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Article ; Online: Prognostic impact of soluble CD163 in patients with diffuse large B-cell lymphoma.

Vajavaara, Heli / Ekeblad, Frida / Holte, Harald / Jorgensen, Judit / Leivonen, Suvi-Katri / Berglund, Mattias / Kamper, Peter / Moller, Holger J / D'Amore, Francesco / Molin, Daniel / Enblad, Gunilla / Ludvigsen, Maja / Glimelius, Ingrid / Leppa, Sirpa

Haematologica

2021 Volume 106, Issue 9, Page(s) 2502–2506

MeSH term(s)	Antigens, CD ; Antigens, Differentiation, Myelomonocytic ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Humans ; Lymphoma, Large B-Cell, Diffuse/diagnosis ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Prognosis ; Receptors, Cell Surface
Chemical Substances	Antigens, CD ; Antigens, Differentiation, Myelomonocytic ; CD163 antigen ; Receptors, Cell Surface
Language	English
Publishing date	2021-09-01
Publishing country	Italy
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	2333-4
ISSN	1592-8721 ; 0017-6567 ; 0390-6078
ISSN (online)	1592-8721
ISSN	0017-6567 ; 0390-6078
DOI	10.3324/haematol.2020.278182
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Article ; Online: Recent advances in rectal cancer treatment - are we on the right track?

Glimelius, Bengt

Upsala journal of medical sciences

2024 Volume 129

Abstract: Background: Staging and treatment of rectal cancer have evolved over several decades with considerably fewer locoregional recurrences but no marked improved survival since systemic recurrence risks remain virtually unchanged. This development will ... ...

Abstract	Background: Staging and treatment of rectal cancer have evolved over several decades with considerably fewer locoregional recurrences but no marked improved survival since systemic recurrence risks remain virtually unchanged. This development will briefly be summarised followed by a thorough discussion of two recent developments. Methods: A systematic approach towards the literature is aimed at focusing on organ preservation and the delivery of all non-surgical treatments prior to surgery or total neoadjuvant treatment (TNT). Results: Organ preservation, that is to defer surgery if the tumour happens to disappear completely after any pre-treatment given to locally advanced tumours to decrease recurrence risks has increased in popularity and is, if not universally, widely accepted. To give neo-adjuvant treatment to intentionally obtain a clinically complete remission to avoid surgery is practised in some environments but is mostly still experimental. TNT, that is to provide both radiotherapy and chemotherapy aimed at killing microscopic disease in the pelvis or elsewhere has been subject to several trials. Collectively, they show that the chance of achieving a complete response, pathologically or clinically, has approximately doubled, increasing the chance for organ preservation, and the risk of distant metastasis has decreased at least in some trials. The best schedule remains to be established. Conclusions: To obtain substantial progress and also improve survival, the systemic treatments need to be improved even if preoperative delivery is more effective and better tolerated than postoperative. The locoregional treatment may be further optimised through better risk prediction.
MeSH term(s)	Humans ; Rectal Neoplasms/therapy ; Pelvis ; Adjuvants, Pharmaceutic ; Pathologic Complete Response
Chemical Substances	Adjuvants, Pharmaceutic
Language	English
Publishing date	2024-02-21
Publishing country	Sweden
Document type	Journal Article ; Review
ZDB-ID	183949-4
ISSN	2000-1967 ; 0300-9734
ISSN (online)	2000-1967
ISSN	0300-9734
DOI	10.48101/ujms.v129.10537
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Article ; Online: Association of polygenic risk score with the risk of chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis.

