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Article: Efficient C–C Bond Formation between Two Levulinic Acid Molecules To Produce C10 Compounds with the Cooperation Effect of Lewis and Brønsted Acids

Li, Zheng / Chunyan Chen / Hongliang Wang / Jiaojiao Zhang / Junli Xu / Michael Martin Nielsen / Tiansheng Deng / Xianglin Hou / Yingxiong Wang

ACS sustainable chemistry & engineering. 2018 Apr. 06, v. 6, no. 5

2018

Abstract: An original route for levulinic acid (LA) conversion was achieved via C–C bond formation in a co ... catalysis system containing Lewis and Brønsted acids. Different from conventional base-catalyzed processes ...

Abstract	An original route for levulinic acid (LA) conversion was achieved via C–C bond formation in a co-catalysis system containing Lewis and Brønsted acids. Different from conventional base-catalyzed processes, this acidic reaction system inhibits the carboxylic acid from deactivating the base catalyst, additionally simplifies the technical processes. The synergistic effect of the two types of acids effeciently catalyzed the dimerization reaction of LA to generate two C10 compounds, tetrahydro-2-methyl-5,γ-dioxo-2-furanpentanoic acid and 3-(2-methyl-5-oxo-tetrahydrofuran-2-yl)-4-oxopentanoic acid, with the total yield of 50.9% at 59.7% conversion. These products present high added value as fuel or fine chemical precursors.
Keywords	Bronsted acids ; catalysts ; chemical bonding ; dimerization ; fuels ; levulinic acid ; synergism
Language	English
Dates of publication	2018-0406
Size	p. 5708-5711.
Publishing place	American Chemical Society
Document type	Article
ISSN	2168-0485
DOI	10.1021/acssuschemeng.7b04621
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Widely tunable cavity-enhanced frequency combs.

Silfies, Myles C / Kowzan, Grzegorz / Chen, Yuning / Lewis, Neomi / Hou, Ryan / Baehre, Robin / Gross, Tobias / Allison, Thomas K

Optics letters

2020 Volume 45, Issue 7, Page(s) 2123–2126

Abstract: We describe the cavity enhancement of frequency combs over a wide tuning range of 450-700 nm (${ \gt }7900\;{{\rm cm}^{ - 1}} $> ... ...

Abstract	We describe the cavity enhancement of frequency combs over a wide tuning range of 450-700 nm (${ \gt }7900\;{{\rm cm}^{ - 1}} $>7900cm
Language	English
Publishing date	2020-04-01
Publishing country	United States
Document type	Journal Article
ISSN	1539-4794
ISSN (online)	1539-4794
DOI	10.1364/OL.389412
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Article ; Online: A blood-based prognostic biomarker in IBD.

Biasci, Daniele / Lee, James C / Noor, Nurulamin M / Pombal, Diana R / Hou, Monica / Lewis, Nina / Ahmad, Tariq / Hart, Ailsa / Parkes, Miles / McKinney, Eoin F / Lyons, Paul A / Smith, Kenneth G C

Gut

2019 Volume 68, Issue 8, Page(s) 1386–1395

Abstract: Objective: We have previously described a prognostic transcriptional signature in CD8 T cells that separates patients with IBD into two phenotypically distinct subgroups, termed IBD1 and IBD2. Here we sought to develop a blood-based test that could ... ...

