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  1. Book ; Online ; Thesis: Immunometabolism in chronic HIV-1 infection

    Korencak, Marek [Verfasser] / Streeck, Hendrik [Akademischer Betreuer]

    2020  

    Author's details Marek Korencak ; Betreuer: Hendrik Streeck
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Duisburg ; Universität Duisburg-Essen
    Publishing place Essen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  2. Article ; Online: Reduction of CD8 T Cell Functionality but Not Inhibitory Capacity by Integrase Inhibitors.

    Richter, Enrico / Bornemann, Lea / Korencak, Marek / Alter, Galit / Schuster, Marc / Esser, Stefan / Boesecke, Christoph / Rockstroh, Juergen / Gunzer, Matthias / Streeck, Hendrik

    Journal of virology

    2022  Volume 96, Issue 5, Page(s) e0173021

    Abstract: Although HIV-specific CD8 T cells are effective in controlling HIV infection, they fail to clear infection even in the presence of antiretroviral therapy (ART) and cure strategies such as "shock-and-kill." Little is known how ART is contributing to HIV- ... ...

    Abstract Although HIV-specific CD8 T cells are effective in controlling HIV infection, they fail to clear infection even in the presence of antiretroviral therapy (ART) and cure strategies such as "shock-and-kill." Little is known how ART is contributing to HIV-specific CD8 T cell function and the ability to clear HIV infection. Therefore, we first assessed the cytokine polyfunctionality and proliferation of CD8 T cells from ART-treated HIV+ individuals directly
    MeSH term(s) Anti-HIV Agents/pharmacology ; Anti-HIV Agents/therapeutic use ; CD8-Positive T-Lymphocytes/drug effects ; HIV Infections/drug therapy ; HIV Integrase Inhibitors/pharmacology ; Humans ; Reverse Transcriptase Inhibitors/therapeutic use
    Chemical Substances Anti-HIV Agents ; HIV Integrase Inhibitors ; Reverse Transcriptase Inhibitors
    Language English
    Publishing date 2022-01-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/JVI.01730-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Reconstruction of the origin of the first major SARS-CoV-2 outbreak in Germany

    Korencak, Marek / Sivalingam, Sugirthan / Sahu, Anshupa / Dressen, Dietmar / Schmidt, Axel / Brand, Fabian / Krawitz, Peter / Hart, Libor / Maria Eis-Hübinger, Anna / Buness, Andreas / Streeck, Hendrik

    Computational and Structural Biotechnology Journal. 2022, v. 20

    2022  

    Abstract: The first major COVID-19 outbreak in Germany occurred in Heinsberg in February 2020 with 388 officially reported cases. Unexpectedly, the first outbreak happened in a small town with little to no travelers. We used phylogenetic analyses to investigate ... ...

    Abstract The first major COVID-19 outbreak in Germany occurred in Heinsberg in February 2020 with 388 officially reported cases. Unexpectedly, the first outbreak happened in a small town with little to no travelers. We used phylogenetic analyses to investigate the origin and spread of the virus in this outbreak. We sequenced 90 (23%) SARS-CoV-2 genomes from the 388 reported cases including the samples from the first documented cases. Phylogenetic analyses of these sequences revealed mainly two circulating strains with 74 samples assigned to lineage B.3 and 6 samples assigned to lineage B.1. Lineage B.3 was introduced first and probably caused the initial spread. Using phylogenetic analysis tools, we were able to identify closely related strains in France and hypothesized the possible introduction from France.
    Keywords COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; biotechnology ; genome ; phylogeny ; viruses ; France ; Germany
    Language English
    Size p. 2292-2296.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 2694435-2
    ISSN 2001-0370
    ISSN 2001-0370
    DOI 10.1016/j.csbj.2022.05.011
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: Case Report: Infection With SARS-CoV-2 in the Presence of High Levels of Vaccine-Induced Neutralizing Antibody Responses.

