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Article: Objective Non-Invasive Bio-Parametric Evaluation of Regenerated Skin: A Comparison of Two Acellular Dermal Substitutes.

Rampazzo, Silvia / Ferrari, Marco / Sotgiu, Maria Alessandra / Piu, Gabriella / Solinas, Maria Giuliana / Usai, Noemi / Bulla, Antonio / Serra, Pietro Luciano / Grieco, Federica / Montella, Andrea / Mazzarello, Vittorio / Rubino, Corrado

Life (Basel, Switzerland)

2024 Volume 14, Issue 1

Abstract: Several dermal substitutes are available on the market, but there is no precise indication that helps surgeons choose the proper one. Few studies have tried to compare different xenogeneic bioengineered products, but no objective bio-parametric ... ...

Abstract	Several dermal substitutes are available on the market, but there is no precise indication that helps surgeons choose the proper one. Few studies have tried to compare different xenogeneic bioengineered products, but no objective bio-parametric comparison has been made yet. Fifteen patients who underwent skin reconstruction with Integra
Language	English
Publishing date	2024-01-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life14010121
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Article ; Online: Pediatric severe asthma: a case series report and perspectives on anti-IgE treatment.

Mirra, Virginia / Montella, Silvia / Santamaria, Francesca

BMC pediatrics

2018 Volume 18, Issue 1, Page(s) 73

Abstract: Background: The primary goal of asthma management is to achieve disease control for reducing the risk of future exacerbations and progressive loss of lung function. Asthma not responding to treatment may result in significant morbidity. In many children ...

Abstract	Background: The primary goal of asthma management is to achieve disease control for reducing the risk of future exacerbations and progressive loss of lung function. Asthma not responding to treatment may result in significant morbidity. In many children with uncontrolled symptoms, the diagnosis of asthma may be wrong or adherence to treatment may be poor. It is then crucial to distinguish these cases from the truly "severe therapy-resistant" asthmatics by a proper filtering process. Herein we report on four cases diagnosed as difficult asthma, detail the workup that resulted in the ultimate diagnosis, and provide the process that led to the prescription of omalizumab. Case presentation: All children had been initially referred because of asthma not responding to long-term treatment with high-dose inhaled steroids, long-acting β Conclusions: The management of asthma is becoming much more patient-specific, as more and more is learned about the biology behind the development and progression of asthma. The addition of omalizumab, the first targeted biological treatment approved for asthma, has led to renewed optimism in the management of children and adolescents with atopic severe asthma.
MeSH term(s)	Anti-Asthmatic Agents/therapeutic use ; Antibodies, Anti-Idiotypic/therapeutic use ; Asthma/diagnosis ; Asthma/drug therapy ; Child ; Child, Preschool ; Humans ; Male ; Omalizumab/therapeutic use ; Severity of Illness Index
Chemical Substances	Anti-Asthmatic Agents ; Antibodies, Anti-Idiotypic ; anti-IgE antibodies ; Omalizumab (2P471X1Z11)
Language	English
Publishing date	2018-02-21
Publishing country	England
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	2041342-7
ISSN	1471-2431 ; 1471-2431
ISSN (online)	1471-2431
ISSN	1471-2431
DOI	10.1186/s12887-018-1019-9
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Article ; Online: Recurrent Pneumonia in Children: A Reasoned Diagnostic Approach and a Single Centre Experience.

Montella, Silvia / Corcione, Adele / Santamaria, Francesca

International journal of molecular sciences

2017 Volume 18, Issue 2

Abstract: Recurrent pneumonia (RP), i.e., at least two episodes of pneumonia in one year or three episodes ever with intercritical radiographic clearing of densities, occurs in 7.7%-9% of children with community-acquired pneumonia. In RP, the challenge is to ... ...

Abstract	Recurrent pneumonia (RP), i.e., at least two episodes of pneumonia in one year or three episodes ever with intercritical radiographic clearing of densities, occurs in 7.7%-9% of children with community-acquired pneumonia. In RP, the challenge is to discriminate between children with self-limiting or minor problems, that do not require a diagnostic work-up, and those with an underlying disease. The aim of the current review is to discuss a reasoned diagnostic approach to RP in childhood. Particular emphasis has been placed on which children should undergo a diagnostic work-up and which tests should be performed. A pediatric case series is also presented, in order to document a single centre experience of RP. A management algorithm for the approach to children with RP, based on the evidence from a literature review, is proposed. Like all algorithms, it is not meant to replace clinical judgment, but it should drive physicians to adopt a systematic approach to pediatric RP and provide a useful guide to the clinician.
MeSH term(s)	Adolescent ; Age Factors ; Child ; Child, Preschool ; Community-Acquired Infections/diagnosis ; Community-Acquired Infections/epidemiology ; Community-Acquired Infections/etiology ; Comorbidity ; Disease Management ; Female ; Humans ; Infant ; Infant, Newborn ; Italy/epidemiology ; Male ; Pneumonia/diagnosis ; Pneumonia/epidemiology ; Pneumonia/etiology ; Recurrence ; Risk Factors
Language	English
Publishing date	2017-01-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms18020296
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Article ; Online: Recurrent Pneumonia in Children