Abstract	Objective: We have previously described a prognostic transcriptional signature in CD8 T cells that separates patients with IBD into two phenotypically distinct subgroups, termed IBD1 and IBD2. Here we sought to develop a blood-based test that could identify these subgroups without cell separation, and thus be suitable for clinical use in Crohn's disease (CD) and ulcerative colitis (UC). Design: Patients with active IBD were recruited before treatment. Transcriptomic analyses were performed on purified CD8 T cells and/or whole blood. Phenotype data were collected prospectively. IBD1/IBD2 patient subgroups were identified by consensus clustering of CD8 T cell transcriptomes. In a training cohort, machine learning was used to identify groups of genes ('classifiers') whose differential expression in whole blood recreated the IBD1/IBD2 subgroups. Genes from the best classifiers were quantitative (q)PCR optimised, and further machine learning was used to identify the optimal qPCR classifier, which was locked down for further testing. Independent validation was sought in separate cohorts of patients with CD (n=66) and UC (n=57). Results: In both validation cohorts, a 17-gene qPCR-based classifier stratified patients into two distinct subgroups. Irrespective of the underlying diagnosis, IBDhi patients (analogous to the poor prognosis IBD1 subgroup) experienced significantly more aggressive disease than IBDlo patients (analogous to IBD2), with earlier need for treatment escalation (hazard ratio=2.65 (CD), 3.12 (UC)) and more escalations over time (for multiple escalations within 18 months: sensitivity=72.7% (CD), 100% (UC); negative predictive value=90.9% (CD), 100% (UC)). Conclusion: This is the first validated prognostic biomarker that can predict prognosis in newly diagnosed patients with IBD and represents a step towards personalised therapy.
MeSH term(s)	Adult ; Biomarkers/blood ; CD8-Positive T-Lymphocytes/metabolism ; Colitis, Ulcerative/blood ; Colitis, Ulcerative/diagnosis ; Crohn Disease/blood ; Crohn Disease/diagnosis ; Diagnosis, Differential ; Female ; Gene Expression ; Gene Expression Profiling/methods ; Humans ; Machine Learning ; Male ; Middle Aged ; Phenotype ; Predictive Value of Tests ; Prognosis ; Reproducibility of Results ; Sensitivity and Specificity ; Severity of Illness Index
Chemical Substances	Biomarkers
Language	English
Publishing date	2019-04-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80128-8
ISSN	1468-3288 ; 0017-5749
ISSN (online)	1468-3288
ISSN	0017-5749
DOI	10.1136/gutjnl-2019-318343
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Article ; Online: Targeting EphA2 suppresses hepatocellular carcinoma initiation and progression by dual inhibition of JAK1/STAT3 and AKT signaling.

Wang, Hao / Hou, Wei / Perera, Aldeb / Bettler, Carlee / Beach, Jordan R / Ding, Xianzhong / Li, Jun / Denning, Mitchell F / Dhanarajan, Asha / Cotler, Scott J / Joyce, Cara / Yin, Jun / Ahmed, Fowsiyo / Roberts, Lewis R / Qiu, Wei

Cell reports

2021 Volume 34, Issue 8, Page(s) 108765

Abstract: Hepatocellular carcinoma (HCC) remains one of the deadliest malignancies worldwide. One major obstacle to treatment is a lack of effective molecular-targeted therapies. In this study, we find that EphA2 expression and signaling are enriched in human HCC ... ...

Abstract	Hepatocellular carcinoma (HCC) remains one of the deadliest malignancies worldwide. One major obstacle to treatment is a lack of effective molecular-targeted therapies. In this study, we find that EphA2 expression and signaling are enriched in human HCC and associated with poor prognosis. Loss of EphA2 suppresses the initiation and growth of HCC both in vitro and in vivo. Furthermore, CRISPR/CAS9-mediated EphA2 inhibition significantly delays tumor development in a genetically engineered murine model of HCC. Mechanistically, we discover that targeting EphA2 suppresses both AKT and JAK1/STAT3 signaling, two separate oncogenic pathways in HCC. We also identify a small molecule kinase inhibitor of EphA2 that suppresses tumor progression in a murine HCC model. Together, our results suggest EphA2 as a promising therapeutic target for HCC.
MeSH term(s)	Animals ; Antineoplastic Agents/pharmacology ; Benzamides/pharmacology ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/enzymology ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/pathology ; Cell Line, Tumor ; Databases, Genetic ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Janus Kinase 1/genetics ; Janus Kinase 1/metabolism ; Liver Neoplasms/drug therapy ; Liver Neoplasms/enzymology ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; Male ; Mice, Inbred C57BL ; Molecular Targeted Therapy ; Niacinamide/analogs & derivatives ; Niacinamide/pharmacology ; Phosphorylation ; Proto-Oncogene Proteins c-akt/metabolism ; Receptor, EphA2/antagonists & inhibitors ; Receptor, EphA2/genetics ; Receptor, EphA2/metabolism ; Retrospective Studies ; STAT3 Transcription Factor/genetics ; STAT3 Transcription Factor/metabolism ; Signal Transduction ; Tumor Burden/drug effects ; Xenograft Model Antitumor Assays ; Mice
Chemical Substances	ALW-II-41-27 ; Antineoplastic Agents ; Benzamides ; EPHA2 protein, human ; STAT3 Transcription Factor ; STAT3 protein, human ; Stat3 protein, mouse ; Niacinamide (25X51I8RD4) ; Receptor, EphA2 (EC 2.7.10.1) ; JAK1 protein, human (EC 2.7.10.2) ; Jak1 protein, mouse (EC 2.7.10.2) ; Janus Kinase 1 (EC 2.7.10.2) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2021-02-24
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2021.108765
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Article ; Online: Physical, Psychological, and Social Outcomes in Pediatric Burn Survivors Ages 5 to 18 Years: A Systematic Review.