Kleinstern, Geffen / Camp, Nicola J / Goldin, Lynn R / Vachon, Celine M / Vajdic, Claire M / de Sanjose, Silvia / Weinberg, J Brice / Benavente, Yolanda / Casabonne, Delphine / Liebow, Mark / Nieters, Alexandra / Hjalgrim, Henrik / Melbye, Mads / Glimelius, Bengt / Adami, Hans-Olov / Boffetta, Paolo / Brennan, Paul / Maynadie, Marc / McKay, James /

Cocco, Pier Luigi / Shanafelt, Tait D / Call, Timothy G / Norman, Aaron D / Hanson, Curtis / Robinson, Dennis / Chaffee, Kari G / Brooks-Wilson, Angela R / Monnereau, Alain / Clavel, Jacqueline / Glenn, Martha / Curtin, Karen / Conde, Lucia / Bracci, Paige M / Morton, Lindsay M / Cozen, Wendy / Severson, Richard K / Chanock, Stephen J / Spinelli, John J / Johnston, James B / Rothman, Nathaniel / Skibola, Christine F / Leis, Jose F / Kay, Neil E / Smedby, Karin E / Berndt, Sonja I / Cerhan, James R / Caporaso, Neil / Slager, Susan L

Blood

2018 Volume 131, Issue 23, Page(s) 2541–2551

Abstract: ... with CLL risk and its precursor, monoclonal B-cell lymphocytosis (MBL). We assessed its validity and ...

Abstract	Inherited loci have been found to be associated with risk of chronic lymphocytic leukemia (CLL). A combined polygenic risk score (PRS) of representative single nucleotide polymorphisms (SNPs) from these loci may improve risk prediction over individual SNPs. Herein, we evaluated the association of a PRS with CLL risk and its precursor, monoclonal B-cell lymphocytosis (MBL). We assessed its validity and discriminative ability in an independent sample and evaluated effect modification and confounding by family history (FH) of hematological cancers. For discovery, we pooled genotype data on 41 representative SNPs from 1499 CLL and 2459 controls from the InterLymph Consortium. For validation, we used data from 1267 controls from Mayo Clinic and 201 CLL, 95 MBL, and 144 controls with a FH of CLL from the Genetic Epidemiology of CLL Consortium. We used odds ratios (ORs) to estimate disease associations with PRS and c-statistics to assess discriminatory accuracy. In InterLymph, the continuous PRS was strongly associated with CLL risk (OR, 2.49;
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; B-Lymphocytes/metabolism ; B-Lymphocytes/pathology ; Female ; Genetic Loci ; Genetic Predisposition to Disease ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/etiology ; Leukemia, Lymphocytic, Chronic, B-Cell/genetics ; Lymphocytosis/complications ; Lymphocytosis/genetics ; Male ; Middle Aged ; Odds Ratio ; Polymorphism, Single Nucleotide ; Risk Factors
Language	English
Publishing date	2018-04-19
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood-2017-11-814608
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Article ; Online: Patients in complete remission after R-CHOP(-like) therapy for diffuse large B-cell lymphoma have limited excess use of health care services in Denmark.

Jakobsen, Lasse Hjort / Øvlisen, Andreas Kiesbye / Severinsen, Marianne Tang / Bæch, Joachim / Kragholm, Kristian Hay / Glimelius, Ingrid / Gang, Anne Ortved / Jørgensen, Judit Mészáros / Frederiksen, Henrik / Poulsen, Christian Bjørn / Clausen, Michael Roost / Pedersen, Per Trøllund / Pedersen, Robert Schou / Torp-Pedersen, Christian / Eloranta, Sandra / El-Galaly, Tarec Christoffer

Blood cancer journal

2022 Volume 12, Issue 1, Page(s) 16

Abstract: For most patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL), R-CHOP ...

