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Article: Recurrent Acute Otitis Media: What Are the Options for Treatment and Prevention?

Granath, Anna

Current otorhinolaryngology reports

2017 Volume 5, Issue 2, Page(s) 93–100

Abstract: Purpose of review: To survey current strategies for treatment and prevention of recurrent acute otitis media (rAOM).: Recent findings: Treatment with systemic antibiotics is required in recurrent episodes of acute otitis media. A cautious attitude is ...

Abstract	Purpose of review: To survey current strategies for treatment and prevention of recurrent acute otitis media (rAOM). Recent findings: Treatment with systemic antibiotics is required in recurrent episodes of acute otitis media. A cautious attitude is recommended due to antibiotic resistance. Antibiotics also provide effective prophylaxis for rAOM. Topical treatment with ear drops is recommended in rAOM with otorrhea from tympanostomy tubes. Pneumococcal conjugated vaccines seem to have a moderate reductive effect on overall otitis media. The effect on rAOM is still unclear. Different administrations of immunoglobulins have not been effective against rAOM. Breastfeeding had a protective effect against rAOM. A recommendation against cigarette smoke exposure as a measure to prevent otitis seems warranted. An effect for adenoidectomy in children <2 years old with rAOM has been suggested. There is a strong genetic connection with rAOM. Probiotics and nasal spray with Summary: Systemic antibiotics are still needed as treatment against episodes of AOM in rAOM children. There are several preventive measures that can be taken to reduce the burden of AOM but they all have a small-moderate effect. Systemic antibiotics provide effective prophylaxis in rAOM, but must be used with extreme caution due to the emerging antibiotic resistance.
Language	English
Publishing date	2017-05-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ISSN	2167-583X
ISSN	2167-583X
DOI	10.1007/s40136-017-0151-7
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Article ; Online: On the cutting edge: perspectives in bioenergetics.

Granath-Panelo, Melia / Krook, Anna / Rutter, Jared / Kajimura, Shingo

Nature reviews. Endocrinology

2023 Volume 19, Issue 5, Page(s) 250–251

MeSH term(s)	Humans ; Energy Metabolism
Language	English
Publishing date	2023-01-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2489381-X
ISSN	1759-5037 ; 1759-5029
ISSN (online)	1759-5037
ISSN	1759-5029
DOI	10.1038/s41574-023-00820-9
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Article ; Online: Regional variations in the management of primary hyperparathyroidism in Sweden: population-based case-control study.

Thorsteinsson, David / Granath, Fredrik / Bränström, Robert / Koman, Anna / Zedenius, Jan / Nilsson, Inga-Lena

BJS open

2024 Volume 8, Issue 1

Abstract: Background: Substantial disparities in the utilization of parathyroidectomy for primary hyperparathyroidism have been reported. This study aimed to analyse regional variations in parathyroidectomy incidence with respect to the patient's disease burden ... ...

