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  1. Article ; Online: MIM-CyCIF: masked imaging modeling for enhancing cyclic immunofluorescence (CyCIF) with panel reduction and imputation.

    Sims, Zachary / Mills, Gordon B / Chang, Young Hwan

    Communications biology

    2024  Volume 7, Issue 1, Page(s) 409

    Abstract: Cyclic Immunofluorescence (CyCIF) can quantify multiple biomarkers, but panel capacity is limited by technical challenges. We propose a computational panel reduction approach that can impute the information content from 25 markers using only 9 markers, ... ...

    Abstract Cyclic Immunofluorescence (CyCIF) can quantify multiple biomarkers, but panel capacity is limited by technical challenges. We propose a computational panel reduction approach that can impute the information content from 25 markers using only 9 markers, learning co-expression and morphological patterns while concurrently increasing speed and panel content and decreasing cost. We demonstrate strong correlations in predictions and generalizability across breast and colorectal cancer, illustrating applicability of our approach to diverse tissue types.
    MeSH term(s) Fluorescent Antibody Technique ; Diagnostic Imaging
    Language English
    Publishing date 2024-04-03
    Publishing country England
    Document type Journal Article
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-024-06110-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: MIM-CyCIF: Masked Imaging Modeling for Enhancing Cyclic Immunofluorescence (CyCIF) with Panel Reduction and Imputation.

    Chang, Young Hwan / Sims, Zachary / Mills, Gordon

    Research square

    2023  

    Abstract: CyCIF can quantify multiple biomarkers, but panel capacity is limited by technical challenges. We propose a computational panel reduction approach that can impute the information content from 25 markers using only 9 markers, learning co-expression and ... ...

    Abstract CyCIF can quantify multiple biomarkers, but panel capacity is limited by technical challenges. We propose a computational panel reduction approach that can impute the information content from 25 markers using only 9 markers, learning co-expression and morphological patterns while concurrently increasing speed and panel content and decreasing cost. We demonstrate strong correlations in predictions and generalizability across breast and colorectal cancer, illustrating applicability of our approach to diverse tissue types.
    Language English
    Publishing date 2023-09-21
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-3270272/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Novel Screw Placement Method for Extremely Small Lumbar Pedicles in Scoliosis.

    Hwang, Chang-Ju / Lee, Joo-Young / Lee, Dong-Ho / Cho, Jae-Hwan / Lee, Choon-Sung / Lee, Mi-Young / Yoon, So-Jung

    Journal of clinical medicine

    2024  Volume 13, Issue 4

    Abstract: Study Design: ...

    Abstract Study Design:
    Language English
    Publishing date 2024-02-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13041115
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: MIM-CyCIF: Masked Imaging Modeling for Enhancing Cyclic Immunofluorescence (CyCIF) with Panel Reduction and Imputation.

    Sims, Zachary / Mills, Gordon B / Chang, Young Hwan

    bioRxiv : the preprint server for biology

    2023  

    Abstract: CyCIF quantifies multiple biomarkers, but panel capacity is compromised by technical challenges including tissue loss. We propose a computational panel reduction, inferring surrogate CyCIF data from a subset of biomarkers. Our model reconstructs the ... ...

    Abstract CyCIF quantifies multiple biomarkers, but panel capacity is compromised by technical challenges including tissue loss. We propose a computational panel reduction, inferring surrogate CyCIF data from a subset of biomarkers. Our model reconstructs the information content from 25 markers using only 9 markers, learning co-expression and morphological patterns. We demonstrate strong correlations in predictions and generalizability across breast and colorectal cancer tissue microarrays, illustrating broader applicability to diverse tissue types.
    Language English
    Publishing date 2023-08-16
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.05.10.540265
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Quadriplegia, Dysphagia and Ataxia Manifested in a Child With COVID-19 Related Acute Necrotizing Encephalopathy: A Case Report.

    Ku, Young-Su / Joa, Kyung-Lim / Kim, Myeong-Ok / Kim, Chang-Hwan / Jung, Han-Young

    Brain & NeuroRehabilitation

    2024  Volume 17, Issue 1, Page(s) e2

    Abstract: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, presents primarily with respiratory symptoms. However, children with COVID-19 are usually asymptomatic or mild acute symptoms and also neurological ... ...

    Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, presents primarily with respiratory symptoms. However, children with COVID-19 are usually asymptomatic or mild acute symptoms and also neurological manifestations have also been observed. We report the case of a 7-year-old girl who presented with high fever and altered mental status, leading to a diagnosis of COVID-19 and acute necrotizing encephalopathy (ANE). The patient received intensive medical care in the intensive care unit and subsequently underwent rehabilitation programs due to neurological functional sequelae. Neurological complications in COVID-19, including ANE, may result from potential viral nerve involvement, cytokine storms, and the blood-brain barrier disruption. Early rehabilitation plays a pivotal role in managing COVID-19-related neurological complications and enhancing patients' functional outcomes. Further research is essential to gain a better understanding of the mechanisms and treatment strategies for neurological manifestations in pediatric COVID-19 patients, particularly those with multisystem inflammatory syndrome in child.
    Language English
    Publishing date 2024-01-04
    Publishing country Korea (South)
    Document type Case Reports
    ISSN 2383-9910
    ISSN (online) 2383-9910
    DOI 10.12786/bn.2024.17.e2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Corrigendum to 'Effects of microfiber and bead microplastic exposure in the goldfish Carassius auratus: Bioaccumulation, antioxidant responses, and cell damage' [Aquat. Toxicol. 263 (2023) 106684].