Abstract	For most patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL), R-CHOP immunochemotherapy leads to complete remission and 60-70% of patients remain progression-free after 5 years. Given a median age of 65, it is relevant to disentangle how DLBCL and DLBCL therapy influence health care use among the survivors. In this nationwide study, the health care use among Danish DLBCL patients diagnosed in 2007-2015, who achieved complete remission after R-CHOP(-like) therapy, was explored and compared to matched comparators from the Danish general population. The post-remission 5-year risk of hospitalization was significantly higher among DLBCL survivors (55%) compared to matched comparators (49%, P < 0.001). DLBCL survivors had on average 10.3 (9.3-11.3) inpatient bed days within 5 years of response evaluation, whereas matched comparators had 8.4 (7.9-8.8). The rate of outpatient visits was also significantly higher(excluding routine follow-up visits, incidence rate ratio, 1.3, P < 0.001), but translated into only a very small absolute difference of <1 outpatient visits within 5 years between DLBCL survivors (4.2 visits, 95% CI, 4.0-4.4) and matched comparators (3.8 visits, 95% CI, 3.7-3.9). In conclusion, DLBCL survivors have an increased incidence of hospital visits due to a wide range of conditions, but in absolute terms the excess use of health care services in DLBCL survivors was small.
MeSH term(s)	Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cyclophosphamide/therapeutic use ; Delivery of Health Care ; Denmark/epidemiology ; Doxorubicin/therapeutic use ; Female ; Hospitalization ; Humans ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Lymphoma, Large B-Cell, Diffuse/epidemiology ; Male ; Middle Aged ; Outpatients ; Prednisone/therapeutic use ; Remission Induction ; Rituximab/therapeutic use ; Vincristine/therapeutic use ; Young Adult
Chemical Substances	R-CHOP protocol ; Rituximab (4F4X42SYQ6) ; Vincristine (5J49Q6B70F) ; Doxorubicin (80168379AG) ; Cyclophosphamide (8N3DW7272P) ; Prednisone (VB0R961HZT)
Language	English
Publishing date	2022-01-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2600560-8
ISSN	2044-5385 ; 2044-5385
ISSN (online)	2044-5385
ISSN	2044-5385
DOI	10.1038/s41408-022-00614-8
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Article ; Online: Age is the most important predictor of survival in diffuse large B-cell lymphoma patients achieving event-free survival at 24 months: a Swedish population-based study.

Abu Sabaa, Amal / Mörth, Charlott / Hasselblom, Sverker / Hedström, Gustaf / Flogegård, Max / Stern, Mimmi / Andersson, Per-Ola / Glimelius, Ingrid / Enblad, Gunilla

British journal of haematology

2021 Volume 193, Issue 5, Page(s) 906–914

Abstract: Routine follow-up for diffuse large B-cell lymphoma have been shortened to 2 years ...

Abstract	Routine follow-up for diffuse large B-cell lymphoma have been shortened to 2 years when event-free survival at 24 months (EFS24) emerged as a new milestone. In the present study, we aimed to determine whether the achievement of this milestone affected overall survival (OS). We compared OS to that of an age- and sex-matched population, analysed other factors governing OS, and reviewed the causes of death. Data were collected from the Swedish Cancer Registry and from individual patient's records. We included 1169 adult patients from five counties between the years 2001 and 2014. The median (range) age was 64·6 (18-91) years, 56·6% were men and the median follow-up was 82·3 months. For early stages, the achievement of EFS12 did not improve OS. More than two-thirds of the patients (n = 837, 71·6%) achieved EFS24, of which 190 (22·7%) died during follow-up. Lymphoma (20%), cardiovascular disease (22·4%) and malignancies (16%) contributed to causes of death. Patients aged <60 years had an OS that matched the standard population. In multivariate analysis, only age >60 years significantly affected OS after EFS24 compared with the standard population. We concluded that follow-up beyond EFS24 should be considered for patients aged >60 years.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols ; Cyclophosphamide ; Disease-Free Survival ; Doxorubicin ; Female ; Follow-Up Studies ; Humans ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Lymphoma, Large B-Cell, Diffuse/mortality ; Male ; Middle Aged ; Prednisone ; Registries ; Retrospective Studies ; Rituximab ; Survival Rate ; Sweden/epidemiology ; Vincristine
Chemical Substances	R-CHOP protocol ; Rituximab (4F4X42SYQ6) ; Vincristine (5J49Q6B70F) ; Doxorubicin (80168379AG) ; Cyclophosphamide (8N3DW7272P) ; Prednisone (VB0R961HZT)
Language	English
Publishing date	2021-05-05
Publishing country	England
Document type	Clinical Trial ; Comparative Study ; Journal Article ; Multicenter Study
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.17206
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Article: Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma.

