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  1. Article ; Online: The crossbow sign in extracranial giant cell arteritis.

    Duret, Pierre-Marie / Spielmann, Lionel / Messer, Laurent

    ACR open rheumatology

    2021  Volume 3, Issue 11, Page(s) 764

    Language English
    Publishing date 2021-10-21
    Publishing country United States
    Document type Journal Article
    ISSN 2578-5745
    ISSN (online) 2578-5745
    DOI 10.1002/acr2.11321
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  2. Article ; Online: Response to: 'Correspondence on Recovery from COVID-19 in a patient with spondyloarthritis treated with TNF-alpha inhibitor etanercept. A report on a COVID-19 patient with psoriatic arthritis receiving ustekinumab' by Messina

    Duret, Pierre-Marie / Spielmann, Lionel / Messer, Laurent

    Annals of the rheumatic diseases

    2020  Volume 80, Issue 5, Page(s) e80

    MeSH term(s) Antirheumatic Agents/therapeutic use ; Arthritis, Psoriatic/drug therapy ; COVID-19 ; Etanercept/therapeutic use ; Humans ; SARS-CoV-2 ; Spondylarthritis/drug therapy ; Tumor Necrosis Factor Inhibitors ; Tumor Necrosis Factor-alpha ; Ustekinumab/therapeutic use
    Chemical Substances Antirheumatic Agents ; Tumor Necrosis Factor Inhibitors ; Tumor Necrosis Factor-alpha ; Ustekinumab (FU77B4U5Z0) ; Etanercept (OP401G7OJC)
    Language English
    Publishing date 2020-08-18
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2020-218147
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  3. Article ; Online: Diffuse idiopathic skeletal hyperostosis associated ossification of the posterior longitudinal ligament.

    Spielmann, Lionel / Duret, Pierre-Marie / Widawski, Laura / Rinagel, Marina / Messer, Laurent / Manoila, Ionela

    Joint bone spine

    2022  Volume 89, Issue 6, Page(s) 105429

    MeSH term(s) Humans ; Hyperostosis, Diffuse Idiopathic Skeletal/complications ; Hyperostosis, Diffuse Idiopathic Skeletal/diagnostic imaging ; Longitudinal Ligaments ; Osteogenesis ; Ossification, Heterotopic/diagnostic imaging ; Cervical Vertebrae
    Language English
    Publishing date 2022-06-20
    Publishing country France
    Document type Journal Article
    ZDB-ID 2020487-5
    ISSN 1778-7254 ; 1297-319X
    ISSN (online) 1778-7254
    ISSN 1297-319X
    DOI 10.1016/j.jbspin.2022.105429
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    Zs.A 4590: Show issues Location:
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  4. Article ; Online: Impact of hyperuricaemia on patients with psoriatic arthritis treated with secukinumab in the FUTURE 2-5 and MAXIMISE studies.

    Felten, Renaud / Widawski, Laura / Spielmann, Lionel / Gaillez, Corine / Bao, Weibin / Gottenberg, Jacques-Eric / Duret, Pierre-Marie / Messer, Laurent

    RMD open

    2023  Volume 9, Issue 4

    Abstract: Objectives: Patients with psoriatic arthritis (PsA) are at a significantly increased risk of hyperuricaemia and development of gout, and those with hyperuricaemia have been found to respond poorly to PsA treatment and have more peripheral and ... ...