Patel, Khushbu F / Rodríguez-Mercedes, Silvanys L / Grant, Gabrielle G / Rencken, Camerin A / Kinney, Erin M / Austen, Amelia / Hou, Carina / Brady, Keri J S / Schneider, Jeffrey C / Kazis, Lewis E / Ryan, Colleen M

Journal of burn care & research : official publication of the American Burn Association

2021 Volume 43, Issue 2, Page(s) 343–352

Abstract: Acute pediatric burn injuries often result in chronic sequelae that affect physical, psychological, and social outcomes. To date, no review has comprehensively reported on the impact of burn injuries across all three domains in school-aged children. The ... ...

Abstract	Acute pediatric burn injuries often result in chronic sequelae that affect physical, psychological, and social outcomes. To date, no review has comprehensively reported on the impact of burn injuries across all three domains in school-aged children. The aim of this systematic review was to identify published literature that focuses on the impact of burn injuries on physical, psychological, or social functioning, and report upon the nature of study characteristics and their outcomes. We included literature published after 1980, focusing on burn outcomes in children aged 5 to 18 years. Each eligible study was systematically reviewed and primary outcomes were classified into outcome domains based on existing frameworks. Fifty-eight studies met inclusion criteria, and reported on physical (n = 24), psychological (n = 47), and social (n = 29) domains. The majority of the studies had sample sizes of <100 participants, burn size of <40%, and findings reported by parents and/or burn survivors. Only eight of 107 different measures were used in three or more studies. Parents and burn survivors generally reported better physical and social outcomes and worse psychological functioning compared to non-burn populations. Physical disabilities were associated with psychological and social functioning in several studies. Follow-up data reported improvements across domains. This review demonstrates the importance of physical, psychological, and social status as long-term outcomes in burn survivors. Mixed findings across three outcome domains warrant long-term research. Findings of this review will guide the foundation of comprehensive burn and age-specific instruments to assess burn recovery.
MeSH term(s)	Burns/psychology ; Burns/therapy ; Child ; Disabled Persons ; Humans ; Parents ; Quality of Life ; Survivors/psychology
Language	English
Publishing date	2021-12-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Systematic Review
ZDB-ID	2224246-6
ISSN	1559-0488 ; 1559-047X
ISSN (online)	1559-0488
ISSN	1559-047X
DOI	10.1093/jbcr/irab225
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Zs.A 6223: Show issues

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Article ; Online: Biomimetic human small muscular pulmonary arteries.

Jin, Qianru / Bhatta, Anil / Pagaduan, Jayson V / Chen, Xing / West-Foyle, Hoku / Liu, Jiayu / Hou, Annie / Berkowitz, Dan / Kuo, Scot C / Askin, Frederic B / Nguyen, Thao D / Gracias, David H / Romer, Lewis H

Science advances

2020 Volume 6, Issue 13, Page(s) eaaz2598

Abstract: Changes in structure and function of small muscular arteries play a major role in the pathophysiology of pulmonary hypertension, a burgeoning public health challenge. Improved anatomically mimetic in vitro models of these microvessels are urgently needed ...

Abstract	Changes in structure and function of small muscular arteries play a major role in the pathophysiology of pulmonary hypertension, a burgeoning public health challenge. Improved anatomically mimetic in vitro models of these microvessels are urgently needed because nonhuman vessels and previous models do not accurately recapitulate the microenvironment and architecture of the human microvascular wall. Here, we describe parallel biofabrication of photopatterned self-rolled biomimetic pulmonary arterial microvessels of tunable size and infrastructure. These microvessels feature anatomically accurate layering and patterning of aligned human smooth muscle cells, extracellular matrix, and endothelial cells and exhibit notable increases in endothelial longevity and nitric oxide production. Computational image processing yielded high-resolution 3D perspectives of cells and proteins. Our studies provide a new paradigm for engineering multicellular tissues with precise 3D spatial positioning of multiple constituents in planar moieties, providing a biomimetic platform for investigation of microvascular pathobiology in human disease.
MeSH term(s)	Algorithms ; Biomarkers ; Biomimetics ; Cells, Cultured ; Coculture Techniques ; Humans ; Mechanical Phenomena ; Models, Theoretical ; Muscle, Smooth ; Myocytes, Smooth Muscle/metabolism ; Pulmonary Artery ; Signal Transduction ; Tissue Engineering/methods
Chemical Substances	Biomarkers
Language	English
Publishing date	2020-03-25
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.aaz2598
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Article: Whole Genome Sequencing Based Analysis of Inflammation Biomarkers in the Trans-Omics for Precision Medicine (TOPMed) Consortium.

