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  1. Book: Focus on bradykinin mediated angioedema

    Zuraw, Bruce L. / Bork, Konrad

    (Immunology and allergy clinics of North America ; 30, Suppl. 1)

    2010  

    Title variant Focus on bradykinin-mediated angioedema
    Author's details guest ed. Bruce L. Zuraw. Authors Konrad Bork
    Series title Immunology and allergy clinics of North America ; 30, Suppl. 1
    Collection
    Language English
    Size 63 S. : Ill., graph. Darst.
    Publisher Saunders, a division of Elsevier
    Publishing place Philadelphia, PA
    Publishing country United States
    Document type Book
    HBZ-ID HT016689158
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 710 -30,Suppl.1- verfügbar in Königswinter Königswinter

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  2. Book: Hautkrankheiten in der Praxis

    Bork, Konrad / Bräuninger, Wolfgang

    Diagnostik und Therapie ; mit 6 Tabellen

    2005  

    Author's details Konrad Bork ; Wolfgang Bräuninger
    Keywords Skin Diseases / diagnosis ; Skin Diseases / therapy ; Hautkrankheit
    Subject Dermatose ; Haut ; Hauterkrankung ; Hautkrankheiten
    Language German
    Size X, 291 S. : zahlr. Ill., 280 mm x 210 mm
    Edition 3., aktualisierte und erw. Aufl.
    Publisher Schattauer
    Publishing place Stuttgart u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT014093041
    ISBN 3-7945-2321-0 ; 978-3-7945-2321-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2004 A 4846 order for loan Magazin
    2004 A 7152 order for loan Magazin

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  3. Article ; Online: Angioedema With Normal Complement Studies: What Do We Know?

    Katelaris, Constance H / Grumach, Anete S / Bork, Konrad

    The journal of allergy and clinical immunology. In practice

    2023  Volume 11, Issue 8, Page(s) 2309–2314

    Abstract: Angioedema is generally readily recognizable clinically and is characterized by localized nonpitting edema involving subcutaneous, submucosal, or deep dermal tissue caused by increased vascular permeability and extravasation of intravascular fluid. It ... ...

    Abstract Angioedema is generally readily recognizable clinically and is characterized by localized nonpitting edema involving subcutaneous, submucosal, or deep dermal tissue caused by increased vascular permeability and extravasation of intravascular fluid. It can occur via a variety of mechanisms. A number of clinical conditions (masqueraders) are occasionally mistaken for angioedema. Clinical classification of the various angioedema forms begins with noting the presence or absence of concurrent urticaria or wheals. Pathogenesis can be considered through two broad categories: mast cell-mediated with release of vasoactive mediators causing angioedema usually associated with urticaria or in the context of an anaphylactic reaction; and bradykinin (BK)-driven, in which increased vascular permeability is mediated by BK. BK-mediated angioedema does not occur with urticaria, nor does it respond to antiallergic medications. The various forms of hereditary angioedema are included in this category, requiring specific tests of C4 and C1 inhibitor level and function to confirm the diagnosis. Angiotensin converting enzyme inhibitors, which impair the degradation of BK, account for up to a third of all patients with angioedema presenting to the emergency department. Finally, angioedema may occur by yet unknown mechanisms; under this circumstance, it is difficult to manage.
    MeSH term(s) Humans ; Angioedema/drug therapy ; Urticaria/diagnosis ; Urticaria/drug therapy ; Angioedemas, Hereditary/drug therapy ; Complement C1 Inhibitor Protein/therapeutic use ; Bradykinin/therapeutic use ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use
    Chemical Substances Complement C1 Inhibitor Protein ; Bradykinin (S8TIM42R2W) ; Angiotensin-Converting Enzyme Inhibitors
    Language English
    Publishing date 2023-06-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2023.06.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: A Decade of Change: Recent Developments in Pharmacotherapy of Hereditary Angioedema (HAE).

    Bork, Konrad

    Clinical reviews in allergy & immunology

    2016  Volume 51, Issue 2, Page(s) 183–192

    Abstract: Hereditary angioedema (HAE) due to C1 esterase inhibitor (C1-INH) deficiency (HAE-C1-INH) is a rare but medically significant disease that can be associated with considerable morbidity and mortality. Research into the pathogenesis of HAE-C1-INH has ... ...