Bernatsky, Sasha / Velásquez García, Héctor A / Spinelli, John J / Gaffney, Patrick / Smedby, Karin E / Ramsey-Goldman, Rosalind / Wang, Sophia S / Adami, Hans-Olov / Albanes, Demetrius / Angelucci, Emanuele / Ansell, Stephen M / Asmann, Yan W / Becker, Nikolaus / Benavente, Yolanda / Berndt, Sonja I / Bertrand, Kimberly A / Birmann, Brenda M / Boeing, Heiner / Boffetta, Paolo /

Bracci, Paige M / Brennan, Paul / Brooks-Wilson, Angela R / Cerhan, James R / Chanock, Stephen J / Clavel, Jacqueline / Conde, Lucia / Cotenbader, Karen H / Cox, David G / Cozen, Wendy / Crouch, Simon / De Roos, Anneclaire J / de Sanjose, Silvia / Di Lollo, Simonetta / Diver, W Ryan / Dogan, Ahmet / Foretova, Lenka / Ghesquières, Hervé / Giles, Graham G / Glimelius, Bengt / Habermann, Thomas M / Haioun, Corinne / Hartge, Patricia / Hjalgrim, Henrik / Holford, Theodore R / Holly, Elizabeth A / Jackson, Rebecca D / Kaaks, Rudolph / Kane, Eleanor / Kelly, Rachel S / Klein, Robert J / Kraft, Peter / Kricker, Anne / Lan, Qing / Lawrence, Charles / Liebow, Mark / Lightfoot, Tracy / Link, Brian K / Maynadie, Marc / McKay, James / Melbye, Mads / Molina, Thierry J / Monnereau, Alain / Morton, Lindsay M / Nieters, Alexandra / North, Kari E / Novak, Anne J / Offit, Kenneth / Purdue, Mark P / Rais, Marco / Riby, Jacques / Roman, Eve / Rothman, Nathaniel / Salles, Gilles / Severi, Gianluca / Severson, Richard K / Skibola, Christine F / Slager, Susan L / Smith, Alex / Smith, Martyn T / Southey, Melissa C / Staines, Anthony / Teras, Lauren R / Thompson, Carrie A / Tilly, Hervé / Tinker, Lesley F / Tjonneland, Anne / Turner, Jenny / Vajdic, Claire M / Vermeulen, Roel C H / Vijai, Joseph / Vineis, Paolo / Virtamo, Jarmo / Wang, Zhaoming / Weinstein, Stephanie / Witzig, Thomas E / Zelenetz, Andrew / Zeleniuch-Jacquotte, Anne / Zhang, Yawei / Zheng, Tongzhang / Zucca, Mariagrazia / Clarke, Ann E

Lupus science & medicine

2017 Volume 4, Issue 1, Page(s) e000187

Abstract: Objective: Determinants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are ...

Abstract	Objective: Determinants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genome-wide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL. Methods: GWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls. Data were pooled in a random-effects meta-analysis. Results: Among the 28 SLE-related SNPs investigated, the two most convincingly associated with risk of DLBCL included the CD40 SLE risk allele rs4810485 on chromosome 20q13 (OR per risk allele=1.09, 95% CI 1.02 to 1.16, p=0.0134), and the HLA SLE risk allele rs1270942 on chromosome 6p21.33 (OR per risk allele=1.17, 95% CI 1.01 to 1.36, p=0.0362). Of additional possible interest were rs2205960 and rs12537284. The rs2205960 SNP, related to a cytokine of the tumour necrosis factor superfamily TNFSF4, was associated with an OR per risk allele of 1.07, 95% CI 1.00 to 1.16, p=0.0549. The OR for the rs12537284 (chromosome 7q32, IRF5 gene) risk allele was 1.08, 95% CI 0.99 to 1.18, p=0.0765. Conclusions: These data suggest several plausible genetic links between DLBCL and SLE.
Language	English
Publishing date	2017-11-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2779620-6
ISSN	2053-8790
ISSN	2053-8790
DOI	10.1136/lupus-2016-000187
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Article ; Online: High tumour plasma cell infiltration reflects an important microenvironmental component in classic Hodgkin lymphoma linked to presence of B-symptoms.

