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  1. Article: The Role of Mitochondrial Dysfunction in Idiopathic Pulmonary Fibrosis: New Perspectives for a Challenging Disease.

    Cala-Garcia, Juan David / Medina-Rincon, German Jose / Sierra-Salas, Paula Andrea / Rojano, Julio / Romero, Freddy

    Biology

    2023  Volume 12, Issue 9

    Abstract: Mitochondrial biology has always been a relevant field in chronic diseases such as fibrosis or cancer in different organs of the human body, not to mention the strong association between mitochondrial dysfunction and aging. With the development of new ... ...

    Abstract Mitochondrial biology has always been a relevant field in chronic diseases such as fibrosis or cancer in different organs of the human body, not to mention the strong association between mitochondrial dysfunction and aging. With the development of new technologies and the emergence of new methodologies in the last few years, the role of mitochondria in pulmonary chronic diseases such as idiopathic pulmonary fibrosis (IPF) has taken an important position in the field. With this review, we will highlight the latest advances in mitochondrial research on pulmonary fibrosis, focusing on the role of the mitochondria in the aging lung, new proposals for mechanisms that support mitochondrial dysfunction as an important cause for IPF, mitochondrial dysfunction in different cell populations of the lung, and new proposals for treatment of the disease.
    Language English
    Publishing date 2023-09-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology12091237
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Recovery of COVID-19 acute respiratory distress syndrome with tocilizumab: successful outcome in two critically ill patients.

    Cala-García, Juan David / Sierra-Bretón, Juan David / Cavelier-Baiz, Jorge Eduardo / Faccini-Martínez, Álvaro A / Pérez-Díaz, Carlos Eduardo

    Immunotherapy

    2020  Volume 12, Issue 15, Page(s) 1127–1132

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Antibodies, Monoclonal, Humanized/therapeutic use ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/pathology ; Coronavirus Infections/therapy ; Critical Illness ; Cytokine Release Syndrome/pathology ; Cytokine Release Syndrome/therapy ; Female ; Humans ; Immunotherapy ; Middle Aged ; Pandemics ; Pneumonia, Viral/pathology ; Pneumonia, Viral/therapy ; Receptors, Interleukin-6/antagonists & inhibitors ; Respiratory Distress Syndrome/pathology ; Respiratory Distress Syndrome/therapy ; SARS-CoV-2 ; Time-to-Treatment ; Treatment Outcome
    Chemical Substances Antibodies, Monoclonal, Humanized ; Receptors, Interleukin-6 ; tocilizumab (I031V2H011)
    Keywords covid19
    Language English
    Publishing date 2020-07-14
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1750-7448
    ISSN (online) 1750-7448
    DOI 10.2217/imt-2020-0154
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Therapeutic Drug Monitoring of Antifungal Agents in Critically Ill Patients: Is There a Need for Dose Optimisation?

    Baracaldo-Santamaría, Daniela / Cala-Garcia, Juan David / Medina-Rincón, Germán José / Rojas-Rodriguez, Luis Carlos / Calderon-Ospina, Carlos-Alberto

    Antibiotics (Basel, Switzerland)

    2022  Volume 11, Issue 5

    Abstract: Invasive fungal infections are an important cause of morbidity and mortality, especially in critically ill patients. Increasing resistance rates and inadequate antifungal exposure have been documented in these patients, due to clinically relevant ... ...