    Schulte, Bianca / Marx, Benjamin / Korencak, Marek / Emmert, Dorian / Aldabbagh, Souhaib / Eis-Hübinger, Anna Maria / Streeck, Hendrik

    Frontiers in medicine

    2021  Volume 8, Page(s) 704719

    Abstract: We present a case of SARS-CoV-2 B.1. 525 infection in a healthcare worker despite the presence of highly neutralizing, multivariant-specific antibodies 7 weeks after full vaccination with the mRNA vaccine BNT162b2. We show that the virus replicated to ... ...

    Abstract We present a case of SARS-CoV-2 B.1. 525 infection in a healthcare worker despite the presence of highly neutralizing, multivariant-specific antibodies 7 weeks after full vaccination with the mRNA vaccine BNT162b2. We show that the virus replicated to high levels in the upper respiratory tract over the course of several days in the presence of strong antibody responses. The virus was readily propagatable
    Language English
    Publishing date 2021-07-23
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.704719
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  5. Article: Reconstruction of the origin of the first major SARS-CoV-2 outbreak in Germany.

    Korencak, Marek / Sivalingam, Sugirthan / Sahu, Anshupa / Dressen, Dietmar / Schmidt, Axel / Brand, Fabian / Krawitz, Peter / Hart, Libor / Maria Eis-Hübinger, Anna / Buness, Andreas / Streeck, Hendrik

    Computational and structural biotechnology journal

    2022  Volume 20, Page(s) 2292–2296

    Abstract: The first major COVID-19 outbreak in Germany occurred in Heinsberg in February 2020 with 388 officially reported cases. Unexpectedly, the first outbreak happened in a small town with little to no travelers. We used phylogenetic analyses to investigate ... ...

    Abstract The first major COVID-19 outbreak in Germany occurred in Heinsberg in February 2020 with 388 officially reported cases. Unexpectedly, the first outbreak happened in a small town with little to no travelers. We used phylogenetic analyses to investigate the origin and spread of the virus in this outbreak. We sequenced 90 (23%) SARS-CoV-2 genomes from the 388 reported cases including the samples from the first documented cases. Phylogenetic analyses of these sequences revealed mainly two circulating strains with 74 samples assigned to lineage B.3 and 6 samples assigned to lineage B.1. Lineage B.3 was introduced first and probably caused the initial spread. Using phylogenetic analysis tools, we were able to identify closely related strains in France and hypothesized the possible introduction from France.
    Language English
    Publishing date 2022-05-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2694435-2
    ISSN 2001-0370
    ISSN 2001-0370
    DOI 10.1016/j.csbj.2022.05.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Case Report

    Bianca Schulte / Benjamin Marx / Marek Korencak / Dorian Emmert / Souhaib Aldabbagh / Anna Maria Eis-Hübinger / Hendrik Streeck

    Frontiers in Medicine, Vol

    Infection With SARS-CoV-2 in the Presence of High Levels of Vaccine-Induced Neutralizing Antibody Responses

    2021  Volume 8

    Abstract: We present a case of SARS-CoV-2 B.1. 525 infection in a healthcare worker despite the presence of highly neutralizing, multivariant-specific antibodies 7 weeks after full vaccination with the mRNA vaccine BNT162b2. We show that the virus replicated to ... ...

    Abstract We present a case of SARS-CoV-2 B.1. 525 infection in a healthcare worker despite the presence of highly neutralizing, multivariant-specific antibodies 7 weeks after full vaccination with the mRNA vaccine BNT162b2. We show that the virus replicated to high levels in the upper respiratory tract over the course of several days in the presence of strong antibody responses. The virus was readily propagatable in vitro, demonstrating the potential to transmit to others, bolstered by the fact that several household members were equally infected. This highlights the importance of protective measures even in vaccinated individuals.
    Keywords SARS-CoV-2 ; breakthrough infection ; mRNA vaccines ; virus variants ; neutralizing antibodies ; Medicine (General) ; R5-920
    Language English
    Publishing date 2021-07-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: T Cell-Specific Overexpression of Acid Sphingomyelinase Results in Elevated T Cell Activation and Reduced Parasitemia During

    Hose, Matthias / Günther, Anne / Abberger, Hanna / Begum, Salina / Korencak, Marek / Becker, Katrin A / Buer, Jan / Westendorf, Astrid M / Hansen, Wiebke

    Frontiers in immunology

    2019  Volume 10, Page(s) 1225

    Abstract: The enzyme acid sphingomyelinase (ASM) hydrolyzes sphingomyelin to ceramide and is thereby involved in several cellular processes such as differentiation, proliferation, and apoptosis in different cell types. However, the function of ASM in T cells is ... ...