Silvia Montella / Adele Corcione / Francesca Santamaria

International Journal of Molecular Sciences, Vol 18, Iss 2, p

A Reasoned Diagnostic Approach and a Single Centre Experience

2017 Volume 296

Abstract: Recurrent pneumonia (RP), i.e., at least two episodes of pneumonia in one year or three episodes ever with intercritical radiographic clearing of densities, occurs in 7.7%–9% of children with community-acquired pneumonia. In RP, the challenge is to ... ...

Abstract	Recurrent pneumonia (RP), i.e., at least two episodes of pneumonia in one year or three episodes ever with intercritical radiographic clearing of densities, occurs in 7.7%–9% of children with community-acquired pneumonia. In RP, the challenge is to discriminate between children with self-limiting or minor problems, that do not require a diagnostic work-up, and those with an underlying disease. The aim of the current review is to discuss a reasoned diagnostic approach to RP in childhood. Particular emphasis has been placed on which children should undergo a diagnostic work-up and which tests should be performed. A pediatric case series is also presented, in order to document a single centre experience of RP. A management algorithm for the approach to children with RP, based on the evidence from a literature review, is proposed. Like all algorithms, it is not meant to replace clinical judgment, but it should drive physicians to adopt a systematic approach to pediatric RP and provide a useful guide to the clinician.
Keywords	community-acquired pneumonia ; lower respiratory tract infections ; recurrent pneumonia ; diagnosis ; children ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	610
Language	English
Publishing date	2017-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Long-term assessment of quality of life in primary ciliary dyskinesia: time for new tools?

Maglione, Marco / Montella, Silvia / Mirra, Virginia / Bruzzese, Dario / Santamaria, Francesca

Chest

2014 Volume 146, Issue 6, Page(s) e232–e233

MeSH term(s)	Bronchiectasis/psychology ; Health Status ; Humans ; Psychometrics/methods ; Quality of Life ; Self Report ; Surveys and Questionnaires
Language	English
Publishing date	2014-12
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1378/chest.14-1002
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Article: Congenital Lung Malformations: Unresolved Issues and Unanswered Questions.

Annunziata, Federica / Bush, Andrew / Borgia, Francesco / Raimondi, Francesco / Montella, Silvia / Poeta, Marco / Borrelli, Melissa / Santamaria, Francesca

Frontiers in pediatrics

2019 Volume 7, Page(s) 239

Abstract: Advances in prenatal and postnatal diagnosis, perioperative management, and postoperative care have dramatically increased the number of scientific reports on congenital thoracic malformations (CTM). Nearly all CTM are detected prior to birth, generally ... ...

Abstract	Advances in prenatal and postnatal diagnosis, perioperative management, and postoperative care have dramatically increased the number of scientific reports on congenital thoracic malformations (CTM). Nearly all CTM are detected prior to birth, generally by antenatal ultrasound. After delivery, most infants do well and remain asymptomatic for a long time. However, complications may occur beyond infancy, including in adolescence and adulthood. Prenatal diagnosis is sometimes missed and detection may occur later, either by chance or because of unexplained recurrent or persistent respiratory symptoms or signs, with difficult implications for family counseling and substantial delay in surgical planning. Although landmark studies have been published, postnatal management of asymptomatic children is still controversial and needs a resolution. Our aim is to provide a focused overview on a number of unresolved issues arising from the lack of an evidence-based consensus on the management of patients with CTM. We summarized findings from current literature, with a particular emphasis on the vigorous controversies on the type and timing of diagnostic procedures, treatments and the still obscure relationship between CTM and malignancies, a matter of great concern for both families and physicians. We also present an algorithm for the assessment and follow-up of CTM detected either in the antenatal or postnatal period. A standardized approach across Europe, based on a multidisciplinary team, is urgently needed for achieving an evidence-based management protocol for CTM.
Language	English
Publishing date	2019-06-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2019.00239
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Article ; Online: Chest CTs in primary ciliary dyskinesia: not too few, but not too many!

