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Article: Comparative Evaluation of DFDBA versus PRF with DFDBA in Treatment of Grade-II Furcation Defects - A Clinical Trial.

Desai, Kinjal N / Thakkar, Rohit R / Patel, Jalpa / Gupta, Ekta / Trivedi, Namrata / Sampat, Dipali

Journal of pharmacy & bioallied sciences

2024 Volume 16, Issue Suppl 1, Page(s) S794–S796

Abstract: Background: In order to determine whether a method is more successful for treating a grade-II furcation deficiency, this randomized trial will compare demineralized freeze-dried bone allograft (DFDBA) to platelet-rich fibrin with DFDBA.: Materials and ...

Abstract	Background: In order to determine whether a method is more successful for treating a grade-II furcation deficiency, this randomized trial will compare demineralized freeze-dried bone allograft (DFDBA) to platelet-rich fibrin with DFDBA. Materials and methods: Twenty systematically healthy patients between the ages of 30 and 60 with a grade-II furcation were evaluated pre and postoperatively for changes in the modified plaque index, probing depth, relative vertical and horizontal clinical attachment level, gingival marginal level, and radiographic bone defect. Results: The test group significantly outperformed the control group on all clinical and radiological measures. Conclusion: The experimental group improved at both clinical attachment levels and had a higher decrease in probing depth than the control group did.
Language	English
Publishing date	2024-02-29
Publishing country	India
Document type	Journal Article
ZDB-ID	2573569-X
ISSN	0975-7406 ; 0976-4879
ISSN (online)	0975-7406
ISSN	0976-4879
DOI	10.4103/jpbs.jpbs_1016_23
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Article ; Online: Recovery, restoration, and risk: a cross-sectional survey of the impact of COVID-19 on GPs in the first UK city to lock down.

Trivedi, Namrata / Trivedi, Vivek / Moorthy, Arumugam / Trivedi, Hina

BJGP open

2021 Volume 5, Issue 1

Abstract: Background: The COVID-19 pandemic has impacted GPs immensely. Work patterns have changed, risk stratification has been proposed, and the mental health of clinicians has been adversely affected. The COVID-19 prevalence among GPs is unknown. This study ... ...

Abstract	Background: The COVID-19 pandemic has impacted GPs immensely. Work patterns have changed, risk stratification has been proposed, and the mental health of clinicians has been adversely affected. The COVID-19 prevalence among GPs is unknown. This study focuses on assessing the impact of COVID-19 on GPs in Leicestershire, the first UK city to lock down locally. Aim: This survey assessed the prevalence of COVID-19 in GPs and explored GP work patterns in comparison with national guidance. It used a validated perceived stress tool to evaluate the impact of COVID-19 on GP stress perception. Design & setting: The cross-sectional retrospective survey was sent to all the GPs in Leicestershire. Method: A total of 111 GPs in Leicestershire took part voluntarily in an anonymised questionnaire-based study. A 29-item survey using SmartSurvey software was designed with multiple choice and Likert response scale questions. Results: COVID-19 prevalence in GPs in Leicestershire was 8.1%; 70.3% of GPs were of Black, Asian, and minority ethnic (BAME) origin; 91.9% of GPs had undergone risk stratification; and 79.3% of GPs felt supported by their practice, but only 59.5% felt supported with mental health. GPs described feeling more stressed during the COVID-19 pandemic than they had been previously. Conclusion: This is the first study evaluating COVID-19 prevalence among GPs in Leicestershire. Despite government interventions, GPs felt less supported with their mental health compared with pre-COVID-19 times. Thus, the NHS in England should focus on GP stress and wellbeing as they work towards the restoration and recovery of primary care while battling the second wave.
Keywords	covid19
Language	English
Publishing date	2021-02-23
Publishing country	England
Document type	Journal Article
ISSN	2398-3795
ISSN (online)	2398-3795
DOI	10.3399/BJGPO.2020.0151
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Article: COVID-19: The disease of loneliness and solitary demise.