    Abstract Hereditary angioedema (HAE) due to C1 esterase inhibitor (C1-INH) deficiency (HAE-C1-INH) is a rare but medically significant disease that can be associated with considerable morbidity and mortality. Research into the pathogenesis of HAE-C1-INH has expanded greatly in the last six decades and has led to new clinical trials with novel therapeutic agents and treatment strategies. Mechanisms of pharmacotherapy include (a) supplementing C1-INH, the missing serine-protease inhibitor in HAE; (b) inhibiting the activation of the contact system and the uncontrolled release of proteases in the kallikrein-kinin system, by blocking the production/function of its components; (c) inhibiting the fibrinolytic system by blocking the production/function of its components; and (d) inhibiting the function of bradykinin at the endothelial level. Strategies for managing HAE-C1-INH are aimed at treating acute attacks, or preventing attacks, through the use of prophylactic treatment. Available agents for treating acute attacks include plasma-derived C1-INH concentrates, a recombinant C1-INH, a bradykinin B2 receptor antagonist, and a plasma kallikrein inhibitor. Long-term prophylactic treatments include attenuated androgens, plasma-derived C1-INH concentrates, and anti-fibrinolytics. Plasma-derived C1-INH and a bradykinin B2 receptor antagonist are already approved for self-administration at home. The number of management options for HAE-C1-INH has increased considerably within the past decade, thus helping to alleviate the burden of this rare disease.
    MeSH term(s) Angioedemas, Hereditary/drug therapy ; Angioedemas, Hereditary/etiology ; Angioedemas, Hereditary/metabolism ; Angioedemas, Hereditary/prevention & control ; Antifibrinolytic Agents/therapeutic use ; Bradykinin Receptor Antagonists/therapeutic use ; Complement C1 Inhibitor Protein/therapeutic use ; Disease Progression ; Humans ; Kallikreins/antagonists & inhibitors ; Kinins/antagonists & inhibitors ; Premedication
    Chemical Substances Antifibrinolytic Agents ; Bradykinin Receptor Antagonists ; Complement C1 Inhibitor Protein ; Kinins ; Kallikreins (EC 3.4.21.-)
    Language English
    Publishing date 2016-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1239045-8
    ISSN 1559-0267 ; 1080-0549
    ISSN (online) 1559-0267
    ISSN 1080-0549
    DOI 10.1007/s12016-016-8544-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1844: Show issues Location:
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  5. Book: The clinical efficacy of mupirocin in the treatment of primary and secondary skin infections

    Bork, Konrad

    (International clinical practice series ; 12)

    1996  

    Author's details ed. by K. Bork
    Series title International clinical practice series ; 12
    Collection
    Keywords Mupirocin / administration & dosage ; Mupirocin / therapeutic use ; Antibiotics / administration & dosage ; Antibiotics / therapeutic use ; Administration, Cutaneous ; Skin Diseases, Infectious / drug therapy
    Language English
    Size 43 S. : graph. Darst.
    Publisher Wells Med
    Publishing place Royal Tunbridge Wells
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT007324004
    ISBN 1-85939-040-4 ; 978-1-85939-040-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1996 A 5594 order for loan Magazin

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  6. Book: Arzneimittelnebenwirkungen an der Haut

    Bork, Konrad

    Klinik - Diagnostik zur Erkennung der auslösenden Medikamente - Pathogenese - Therapie ; mit 90 Tabellen

    1999  

    Author's details K. Bork
    Keywords Hautkrankheit ; Arzneimittelnebenwirkung
    Subject Arzneimittel ; Unerwünschte Arzneimittelwirkung ; UAW ; Dermatose ; Haut ; Hauterkrankung ; Hautkrankheiten
    Language German
    Size XVI, 392 S. : Ill., graph. Darst.
    Edition 2., überarb. und erw. Aufl.
    Publisher Schattauer
    Publishing place Stuttgart u.a.
    Publishing country Germany
    Document type Book
    Old title 1. Aufl. u.d.T. Bork, Konrad: Kutane Arzneimittelnebenwirkungen
    HBZ-ID HT009714813
    ISBN 3-7945-1860-8 ; 978-3-7945-1860-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2004 A 7139 order for loan Magazin

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  7. Book: Haut und Brust

    Bork, Konrad

    dermatologische Aspekte der Brustkrankheiten ; Atlas und Lehrbuch

    1995  

    Author's details Konrad Bork
    Keywords Breast Diseases ; Skin Diseases ; Skin Manifestations ; Mamma ; Hautkrankheit
    Subject Dermatose ; Haut ; Hauterkrankung ; Hautkrankheiten ; Brust ; Busen ; Weibliche Brust
    Language German
    Size XVI, 478 S. : zahlr. Ill.
    Publisher Fischer
    Publishing place Stuttgart u.a.
    Document type Book
    HBZ-ID HT006755050
    ISBN 3-437-11578-2 ; 978-3-437-11578-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2004 A 7227 order for loan Magazin
    1996 A 3019 order for loan Magazin

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  8. Article ; Online: Angioedema.

    Bork, Konrad

    Immunology and allergy clinics of North America

    2014  Volume 34, Issue 1, Page(s) 23–31

    Abstract: Urticarial wheals and angioedema are 2 different clinical symptoms. Both belong to various disease entities, and may occur in combination or be isolated. Increased vasodilation and vasopermeability is a common feature. Histamine and bradykinin are well- ... ...