Abstract	Background: Substantial disparities in the utilization of parathyroidectomy for primary hyperparathyroidism have been reported. This study aimed to analyse regional variations in parathyroidectomy incidence with respect to the patient's disease burden and socioeconomic status. Methods: A population-based case-control study included all patients with primary hyperparathyroidism who underwent parathyroidectomy in Sweden between 2008 and 2017 and 10 matched controls. Data on demographic and socioeconomic variables, co-morbidities and drug prescriptions were collected from relevant national registers. Conditional logistic regression was used to analyse predictors of parathyroidectomy. Results: A total of 8626 patients with primary hyperparathyroidism (77% women) underwent parathyroidectomy during the study interval. The annual incidence of parathyroidectomy was 9.0 per 100 000 persons. The annual age-adjusted regional incidences of parathyroidectomy varied between 3.3 and 16.9 operations per 100 000 inhabitants. Except for a small underrepresentation of patients with lower education, no effect of socioeconomic variables was observed. Compared with matched controls, the parathyroidectomy group had increased odds ratios of having developed classical symptoms of primary hyperparathyroidism and being prescribed medication against cardiovascular disorders and psychiatric illness at the time of parathyroidectomy. Increased risks of kidney stones and osteoporosis were observed 5 years before parathyroidectomy. Patients with primary hyperparathyroidism selected for parathyroidectomy from regions with a low incidence of operations had a higher prevalence of kidney stones, osteoporosis and hypertension, as well as larger adenomas and higher calcium levels at the time of parathyroidectomy compared with patients in high-incidence regions. Conclusion: The considerable variation in parathyroidectomy seems more likely associated with different clinical thresholds for detection of primary hyperparathyroidism and referral to surgery than socioeconomic disparities.
MeSH term(s)	Humans ; Female ; Male ; Sweden ; Case-Control Studies ; Hyperparathyroidism, Primary ; Kidney Calculi ; Osteoporosis
Language	English
Publishing date	2024-02-07
Publishing country	England
Document type	Journal Article
ISSN	2474-9842
ISSN (online)	2474-9842
DOI	10.1093/bjsopen/zrad154
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Article ; Online: The pneumococcal conjugate vaccine had a sustained effect on Swedish children 8 years after its introduction.

Alfvén, Tobias / Bennet, Rutger / Granath, Anna / Dennison, Sofia Hultman / Eriksson, Margareta

Acta paediatrica (Oslo, Norway : 1992)

2024 Volume 113, Issue 4, Page(s) 764–770

Abstract: Aim: The pneumococcal conjugate vaccine, which covered seven serotypes of Streptococcus pneumoniae (PCV7), was introduced in Stockholm, Sweden, in 2007. It was replaced by a 13-valent vaccine (PCV13) in 2011. We previously reported a decreased incidence ...

Abstract	Aim: The pneumococcal conjugate vaccine, which covered seven serotypes of Streptococcus pneumoniae (PCV7), was introduced in Stockholm, Sweden, in 2007. It was replaced by a 13-valent vaccine (PCV13) in 2011. We previously reported a decreased incidence of pneumonia and sinusitis among young children 4 years after the introduction of the PCV7. This study followed the incidence of pneumonia, sinusitis, mastoiditis and meningitis for four more years. Methods: We studied validated hospital registry data covering children up to 17 years of age, who were hospitalised in the Stockholm region from 2003 to 2016, when the child population peaked at 485 687. All 11 115 cases diagnosed with pneumonia, coded as bacterial pneumonia, sinusitis, mastoiditis, bacterial meningitis or empyema, were identified. The controls had viral pneumonia or pyelonephritis. Results: The incidence rates for children under 2 years of age hospitalised for sinusitis, mastoiditis and meningitis decreased significantly by 61%-79% during the eight-year post-vaccination period. Hospitalisations for bacterial pneumonia decreased by 19%-25% in the same age group. These changes were probably due to both the vaccines and changes in diagnosis routines. Conclusion: The effect of vaccination on children under 2 years of age was sustained 8 years after the introduction of the pneumococcal conjugate vaccines.
MeSH term(s)	Child ; Humans ; Infant ; Child, Preschool ; Pneumococcal Infections/epidemiology ; Pneumococcal Infections/prevention & control ; Pneumococcal Vaccines ; Heptavalent Pneumococcal Conjugate Vaccine ; Vaccines, Conjugate ; Sweden/epidemiology ; Mastoiditis/epidemiology ; Sinusitis ; Pneumonia, Viral ; Pneumonia, Bacterial ; Meningitis
Chemical Substances	Pneumococcal Vaccines ; Heptavalent Pneumococcal Conjugate Vaccine ; Vaccines, Conjugate
Language	English
Publishing date	2024-01-12
Publishing country	Norway
Document type	Journal Article
ZDB-ID	203487-6
ISSN	1651-2227 ; 0365-1436 ; 0803-5253
ISSN (online)	1651-2227
ISSN	0365-1436 ; 0803-5253
DOI	10.1111/apa.17108
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Article ; Online: Healthcare workers' perceptions of how eHealth applications can support self-care for patients undergoing planned major surgery.