Gholiha, Alex R / Hollander, Peter / Hedstrom, Gustaf / Sundstrom, Christer / Molin, Daniel / Smedby, Karin E / Hjalgrim, Henrik / Glimelius, Ingrid / Amini, Rose-Marie / Enblad, Gunilla

British journal of haematology

2018 Volume 184, Issue 2, Page(s) 192–201

Abstract: ... infiltration was associated with the presence of B-symptoms (P = 0·028) and advanced stage, IIB-IVB (P = 0·009 ...

Abstract	Plasma cells are important prognostic actors in different malignancies. The tumour microenvironmental composition in classic Hodgkin lymphoma (cHL) is a major prognostic key element; however, clinicopathological studies regarding plasma cells in cHL are lacking. The aim of this study was to investigate CD138+ (also termed SDC1+) plasma cell and IgG4 producing (IgG4+) plasma cells infiltration in the microenvironment of cHL. Immunohistochemistry with anti-CD138 and IgG4 antibodies was performed on diagnostic tumour biopsies from 124 patients with cHL, on tissue micro array (TMA). In 120 cases, CD138+ plasma cell-infiltration was associated with the presence of B-symptoms (P = 0·028) and advanced stage, IIB-IVB (P = 0·009). In multivariate analysis, CD138+ plasma cells correlated with eosinophil infiltration (P = 0·013). The subgroup of IgG4+ plasma cells was analysed in 122 cases and only correlated to CD138+ plasma cells (P = 0·004). Patients with high proportion of tumour infiltrating CD138+ plasma cells (defined as ≥10%), had a more inferior event-free survival (P = 0·007) and overall survival (P = 0·004) than patients with a low proportion of infiltrating CD138+ plasma cells (<10%), although significance was not maintained in multivariate analysis. In summary, a high proportion of tumour-associated plasma cells in cHL reflect an important component in the microenvironment of cHL.
MeSH term(s)	Adolescent ; Adult ; Aged ; Disease-Free Survival ; Female ; Follow-Up Studies ; Hodgkin Disease/metabolism ; Hodgkin Disease/mortality ; Hodgkin Disease/pathology ; Humans ; Immunoglobulin G/metabolism ; Kaplan-Meier Estimate ; Lymphoma, B-Cell/metabolism ; Lymphoma, B-Cell/mortality ; Lymphoma, B-Cell/pathology ; Male ; Middle Aged ; Neoplasm Proteins/metabolism ; Plasma Cells/metabolism ; Plasma Cells/pathology ; Survival Rate ; Syndecan-1/metabolism ; Tumor Microenvironment
Chemical Substances	Immunoglobulin G ; Neoplasm Proteins ; SDC1 protein, human ; Syndecan-1
Language	English
Publishing date	2018-12-02
Publishing country	England
Document type	Clinical Trial ; Journal Article ; Multicenter Study
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.15703
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Article ; Online: Genetically predicted longer telomere length is associated with increased risk of B-cell lymphoma subtypes.

Machiela, Mitchell J / Lan, Qing / Slager, Susan L / Vermeulen, Roel C H / Teras, Lauren R / Camp, Nicola J / Cerhan, James R / Spinelli, John J / Wang, Sophia S / Nieters, Alexandra / Vijai, Joseph / Yeager, Meredith / Wang, Zhaoming / Ghesquières, Hervé / McKay, James / Conde, Lucia / de Bakker, Paul I W / Cox, David G / Burdett, Laurie /