Trivedi, Hina / Trivedi, Namrata / Trivedi, Vivek / Moorthy, Arumugam

Future healthcare journal

2021 Volume 8, Issue 1, Page(s) e164–e165

Abstract: The birth of the COVID-19 pandemic has transformed working lives of British Asian general practitioners (GPs), such as one of the authors. The effects of the national lockdown and the subsequent loneliness have impacted every aspect of our lives and ... ...

Abstract	The birth of the COVID-19 pandemic has transformed working lives of British Asian general practitioners (GPs), such as one of the authors. The effects of the national lockdown and the subsequent loneliness have impacted every aspect of our lives and increased mental health problems. The added social isolation of local lockdowns, such as in Leicester, will undoubtedly exacerbate some health problems due to a lack of patient willingness to attend healthcare services and the postponement of some appointments. The lack of culturally competent support is likely to add to the isolation in non-English-speaking people. Thus, we should pre-empt these issues in a culturally effective manner. To prepare for subsequent waves, GPs are risk-stratifying patients for COVID-19 and have commenced ReSPECT care-plan conversations with higher-risk patients. But with the increased risk from COVID-19 to Black, Asian and minority ethnic patients, should this and other groups of patients also have a ReSPECT care plan? Is now the time to consider community-hospice settings for our palliative COVID-19 patients? This pandemic has uncovered a training need for healthcare professionals to feel more comfortable in discussing end of life as an integral consultation component. We should focus our efforts in alleviating suffering by achieving 'shared understanding' and 'negotiating management' of our ReSPECT conversations.
Language	English
Publishing date	2021-03-29
Publishing country	England
Document type	Journal Article
ZDB-ID	3016427-8
ISSN	2514-6653 ; 2514-6645
ISSN (online)	2514-6653
ISSN	2514-6645
DOI	10.7861/fhj.2020-0154
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Article ; Online: Recovery, restoration, and risk

Namrata Trivedi / Vivek Trivedi / Arumugam Moorthy / Hina Trivedi

BJGP Open, Vol 5, Iss

a cross-sectional survey of the impact of COVID-19 on GPs in the first UK city to lock down

2020 Volume 1

Abstract	Background: The COVID-19 pandemic has impacted GPs immensely. Work patterns have changed, risk stratification has been proposed, and the mental health of clinicians has been adversely affected. The COVID-19 prevalence among GPs is unknown. This study focuses on assessing the impact of COVID-19 on GPs in Leicestershire, the first UK city to lock down locally. Aim: This survey assessed the prevalence of COVID-19 in GPs and explored GP work patterns in comparison with national guidance. It used a validated perceived stress tool to evaluate the impact of COVID-19 on GP stress perception. Design & setting: The cross-sectional retrospective survey was sent to all the GPs in Leicestershire. Method: A total of 111 GPs in Leicestershire took part voluntarily in an anonymised questionnaire-based study. A 29-item survey using SmartSurvey software was designed with multiple choice and Likert response scale questions. Results: COVID-19 prevalence in GPs in Leicestershire was 8.1%; 70.3% of GPs were of Black, Asian, and minority ethnic (BAME) origin; 91.9% of GPs had undergone risk stratification; and 79.3% of GPs felt supported by their practice, but only 59.5% felt supported with mental health. GPs described feeling more stressed during the COVID-19 pandemic than they had been previously. Conclusion: This is the first study evaluating COVID-19 prevalence among GPs in Leicestershire. Despite government interventions, GPs felt less supported with their mental health compared with pre-COVID-19 times. Thus, the NHS in England should focus on GP stress and wellbeing as they work towards the restoration and recovery of primary care while battling the second wave.
Keywords	covid-19 ; coronavirus ; mental health ; personal protective equipment ; general practice ; Medicine (General) ; R5-920
Subject code	360
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Royal College of General Practitioners
Document type	Article ; Online
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Article ; Online: A Highly Selective Pyrene Appended Oxacalixarene Receptor for MNA and 4-NP Detection: an Experimental and Computational Study.

Upadhyay, Himali / Harikrishnan, Uma / Bhatt, Devanshi / Dhadnekar, Namrata / Kumar, Kapil / Panchal, Manthan / Trivedi, Pooja / Gaurang Sindhav / Modi, Krunal

Journal of fluorescence

2023

Abstract: A novel pyrene-substituted oxacalixarene was designed and synthesized as a selective probe for the simultaneous detection of MNA and 4-NP. Utilizing 1H-NMR, 13C-NMR, and FT-IR analysis techniques, its structure was characterized. The binding property of ... ...