Jiang, Min-Zhi / Gaynor, Sheila M / Li, Xihao / Van Buren, Eric / Stilp, Adrienne / Buth, Erin / Wang, Fei Fei / Manansala, Regina / Gogarten, Stephanie M / Li, Zilin / Polfus, Linda M / Salimi, Shabnam / Bis, Joshua C / Pankratz, Nathan / Yanek, Lisa R / Durda, Peter / Tracy, Russell P / Rich, Stephen S / Rotter, Jerome I /

Mitchell, Braxton D / Lewis, Joshua P / Psaty, Bruce M / Pratte, Katherine A / Silverman, Edwin K / Kaplan, Robert C / Avery, Christy / North, Kari / Mathias, Rasika A / Faraday, Nauder / Lin, Honghuang / Wang, Biqi / Carson, April P / Norwood, Arnita F / Gibbs, Richard A / Kooperberg, Charles / Lundin, Jessica / Peters, Ulrike / Dupuis, Josée / Hou, Lifang / Fornage, Myriam / Benjamin, Emelia J / Reiner, Alexander P / Bowler, Russell P / Lin, Xihong / Auer, Paul L / Raffield, Laura M

bioRxiv : the preprint server for biology

2023

Abstract: Inflammation biomarkers can provide valuable insight into the role of inflammatory processes in many diseases and conditions. Sequencing based analyses of such biomarkers can also serve as an exemplar of the genetic architecture of quantitative traits. ... ...

Abstract	Inflammation biomarkers can provide valuable insight into the role of inflammatory processes in many diseases and conditions. Sequencing based analyses of such biomarkers can also serve as an exemplar of the genetic architecture of quantitative traits. To evaluate the biological insight, which can be provided by a multi-ancestry, whole-genome based association study, we performed a comprehensive analysis of 21 inflammation biomarkers from up to 38,465 individuals with whole-genome sequencing from the Trans-Omics for Precision Medicine (TOPMed) program. We identified 22 distinct single-variant associations across 6 traits - E-selectin, intercellular adhesion molecule 1, interleukin-6, lipoprotein-associated phospholipase A2 activity and mass, and P-selectin - that remained significant after conditioning on previously identified associations for these inflammatory biomarkers. We further expanded upon known biomarker associations by pairing the single-variant analysis with a rare variant set-based analysis that further identified 19 significant rare variant set-based associations with 5 traits. These signals were distinct from both significant single variant association signals within TOPMed and genetic signals observed in prior studies, demonstrating the complementary value of performing both single and rare variant analyses when analyzing quantitative traits. We also confirm several previously reported signals from semi-quantitative proteomics platforms. Many of these signals demonstrate the extensive allelic heterogeneity and ancestry-differentiated variant-trait associations common for inflammation biomarkers, a characteristic we hypothesize will be increasingly observed with well-powered, large-scale analyses of complex traits.
Language	English
Publishing date	2023-09-12
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.09.10.555215
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Article ; Online: The origin of suspended particulate matter in the Great Barrier Reef.

Bahadori, Mohammad / Chen, Chengrong / Lewis, Stephen / Wang, Juntao / Shen, Jupei / Hou, Enqing / Rashti, Mehran Rezaei / Huang, Qiaoyun / Bainbridge, Zoe / Stevens, Tom

Nature communications

2023 Volume 14, Issue 1, Page(s) 5629

Abstract: River run-off has long been regarded as the largest source of organic-rich suspended particulate matter (SPM) in the Great Barrier Reef (GBR), contributing to high turbidity, pollutant exposure and increasing vulnerability of coral reef to climate change. ...

Abstract	River run-off has long been regarded as the largest source of organic-rich suspended particulate matter (SPM) in the Great Barrier Reef (GBR), contributing to high turbidity, pollutant exposure and increasing vulnerability of coral reef to climate change. However, the terrestrial versus marine origin of the SPM in the GBR is uncertain. Here we provide multiple lines of evidence (
MeSH term(s)	Biological Transport ; Climate Change ; Coral Reefs ; Environmental Pollutants ; Particulate Matter
Chemical Substances	Environmental Pollutants ; Particulate Matter
Language	English
Publishing date	2023-09-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-41183-z
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Article ; Online: Substitution of PINK1 Gly411 modulates substrate receptivity and turnover.