Monnereau, Alain / Flowers, Christopher R / De Roos, Anneclaire J / Brooks-Wilson, Angela R / Giles, Graham G / Melbye, Mads / Gu, Jian / Jackson, Rebecca D / Kane, Eleanor / Purdue, Mark P / Vajdic, Claire M / Albanes, Demetrius / Kelly, Rachel S / Zucca, Mariagrazia / Bertrand, Kimberly A / Zeleniuch-Jacquotte, Anne / Lawrence, Charles / Hutchinson, Amy / Zhi, Degui / Habermann, Thomas M / Link, Brian K / Novak, Anne J / Dogan, Ahmet / Asmann, Yan W / Liebow, Mark / Thompson, Carrie A / Ansell, Stephen M / Witzig, Thomas E / Tilly, Hervé / Haioun, Corinne / Molina, Thierry J / Hjalgrim, Henrik / Glimelius, Bengt / Adami, Hans-Olov / Roos, Göran / Bracci, Paige M / Riby, Jacques / Smith, Martyn T / Holly, Elizabeth A / Cozen, Wendy / Hartge, Patricia / Morton, Lindsay M / Severson, Richard K / Tinker, Lesley F / North, Kari E / Becker, Nikolaus / Benavente, Yolanda / Boffetta, Paolo / Brennan, Paul / Foretova, Lenka / Maynadie, Marc / Staines, Anthony / Lightfoot, Tracy / Crouch, Simon / Smith, Alex / Roman, Eve / Diver, W Ryan / Offit, Kenneth / Zelenetz, Andrew / Klein, Robert J / Villano, Danylo J / Zheng, Tongzhang / Zhang, Yawei / Holford, Theodore R / Turner, Jenny / Southey, Melissa C / Clavel, Jacqueline / Virtamo, Jarmo / Weinstein, Stephanie / Riboli, Elio / Vineis, Paolo / Kaaks, Rudolph / Boeing, Heiner / Tjønneland, Anne / Angelucci, Emanuele / Di Lollo, Simonetta / Rais, Marco / De Vivo, Immaculata / Giovannucci, Edward / Kraft, Peter / Huang, Jinyan / Ma, Baoshan / Ye, Yuanqing / Chiu, Brian C H / Liang, Liming / Park, Ju-Hyun / Chung, Charles C / Weisenburger, Dennis D / Fraumeni, Joseph F / Salles, Gilles / Glenn, Martha / Cannon-Albright, Lisa / Curtin, Karen / Wu, Xifeng / Smedby, Karin E / de Sanjose, Silvia / Skibola, Christine F / Berndt, Sonja I / Birmann, Brenda M / Chanock, Stephen J / Rothman, Nathaniel

Human molecular genetics

2016 Volume 25, Issue 8, Page(s) 1663–1676

Abstract: ... of the four most common B-cell histologic types and 9562 controls using a genetic risk score (GRS) comprising ... GRS resulted in an association between longer telomere length and increased NHL risk [four B-cell ...

Abstract	Evidence from a small number of studies suggests that longer telomere length measured in peripheral leukocytes is associated with an increased risk of non-Hodgkin lymphoma (NHL). However, these studies may be biased by reverse causation, confounded by unmeasured environmental exposures and might miss time points for which prospective telomere measurement would best reveal a relationship between telomere length and NHL risk. We performed an analysis of genetically inferred telomere length and NHL risk in a study of 10 102 NHL cases of the four most common B-cell histologic types and 9562 controls using a genetic risk score (GRS) comprising nine telomere length-associated single-nucleotide polymorphisms. This approach uses existing genotype data and estimates telomere length by weighing the number of telomere length-associated variant alleles an individual carries with the published change in kb of telomere length. The analysis of the telomere length GRS resulted in an association between longer telomere length and increased NHL risk [four B-cell histologic types combined; odds ratio (OR) = 1.49, 95% CI 1.22-1.82,P-value = 8.5 × 10(-5)]. Subtype-specific analyses indicated that chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL) was the principal NHL subtype contributing to this association (OR = 2.60, 95% CI 1.93-3.51,P-value = 4.0 × 10(-10)). Significant interactions were observed across strata of sex for CLL/SLL and marginal zone lymphoma subtypes as well as age for the follicular lymphoma subtype. Our results indicate that a genetic background that favors longer telomere length may increase NHL risk, particularly risk of CLL/SLL, and are consistent with earlier studies relating longer telomere length with increased NHL risk.
MeSH term(s)	Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Female ; Genetic Association Studies/methods ; Genetic Predisposition to Disease ; Humans ; Lymphoma, B-Cell/genetics ; Lymphoma, B-Cell/pathology ; Male ; Middle Aged ; Prospective Studies ; Telomere/pathology
Language	English
Publishing date	2016-02-09
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	1108742-0
ISSN	1460-2083 ; 0964-6906
ISSN (online)	1460-2083
ISSN	0964-6906
DOI	10.1093/hmg/ddw027
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Article ; Online: Impact of comorbidity on disease characteristics, treatment intent and outcome in diffuse large B-cell lymphoma: a Swedish lymphoma register study.