Abstract	A novel pyrene-substituted oxacalixarene was designed and synthesized as a selective probe for the simultaneous detection of MNA and 4-NP. Utilizing 1H-NMR, 13C-NMR, and FT-IR analysis techniques, its structure was characterized. The binding property of BPOC to a variety of NACs, including 1,3-DNB, 2,3-DNT, 2,4-DNT, 2,6-DNT, 4-NP, 4-NT, and PA, revealed that the sensor binds to MNA and 4-NP with remarkable selectivity. Binding constant reveals lower detection limits of MNA is 0.2 µM and 0.3 µM for 4-NP. Using docking and density functional theory (DFT), computational insights were provided for investigating the stability and spectroscopic analysis of the inclusion complex. From molecular docking study, we observed the best docking score of BPOC with 4-NT and MNA complex. The calculations supplement the findings significantly and clarify the structural geometry and mode of interactions in supramolecular complexation. In an MTT experiment on human PBMC to check for cytotoxicity, this chemical was found to influence 1 × 10
Language	English
Publishing date	2023-11-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2016892-5
ISSN	1573-4994 ; 1053-0509
ISSN (online)	1573-4994
ISSN	1053-0509
DOI	10.1007/s10895-023-03470-2
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Article: Recovery, Restoration and Risk: A Cross Sectional Survey of the Impact of COVID-19 on General Practitioners in the First UK City to Lockdown

Trivedi, Namrata / Trivedi, Vivek / Moorthy, Arumugam / Trivedi, Hina

Abstract: Background The COVID-19 pandemic has impacted General Practitioners (GPs) immensely. Work patterns have changed, risk stratification has been proposed and clinicians' mental health have been adversely affected. The COVID-19 prevalence amongst GPs is ... ...

Abstract	Background The COVID-19 pandemic has impacted General Practitioners (GPs) immensely. Work patterns have changed, risk stratification has been proposed and clinicians' mental health have been adversely affected. The COVID-19 prevalence amongst GPs is unknown. This study focuses on assessing the impact of COVID-19 on GPs in Leicestershire, the first UK city to lockdown locally. Aim This survey assessed the prevalence of COVID-19 in GPs and explored GP work patterns in comparison to national guidance. It evaluated the impact of COVID-19 on GP stress perception, using a validated perceived stress tool. Design and Setting The cross-sectional retrospective survey was sent to all the GPs in Leicestershire. Methodology 111 GPs in Leicestershire took part voluntarily in an anonymised questionnaire-based study. A 29-item survey using SMARTsurvey software was designed with multiple choice and Linkert response scale questions. Ethical approval was not applicable. Results The COVID-19 prevalence in GPs was 8.1%. 70.3% of GPs were of Black, Asian and Minority Ethnic (BAME) origin. 91.9% of GPs had undergone risk stratification. 79.3% of GPs felt supported by their practice but only 59.5% felt supported with mental health. GPs described feeling more stressed during the COVID-19 pandemic than they had been previously. Conclusion This is the first study evaluating COVID-19 prevalence amongst GPs in Leicestershire. Despite government interventions, GPs felt less supported with their mental health. Thus, the National Health Service England should focus on GP stress and wellbeing as they work towards the restoration and recovery of primary care and prepare for a second peak.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #926273
Database	COVID19

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Article ; Online: FORMULATION & DEVELOPMENT OF PELLETS OF TOLTERODINE TARTRATE

Namrata Gautam / Piyush Trivedi

Journal of Drug Delivery and Therapeutics, Vol 2, Iss

A QUALITATIVE STUDY ON WURSTER BASED FLUIDIZED BED COATING TECHNOLOGY

2012 Volume 4

Abstract: In recent pharmaceutical applications, multiparticulate dosage forms are gaining much importance over single-unit dosage forms. The purpose of designing multiparticulate dosage form is to develop a reliable formulation that has all the advantages of a ... ...

