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  1. Article ; Online: Brain-derived neurotrophic factor in hematological malignancies: From detrimental to potentially beneficial.

    Azoulay, David / Horowitz, Netanel A

    Blood reviews

    2021  Volume 51, Page(s) 100871

    Abstract: Emerging studies have highlighted brain-derived neurotrophic factor (BDNF), a neuronal growth factor abundant in the peripheral blood, and its tyrosine kinase receptor TRKB, as onco-genes and proteins that support the survival of malignant hematological ... ...

    Abstract Emerging studies have highlighted brain-derived neurotrophic factor (BDNF), a neuronal growth factor abundant in the peripheral blood, and its tyrosine kinase receptor TRKB, as onco-genes and proteins that support the survival of malignant hematological cells. In contrast, other researchers reported on a favorable association between BDNF blood levels and prognosis, chemotherapy response and neurological side effects in patients with hematological malignancies. Here, we review the accumulated data regarding the expression of BDNF and its receptors in normal hematopoietic and lymphatic cells and tissue. In addition, in-vitro experiments, animal models and human sample studies that investigated the role of BDNF and its receptors in hematological malignancies are discussed. Finally, directions for future research aimed at revealing the mechanisms underlying the protective effect of BDNF in patients with these diseases are suggested.
    MeSH term(s) Animals ; Brain-Derived Neurotrophic Factor/genetics ; Brain-Derived Neurotrophic Factor/metabolism ; Hematologic Neoplasms/genetics ; Hematologic Neoplasms/therapy ; Humans ; Receptor, trkB/genetics ; Receptor, trkB/metabolism
    Chemical Substances Brain-Derived Neurotrophic Factor ; Receptor, trkB (EC 2.7.10.1)
    Language English
    Publishing date 2021-07-28
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639015-8
    ISSN 1532-1681 ; 0268-960X
    ISSN (online) 1532-1681
    ISSN 0268-960X
    DOI 10.1016/j.blre.2021.100871
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2207: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: Real-Time Metasurface Sensor for Monitoring Micropoisons in Aqueous Solutions Based on Gold Nanoparticles and Terahertz Spectroscopy.

    Abramovich, Amir / Azoulay, Yossi / Rotshild, David

    Sensors (Basel, Switzerland)

    2022  Volume 22, Issue 3

    Abstract: Proof of concept of a new real-time metasurface sensor for micropoison monitoring in aqueous solutions is proposed in this study. The sensor comprises a perfect absorber metasurface and gold nanoparticle layer on the front side of it. Frequency-domain ... ...

    Abstract Proof of concept of a new real-time metasurface sensor for micropoison monitoring in aqueous solutions is proposed in this study. The sensor comprises a perfect absorber metasurface and gold nanoparticle layer on the front side of it. Frequency-domain terahertz spectroscopy system was used to measure the resonance frequency shift due to the presence of the micropoison. The perfect absorber metasurface sensor was fabricated using a double-sided FR4 substrate printed board circuit, which is very inexpensive. A significant increase in the metasurface sensor sensitivity was achieved by adding a gold nanoparticle layer to the gap of the double split rectangular resonator on the front side of the metasurface sensor.
    MeSH term(s) Equipment Design ; Gold ; Metal Nanoparticles ; Terahertz Spectroscopy
    Chemical Substances Gold (7440-57-5)
    Language English
    Publishing date 2022-02-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s22031279
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  3. Article ; Online: Brain-derived neurotrophic factor as a potential biomarker of chemotherapy-induced peripheral neuropathy and prognosis in haematological malignancies; what we have learned, the challenges and a need for global standardization.

    Azoulay, David / Horowitz, Netanel A

    British journal of haematology

    2020  Volume 191, Issue 1, Page(s) 17–18

    MeSH term(s) Antineoplastic Agents/adverse effects ; Biomarkers ; Brain-Derived Neurotrophic Factor ; Hematologic Neoplasms/drug therapy ; Humans ; Multiple Myeloma ; Peripheral Nervous System Diseases/chemically induced ; Peripheral Nervous System Diseases/diagnosis ; Polyneuropathies ; Prognosis ; Reference Standards
    Chemical Substances Antineoplastic Agents ; Biomarkers ; Brain-Derived Neurotrophic Factor
    Language English
    Publishing date 2020-06-18
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.16893
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    Uh III Zs.182: Show issues Location:
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  4. Article: The quest for optimal and reliable guidelines based on robust evidence for the treatment of cholangiocarcinoma.