Granath, Anna / Eriksson, Kerstin / Wikström, Lotta

BMC health services research

2022 Volume 22, Issue 1, Page(s) 844

Abstract: Background: In planned major surgery the duration of inpatient hospital care during the last decade has decreased because of a combination of different perioperative interventions. It is expected that patients can manage the needed pre- and ... ...

Abstract	Background: In planned major surgery the duration of inpatient hospital care during the last decade has decreased because of a combination of different perioperative interventions. It is expected that patients can manage the needed pre- and postoperative self-care to a large extent on their own. This entails challenges to healthcare system to deliver appropriate information to patients in a safe and efficient manner. The aim of this study was therefore to describe healthcare workers' perceptions of how eHealth applications can support patients' self-care in relation to planned major surgery. Methods: Semi-structured interviews were performed with sixteen healthcare workers from different disciplines. The interviews were transcribed and analysed using the phenomenography approach. Results: Healthcare workers perceived both positive aspects and challenges with eHealth applications for self-care. eHealth applications can work as an information source, affect patients' understanding of self-care, improve patients' participation in self-care, streamline communication with healthcare professionals and improve patient safety during the pre- and postoperative period. The challenges included perceptions of that eHealth applications may have negative impact on personal interaction in care. eHealth applications may not be useful to all patients because of lack of equipment or knowledge and may increase patients' suffering if physical visits are replaced by digital solutions. Conclusions: This study improves our understanding of healthcare workers' perceptions of how the use of self-care eHealth applications can support patients in performing pre- and postoperative self-care for major surgery. Access to appropriate and personalized information and instructions can improve patients' understanding of self-care and enhance the participation and safety of those who can afford and handle digital tools. All these aspects must be considered in future digital development of eHealth applications to guarantee a person-centered care.
MeSH term(s)	Communication ; Delivery of Health Care ; Health Personnel ; Humans ; Self Care ; Telemedicine
Language	English
Publishing date	2022-06-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2050434-2
ISSN	1472-6963 ; 1472-6963
ISSN (online)	1472-6963
ISSN	1472-6963
DOI	10.1186/s12913-022-08219-4
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Article ; Online: Healthcare workers’ perceptions of how eHealth applications can support self-care for patients undergoing planned major surgery

Anna Granath / Kerstin Eriksson / Lotta Wikström

BMC Health Services Research, Vol 22, Iss 1, Pp 1-

2022 Volume 11

Abstract: Abstract Background In planned major surgery the duration of inpatient hospital care during the last decade has decreased because of a combination of different perioperative interventions. It is expected that patients can manage the needed pre- and ... ...

Abstract	Abstract Background In planned major surgery the duration of inpatient hospital care during the last decade has decreased because of a combination of different perioperative interventions. It is expected that patients can manage the needed pre- and postoperative self-care to a large extent on their own. This entails challenges to healthcare system to deliver appropriate information to patients in a safe and efficient manner. The aim of this study was therefore to describe healthcare workers’ perceptions of how eHealth applications can support patients’ self-care in relation to planned major surgery. Methods Semi-structured interviews were performed with sixteen healthcare workers from different disciplines. The interviews were transcribed and analysed using the phenomenography approach. Results Healthcare workers perceived both positive aspects and challenges with eHealth applications for self-care. eHealth applications can work as an information source, affect patients’ understanding of self-care, improve patients’ participation in self-care, streamline communication with healthcare professionals and improve patient safety during the pre- and postoperative period. The challenges included perceptions of that eHealth applications may have negative impact on personal interaction in care. eHealth applications may not be useful to all patients because of lack of equipment or knowledge and may increase patients’ suffering if physical visits are replaced by digital solutions. Conclusions This study improves our understanding of healthcare workers’ perceptions of how the use of self-care eHealth applications can support patients in performing pre- and postoperative self-care for major surgery. Access to appropriate and personalized information and instructions can improve patients’ understanding of self-care and enhance the participation and safety of those who can afford and handle digital tools. All these aspects must be considered in future digital development of eHealth applications to guarantee a person-centered ...
Keywords	eHealth ; Healthcare workers ; Perceptions ; Major surgery ; Self-care ; Public aspects of medicine ; RA1-1270
Subject code	360
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
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Article ; Online: The Sliding Scale between Usufruct and Ownership