    Abstract Objectives: Patients with psoriatic arthritis (PsA) are at a significantly increased risk of hyperuricaemia and development of gout, and those with hyperuricaemia have been found to respond poorly to PsA treatment and have more peripheral and destructive joint damage. We present a comprehensive post hoc analysis using pooled data from the FUTURE 2-5 studies and the MAXIMISE study to further evaluate the impact of hyperuricaemia on clinical presentation/disease severity and response to secukinumab in patients with PsA.
    Methods: Patients were stratified into two groups based on baseline serum uric acid (SUA) level (threshold of 360 µmol/L). A sensitivity analysis was also performed based on SUA thresholds of 300 µmol/L and 420 µmol/L. Demographics, clinical, radiological characteristics and comorbidities data were collected.
    Results: At baseline, patients with hyperuricaemia were mostly male, reported a higher prevalence of hypertension, with more clinical dactylitis, more psoriasis and more severe skin disease compared with patients with normouricaemia. A similar proportion of patients in the normouricaemic and hyperuricaemic cohorts achieved American College of Rheumatology responses, resolution of enthesitis and dactylitis, inhibition of structural damage progression and improvement in health-related quality of life across all secukinumab doses at week 52.
    Conclusion: Patients with PsA and hyperuricaemia have different clinical characteristics from patients with PsA and normouricaemia. Identification of these patients at an early stage may facilitate a personalised treatment approach and improved management of comorbidities. Furthermore, secukinumab provided a rapid and sustained response across all manifestations of PsA up to week 52, irrespective of baseline uricaemia status.
    MeSH term(s) Humans ; Male ; Female ; Arthritis, Psoriatic/complications ; Arthritis, Psoriatic/drug therapy ; Quality of Life ; Hyperuricemia/complications ; Hyperuricemia/drug therapy ; Uric Acid
    Chemical Substances secukinumab (DLG4EML025) ; Uric Acid (268B43MJ25)
    Language English
    Publishing date 2023-11-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2812592-7
    ISSN 2056-5933 ; 2056-5933
    ISSN (online) 2056-5933
    ISSN 2056-5933
    DOI 10.1136/rmdopen-2023-003428
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  5. Article ; Online: Impact of hyperuricaemia on patients with psoriatic arthritis treated with secukinumab in the FUTURE 2–5 and MAXIMISE studies

    Renaud Felten / Jacques-Eric Gottenberg / Lionel Spielmann / Pierre-Marie Duret / Laurent Messer / Corine Gaillez / Weibin Bao / Laura Widawski

    RMD Open, Vol 9, Iss

    2023  Volume 4

    Abstract: Objectives Patients with psoriatic arthritis (PsA) are at a significantly increased risk of hyperuricaemia and development of gout, and those with hyperuricaemia have been found to respond poorly to PsA treatment and have more peripheral and destructive ... ...

    Abstract Objectives Patients with psoriatic arthritis (PsA) are at a significantly increased risk of hyperuricaemia and development of gout, and those with hyperuricaemia have been found to respond poorly to PsA treatment and have more peripheral and destructive joint damage. We present a comprehensive post hoc analysis using pooled data from the FUTURE 2–5 studies and the MAXIMISE study to further evaluate the impact of hyperuricaemia on clinical presentation/disease severity and response to secukinumab in patients with PsA.Methods Patients were stratified into two groups based on baseline serum uric acid (SUA) level (threshold of 360 µmol/L). A sensitivity analysis was also performed based on SUA thresholds of 300 µmol/L and 420 µmol/L. Demographics, clinical, radiological characteristics and comorbidities data were collected.Results At baseline, patients with hyperuricaemia were mostly male, reported a higher prevalence of hypertension, with more clinical dactylitis, more psoriasis and more severe skin disease compared with patients with normouricaemia. A similar proportion of patients in the normouricaemic and hyperuricaemic cohorts achieved American College of Rheumatology responses, resolution of enthesitis and dactylitis, inhibition of structural damage progression and improvement in health-related quality of life across all secukinumab doses at week 52.Conclusion Patients with PsA and hyperuricaemia have different clinical characteristics from patients with PsA and normouricaemia. Identification of these patients at an early stage may facilitate a personalised treatment approach and improved management of comorbidities. Furthermore, secukinumab provided a rapid and sustained response across all manifestations of PsA up to week 52, irrespective of baseline uricaemia status.
    Keywords Medicine ; R
    Subject code 610 ; 616
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
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  6. Article ; Online: Enthesitis of the ligamentum teres femoris in axial spondyloarthritis.