    Azoulay, Daniel / Bomze, David / Meirson, Tomer

    Hepatobiliary surgery and nutrition

    2021  Volume 10, Issue 6, Page(s) 913–915

    Language English
    Publishing date 2021-07-30
    Publishing country China (Republic : 1949- )
    Document type Editorial ; Comment
    ZDB-ID 2812398-0
    ISSN 2304-389X ; 2304-3881
    ISSN (online) 2304-389X
    ISSN 2304-3881
    DOI 10.21037/hbsn-21-117
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  5. Article ; Online: Sintilimab plus IBI305 for hepatocellular carcinoma.

    Bomze, David / Meirson, Tomer / Azoulay, Daniel

    The Lancet. Oncology

    2021  Volume 22, Issue 9, Page(s) e386

    MeSH term(s) Antibodies, Monoclonal, Humanized/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/epidemiology ; Humans ; Liver Neoplasms/drug therapy
    Chemical Substances Antibodies, Monoclonal, Humanized ; sintilimab (8FU7FQ8UPK)
    Language English
    Publishing date 2021-09-03
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(21)00388-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5696: Show issues Location:
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    Zs.MO 460: Show issues

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  6. Article ; Online: Laboratory Indices in Patients with Positive and Borderline Flow Cytometry Eosin-5-Maleimide-Screening Test Results for Hereditary Spherocytosis.

    Azoulay, David / Levov, Ilan / Shaoul, Ety / Kuperman, Amir Asher

    The Journal of pediatrics

    2022  Volume 243, Page(s) 142–145

    Abstract: Objective: To evaluate laboratory indices in patients with hereditary spherocytosis, with positive and borderline flow cytometry eosin-5-melamide (EMA)-bound red blood cells screening test.: Study design: We compared laboratory indices of 151 samples ...

    Abstract Objective: To evaluate laboratory indices in patients with hereditary spherocytosis, with positive and borderline flow cytometry eosin-5-melamide (EMA)-bound red blood cells screening test.
    Study design: We compared laboratory indices of 151 samples obtained from 139 different individual patients with negative, borderline, or positive EMA-test results. We also compared the clinical data of the patients in each EMA test results group.
    Results: Borderline EMA-test results were obtained for 13 patients and were associated with more severe anemia, and lower reticulocyte count and reticulocyte production index compared with samples with positive EMA-test results. A receiving operator characteristic analysis identified mean corpuscular hemoglobin concentration of <32.5 g/dL as a cut-off, between positive/borderline and negative test results with 100% sensitivity. A higher prevalence of clinical markers typical of hereditary spherocytosis was found in patients with borderline or positive compared with negative EMA test samples.
    Conclusions: Based on laboratory data, borderline EMA-test results may be an indication of a more severe form of hereditary spherocytosis. Using mean corpuscular hemoglobin concentration as a cut-off may help predict and reduce negative EMA tests without compromising sensitivity. This finding needs to be further validated in other flow cytometry laboratories with a large EMA test sample pool.
    MeSH term(s) Eosine Yellowish-(YS)/analysis ; Flow Cytometry/methods ; Humans ; Laboratories ; Maleimides ; Spherocytosis, Hereditary/diagnosis
    Chemical Substances Maleimides ; Eosine Yellowish-(YS) (TDQ283MPCW)
    Language English
    Publishing date 2022-01-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2021.11.074
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    Um IV Zs.116: Show issues Location:
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  7. Article ; Online: Immunotherapy With Programmed Cell Death 1 vs Programmed Cell Death Ligand 1 Inhibitors in Patients With Cancer.

    Bomze, David / Azoulay, Daniel / Meirson, Tomer

    JAMA oncology

    2020  Volume 6, Issue 7, Page(s) 1114–1115

    MeSH term(s) Apoptosis ; Humans ; Immune Checkpoint Inhibitors ; Immunotherapy ; Ligands ; Neoplasms/drug therapy
    Chemical Substances Immune Checkpoint Inhibitors ; Ligands
    Language English
    Publishing date 2020-04-29
    Publishing country United States
    Document type Letter ; Comment
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2020.0628
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  8. Article ; Online: Atezolizumab and Bevacizumab in Hepatocellular Carcinoma.