Abstract	In recent pharmaceutical applications, multiparticulate dosage forms are gaining much importance over single-unit dosage forms. The purpose of designing multiparticulate dosage form is to develop a reliable formulation that has all the advantages of a single unit formulation and yet devoid of the danger of alteration in drug release profile and formulation behavior due to unit to unit variation. The aim of present work is qualitative study on formulation of multiparticulate modified release pellets of Tolterodine Tartrate, by “ Wurster Based Fluidized Bed Coating Process ”(layering technique).The main purpose of the present study was to investigate the feasibility of the wurster process for preparing extended release pellets and subsequently comparing the release profile of the pellets so prepared with a marketed reference product in various media. Additionally, the effects of some independent process variables were evaluated. The effect of the various process parameters i.e. inlet air temperature, product temperature, exhaust temperature, atomization speed, spray pump speed, atomization air volume and air flow on the wurster process was studied. The results suggested that the values of process parameters greatly vary with the physical properties of the drug, polymers and solvents used in process for layering of pellets. Key Words : non-pariel-seeds (N.P.S), E.R coating (extended release coating), Wurster technology, process parameters
Keywords	Therapeutics. Psychotherapy ; RC475-489 ; Psychiatry ; RC435-571 ; Neurology. Diseases of the nervous system ; RC346-429 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Therapeutics ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	660
Language	English
Publishing date	2012-07-01T00:00:00Z
Document type	Article ; Online
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Article ; Online: Corrigendum to "(6)-Gingerol induced myeloid leukemia cell death is initiated by reactive oxygen species and activation of miR-27b expression" [Free Radic. Biol. Med. 68 (2014) 288-301].

Rastogi, Namrata / Gara, Rishi Kumar / Trivedi, Rachana / Singh, Akanksha / Dixit, Preety / Maurya, Rakesh / Duggal, Shivali / Bhatt, M L B / Singh, Sarika / Mishra, Durga Prasad

Free radical biology & medicine

2019 Volume 146, Page(s) 404

Language	English
Publishing date	2019-08-29
Publishing country	United States
Document type	Published Erratum
ZDB-ID	807032-5
ISSN	1873-4596 ; 0891-5849
ISSN (online)	1873-4596
ISSN	0891-5849
DOI	10.1016/j.freeradbiomed.2019.08.017
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Article ; Online: Inhibition of STAT3, FAK and Src mediated signaling reduces cancer stem cell load, tumorigenic potential and metastasis in breast cancer.

Thakur, Ravi / Trivedi, Rachana / Rastogi, Namrata / Singh, Manisha / Mishra, Durga Prasad

Scientific reports

2015 Volume 5, Page(s) 10194

Abstract: Cancer stem cells (CSCs) are responsible for aggressive tumor growth, metastasis and therapy resistance. In this study, we evaluated the effects of Shikonin (Shk) on breast cancer and found its anti-CSC potential. Shk treatment decreased the expression ... ...

Abstract	Cancer stem cells (CSCs) are responsible for aggressive tumor growth, metastasis and therapy resistance. In this study, we evaluated the effects of Shikonin (Shk) on breast cancer and found its anti-CSC potential. Shk treatment decreased the expression of various epithelial to mesenchymal transition (EMT) and CSC associated markers. Kinase profiling array and western blot analysis indicated that Shk inhibits STAT3, FAK and Src activation. Inhibition of these signaling proteins using standard inhibitors revealed that STAT3 inhibition affected CSCs properties more significantly than FAK or Src inhibition. We observed a significant decrease in cell migration upon FAK and Src inhibition and decrease in invasion upon inhibition of STAT3, FAK and Src. Combined inhibition of STAT3 with Src or FAK reduced the mammosphere formation, migration and invasion more significantly than the individual inhibitions. These observations indicated that the anti-breast cancer properties of Shk are due to its potential to inhibit multiple signaling proteins. Shk also reduced the activation and expression of STAT3, FAK and Src in vivo and reduced tumorigenicity, growth and metastasis of 4T1 cells. Collectively, this study underscores the translational relevance of using a single inhibitor (Shk) for compromising multiple tumor-associated signaling pathways to check cancer metastasis and stem cell load.
MeSH term(s)	Adult ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Breast Neoplasms/drug therapy ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Drugs, Chinese Herbal/pharmacology ; Epithelial-Mesenchymal Transition/drug effects ; Female ; Focal Adhesion Kinase 1/antagonists & inhibitors ; Humans ; MCF-7 Cells ; Middle Aged ; Naphthoquinones/pharmacology ; Neoplasm Invasiveness/pathology ; Neoplastic Stem Cells ; Proto-Oncogene Proteins pp60(c-src)/antagonists & inhibitors ; STAT3 Transcription Factor/antagonists & inhibitors ; Signal Transduction ; Spheroids, Cellular/drug effects ; Tumor Burden/drug effects ; Tumor Cells, Cultured
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; Drugs, Chinese Herbal ; Naphthoquinones ; STAT3 Transcription Factor ; STAT3 protein, human ; shikonin (3IK6592UBW) ; Focal Adhesion Kinase 1 (EC 2.7.10.2) ; PTK2 protein, human (EC 2.7.10.2) ; Proto-Oncogene Proteins pp60(c-src) (EC 2.7.10.2)
Language	English
Publishing date	2015-05-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/srep10194
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Article ; Online: Analytical similarity assessment of MYL-1402O to reference Bevacizumab.