Anna Granath Hansson / Peter Ekbäck / Jenny Paulsson

Land, Vol 10, Iss 311, p

The Example of Swedish Multi-Family Housing

2021 Volume 311

Abstract: This paper aims to elucidate the sliding scale between usufruct and ownership by applying a property rights framework to three Swedish forms of tenure in multifamily housing. The framework deconstructs the bundles of rights of rental, tenant-ownership ... ...

Abstract	This paper aims to elucidate the sliding scale between usufruct and ownership by applying a property rights framework to three Swedish forms of tenure in multifamily housing. The framework deconstructs the bundles of rights of rental, tenant-ownership and ownership to highlight commonalities and differences connected to the right to use and exclude, the right to transfer and the right to the value. It is concluded that the three tenure forms have many traits in common but that there are distinct differences in some areas, most notably in connection to the right to the value. The property rights framework applied in the study may be applicable also on a general level as a method to analyze and compare tenures of different types in different countries. Further, ways to improve the framework and cover more facets of outcomes of property rights patterns are suggested.
Keywords	tenure forms ; property rights ; rental ; tenant-ownership ; ownership ; Agriculture ; S
Subject code	333
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article: Promoting planning for housing development: What can Sweden learn from Germany?

Granath Hansson, Anna

Land use policy. 2017 May, v. 64

2017

Abstract: In the years 2006–2014, urban planning reform was seen as the major remedy against housing shortage in Sweden. The present government has the continuation of such reform on its agenda, but as of yet has made no proposals; instead, other housing policy ... ...

Abstract	In the years 2006–2014, urban planning reform was seen as the major remedy against housing shortage in Sweden. The present government has the continuation of such reform on its agenda, but as of yet has made no proposals; instead, other housing policy measures have been introduced.In light of the uncertainty as to the future course of urban planning reform, possible future steps can be discussed. This article accordingly investigates whether German urban planning law and implementation could provide interesting reference points for discussion of further urban planning reform in Sweden, and if so, what parts of the German experience should be the center of attention.The article covers three aspects of German planning that influence the uncertainty, duration, and cost of residential planning as well as social goals addressed through planning: planning law, focusing on facilitated planning procedures of German planning law, measures taken in the organization of planning authorities to make development planning more efficient, and planning-related city demands for affordable housing.The conclusions encompass proposals for the further reform of the Swedish planning process in the form of a facilitated and accelerated development planning procedure for housing projects, as well as the introduction of private initiative in development planning. Further improvements to the organization and incentives of planning authorities are proposed. More research is required into municipal demands for affordable housing in the form of inclusionary zoning; such research should draw on the extensive international experience of such zoning, relating it to a Swedish pilot project.
Keywords	affordability ; issues and policy ; residential housing ; uncertainty ; urban planning ; zoning ; Germany ; Sweden
Language	English
Dates of publication	2017-05
Size	p. 470-478.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	852476-2
ISSN	0264-8377
ISSN	0264-8377
DOI	10.1016/j.landusepol.2017.03.012
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Oncological outcomes after complete mesocolic excision in right-sided colon cancer: a population-based study.

Bernhoff, Richard / Sjövall, Annika / Granath, Fredrik / Holm, Torbjörn / Martling, Anna / Buchli, Christian

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

2021 Volume 23, Issue 6, Page(s) 1404–1413

Abstract: Aim: Complete mesocolic excision (CME) has been proposed as the preferred surgical technique for resection of colon cancer. This prospective cohort study evaluates the effect of CME surgery on colon cancer mortality after right-sided hemicolectomy on a ... ...