Maglione, Marco / Montella, Silvia / Santamaria, Francesca

Pediatric pulmonology

2012 Volume 47, Issue 8, Page(s) 733–735

MeSH term(s)	Bronchiectasis/physiopathology ; Disease Progression ; Female ; Humans ; Kartagener Syndrome/physiopathology ; Lung/physiopathology ; Male ; Spirometry ; Tomography, X-Ray Computed
Language	English
Publishing date	2012-08
Publishing country	United States
Document type	Comment ; Journal Article
ZDB-ID	632784-9
ISSN	1099-0496 ; 8755-6863
ISSN (online)	1099-0496
ISSN	8755-6863
DOI	10.1002/ppul.22589
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Article ; Online: Effects of pidotimod and bifidobacteria mixture on clinical symptoms and urinary metabolomic profile of children with recurrent respiratory infections: a randomized placebo-controlled trial.

Santamaria, Francesca / Montella, Silvia / Stocchero, Matteo / Pirillo, Paola / Bozzetto, Sara / Giordano, Giuseppe / Poeta, Marco / Baraldi, Eugenio

Pulmonary pharmacology & therapeutics

2019 Volume 58, Page(s) 101818

Abstract: Background: Many preschool children develop recurrent respiratory tract infections (RRI). Strategies to prevent RRI include the use of immunomodulators as pidotimod or probiotics, but there is limited evidence of their efficacy on clinical features or ... ...

Abstract	Background: Many preschool children develop recurrent respiratory tract infections (RRI). Strategies to prevent RRI include the use of immunomodulators as pidotimod or probiotics, but there is limited evidence of their efficacy on clinical features or on urine metabolic profile. Objective: To evaluate whether pidotimod and/or bifidobacteria can reduce RRI morbidity and influence the urine metabolic profile in preschool children. Materials and methods: Children aged 3-6 years with RRI were enrolled in a four-arm, exploratory, prospective, randomized, double-blinded, placebo-controlled trial. Patients were randomly assigned to receive pidotimod plus bifidobacteria, pidotimod plus placebo, bifidobacteria plus placebo or double placebo for the first 10 days of each month over 4 consecutive months. Respiratory symptoms and infections were recorded with a daily diary by parents during the study. Metabolomic analyses on urine samples collected before and after treatment were performed. Results: Compared to placebo, children receiving pidotimod, alone or with bifidobacteria, had more symptom-free days (69 versus 44, p = 0.003; and 65 versus 44, p = 0.02, respectively) and a lower percentage of days with common cold (17% versus 37%, p = 0.005; and 15% versus 37%, p = 0.004, respectively). The metabolomic analysis showed that children treated with Pidotimod (alone or in combination with bifidobacteria) present, respect to children treated with placebo, a biochemical profile characterized by compounds related to the pathway of steroids hormones, hippuric acid and tryptophan. No significant difference in the metabolic profile was found between children receiving bifidobacteria alone and controls. Conclusions: Preschool children with RRI treated with pidotimod have better clinical outcomes and a different urine metabolomic profile than subjects receiving placebo. Further investigations are needed to clarify the connection between pidotimod and gut microbiome.
MeSH term(s)	Adjuvants, Immunologic/therapeutic use ; Bifidobacterium ; Child ; Child, Preschool ; Female ; Humans ; Placebos ; Pregnancy ; Probiotics/pharmacology ; Prospective Studies ; Pyrrolidonecarboxylic Acid/analogs & derivatives ; Pyrrolidonecarboxylic Acid/therapeutic use ; Respiratory Tract Infections/drug therapy ; Thiazolidines/therapeutic use ; Trial of Labor
Chemical Substances	Adjuvants, Immunologic ; Placebos ; Thiazolidines ; pidotimod (785363R681) ; Pyrrolidonecarboxylic Acid (SZB83O1W42)
Language	English
Publishing date	2019-07-11
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	1399707-5
ISSN	1522-9629 ; 1094-5539
ISSN (online)	1522-9629
ISSN	1094-5539
DOI	10.1016/j.pupt.2019.101818
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Article ; Online: Advances in paediatrics in 2016: current practices and challenges in allergy, autoimmune diseases, cardiology, endocrinology, gastroenterology, infectious diseases, neonatology, nephrology, neurology, nutrition, pulmonology.

Caffarelli, Carlo / Santamaria, Francesca / Di Mauro, Dora / Mastrorilli, Carla / Montella, Silvia / Bernasconi, Sergio

Italian journal of pediatrics

2017 Volume 43, Issue 1, Page(s) 80

Abstract: This review reports main progresses in various pediatric issues published in Italian Journal of Pediatrics and in international journals in 2016. New insights in clinical features or complications of several disorders may be useful for our better ... ...