    Bomze, David / Meirson, Tomer / Azoulay, Daniel

    The New England journal of medicine

    2020  Volume 383, Issue 7, Page(s) 693–694

    MeSH term(s) Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Bevacizumab ; Carcinoma, Hepatocellular ; Humans ; Liver Neoplasms
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Bevacizumab (2S9ZZM9Q9V) ; atezolizumab (52CMI0WC3Y)
    Language English
    Publishing date 2020-08-12
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2021840
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    Ua VI Zs.34: Show issues Location:
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  9. Article ; Online: Comment on "ALPPS Improves Survival Compared With TSH in Patients Affected of CRLM. Survival Analysis From the Randomized Controlled Trial LIGRO" by K. Hasselgren, et al., Annals of Surgery 2020 The Jury is Still Out.

    Bomze, David / Markel, Gal / Meirson, Tomer / Azoulay, Daniel

    Annals of surgery

    2020  Volume 274, Issue 6, Page(s) e807–e809

    MeSH term(s) Hepatectomy ; Humans ; Portal Vein ; Survival Analysis ; Thyrotropin
    Chemical Substances Thyrotropin (9002-71-5)
    Language English
    Publishing date 2020-10-13
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/SLA.0000000000004537
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    Uk I Zs.35/1: Show issues Location:
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  10. Article: Systemic review of the robustness of randomized controlled trials for the treatment of cholangiocarcinoma in three domains: survival-inferred fragility index, restricted mean survival time, and the spin effect.

    Horesh, Nir / Bomze, David / Lim, Chetana / Markel, Gal / Meirson, Tomer / Azoulay, Daniel

    Hepatobiliary surgery and nutrition

    2022  Volume 11, Issue 6, Page(s) 861–869

    Abstract: Background: The vast majority of patients with cholangiocarcinoma (CC) have advanced disease at diagnosis and are candidates for palliative treatment only. The robustness of the randomized controlled trials regarding the treatment of CC are assessed.: ...

    Abstract Background: The vast majority of patients with cholangiocarcinoma (CC) have advanced disease at diagnosis and are candidates for palliative treatment only. The robustness of the randomized controlled trials regarding the treatment of CC are assessed.
    Methods: A systematic review of all randomized control trials (RCT) of treatments for both intra- and extrahepatic CC between 2010 and 2020 was performed. The survival-inferred fragility index (SIFI; the minimum number of reassignments of the best survivors between arms that would overturn the statistical outcomes) was calculated. In addition, the gain, or loss, in survival in RCTs was evaluated by the restricted mean survival time (RMST) difference. Finally, the level of spin i.e., misrepresentation of study outcomes, was measured in inconclusive studies to assess distorted reporting strategies.
    Results: Out of 6,167 studies retrieved, 11 could be retained for full text revision (7 with both intra- and extrahepatic CC, 3 with peri-hilar CC, and 1 with peri-hilar or distal CC). Only 3 studies included resected patients (2 with both intra- and extrahepatic CC and 1 with peri-hilar or distal CC). Nine studies investigated systemic chemotherapy (including 3 after surgical resection), one study evaluated photodynamic therapy, and another investigated the use of an endoscopically inserted stent in the biliary tract. The median SIFI was -2 [interquartile range (IQR): -6.25, -0.25] across all studies. Overall, the median RMST difference was 0.56 months (IQR: 0.10, 0.95). Finally, for inconclusive studies, the level of spin was high, moderate, and low in respectively 12.5%, 25%, and 62.5% of the studies.
    Conclusions: RCTs of CC showed a low degree of robustness with a frequent proportion of associated spin.
    Language English
    Publishing date 2022-12-13
    Publishing country China (Republic : 1949- )
    Document type Journal Article ; Review
    ZDB-ID 2812398-0
    ISSN 2304-389X ; 2304-3881
    ISSN (online) 2304-389X
    ISSN 2304-3881
    DOI 10.21037/hbsn-21-118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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