Wästerlid, T / Mohammadi, M / Smedby, K E / Glimelius, I / Jerkeman, M / Bottai, M / Eloranta, S

Journal of internal medicine

2018 Volume 285, Issue 4, Page(s) 455–468

Abstract: Background: Comorbidity impacts overall survival amongst patients with diffuse large B-cell ...

Abstract	Background: Comorbidity impacts overall survival amongst patients with diffuse large B-cell lymphoma (DLBCL). However, associations of comorbidity with lymphoma characteristics, treatment selection and lymphoma-specific mortality are less well known. Objective: To examine the impact of comorbidity on DLBCL characteristics, treatment intent and cause of death. Methods: We identified 3905 adult patients diagnosed with DLBCL 2007-2013 through the Swedish Lymphoma Register. We assessed comorbid disease history according to the Charlson comorbidity index (CCI). Comorbidity data and causes of death were collected through register linkage. Associations were estimated using multinomial regression and flexible parametric survival models. Results: Overall, 45% of the patients (n = 1737) had a history of at least one comorbidity at DLBCL diagnosis (cardiovascular disease, diabetes and solid cancer were most frequent), and 997 (26%) had a CCI score of ≥2. The relative probability of presenting with poor performance status (PS > 2) was higher amongst comorbid patients [Relative Risk Ratio (RRR) Conclusion: Comorbidity is associated with inferior DLBCL outcome, mainly due to a lower likelihood of receiving treatment with curative intent. Possibly, more comorbid DLBCL patients could be treated with curative intent if comorbid conditions were optimized in parallel.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Cause of Death ; Comorbidity ; Disease-Free Survival ; Female ; Humans ; Lymphoma, Large B-Cell, Diffuse/complications ; Lymphoma, Large B-Cell, Diffuse/epidemiology ; Lymphoma, Large B-Cell, Diffuse/mortality ; Lymphoma, Large B-Cell, Diffuse/therapy ; Male ; Middle Aged ; Registries ; Survival Analysis ; Sweden ; Treatment Outcome ; Young Adult
Language	English
Publishing date	2018-11-08
Publishing country	England
Document type	Journal Article
ZDB-ID	96274-0
ISSN	1365-2796 ; 0954-6820
ISSN (online)	1365-2796
ISSN	0954-6820
DOI	10.1111/joim.12849
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Article ; Online: TOSCA-a delicious Swedish almond cake, an Italian opera and an Italian trial with important new data.

Glimelius, B

Annals of oncology : official journal of the European Society for Medical Oncology

2020 Volume 32, Issue 1, Page(s) 6–8

MeSH term(s)	Chemotherapy, Adjuvant ; Humans ; Italy ; Prunus dulcis ; Sweden/epidemiology
Language	English
Publishing date	2020-11-06
Publishing country	England
Document type	Editorial ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	1025984-3
ISSN	1569-8041 ; 0923-7534
ISSN (online)	1569-8041
ISSN	0923-7534
DOI	10.1016/j.annonc.2020.10.598
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