    Blaess, Julien / Widawski, Laura / Spielmann, Lionel / Moreau, Paul / Duret, Pierre-Marie / Messer, Laurent

    Joint bone spine

    2021  Volume 88, Issue 5, Page(s) 105225

    MeSH term(s) Enthesopathy ; Humans ; Round Ligament of Femur ; Spondylarthritis/diagnostic imaging
    Language English
    Publishing date 2021-05-24
    Publishing country France
    Document type Journal Article
    ZDB-ID 2020487-5
    ISSN 1778-7254 ; 1297-319X
    ISSN (online) 1778-7254
    ISSN 1297-319X
    DOI 10.1016/j.jbspin.2021.105225
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    Zs.A 4590: Show issues Location:
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  7. Article ; Online: Examining the biological pathways underlying clinical heterogeneity in Sjogren's syndrome: proteomic and network analysis.

    Berry, Joe Scott / Tarn, Jessica / Casement, John / Duret, Pierre-Marie / Scott, Lauren / Wood, Karl / Johnsen, Svein-Joar / Nordmark, Gunnel / Devauchelle-Pensec, Valérie / Seror, Raphaele / Fisher, Benjamin / Barone, Fransesca / Bowman, Simon J / Bombardieri, Michele / Lendrem, Dennis / Felten, Renaud / Gottenberg, Jacques-Eric / Ng, Wan-Fai

    Annals of the rheumatic diseases

    2024  Volume 83, Issue 1, Page(s) 88–95

    Abstract: Objectives: Stratification approaches are vital to address clinical heterogeneity in Sjogren's syndrome (SS). We previously described that the Newcastle Sjogren's Stratification Tool (NSST) identified four distinct clinical subtypes of SS. We performed ... ...

    Abstract Objectives: Stratification approaches are vital to address clinical heterogeneity in Sjogren's syndrome (SS). We previously described that the Newcastle Sjogren's Stratification Tool (NSST) identified four distinct clinical subtypes of SS. We performed proteomic and network analysis to analyse the underlying pathobiology and highlight potential therapeutic targets for different SS subtypes.
    Method: We profiled serum proteins using O-link technology of 180 SS subjects. We used 5 O-link proteomics panels which included a total of 454 unique proteins. Network reconstruction was performed using the ARACNE algorithm, with differential expression estimates overlaid on these networks to reveal the key subnetworks of differential expression. Furthermore, data from a phase III trial of tocilizumab in SS were reanalysed by stratifying patients at baseline using NSST.
    Results: Our analysis highlights differential expression of chemokines, cytokines and the major autoantigen TRIM21 between the SS subtypes. Furthermore, we observe differential expression of several transcription factors associated with energy metabolism and redox balance namely APE1/Ref-1, FOXO1, TIGAR and BACH1. The differentially expressed proteins were inter-related in our network analysis, supporting the concept that distinct molecular networks underlie the clinical subtypes of SS. Stratification of patients at baseline using NSST revealed improvement of fatigue score only in the subtype expressing the highest levels of serum IL-6.
    Conclusions: Our data provide clues to the pathways contributing to the glandular and non-glandular manifestations of SS and to potential therapeutic targets for different SS subtypes. In addition, our analysis highlights the need for further exploration of altered metabolism and mitochondrial dysfunction in the context of SS subtypes.
    MeSH term(s) Humans ; Sjogren's Syndrome/drug therapy ; Sjogren's Syndrome/genetics ; Sjogren's Syndrome/complications ; Proteomics ; Chemokines ; Cytokines/metabolism
    Chemical Substances Chemokines ; Cytokines
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/ard-2023-224503
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  8. Article ; Online: Rheumatic diseases and COVID-19

    Duret, Pierre-Marie / Spielmann, Lionel / Messer, Laurent

    Annals of the Rheumatic Diseases

    a cohort of 17 patients under DMARDs. Response to: ‘Comment on: Recovery from COVID-19 in a patient with spondyloarthritis treated with TNF-alpha inhibitor etanercept. A report on a COVID-19 patient with psoriatic arthritis receiving ustekinumab’ by Messina et al

    2020  , Page(s) annrheumdis–2020–218147

    Keywords Immunology ; General Biochemistry, Genetics and Molecular Biology ; Immunology and Allergy ; Rheumatology ; covid19
    Language English
    Publisher BMJ
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2020-218147
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  9. Article ; Online: Recovery from COVID-19 in a patient with spondyloarthritis treated with TNF-alpha inhibitor etanercept.

