 978-0-7817-5170-4
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Se 198 -98- verfügbar in Königswinter Königswinter

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  5. Article ; Online: Recent advances and remaining questions of autologous hematopoietic stem cell transplantation in multiple sclerosis.

    Bose, Gauruv / Freedman, Mark S

    Journal of the neurological sciences

    2021  Volume 421, Page(s) 117324

    Abstract: The judicious use of autologous hematopoietic stem cell transplantation (AHSCT) for MS requires understanding the potential benefits, identifying the most appropriate patient, and acknowledging the risks and differences between different protocols. ... ...

    Abstract The judicious use of autologous hematopoietic stem cell transplantation (AHSCT) for MS requires understanding the potential benefits, identifying the most appropriate patient, and acknowledging the risks and differences between different protocols. Recently, AHSCT for MS is occurring more frequently, with a better safety profile than earlier studies. This review assesses recently published studies to determine the advances that have been made and remaining questions that future studies are poised to answer. We included studies from January 2016 to November 2020 with 20 or more patients. The benefits of AHSCT, including "no evidence of disease activity", functional and patient-reported outcomes, novel biomarkers such as brain atrophy or neurofilament light chain, and cost-effectiveness were assessed. The patient selection, treatment protocols, and safety outcomes differ between reports. The overall efficacy of AHSCT is better than standard treatments. Younger patients with highly active disease have greater chance for improvement, while patients who have comorbidities, failed more treatments, and are transitioning to a more progressive phase may not respond as well to AHSCT. The safety profiles for all AHSCT protocols is improving, however the durability of treatment response may not be the same for all protocols. The goal of AHSCT is to stop disease activity, avoid worsening disability, and obviate the need for further disease-modifying treatment, while improving patient quality of life and minimizing treatment-related risk. Results from currently enrolling randomized controlled trials, as well as ongoing registries, will provide more evidence for the safe and appropriate use of AHSCT.
    MeSH term(s) Cost-Benefit Analysis ; Hematopoietic Stem Cell Transplantation ; Humans ; Multiple Sclerosis/therapy ; Quality of Life ; Transplantation, Autologous
    Language English
    Publishing date 2021-01-18
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 80160-4
    ISSN 1878-5883 ; 0022-510X ; 0374-8642
    ISSN (online) 1878-5883
    ISSN 0022-510X ; 0374-8642
    DOI 10.1016/j.jns.2021.117324
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    Zs.A 308: Show issues Location:
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  6. Article ; Online: Sphingosine 1-phosphate receptor modulators in multiple sclerosis treatment: A practical review.

    Coyle, Patricia K / Freedman, Mark S / Cohen, Bruce A / Cree, Bruce A C / Markowitz, Clyde E

    Annals of clinical and translational neurology

    2024  Volume 11, Issue 4, Page(s) 842–855

    Abstract: Four sphingosine 1-phosphate (S1P) receptor modulators (fingolimod, ozanimod, ponesimod, and siponimod) are approved by the US Food and Drug Administration for the treatment of multiple sclerosis. This review summarizes efficacy and safety data on these ... ...

    Abstract Four sphingosine 1-phosphate (S1P) receptor modulators (fingolimod, ozanimod, ponesimod, and siponimod) are approved by the US Food and Drug Administration for the treatment of multiple sclerosis. This review summarizes efficacy and safety data on these S1P receptor modulators, with an emphasis on similarities and differences. Efficacy data from the pivotal clinical trials are generally similar for the four agents. However, because no head-to-head clinical studies were conducted, direct efficacy comparisons cannot be made. Based on the adverse event profile of S1P receptor modulators, continued and regular monitoring of patients during treatment will be instructive. Notably, the authors recommend paying attention to the cardiac monitoring guidelines for these drugs, and when indicated screening for macular edema and cutaneous malignancies before starting treatment. To obtain the best outcome, clinicians should choose the drug based on disease type, history, and concomitant medications for each patient. Real-world data should help to determine whether there are meaningful differences in efficacy or side effects between these agents.
    MeSH term(s) United States ; Humans ; Multiple Sclerosis/drug therapy ; Sphingosine 1 Phosphate Receptor Modulators/adverse effects ; Sphingosine-1-Phosphate Receptors/therapeutic use ; Fingolimod Hydrochloride/adverse effects ; Administration, Oral
    Chemical Substances Sphingosine 1 Phosphate Receptor Modulators ; Sphingosine-1-Phosphate Receptors ; Fingolimod Hydrochloride (G926EC510T)
    Language English
    Publishing date 2024-02-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2740696-9
    ISSN 2328-9503 ; 2328-9503
    ISSN (online) 2328-9503
    ISSN 2328-9503
    DOI 10.1002/acn3.52017
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  7. Article: Multiple sclerosis therapeutic strategies: Use second-line agents as first-line agents when time is of the essence.