    Abstract Invasive fungal infections are an important cause of morbidity and mortality, especially in critically ill patients. Increasing resistance rates and inadequate antifungal exposure have been documented in these patients, due to clinically relevant pharmacokinetic (PK) and pharmacodynamic (PD) alterations, leading to treatment failure. Physiological changes such as third spacing (movement of fluid from the intravascular compartment to the interstitial space), hypoalbuminemia, renal failure and hepatic failure, as well as common interventions in the intensive care unit, such as renal replacement therapy and extracorporeal membrane oxygenation, can lead to these PK and PD alterations. Consequently, a therapeutic target concentration that may be useful for one patient may not be appropriate for another. Regular doses do not take into account the important PK variations in the critically ill, and the need to select an effective dose while minimising toxicity advocates for the use of therapeutic drug monitoring (TDM). This review aims to describe the current evidence regarding optimal PK/PD indices associated with the clinical efficacy of the most commonly used antifungal agents in critically ill patients (azoles, echinocandins, lipid complexes of amphotericin B, and flucytosine), provide a comprehensive understanding of the factors affecting the PK of each agent, document the PK parameters of critically ill patients compared to healthy volunteers, and, finally, make recommendations for therapeutic drug monitoring (TDM) of antifungals in critically ill patients.
    Language English
    Publishing date 2022-05-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics11050645
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The Role of Mitochondrial Dysfunction in Idiopathic Pulmonary Fibrosis

    Juan David Cala-Garcia / German Jose Medina-Rincon / Paula Andrea Sierra-Salas / Julio Rojano / Freddy Romero

    Biology, Vol 12, Iss 1237, p

    New Perspectives for a Challenging Disease

    2023  Volume 1237

    Abstract: Mitochondrial biology has always been a relevant field in chronic diseases such as fibrosis or cancer in different organs of the human body, not to mention the strong association between mitochondrial dysfunction and aging. With the development of new ... ...

    Abstract Mitochondrial biology has always been a relevant field in chronic diseases such as fibrosis or cancer in different organs of the human body, not to mention the strong association between mitochondrial dysfunction and aging. With the development of new technologies and the emergence of new methodologies in the last few years, the role of mitochondria in pulmonary chronic diseases such as idiopathic pulmonary fibrosis (IPF) has taken an important position in the field. With this review, we will highlight the latest advances in mitochondrial research on pulmonary fibrosis, focusing on the role of the mitochondria in the aging lung, new proposals for mechanisms that support mitochondrial dysfunction as an important cause for IPF, mitochondrial dysfunction in different cell populations of the lung, and new proposals for treatment of the disease.
    Keywords pulmonary fibrosis ; mitochondria ; mitochondrial dysfunction ; mitochondrial biogenesis ; mitophagy ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Recovery of COVID-19 acute respiratory distress syndrome with tocilizumab: successful outcome in two critically ill patients

    Cala-García, Juan David / Sierra-Bretón, Juan David / Cavelier-Baiz, Jorge Eduardo / Faccini-Martínez, Álvaro A / Pérez-Díaz, Carlos Eduardo

    Immunotherapy

    Abstract: Background: Severe pneumonia and acute respiratory distress syndrome (ARDS) due to COVID-19 is a challenge for nowadays medical practice. Although there is no clarity in the principal mechanism of lung damage and ARDS development, it has been suggested ... ...

    Abstract Background: Severe pneumonia and acute respiratory distress syndrome (ARDS) due to COVID-19 is a challenge for nowadays medical practice. Although there is no clarity in the principal mechanism of lung damage and ARDS development, it has been suggested that one of the main reasons of this pathology is the hyperactivation of the immune system, better known as cytokine storm syndrome. Tocilizumab has been proposed to treat COVID-19 severe cases associated to ARDS. Results & methodology: Here we present two successful cases of tocilizumab administration in two COVID-19 patients with prior administration of antiviral therapy (hydroxychloroquine, azithromycin, lopinavir and ritonavir) with adequate response and resolution of ARDS, septic shock and severe pneumonia within the first 72 h. Discussion & conclusion: This case supports the usage of tocilizumab as an effective therapy in COVID-19 associated cytokine storm syndrome. Further studies should be done in order to assess its effectiveness and security.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #646201
    Database COVID19

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    Inter-library loan at ZB MED

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  6. Article ; Online: Refractory hypophosphatemia following ferric carboxymaltose administration.

    Efe, Orhan / García, Juan David Cala / Mount, David Bruce / Sheridan, Alice Marie

    CEN case reports

    2021  Volume 10, Issue 4, Page(s) 473–475

    Abstract: Hypophosphatemia is a rare side effect of intravenous iron replacement. Urinary phosphate wasting due to increased FGF23 is the most likely mechanism. Here, we present a case of intractable hypophosphatemia in a 32-year-old female patient with history of ...