    Kim, Jin A / Kim, Min Ju / Park, Young-Su / Kang, Chang-Keun / Kim, Jun-Hwan / Choi, Cheol Young

    Aquatic toxicology (Amsterdam, Netherlands)

    2024  Volume 268, Page(s) 106857

    Language English
    Publishing date 2024-02-06
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 782699-0
    ISSN 1879-1514 ; 0166-445X
    ISSN (online) 1879-1514
    ISSN 0166-445X
    DOI 10.1016/j.aquatox.2024.106857
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4376: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Characterization of the complete plastid genome of Korean endemic,

    Kamra, Kashish / Jung, Joonhyung / Kim, Hyuk-Jin / Yoon, Chang-Young / Kim, Joo-Hwan

    Mitochondrial DNA. Part B, Resources

    2023  Volume 8, Issue 1, Page(s) 119–123

    Abstract: ... Ajuga ... ...

    Abstract Ajuga spectabilis
    Language English
    Publishing date 2023-01-15
    Publishing country England
    Document type Journal Article
    ISSN 2380-2359
    ISSN (online) 2380-2359
    DOI 10.1080/23802359.2022.2156258
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Connecting the S2 alar-iliac screw head to the satellite rod for surgical correction of degenerative sagittal imbalance.

    Cho, Sung Tan / Lee, Dong-Ho / Cho, Jae Hwan / Park, Sehan / Kim, Jin Hwan / Lee, Mi Young / Yoon, So Jeong / Hwang, Chang Ju

    European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

    2024  

    Abstract: Purpose: The S2AI screw technique has several advantages over the conventional iliac screw fixation technique. However, connecting the S2AI screw head to the main rod is difficult due to its medial entry point. We introduce a new technique for ... ...

    Abstract Purpose: The S2AI screw technique has several advantages over the conventional iliac screw fixation technique. However, connecting the S2AI screw head to the main rod is difficult due to its medial entry point. We introduce a new technique for connecting the S2AI screw head to a satellite rod and compare it with the conventional method of connecting the S2AI screw to the main rod.
    Methods: Seventy-four patients who underwent S2AI fixation for degenerative sagittal imbalance and were followed up for ≥ 2 years were included. All the patients underwent long fusion from T9 or T10 to the pelvis. The S2AI screw head was connected to the satellite rod (SS group) in 43 patients and the main rod (SM group) in 31 patients. In the SS group, the satellite rod was placed medial to the main rod and connected by the S2AI screw and domino connectors. In the SM group, the main rod was connected directly to the S2AI screw head and supported by accessory rods. Radiographic and clinical outcomes were evaluated in both groups.
    Results: There were no significant differences in postoperative complications, including proximal junctional failure, proximal junctional kyphosis, rod breakage, screw loosening, wound problems, and infection between the two groups. Furthermore, the correction power of sagittal deformity and clinical results in the SS group were comparable to those in the SM group.
    Conclusion: Connecting the S2AI screw to the satellite rod is a convenient method comparable to the conventional S2AI connection method in terms of radiological and clinical outcomes.
    Language English
    Publishing date 2024-01-09
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1115375-1
    ISSN 1432-0932 ; 0940-6719
    ISSN (online) 1432-0932
    ISSN 0940-6719
    DOI 10.1007/s00586-023-08106-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3437: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Strategies to Reduce Long-Term Drug Resistance by Considering Effects of Differential Selective Treatments.

    Asnaashari, Tina Ghodsi / Chang, Young Hwan

    Mathematical and computational oncology : third international symposium, ISMCO 2021, virtual event, October 11-13, 2021 : proceedings. ISMCO (Symposium) (3rd : 2021 : Online)

    2021  Volume 13060, Page(s) 49–60

    Abstract: Despite great advances in modeling and cancer therapy using optimal control theory, tumor heterogeneity and drug resistance are major obstacles in cancer treatments. Since recent biological studies demonstrated the evidence of tumor heterogeneity and ... ...

    Abstract Despite great advances in modeling and cancer therapy using optimal control theory, tumor heterogeneity and drug resistance are major obstacles in cancer treatments. Since recent biological studies demonstrated the evidence of tumor heterogeneity and assessed potential biological and clinical implications, tumor heterogeneity should be taken into account in the optimal control problem to improve treatment strategies. Here, first we study the effects of two different treatment strategies (i.e., symmetric and asymmetric) in a minimal two-population model to examine the long-term effects of these treatment methods on the system. Second, by considering tumor adaptation to treatment as a factor of the cost function, the optimal treatment strategy is derived. Numerical examples show that optimal treatment decreases tumor burden for the long-term by decreasing rate of tumor adaptation over time.
    Language English
    Publishing date 2021-12-12
    Publishing country Switzerland
    Document type Journal Article
    DOI 10.1007/978-3-030-91241-3_5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: A case of type A insulin resistance syndrome in a 14-year-old adolescent girl without common clinical features.

    Lee, Na Won / Jeong, Ji Eun / Kim, Young Hwan / Ki, Chang Seok / Kim, Jin Kyung

    Annals of pediatric endocrinology & metabolism

    2023  Volume 28, Issue Suppl 1, Page(s) S17–S19

    Language English
    Publishing date 2023-02-01
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2800460-7
    ISSN 2287-1292 ; 2287-1012
    ISSN (online) 2287-1292
    ISSN 2287-1012
    DOI 10.6065/apem.2244106.053
    Database MEDical Literature Analysis and Retrieval System OnLINE

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