    Abstract The enzyme acid sphingomyelinase (ASM) hydrolyzes sphingomyelin to ceramide and is thereby involved in several cellular processes such as differentiation, proliferation, and apoptosis in different cell types. However, the function of ASM in T cells is still not well characterized. Here, we used T cell-specific ASM overexpressing mice (t-ASM/CD4cre) to clarify the impact of cell-intrinsic ASM activity on T cell function
    MeSH term(s) Animals ; Cell Differentiation ; Cells, Cultured ; Forkhead Transcription Factors/metabolism ; Humans ; Lymphocyte Activation ; Malaria/immunology ; Mice ; Parasitemia ; Plasmodium yoelii/physiology ; Receptors, Antigen, T-Cell/metabolism ; Signal Transduction ; Sphingomyelin Phosphodiesterase/metabolism ; T-Lymphocytes, Regulatory/immunology ; Up-Regulation
    Chemical Substances FOXP3 protein, human ; Forkhead Transcription Factors ; Receptors, Antigen, T-Cell ; Sphingomyelin Phosphodiesterase (EC 3.1.4.12)
    Language English
    Publishing date 2019-05-31
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2019.01225
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Sofosbuvir Activates EGFR-Dependent Pathways in Hepatoma Cells with Implications for Liver-Related Pathological Processes.

    Bojkova, Denisa / Westhaus, Sandra / Costa, Rui / Timmer, Lejla / Funkenberg, Nora / Korencak, Marek / Streeck, Hendrik / Vondran, Florian / Broering, Ruth / Heinrichs, Stefan / Lang, Karl S / Ciesek, Sandra

    Cells

    2020  Volume 9, Issue 4

    Abstract: Direct acting antivirals (DAAs) revolutionized the therapy of chronic hepatitis C infection. However, unexpected high recurrence rates of hepatocellular carcinoma (HCC) after DAA treatment became an issue in patients with advanced cirrhosis and fibrosis. ...

    Abstract Direct acting antivirals (DAAs) revolutionized the therapy of chronic hepatitis C infection. However, unexpected high recurrence rates of hepatocellular carcinoma (HCC) after DAA treatment became an issue in patients with advanced cirrhosis and fibrosis. In this study, we aimed to investigate an impact of DAA treatment on the molecular changes related to HCC development and progression in hepatoma cell lines and primary human hepatocytes. We found that treatment with sofosbuvir (SOF), a backbone of DAA therapy, caused an increase in EGFR expression and phosphorylation. As a result, enhanced translocation of EGFR into the nucleus and transactivation of factors associated with cell cycle progression, B-MYB and Cyclin D1, was detected. Serine/threonine kinase profiling identified additional pathways, especially the MAPK pathway, also activated during SOF treatment. Importantly, the blocking of EGFR kinase activity by erlotinib during SOF treatment prevented all downstream events. Altogether, our findings suggest that SOF may have an impact on pathological processes in the liver via the induction of EGFR signaling. Notably, zidovudine, another nucleoside analogue, exerted a similar cell phenotype, suggesting that the observed effects may be induced by additional members of this drug class.
    MeSH term(s) Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Hepatitis C, Chronic/drug therapy ; Humans ; Liver/drug effects ; Liver/pathology ; Risk Factors ; Sofosbuvir/pharmacology ; Sofosbuvir/therapeutic use
    Chemical Substances Antiviral Agents ; Sofosbuvir (WJ6CA3ZU8B)
    Language English
    Publishing date 2020-04-17
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells9041003
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  9. Article ; Online: Sofosbuvir Activates EGFR-Dependent Pathways in Hepatoma Cells with Implications for Liver-Related Pathological Processes