Fiesel, Fabienne C / Fričová, Dominika / Hayes, Caleb S / Coban, Mathew A / Hudec, Roman / Bredenberg, Jenny M / Broadway, Benjamin J / Markham, Briana N / Yan, Tingxiang / Boneski, Paige K / Fiorino, Gabriella / Watzlawik, Jens O / Hou, Xu / McCarty, Arthur M / Lewis-Tuffin, Laura J / Zhong, Jun / Madden, Benjamin J / Ordureau, Alban / An, Heeseon /

Puschmann, Andreas / Wszolek, Zbigniew K / Ross, Owen A / Harper, J Wade / Caulfield, Thomas R / Springer, Wolfdieter

Autophagy

2022 Volume 19, Issue 6, Page(s) 1711–1732

Abstract: The ubiquitin (Ub) kinase-ligase pair PINK1-PRKN mediates the degradation of damaged mitochondria by macroautophagy/autophagy (mitophagy). PINK1 surveils mitochondria and upon stress accumulates on the mitochondrial surface where it phosphorylates serine ...

Abstract	The ubiquitin (Ub) kinase-ligase pair PINK1-PRKN mediates the degradation of damaged mitochondria by macroautophagy/autophagy (mitophagy). PINK1 surveils mitochondria and upon stress accumulates on the mitochondrial surface where it phosphorylates serine 65 of Ub to activate PRKN and to drive mitochondrial turnover. While loss of either PINK1 or PRKN is genetically linked to Parkinson disease (PD) and activating the pathway seems to have great therapeutic potential, there is no formal proof that stimulation of mitophagy is always beneficial. Here we used biochemical and cell biological methods to study single nucleotide variants in the activation loop of PINK1 to modulate the enzymatic function of this kinase. Structural modeling and
MeSH term(s)	Humans ; Protein Kinases/genetics ; Protein Kinases/metabolism ; Parkinson Disease/genetics ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism ; Autophagy ; Ubiquitin/metabolism
Chemical Substances	Protein Kinases (EC 2.7.-) ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; Ubiquitin
Language	English
Publishing date	2022-12-05
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2454135-7
ISSN	1554-8635 ; 1554-8627
ISSN (online)	1554-8635
ISSN	1554-8627
DOI	10.1080/15548627.2022.2151294
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Zs.A 6741: Show issues

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Article ; Online: Bakuchiol inhibits lung cancer by modulating tumor microenvironment and the expression of PD-L1.

Lin, Mengxin / Xu, Qian / Luo, Yang / Liu, Gaohua / Hou, Peifeng

Journal of biochemical and molecular toxicology

2023 Volume 37, Issue 9, Page(s) e23401

Abstract: ... inoculating murine Lewis lung carcinoma (LLC) cells. BAK of 5 to 40 mg/kg was used for treatment in vivo ...

Abstract	Immune checkpoint therapy is an emerging frontier in cancer therapy. With the aim to develop an efficient herb derived compound to facilitate immune checkpoint therapy, here we investigate if a herb-derived compound, Bakuchiol (BAK), can be used to treat lung cancer and elucidate if BAK could serve as a PD-L1 regulator. To this end, a murine lung cancer model was established by subcutaneously inoculating murine Lewis lung carcinoma (LLC) cells. BAK of 5 to 40 mg/kg was used for treatment in vivo for 15 days. On Day 15, the population of CD4+ and CD8+ T cells, Treg cells. BAK could effectively inhibit tumor growth by starting treatment either on Day 0 or 6 after tumor inoculation at doses of 5-40 mg/kg. BAK treatment increased the population of cytotoxic immune cells (i.e., CD8+ T cells, and M1 macrophages), meanwhile decreasing pro-tumor immune cells (i.e., CD3+ T cells, Treg cells, and M2 macrophages). Anti-inflammatory cytokines, including IL1β, IL2, IFNγ, TNF-α, IL4 and IL10 were upregulated by BAK. PD-L1 expression in the tumor was also lowered by BAK. AKT and STAT3 signaling were inhibited by BAK. BAK is an efficient agent in reducing LLC tumor growth. These data support the potential of BAK as a new drug for treating lung cancer by serving as a PD-L1 inhibitor that suppresses the activation of AKT and STAT3.
MeSH term(s)	Humans ; Animals ; Mice ; Proto-Oncogene Proteins c-akt/metabolism ; B7-H1 Antigen ; Tumor Microenvironment ; Cell Line, Tumor ; Lung Neoplasms/drug therapy ; Lung Neoplasms/metabolism
Chemical Substances	bakuchiol (OT12HJU3AR) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; B7-H1 Antigen
Language	English
Publishing date	2023-06-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	1410020-4
ISSN	1099-0461 ; 1095-6670
ISSN (online)	1099-0461
ISSN	1095-6670
DOI	10.1002/jbt.23401
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