Abstract	This review reports main progresses in various pediatric issues published in Italian Journal of Pediatrics and in international journals in 2016. New insights in clinical features or complications of several disorders may be useful for our better understanding. They comprise severe asthma, changing features of lupus erythematosus from birth to adolescence, celiac disease, functional gastrointestinal disorders, Moebius syndrome, recurrent pneumonia. Risk factors for congenital heart defects, Kawasaki disease have been widely investigated. New diagnostic tools are available for ascertaining brucellosis, celiac disease and viral infections. The usefulness of aCGH as first-tier test is confirmed in patients with neurodevelopmental disorders. Novel information have been provided on the safety of milk for infants. Recent advances in the treatment of common disorders, including neonatal respiratory distress syndrome, hypo-glycemia in newborns, atopic dermatitis, constipation, cyclic vomiting syndrome, nephrotic syndrome, diabetes mellitus, regurgitation, short stature, secretions in children with cerebral palsy have been reported. Antipyretics treatment has been updated by national guidelines and studies have excluded side effects (e.g. asthma risk during acetaminophen therapy). Vaccinations are a painful event and several options are reported to prevent this pain. Adverse effects due to metabolic abnormalities are reported for second generation antipsychotic drugs.
MeSH term(s)	Allergy and Immunology/trends ; Autoimmune Diseases/diagnosis ; Autoimmune Diseases/therapy ; Cardiology/standards ; Cardiology/trends ; Child ; Child, Preschool ; Endocrinology/standards ; Endocrinology/trends ; Female ; Gastroenterology/standards ; Gastroenterology/trends ; Humans ; Infant ; Infant, Newborn ; Italy ; Male ; Neonatology/standards ; Neonatology/trends ; Nephrology/standards ; Nephrology/trends ; Neurology/standards ; Neurology/trends ; Pediatrics/standards ; Pediatrics/trends ; Practice Patterns, Physicians'/standards ; Practice Patterns, Physicians'/trends ; Quality Improvement
Language	English
Publishing date	2017-09-16
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2088556-8
ISSN	1824-7288 ; 1720-8424
ISSN (online)	1824-7288
ISSN	1720-8424
DOI	10.1186/s13052-017-0401-9
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Article ; Online: Longitudinal Follow-up of Chronic Pulmonary Manifestations in Esophageal Atresia: A Clinical Algorithm and Review of the Literature.

Mirra, Virginia / Maglione, Marco / Di Micco, Laida L / Montella, Silvia / Santamaria, Francesca

Pediatrics and neonatology

2017 Volume 58, Issue 1, Page(s) 8–15

Abstract: In the past decades improved surgical techniques and better neonatal supportive care have resulted in reduced mortality of patients with esophageal atresia (EA), with or without tracheoesophageal fistula, and in increased prevalence of long-term ... ...

Abstract	In the past decades improved surgical techniques and better neonatal supportive care have resulted in reduced mortality of patients with esophageal atresia (EA), with or without tracheoesophageal fistula, and in increased prevalence of long-term complications, especially respiratory manifestations. This integrative review describes the techniques currently used in the pediatric clinical practice for assessing EA-related respiratory disease. We also present a novel algorithm for the evaluation and surveillance of lung disease in EA. A total of 2813 articles were identified, of which 1451 duplicates were removed, and 1330 were excluded based on review of titles and abstracts. A total of 32 articles were assessed for eligibility. Six reviews were excluded, and 26 original studies were assessed. Lower respiratory tract infection seems frequent, especially in the first years of life. Chronic asthma, productive cough, and recurrent bronchitis are the most common respiratory complaints. Restrictive lung disease is generally reported to prevail over the obstructive or mixed patterns, and, overall, bronchial hyperresponsiveness can affect up to 78% of patients. At lung imaging, few studies detected bronchiectasis and irregular cross-sectional shape of the trachea, whereas diffuse bronchial thickening, consolidations, and pleural abnormalities were the main chest X-ray findings. Airway endoscopy is seldom included in the available studies, with tracheomalacia and tracheobronchial inflammation being described in a variable proportion of cases. A complete diagnostic approach to long-term respiratory complications after EA is mandatory. In the presence of moderate-to-severe airway disease, patients should undergo regular tertiary care follow-up with functional assessment and advanced chest imaging.
MeSH term(s)	Algorithms ; Chronic Disease ; Esophageal Atresia/complications ; Esophageal Atresia/physiopathology ; Esophageal Atresia/therapy ; Follow-Up Studies ; Humans ; Lung Diseases/etiology ; Lung Diseases/physiopathology ; Lung Diseases/therapy ; Tracheoesophageal Fistula/complications ; Tracheoesophageal Fistula/physiopathology ; Tracheoesophageal Fistula/therapy
Language	English
Publishing date	2017-02
Publishing country	Singapore
Document type	Journal Article ; Review
ZDB-ID	2441816-X
ISSN	2212-1692 ; 1875-9572
ISSN (online)	2212-1692
ISSN	1875-9572
DOI	10.1016/j.pedneo.2016.03.005
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