Abstract	Aim: Complete mesocolic excision (CME) has been proposed as the preferred surgical technique for resection of colon cancer. This prospective cohort study evaluates the effect of CME surgery on colon cancer mortality after right-sided hemicolectomy on a population level. Methods: Data from the Swedish Colorectal Cancer Registry and the Cause of Death Registry on all patients treated with elective right-sided hemicolectomy for colon cancer Stages I-III in the Stockholm County 2008-2012 were analysed. Adherence to principles of CME surgery was determined by structured analysis of anonymized surgical reports regarding the presence of five essential features. The exposure to CME was graded as group 0 (not exposed to CME), group 1 (intermediate) and group 2 (exposed to CME). Results: In total, 1171 patients were analysed with 234 (20.0%) patients in CME group 0, 453 (38.7%) patients in CME group 1 and 484 (41.3%) in CME group 2. The 5-year colon cancer mortality was 20.2% in CME group 0, 13.9% in CME group 1 and 13.1% in CME group 2 (P = 0.026). The adjusted hazard ratio for colon cancer mortality was 0.61 (95% CI 0.42-0.91; P = 0.014) for CME group 1 and 0.52 (95% CI 0.35-0.77; P = 0.001) for CME group 2. Discussion: The presence of predefined CME features in surgical reports was related to a graded benefit on cancer-specific mortality after right-sided hemicolectomy for colon cancer Stages I-III.
MeSH term(s)	Colectomy ; Colonic Neoplasms/surgery ; Humans ; Laparoscopy ; Lymph Node Excision ; Mesocolon/surgery ; Prospective Studies
Language	English
Publishing date	2021-03-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1440017-0
ISSN	1463-1318 ; 1462-8910
ISSN (online)	1463-1318
ISSN	1462-8910
DOI	10.1111/codi.15601
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Article ; Online: Evaluation of preclinical formulations for a poorly water-soluble compound.

Granath, Anna-Karin / Sigfridsson, Kalle

International journal of pharmaceutics

2016 Volume 511, Issue 1, Page(s) 630–637

Abstract: One central aim of the present work was to find a robust oral formulation approach for Compound A, both to achieve reliable pharmacodynamic read outs but also for long time safety assessment studies. The compound has low aqueous solubility (0.4μM at 37°C) ...

Abstract	One central aim of the present work was to find a robust oral formulation approach for Compound A, both to achieve reliable pharmacodynamic read outs but also for long time safety assessment studies. The compound has low aqueous solubility (0.4μM at 37°C), is highly lipophilic and has high Caco-2 permeability, i.e. a typical BCS II compound. A nanocrystal formulation, some oil approaches and a fat diet approach were evaluated in vivo in rats. The two latter strategies resulted in significantly higher in vivo exposures after oral administration compared to the nanocrystal approach. For simplicity, and due to the project development program, a food pellet formulation was selected. In addition, tentative data from a subcutaneous study in mice using nanocrystals of the compound are presented, showing extended profiles on the cost of Cmax. Exposure data in monkeys after administration of nanocrystals both intravenously and per oral are presented. When switched from nanocrystals to an oil formulation, the observed oral exposure behavior was similar as observed in rats.
MeSH term(s)	Animals ; Caco-2 Cells ; Drug Administration Routes ; Drug Compounding/methods ; Drug Evaluation, Preclinical/methods ; Female ; Humans ; Macaca fascicularis ; Male ; Mice ; Pharmaceutical Preparations/administration & dosage ; Pharmaceutical Preparations/chemistry ; Pharmaceutical Preparations/metabolism ; Rats ; Rats, Sprague-Dawley ; Rats, Wistar ; Solubility ; Water/administration & dosage ; Water/chemistry ; Water/metabolism
Chemical Substances	Pharmaceutical Preparations ; Water (059QF0KO0R)
Language	English
Publishing date	2016-09-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	428962-6
ISSN	1873-3476 ; 0378-5173
ISSN (online)	1873-3476
ISSN	0378-5173
DOI	10.1016/j.ijpharm.2016.07.041
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