    Freedman, Mark S

    Neurology. Clinical practice

    2017  Volume 1, Issue 1, Page(s) 66–68

    Language English
    Publishing date 2017-06-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2645818-4
    ISSN 2163-0933 ; 2163-0402
    ISSN (online) 2163-0933
    ISSN 2163-0402
    DOI 10.1212/CPJ.0b013e31823cc2c2
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  8. Article ; Online: Dementia Prevalence, Incidence and Mortality Trends Among US Adults Ages 72 and Older, 2011-2021.

    Freedman, Vicki A / Cornman, Jennifer C

    The journals of gerontology. Series A, Biological sciences and medical sciences

    2024  

    Abstract: Background: U.S.-focused studies have reported decreasing dementia prevalence in recent decades ... pandemic period (45%).: Conclusions: Declines in dementia prevalence continued into years marked ...

    Abstract Background: U.S.-focused studies have reported decreasing dementia prevalence in recent decades, but have not yet focused on the implications of the COVID-19 pandemic for trends.
    Methods: We use the 2011-2021 National Health and Aging Trends Study (N=48,065) to examine dementia prevalence, incidence and mortality trends among adults ages 72 and older, and the contribution to prevalence trends of changes in the distribution of characteristics of the older population ("compositional shifts") during the full and pre-pandemic periods. To minimize classification error, individuals must meet dementia criteria for two consecutive rounds.
    Results: The prevalence of probable dementia declined from 11.9% in 2011 to 9.2% in 2019 and 8.2% in 2021 (3.1% average annual decline). Declines over the 2011-2021 period were concentrated among those ages 80-89 and non-Hispanic White individuals. Declines in dementia incidence were stronger for the 2011-2021 period than for the pre-pandemic period while mortality among those with dementia rose sharply with the onset of the COVID-19 pandemic. Shifts in the composition of the older population accounted for a smaller fraction of the decline over the full period (28%) than over the pre-pandemic period (45%).
    Conclusions: Declines in dementia prevalence continued into years marked by onset of the COVID-19 pandemic, along with declines in incidence and sharp increases in mortality among those with dementia. However, declines are no longer largely attributable to compositional changes in the older population. Continued tracking of dementia prevalence, incidence and mortality among those with and without dementia is needed to understand long-run consequences of the pandemic.
    Language English
    Publishing date 2024-04-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1223643-3
    ISSN 1758-535X ; 1079-5006
    ISSN (online) 1758-535X
    ISSN 1079-5006
    DOI 10.1093/gerona/glae105
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    Uc I Zs.242/A: Show issues Location:
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  9. Article ; Online: Are we in need of NEDA?

    Freedman, Mark S

    Multiple sclerosis (Houndmills, Basingstoke, England)

    2016  Volume 22, Issue 1, Page(s) 5–6

    MeSH term(s) Disease Progression ; Humans ; Multiple Sclerosis/therapy ; Outcome Assessment (Health Care)/standards
    Language English
    Publishing date 2016-01
    Publishing country England
    Document type Editorial
    ZDB-ID 1290669-4
    ISSN 1477-0970 ; 1352-4585
    ISSN (online) 1477-0970
    ISSN 1352-4585
    DOI 10.1177/1352458515617249
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    Zs.A 4428: Show issues Location:
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  10. Article ; Online: Precision medicine in the multiple sclerosis clinic: Selecting the right patient for the right treatment.

    Bose, Gauruv / Freedman, Mark S

    Multiple sclerosis (Houndmills, Basingstoke, England)

    2020  Volume 26, Issue 5, Page(s) 540–547

    Abstract: Multiple sclerosis (MS) is a chronic, inflammatory disease of the central nervous system (CNS), affecting patients of all ages, causing neurologic disability if inadequately treated. Some patients have a relatively benign disease course without ... ...

    Abstract Multiple sclerosis (MS) is a chronic, inflammatory disease of the central nervous system (CNS), affecting patients of all ages, causing neurologic disability if inadequately treated. Some patients have a relatively benign disease course without significant disability after decades, while a more aggressive course ensues in others and disability progression occurs after only several years. Certain risk factors confer a higher chance of a patient having aggressive MS. Currently over 15 disease-modifying treatments (DMTs) are approved for MS with different efficacy and safety profiles. Deciding which DMT to use in a specific patient requires a careful analysis of a patient's disease course for high-risk factors for early progression, consideration of the efficacy and safety profile for potential therapy, as well as understanding of a patient's lifestyle and expectations. The integration of these factors is the art of precision medicine, a necessary practice in the treatment of patients with MS.
    MeSH term(s) Humans ; Immunologic Factors/administration & dosage ; Multiple Sclerosis/diagnosis ; Multiple Sclerosis/drug therapy ; Patient-Centered Care/methods ; Patient-Centered Care/standards ; Precision Medicine/methods ; Precision Medicine/standards
    Chemical Substances Immunologic Factors
    Language English
    Publishing date 2020-01-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1290669-4
    ISSN 1477-0970 ; 1352-4585
    ISSN (online) 1477-0970
    ISSN 1352-4585
    DOI 10.1177/1352458519887324
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