    Abstract Urticarial wheals and angioedema are 2 different clinical symptoms. Both belong to various disease entities, and may occur in combination or be isolated. Increased vasodilation and vasopermeability is a common feature. Histamine and bradykinin are well-known mediators. For clinical purposes, 3 groups of diseases can be differentiated: diseases with urticaria and angioedema, diseases with angioedema alone, and diseases with urticarial lesions without angioedema. The article presents an overview of these groups and the role of the main mediators, and the clinical features of urticaria and angioedema.
    MeSH term(s) Angioedema/diagnosis ; Angioedema/etiology ; Diagnosis, Differential ; Humans ; Urticaria/diagnosis
    Language English
    Publishing date 2014-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 92606-1
    ISSN 1557-8607 ; 0889-8561
    ISSN (online) 1557-8607
    ISSN 0889-8561
    DOI 10.1016/j.iac.2013.09.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Se 710: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  9. Article ; Online: Pasteurized and nanofiltered, plasma-derived C1 esterase inhibitor concentrate for the treatment of hereditary angioedema.

    Bork, Konrad

    Immunotherapy

    2014  Volume 6, Issue 5, Page(s) 533–551

    Abstract: Hereditary angioedema (HAE) is a relatively rare autosomal dominant disorder that is typically characterized by recurrent episodes of edema in various body locations. It is most commonly caused by an inherited deficiency of functionally active C1 ... ...

    Abstract Hereditary angioedema (HAE) is a relatively rare autosomal dominant disorder that is typically characterized by recurrent episodes of edema in various body locations. It is most commonly caused by an inherited deficiency of functionally active C1 esterase inhibitor (C1-INH). Replacement therapy with a human plasma-derived C1-INH concentrate is recommended for the treatment and prophylaxis of acute attacks of HAE due to C1-INH deficiency (HAE-C1-INH). This article will discuss the current therapies available for the treatment of HAE-C1-INH, latest treatment guidelines, results of several studies demonstrating the efficacy and safety of the plasma-derived, pasteurized and nanofiltered C1-INH concentrate Berinert(®) (CSL Behring GmBH, Marburg, Germany), and future perspectives for the treatment and management of HAE-C1-INH.
    MeSH term(s) Angioedemas, Hereditary/therapy ; Complement C1 Inhibitor Protein/chemistry ; Complement C1 Inhibitor Protein/therapeutic use ; Humans ; Pasteurization/methods ; Plasma/chemistry ; Practice Guidelines as Topic
    Chemical Substances Complement C1 Inhibitor Protein
    Language English
    Publishing date 2014
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1750-7448
    ISSN (online) 1750-7448
    DOI 10.2217/imt.14.33
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Current drugs in early development for hereditary angioedema: potential for effective treatment.

    Bork, Konrad

    Expert opinion on investigational drugs

    2014  Volume 23, Issue 7, Page(s) 887–891

    Abstract: Hereditary angioedema (HAE) through C1 inhibitor deficiency is a rare but important disease. It is characterized by recurrent episodes of angioedema, which commonly affects the skin (in the form of swelling in the extremities, face and genitals) as well ... ...

    Abstract Hereditary angioedema (HAE) through C1 inhibitor deficiency is a rare but important disease. It is characterized by recurrent episodes of angioedema, which commonly affects the skin (in the form of swelling in the extremities, face and genitals) as well as the gastrointestinal tract (abdominal pain attacks). In approximately 1% of cases of angiodema-related swelling, there is obstruction of the upper airway, which is potentially life-threatening. Therefore, HAE due to C1 inhibitor deficiency may be associated with significant morbidity and mortality. Recent research has added to our ever-increasing understanding of the pathogenesis of HAE, which has, in addition, new clinical trials with new therapeutic agents and strategies. The following editorial covers drugs currently under investigation that have the potential to be promising new therapeutic options. While some compounds show promise for the future, there are currently no oral treatments available for the treatment of acute attacks. Furthermore, some of the intravenous therapies currently available require numerous injections and do not always prevent acute attacks. Attenuated androgens also may have problematic side effects, highlighting the need for new treatment options.
    MeSH term(s) Angioedemas, Hereditary/drug therapy ; Angioedemas, Hereditary/metabolism ; Animals ; Complement C1 Inhibitor Protein/metabolism ; Humans ; Treatment Outcome
    Chemical Substances Complement C1 Inhibitor Protein
    Language English
    Publishing date 2014-07
    Publishing country England
    Document type Editorial
    ZDB-ID 1182884-5
    ISSN 1744-7658 ; 0967-8298 ; 1354-3784
    ISSN (online) 1744-7658
    ISSN 0967-8298 ; 1354-3784
    DOI 10.1517/13543784.2014.916275
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3739: Show issues Location:
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