Goyal, Parag / Vats, Bhavesh / Subbarao, Malini / Honnappa, Chethan Gejjalagere / Kabadi, Pradeep / Rohil, Sheija / Bera, Arnab / Mehta, Gaurav R / Pai, Harish / Adhikari, Laxmi / Tagore, Ranitendranath / Sharma, Shulagna / Venkatachala, Roopa / Nair, Pradip / Annegowda, Shankara / Sahu, Abhilashi / Trivedi, Sneha / Shastri, Namrata / Gokhale, Yatika /

Thomas, Roshni / Thakur, Anushikha / Mohan, Deepa / Rao K, Umamaheshwara / Melarkode, Ramakrishnan / Ullanat, Rajesh

Expert opinion on biological therapy

2021 Volume 22, Issue 2, Page(s) 271–298

Abstract: Background: Bevacizumab (BEV) is a recombinant humanized monoclonal immunoglobulin G1 antibody that binds to vascular endothelial growth factor (VEGF)-A and acts as an antiangiogenic agent. It is approved for treatment of many cancer indications, ... ...

Abstract	Background: Bevacizumab (BEV) is a recombinant humanized monoclonal immunoglobulin G1 antibody that binds to vascular endothelial growth factor (VEGF)-A and acts as an antiangiogenic agent. It is approved for treatment of many cancer indications, including metastatic colorectal cancer and nonsquamous non-small cell lung cancer. Research design and methods: The analytical similarity of the BEV biosimilar MYL-1402O to reference BEV sourced from the European Union and United States was assessed using physicochemical and functional tests to support the clinical development of MYL-1402O. Assessment of physicochemical and analytical similarity showed that MYL-1402O has the same amino acid sequence and similar posttranslational modification profile as the reference BEV products. Results: The functional and biologic activity of MYL-1402O assessed using inhibition of VEGF-induced cell proliferation in human umbilical vein endothelial cells, inhibition of VEGF-induced VEGF receptor 2 phosphorylation, and fragment antigen and fragment crystallizable receptor binding, was comparable to reference BEV products. Conclusions: The totality of the data assessment confirms the high degree of similarity of MYL-1402O to reference BEV with respect to physicochemical and in vitro functional properties. The product quality data presented here, along with data from phase 1 clinical studies, demonstrate the similarity of MYL-1402O to reference BEV products, supporting further clinical development of this BEV biosimilar.
MeSH term(s)	Bevacizumab/therapeutic use ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Human Umbilical Vein Endothelial Cells ; Humans ; Lung Neoplasms/drug therapy ; Vascular Endothelial Growth Factor A
Chemical Substances	Vascular Endothelial Growth Factor A ; Bevacizumab (2S9ZZM9Q9V)
Language	English
Publishing date	2021-10-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2052501-1
ISSN	1744-7682 ; 1471-2598
ISSN (online)	1744-7682
ISSN	1471-2598
DOI	10.1080/14712598.2021.1973426
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