    Duret, Pierre-Marie / Sebbag, Eden / Mallick, Auriane / Gravier, Simon / Spielmann, Lionel / Messer, Laurent

    Annals of the rheumatic diseases

    2020  Volume 79, Issue 9, Page(s) 1251–1252

    MeSH term(s) Antirheumatic Agents/therapeutic use ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/drug therapy ; Coronavirus Infections/virology ; Etanercept/therapeutic use ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Spondylarthritis/drug therapy ; Spondylarthritis/virology ; Treatment Outcome ; Tumor Necrosis Factor Inhibitors/therapeutic use
    Chemical Substances Antirheumatic Agents ; Tumor Necrosis Factor Inhibitors ; Etanercept (OP401G7OJC)
    Keywords covid19
    Language English
    Publishing date 2020-04-30
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2020-217362
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  10. Article ; Online: At the crossroads of gout and psoriatic arthritis: "psout".

    Felten, Renaud / Duret, Pierre-Marie / Gottenberg, Jacques-Eric / Spielmann, Lionel / Messer, Laurent

    Clinical rheumatology

    2020  Volume 39, Issue 5, Page(s) 1405–1413

    Abstract: Psoriatic arthritis and gout are frequently encountered conditions sharing a number of common risk factors, which render their independent study difficult. Epidemiological studies have demonstrated a strong link between these diseases, suggesting the ... ...

    Abstract Psoriatic arthritis and gout are frequently encountered conditions sharing a number of common risk factors, which render their independent study difficult. Epidemiological studies have demonstrated a strong link between these diseases, suggesting the presence of underlying, intertwined pathophysiological mechanisms that currently remain unknown. Indeed, sodium urate crystals could play a pathogenic role in psoriasis and psoriatic arthritis. In daily practice, the distinction between psoriatic arthritis associated with hyperuricemia and a gouty arthropathy with psoriasis is complex. Several common pathogenic features suggest a more intricate relationship than their mere coexistence in the same patient. Thus, the concurrence of these two diseases should be seen as a novel overlap syndrome, at the boundary between inflammatory and metabolic rheumatism. The present update aims to clarify the determinants of the link and to define this new nosological entity. Its recognition could have therapeutic implications that appear essential for treatment optimization in a personalized setting.Key Points• What is already known about this subject? Psoriatic arthritis (PsA) and gout have strong interconnections, including comorbidities and pathophysiology. One must note that confounding clinical symptoms and radiological signs of PsA and gout are similar and difficult to differentiate in patients whose radiological lesions become too advanced to be differentiated or with less clearly defined phenotypes.• What does this study add? The pathogenic role of chronic hyperuricemia in the development and maintenance of PsA is based on epidemiological, clinical, and fundamental arguments and hence does not appear fortuitous. These two pathological processes can influence each other.• How might this impact on clinical practice? This new line of thinking regarding the convergence of gout and PsA, involving the role of urate crystals, could prompt a potential new approach to treatment (urate-lowering therapy) among patients with active/refractory PsA.
    MeSH term(s) Arthritis, Psoriatic/diagnosis ; Arthritis, Psoriatic/physiopathology ; Comorbidity ; Gout/diagnosis ; Gout/physiopathology ; Humans ; Hyperuricemia/epidemiology ; Risk Factors ; Uric Acid/metabolism
    Chemical Substances Uric Acid (268B43MJ25)
    Language English
    Publishing date 2020-02-15
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 604755-5
    ISSN 1434-9949 ; 0770-3198
    ISSN (online) 1434-9949
    ISSN 0770-3198
    DOI 10.1007/s10067-020-04981-0
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