    Abstract Hypophosphatemia is a rare side effect of intravenous iron replacement. Urinary phosphate wasting due to increased FGF23 is the most likely mechanism. Here, we present a case of intractable hypophosphatemia in a 32-year-old female patient with history of ulcerative colitis (UC), who was primarily hospitalized due to UC flare-up. Her urinary fractional excretion of phosphate was inappropriately elevated at 70%. A careful history revealed that she had been treated with ferric carboxymaltose 2 weeks prior to hospitalization, leading to a diagnosis of iron-induced hypophosphatemia. She was treated with 5 weeks of intravenous sodium phosphate since she did not tolerate oral supplementation. In conclusion, clinicians should be aware of iron-induced hypophosphatemia and be cautious when prescribing intravenous iron.
    MeSH term(s) Administration, Intravenous ; Adult ; Colitis, Ulcerative/complications ; Female ; Ferric Compounds/adverse effects ; Humans ; Hypophosphatemia/chemically induced ; Hypophosphatemia/drug therapy ; Hypophosphatemia/urine ; Maltose/adverse effects ; Maltose/analogs & derivatives ; Phosphates/administration & dosage
    Chemical Substances Ferric Compounds ; Phosphates ; ferric carboxymaltose (6897GXD6OE) ; Maltose (69-79-4) ; sodium phosphate (SE337SVY37)
    Language English
    Publishing date 2021-03-14
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 2660492-9
    ISSN 2192-4449 ; 2192-4449
    ISSN (online) 2192-4449
    ISSN 2192-4449
    DOI 10.1007/s13730-021-00590-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Full protection from SARS-CoV-2 brain infection and damage in susceptible transgenic mice conferred by MVA-CoV2-S vaccine candidate.

    Villadiego, Javier / García-Arriaza, Juan / Ramírez-Lorca, Reposo / García-Swinburn, Roberto / Cabello-Rivera, Daniel / Rosales-Nieves, Alicia E / Álvarez-Vergara, María I / Cala-Fernández, Fernando / García-Roldán, Ernesto / López-Ogáyar, Juan L / Zamora, Carmen / Astorgano, David / Albericio, Guillermo / Pérez, Patricia / Muñoz-Cabello, Ana M / Pascual, Alberto / Esteban, Mariano / López-Barneo, José / Toledo-Aral, Juan José

    Nature neuroscience

    2023  Volume 26, Issue 2, Page(s) 226–238

    Abstract: Vaccines against SARS-CoV-2 have been shown to be safe and effective but their protective efficacy against infection in the brain is yet unclear. Here, in the susceptible transgenic K18-hACE2 mouse model of severe coronavirus disease 2019 (COVID-19), we ... ...

    Abstract Vaccines against SARS-CoV-2 have been shown to be safe and effective but their protective efficacy against infection in the brain is yet unclear. Here, in the susceptible transgenic K18-hACE2 mouse model of severe coronavirus disease 2019 (COVID-19), we report a spatiotemporal description of SARS-CoV-2 infection and replication through the brain. SARS-CoV-2 brain replication occurs primarily in neurons, leading to neuronal loss, signs of glial activation and vascular damage in mice infected with SARS-CoV-2. One or two doses of a modified vaccinia virus Ankara (MVA) vector expressing the SARS-CoV-2 spike (S) protein (MVA-CoV2-S) conferred full protection against SARS-CoV-2 cerebral infection, preventing virus replication in all areas of the brain and its associated damage. This protection was maintained even after SARS-CoV-2 reinfection. These findings further support the use of MVA-CoV2-S as a promising vaccine candidate against SARS-CoV-2/COVID-19.
    MeSH term(s) Mice ; Animals ; Humans ; SARS-CoV-2 ; Mice, Transgenic ; COVID-19 ; COVID-19 Vaccines ; Brain
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2023-01-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1420596-8
    ISSN 1546-1726 ; 1097-6256
    ISSN (online) 1546-1726
    ISSN 1097-6256
    DOI 10.1038/s41593-022-01242-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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