    Denisa Bojkova / Sandra Westhaus / Rui Costa / Lejla Timmer / Nora Funkenberg / Marek Korencak / Hendrik Streeck / Florian Vondran / Ruth Broering / Stefan Heinrichs / Karl S Lang / Sandra Ciesek

    Cells, Vol 9, Iss 1003, p

    2020  Volume 1003

    Abstract: Direct acting antivirals (DAAs) revolutionized the therapy of chronic hepatitis C infection. However, unexpected high recurrence rates of hepatocellular carcinoma (HCC) after DAA treatment became an issue in patients with advanced cirrhosis and fibrosis. ...

    Abstract Direct acting antivirals (DAAs) revolutionized the therapy of chronic hepatitis C infection. However, unexpected high recurrence rates of hepatocellular carcinoma (HCC) after DAA treatment became an issue in patients with advanced cirrhosis and fibrosis. In this study, we aimed to investigate an impact of DAA treatment on the molecular changes related to HCC development and progression in hepatoma cell lines and primary human hepatocytes. We found that treatment with sofosbuvir (SOF), a backbone of DAA therapy, caused an increase in EGFR expression and phosphorylation. As a result, enhanced translocation of EGFR into the nucleus and transactivation of factors associated with cell cycle progression, B-MYB and Cyclin D1, was detected. Serine/threonine kinase profiling identified additional pathways, especially the MAPK pathway, also activated during SOF treatment. Importantly, the blocking of EGFR kinase activity by erlotinib during SOF treatment prevented all downstream events. Altogether, our findings suggest that SOF may have an impact on pathological processes in the liver via the induction of EGFR signaling. Notably, zidovudine, another nucleoside analogue, exerted a similar cell phenotype, suggesting that the observed effects may be induced by additional members of this drug class.
    Keywords direct-acting antivirals ; HCV ; HCC recurrence ; nucleotide analogue ; EGFR pathway ; Biology (General) ; QH301-705.5
    Subject code 610 ; 616
    Language English
    Publishing date 2020-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Elevated protein arginine methyltransferase 1 expression regulates fibroblast motility in pulmonary fibrosis.

    Zakrzewicz, Dariusz / Zakrzewicz, Anna / Didiasova, Miroslava / Korencak, Marek / Kosanovic, Djuro / Schermuly, Ralph T / Markart, Philipp / Wygrecka, Malgorzata

    Biochimica et biophysica acta

    2015  Volume 1852, Issue 12, Page(s) 2678–2688

    Abstract: Objective: Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by epithelial cell injury, fibroblast activation and excessive extracellular matrix deposition. Although protein arginine methyltransferase 1 (PRMT1) was found to ... ...

    Abstract Objective: Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by epithelial cell injury, fibroblast activation and excessive extracellular matrix deposition. Although protein arginine methyltransferase 1 (PRMT1) was found to regulate cell proliferation, differentiation and migration, its role in the development/progression of IPF has not yet been described.
    Results: Expression of PRMT1 was elevated in lung homogenates from IPF patients. Significant upregulation of PRMT1 expression was also observed in the lungs of bleomycin-treated mice. Immunohistochemical analysis revealed PRMT1-positive staining in fibroblasts/myofibroblasts and alveolar type II cells of IPF lungs and in fibrotic lesions of bleomycin-injured lungs. Fibroblasts isolated from IPF lungs demonstrated increased PRMT1 expression. Interleukin-4 (IL-4), a profibrotic cytokine, enhanced the expression of PRMT1 and the migration of donor and IPF fibroblasts. Interference with the expression or the activity of PRMT1 diminished the migration of the cells in response to IL-4. Strikingly, even though the incubation of donor and IPF fibroblasts with IL-4 did not affect their proliferation, depletion, but not blockage of PRMT1 activity suppressed cell growth.
    Conclusions: PRMT1 can contribute to the development of pulmonary fibrosis by regulating fibroblast activities. Thus, interference with its expression and/or activity may provide a novel therapeutic option for patients with IPF.
    Language English
    Publishing date 2015-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 60-7
    ISSN 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbadis.2015.09.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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